{"id":"https://openalex.org/W2004180574","doi":"https://doi.org/10.1016/j.bbmt.2009.12.147","title":"Addition Of Bortezemib To High Dose Melphalan Does Not Improve Response Rate Or Progression-Free Survival","display_name":"Addition Of Bortezemib To High Dose Melphalan Does Not Improve Response Rate Or Progression-Free Survival","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W2004180574","doi":"https://doi.org/10.1016/j.bbmt.2009.12.147","mag":"2004180574"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbmt.2009.12.147","doi":"https://doi.org/10.1016/j.bbmt.2009.12.147","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2009.12.147","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbmt.2009.12.147","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101836399","display_name":"Manish R. Sharma","orcid":"https://orcid.org/0000-0002-6711-1552","observed_orcids":["https://orcid.org/0000-0002-6711-1552"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Sharma","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015342719","display_name":"Muzaffar H. Qazilbash","orcid":"https://orcid.org/0000-0003-2876-2886","observed_orcids":["https://orcid.org/0000-0003-2876-2886"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.H. Qazilbash","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050962913","display_name":"Chitra M. Hosing","orcid":"https://orcid.org/0000-0003-0409-5556","observed_orcids":["https://orcid.org/0000-0003-0409-5556"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.M. Hosing","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002347804","display_name":"Peter F. Thall","orcid":"https://orcid.org/0000-0002-7293-529X","observed_orcids":["https://orcid.org/0000-0002-7293-529X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.F. Thall","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113997812","display_name":"Floralyn L. Mendoza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.L. Mendoza","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001231771","display_name":"Eric Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Han","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027513506","display_name":"M. Wang","orcid":"https://orcid.org/0009-0000-9433-392X","observed_orcids":["https://orcid.org/0009-0000-9433-392X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Wang","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108104588","display_name":"Jatin J. Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Shah","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034104852","display_name":"Amin Majid Alousi","orcid":"https://orcid.org/0000-0002-2498-8573","observed_orcids":["https://orcid.org/0000-0002-2498-8573"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.M. Alousi","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083279961","display_name":"Paolo N. Anderlini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Anderlini","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069460930","display_name":"Partow Kebriaei","orcid":"https://orcid.org/0000-0002-8607-9404","observed_orcids":["https://orcid.org/0000-0002-8607-9404"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Kebriaei","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033737136","display_name":"Issa F. Khouri","orcid":"https://orcid.org/0000-0003-2473-911X","observed_orcids":["https://orcid.org/0000-0003-2473-911X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I.F. Khouri","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066894053","display_name":"Uday Popat","orcid":"https://orcid.org/0000-0002-7592-2224","observed_orcids":["https://orcid.org/0000-0002-7592-2224"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U.R. Popat","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034264716","display_name":"Marcos J. G. De Lima","orcid":"https://orcid.org/0000-0002-8568-4522","observed_orcids":["https://orcid.org/0000-0002-8568-4522"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. de Lima","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048913229","display_name":"Richard E. Champlin","orcid":"https://orcid.org/0000-0002-4314-5037","observed_orcids":["https://orcid.org/0000-0002-4314-5037"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.E. Champlin","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070096873","display_name":"Sergio  A. Giralt","orcid":"https://orcid.org/0000-0003-1944-5053","observed_orcids":["https://orcid.org/0000-0003-1944-5053"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.A. Giralt","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.6009,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.71813773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"16","issue":"2","first_page":"S200","last_page":"S201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.968999981880188},{"id":"https://openalex.org/keywords/high-dose-melphalan","display_name":"high-dose melphalan","score":0.9800000190734863},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.8849999904632568},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9409999847412109},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.921999990940094},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9210000038146973},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.8090000152587891},{"id":"https://openalex.org/keywords/relapsed-multiple-myeloma","display_name":"relapsed multiple myeloma","score":0.6959999799728394},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.4259999990463257},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.3440000116825104},{"id":"https://openalex.org/keywords/bone-marrow-engraftment","display_name":"bone marrow engraftment","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.9277836084365845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9023659229278564},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.8006808757781982},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7390334010124207},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5947025418281555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4490733742713928},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4296359419822693},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4101576805114746},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3828708231449127},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38160252571105957}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bbmt.2009.12.147","doi":"https://doi.org/10.1016/j.bbmt.2009.12.147","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2009.12.147","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bbmt.2009.12.147","doi":"https://doi.org/10.1016/j.bbmt.2009.12.147","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2009.12.147","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2336472643","https://openalex.org/W4237013635","https://openalex.org/W2143621111","https://openalex.org/W2978810464","https://openalex.org/W2015362514","https://openalex.org/W2599522395","https://openalex.org/W2078628446","https://openalex.org/W2588960832","https://openalex.org/W3081943941","https://openalex.org/W4240351589"],"abstract_inverted_index":{"High":[0],"dose":[1,401],"melphalan":[2,61,181,367],"remains":[3],"the":[4,52,63,72,83,92,162,211,373],"preparative":[5,64,85,178,265,368],"regimen":[6,65,179,266,369],"of":[7,49,56,180,248,359,388],"choice":[8],"for":[9,66],"autologous":[10],"hematopoietic":[11],"stem":[12],"cell":[13],"transplantation":[14],"(auto":[15],"HCT)":[16],"in":[17,26,46,62,124,134,148,210,255,283,287,313,324,338,419],"multiple":[18],"myeloma":[19],"(MM).":[20],"Bortezomib":[21],"is":[22],"an":[23,173,252],"active":[24],"agent":[25],"newly":[27],"diagnosed":[28],"or":[29,88,377],"relapsed":[30],"MM,":[31,47],"and":[32,54,78,108,110,170,188,199,230,234,242,271,279,301,304,327,336,349,381],"has":[33],"synergistic":[34],"activity":[35],"with":[36,87,176,267],"melphalan.":[37],"We":[38],"recently":[39],"conducted":[40],"two":[41],"randomized":[42,94,164,215],"phase":[43],"II":[44],"trials":[45],"one":[48],"which":[50],"studied":[51],"safety":[53],"efficacy":[55],"adding":[57,362],"bortezomib":[58,220,223,235,268,274,363],"to":[59,121,145,159,197,207,216,364,397,404],"high-dose":[60,99],"auto":[67,174,253,302,309,393,398],"HCT.":[68],"Here":[69],"we":[70],"report":[71],"response":[73,321,374],"rates,":[74],"progression-free":[75],"survival":[76,80],"(PFS)":[77],"overall":[79],"(OS)":[81],"between":[82,299],"melphalan-based":[84],"regimens":[86],"without":[89,273],"bortezomib.":[90],"In":[91,161,356],"first":[93],"trial":[95,165,213],"48":[96],"patients":[97,133,147,167,250],"received":[98,137,151,172,251,263],"Melphalan":[100],"at":[101,153],"100":[102,182],"mg/m2":[103,183,225,237],"IV":[104,116,141,184,193,203],"on":[105,118,185,194,204,226,238],"days":[106,119,143,157,186,195,205,227,239,403],"-4":[107,187],"-3,":[109,189],"ascorbic":[111],"acid":[112],"(AA)":[113],"1000":[114,191],"mg":[115],"daily":[117],"-9":[120,144,158,196,206],"-3.":[122,160,208],"Patients":[123,209,286],"arm":[125,135,149],"1":[126,224],"did":[127,370],"not":[128,371],"receive":[129],"arsenic":[130],"trioxide":[131],"(ATO);":[132],"2":[136,257],"ATO":[138,152,200],"0.15":[139],"mg/kg":[140,155,202],"from":[142,156,395],"-3;":[146],"3":[150,217],"0.25":[154,201],"second":[163,212],"60":[166],"were":[168,214,292,329,343],"enrolled":[169],"58":[171],"HCT":[175,254,303,310],"a":[177,264,296,307,365,420],"AA":[190],"mg/day":[192],"-3":[198,231,243],"arms;":[218],"no":[219],"(arm":[221,232,244],"1),":[222],"-9,":[228,240],"-6":[229,241],"2),":[233],"1.5":[236],"3).":[245],"A":[246,326,340,383],"total":[247],"106":[249,260,360],"these":[256],"trials.":[258],"Of":[259],"patients,":[261,361],"39":[262],"(Group":[269,275],"A)":[270],"67":[272],"B).":[276],"Patient":[277],"characteristics":[278],"outcome":[280],"are":[281],"summarized":[282],"Table":[284],"1.":[285],"group":[288,314,339],"B":[289,328,342,385],"(without":[290],"bortezomib)":[291],"slightly":[293],"older,":[294],"had":[295,306],"longer":[297],"interval":[298],"diagnosis":[300,396],"21%":[305],"prior":[308],"(vs.":[311],"2%":[312],"A).":[315],"Complete":[316],"+":[317],"very":[318],"good":[319],"partial":[320],"rates":[322],"(CR+VGPR)":[323],"groups":[325],"similar":[330],"(31%":[331],"vs.":[332,341,345,351],"31%).":[333],"Median":[334],"PFS":[335,376,413],"OS":[337,415],"14":[344],"23":[346],"months":[347,353],"(p=0.08)":[348],"80":[350],"82":[352],"(p=0.17),":[354],"respectively.":[355],"this":[357],"analysis":[358],"HD":[366],"improve":[372],"rate,":[375],"OS.Tabled":[378],"1Patient":[379],"Characteristics":[380],"OutcomesGroup":[382],"(Bortezomib)Group":[384],"(No":[386],"Bortezomib)Number":[387],"patients3967Median":[389],"age5955Abnormal":[390],"cytogenetics1311Relapsed":[391],"disease1025Prior":[392],"HCT114Months":[394],"HCT914Median":[399],"CD34":[400],"106/kg3.94.56Median":[402],"engraftment1010Grade":[405],"3-4":[406],"adverse":[407],"effects1220CR7":[408],"(18%)16":[409],"(24%)CR+VGPR12":[410],"(31%)22":[411],"(31%)Median":[412],"(months)1423Median":[414],"(months)8082":[416],"Open":[417],"table":[418],"new":[421],"tab":[422]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}