{"id":"https://openalex.org/W2004165146","doi":"https://doi.org/10.1016/j.bbrc.2004.07.183","title":"Action of solamargine on TNFs and cisplatin-resistant human lung cancer cells","display_name":"Action of solamargine on TNFs and cisplatin-resistant human lung cancer cells","publication_year":2004,"publication_date":"2004-08-26","ids":{"openalex":"https://openalex.org/W2004165146","doi":"https://doi.org/10.1016/j.bbrc.2004.07.183","mag":"2004165146","pmid":"https://pubmed.ncbi.nlm.nih.gov/15336528"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2004.07.183","doi":"https://doi.org/10.1016/j.bbrc.2004.07.183","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2004.07.183","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040553562","display_name":"Chia\u2010Hua Liang","orcid":"https://orcid.org/0000-0001-8589-4805","observed_orcids":["https://orcid.org/0000-0001-8589-4805"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Hua Liang","raw_affiliation_strings":["Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110684","display_name":"Lifeng Liu","orcid":"https://orcid.org/0000-0002-6363-3433","observed_orcids":["https://orcid.org/0000-0002-6363-3433"]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Feng Liu","raw_affiliation_strings":["Department of Medical Radiological Technology, I-shou University, Kaohsiung 807, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Radiological Technology, I-shou University, Kaohsiung 807, Taiwan, ROC","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042032473","display_name":"Li\u2010Yen Shiu","orcid":"https://orcid.org/0000-0002-8353-1514","observed_orcids":["https://orcid.org/0000-0002-8353-1514"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Yen Shiu","raw_affiliation_strings":["Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074884191","display_name":"Yu\u2010Sheng Huang","orcid":"https://orcid.org/0000-0002-1119-7836","observed_orcids":["https://orcid.org/0000-0002-1119-7836","https://orcid.org/0009-0001-8436-3604"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Sheng Huang","raw_affiliation_strings":["Department of Surgery, School of Medicine, Kaohsiung Medical University, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine, Kaohsiung Medical University, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069595223","display_name":"Li-Ching Chang","orcid":"https://orcid.org/0000-0002-8710-0471","observed_orcids":["https://orcid.org/0000-0002-8710-0471"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Ching Chang","raw_affiliation_strings":["Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057517870","display_name":"Kou\u2010Wha Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kou-Wha Kuo","raw_affiliation_strings":["Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Medicine, Kaohsiung Medical University, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057517870"],"corresponding_institution_ids":["https://openalex.org/I152743029"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.0736,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.71348143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"322","issue":"3","first_page":"751","last_page":"758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solamargine","display_name":"solamargine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/solanum-incanum","display_name":"Solanum incanum","score":0.8939999938011169},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tnf-alpha-resistance","display_name":"TNF-alpha resistance","score":0.703000009059906},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-receptor-1","display_name":"TNF receptor 1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tnf-receptor-2","display_name":"TNF receptor 2","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tradd","display_name":"TRADD","score":0.8169999718666077},{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.9959999918937683},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9879999756813049},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9409999847412109},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9139999747276306},{"id":"https://openalex.org/keywords/drug-resistance-sensitization","display_name":"drug resistance sensitization","score":0.6690000295639038},{"id":"https://openalex.org/keywords/synergistic-antitumor-effect","display_name":"synergistic antitumor effect","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.8498334884643555},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.8290047645568848},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6990723013877869},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6264855265617371},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.4840351939201355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4517459571361542},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4464185833930969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4126743972301483},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37824174761772156},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3359661102294922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19993731379508972},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.06554606556892395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012991","descriptor_name":"Solanaceous Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2004.07.183","doi":"https://doi.org/10.1016/j.bbrc.2004.07.183","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2004.07.183","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:15336528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15336528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1264914101","https://openalex.org/W1484124852","https://openalex.org/W1541326155","https://openalex.org/W1806932734","https://openalex.org/W1937163871","https://openalex.org/W1969664700","https://openalex.org/W1970343951","https://openalex.org/W1984547206","https://openalex.org/W1988443461","https://openalex.org/W1996178747","https://openalex.org/W2003335442","https://openalex.org/W2017986614","https://openalex.org/W2020337294","https://openalex.org/W2023964913","https://openalex.org/W2028215219","https://openalex.org/W2028928387","https://openalex.org/W2031514226","https://openalex.org/W2040287500","https://openalex.org/W2042581554","https://openalex.org/W2059972525","https://openalex.org/W2069681479","https://openalex.org/W2077829550","https://openalex.org/W2088580558","https://openalex.org/W2113155222","https://openalex.org/W2119467381","https://openalex.org/W2123927174","https://openalex.org/W2126170636","https://openalex.org/W2147002984","https://openalex.org/W2152247516","https://openalex.org/W2358132255","https://openalex.org/W6638336493","https://openalex.org/W6677217825","https://openalex.org/W6707083233"],"related_works":["https://openalex.org/W2095505037","https://openalex.org/W1972905945","https://openalex.org/W2060580840","https://openalex.org/W2137084067","https://openalex.org/W3029202135","https://openalex.org/W3031181803","https://openalex.org/W2081123345","https://openalex.org/W2211739421","https://openalex.org/W2372446982","https://openalex.org/W2121692188"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
