{"id":"https://openalex.org/W2004150338","doi":"https://doi.org/10.1371/journal.pone.0004627","title":"Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid \u03b2 Protein","display_name":"Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid \u03b2 Protein","publication_year":2009,"publication_date":"2009-02-26","ids":{"openalex":"https://openalex.org/W2004150338","doi":"https://doi.org/10.1371/journal.pone.0004627","mag":"2004150338","pmid":"https://pubmed.ncbi.nlm.nih.gov/19247480","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2645672"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0004627","doi":"https://doi.org/10.1371/journal.pone.0004627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0004627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004627&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018001257","display_name":"Karunya K. Kandimalla","orcid":"https://orcid.org/0000-0001-7786-1915","observed_orcids":["https://orcid.org/0000-0001-7786-1915"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I8248082","display_name":"Florida Agricultural and Mechanical University","ror":"https://ror.org/00c4wc133","country_code":"US","type":"education","lineage":["https://openalex.org/I8248082"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karunya K. Kandimalla","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, United States of America. karunya.kandimalla@famu.edu","Department of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, United States of America","Molecular Neurobiology Laboratory, Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, United States of America. karunya.kandimalla@famu.edu","institution_ids":["https://openalex.org/I8248082"]},{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, United States of America","institution_ids":["https://openalex.org/I8248082"]},{"raw_affiliation_string":"Molecular Neurobiology Laboratory, Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045043306","display_name":"Scott G. Olenych","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210132808","display_name":"National High Magnetic Field Laboratory","ror":"https://ror.org/03s53g630","country_code":"US","type":"facility","lineage":["https://openalex.org/I103163165","https://openalex.org/I1311060795","https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I33213144","https://openalex.org/I4210120050","https://openalex.org/I4210132808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olenych G. Scott","raw_affiliation_strings":["National High Magnetic Field Laboratory and Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National High Magnetic Field Laboratory and Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I4210132808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018347905","display_name":"Smita Fulzele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8248082","display_name":"Florida Agricultural and Mechanical University","ror":"https://ror.org/00c4wc133","country_code":"US","type":"education","lineage":["https://openalex.org/I8248082"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Smita Fulzele","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, United States of America","institution_ids":["https://openalex.org/I8248082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043340480","display_name":"Michael W. Davidson","orcid":"https://orcid.org/0000-0002-6420-952X","observed_orcids":["https://orcid.org/0000-0002-6420-952X"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I4210132808","display_name":"National High Magnetic Field Laboratory","ror":"https://ror.org/03s53g630","country_code":"US","type":"facility","lineage":["https://openalex.org/I103163165","https://openalex.org/I1311060795","https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I33213144","https://openalex.org/I4210120050","https://openalex.org/I4210132808"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Davidson","raw_affiliation_strings":["National High Magnetic Field Laboratory and Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National High Magnetic Field Laboratory and Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America","institution_ids":["https://openalex.org/I103163165","https://openalex.org/I4210132808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111627869","display_name":"Joseph F. Poduslo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph F. Poduslo","raw_affiliation_strings":["Molecular Neurobiology Laboratory, Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neurobiology Laboratory, Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018001257"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I8248082"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.5145,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.93201133,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"2","first_page":"e4627","last_page":"e4627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7429999709129333},{"id":"https://openalex.org/keywords/amyloid-beta-40","display_name":"A\u03b240","score":0.906000018119812},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neuronal-uptake","display_name":"neuronal uptake","score":0.7599999904632568},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurovascular-unit","display_name":"neurovascular unit","score":0.9559999704360962},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/lysosomal-accumulation","display_name":"lysosomal accumulation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.871999979019165},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/receptor-mediated-endocytosis","display_name":"receptor-mediated endocytosis","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.7661784887313843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7015395760536194},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6643636226654053},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.649463951587677},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5323261022567749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45423951745033264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.423079252243042},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3314749002456665},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3283613920211792},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20936992764472961},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20578554272651672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08383902907371521},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0004627","doi":"https://doi.org/10.1371/journal.pone.0004627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0004627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2645672","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2645672","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19247480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19247480","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.807.3403","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.807.3403","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c0/80/pone.0004627.PMC2645672.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8240f111382e4c6b86bfb82b40c3cb22","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8240f111382e4c6b86bfb82b40c3cb22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 2, p e4627 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0004627","doi":"https://doi.org/10.1371/journal.pone.0004627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0004627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3180197867","display_name":"MBRS/SCORE Program at Florida A&M University","funder_award_id":"S06GM008111","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5182747244","display_name":"Magnetic Resonance Imaging of Alzheimer's Amyloid Plaque","funder_award_id":"R01AG022034","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5534881828","display_name":"Center of Excellence for Cancer Research, Training and Community Service","funder_award_id":"P20MD006738","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G8271498087","display_name":"Pharmaceutical Research Center","funder_award_id":"G12RR003020","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004150338.pdf","grobid_xml":"https://content.openalex.org/works/W2004150338.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W58149416","https://openalex.org/W63514696","https://openalex.org/W1963700158","https://openalex.org/W1967168807","https://openalex.org/W1969375579","https://openalex.org/W1972094490","https://openalex.org/W1976419330","https://openalex.org/W1977706869","https://openalex.org/W1984880178","https://openalex.org/W1988909765","https://openalex.org/W1995581289","https://openalex.org/W1996219643","https://openalex.org/W2005993715","https://openalex.org/W2008254819","https://openalex.org/W2014341627","https://openalex.org/W2015074272","https://openalex.org/W2016436495","https://openalex.org/W2016811754","https://openalex.org/W2025944561","https://openalex.org/W2030508474","https://openalex.org/W2030854061","https://openalex.org/W2031441539","https://openalex.org/W2037322147","https://openalex.org/W2041851050","https://openalex.org/W2045548994","https://openalex.org/W2045987097","https://openalex.org/W2048975745","https://openalex.org/W2049732058","https://openalex.org/W2063013822","https://openalex.org/W2070045579","https://openalex.org/W2071865941","https://openalex.org/W2072824994","https://openalex.org/W2074444989","https://openalex.org/W2074783246","https://openalex.org/W2076162696","https://openalex.org/W2084675121","https://openalex.org/W2090097368","https://openalex.org/W2103473142","https://openalex.org/W2105668301","https://openalex.org/W2114923908","https://openalex.org/W2121820797","https://openalex.org/W2155019726","https://openalex.org/W2159717687","https://openalex.org/W2164445091","https://openalex.org/W2166486694","https://openalex.org/W2170755395","https://openalex.org/W2461321470"],"related_works":["https://openalex.org/W7099796333","https://openalex.org/W2291651268","https://openalex.org/W2074446821","https://openalex.org/W2301395465","https://openalex.org/W4417507066","https://openalex.org/W4309758098","https://openalex.org/W2062350109","https://openalex.org/W2014341627","https://openalex.org/W2036411698","https://openalex.org/W4385575575"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,44,77,197],"characterized":[4],"by":[5,46,151,190],"significant":[6,183],"neurodegeneration":[7],"in":[8,28,35,88,123,159,225,237],"the":[9,29,36,47,59,63,67,83,89,93,121,143,201,223,238,265],"cortex":[10],"and":[11,19,26,97,128,135,163,173,221,244,262,269],"hippocampus;":[12],"intraneuronal":[13],"tangles":[14],"of":[15,21,50,69,74,85,92,104,120,126,185,200,219,230,240,267],"hyperphosphorylated":[16],"tau":[17],"protein;":[18],"accumulation":[20,49,119],"beta-amyloid":[22],"(Abeta)":[23],"proteins":[24,52,87,148,261],"40":[25],"42":[27],"brain":[30,109],"parenchyma":[31],"as":[32,34],"well":[33],"cerebral":[37],"vasculature.":[38],"The":[39,72],"current":[40],"understanding":[41,253],"that":[42,146,181],"AD":[43,70],"initiated":[45],"neuronal":[48],"Abeta":[51,86,147,260,273],"due":[53],"to":[54,78,252,272],"their":[55],"inefficient":[56],"clearance":[57],"at":[58,66],"blood-brain-barrier":[60],"(BBB),":[61],"places":[62],"neurovascular":[64,94],"unit":[65],"epicenter":[68],"pathophysiology.":[71],"objective":[73],"this":[75],"study":[76],"investigate":[79],"cellular":[80],"mechanisms":[81],"mediating":[82],"internalization":[84,239],"principle":[90],"constituents":[91],"unit,":[95],"neurons":[96,130,152,168,196,243,271],"BBB":[98,245],"endothelial":[99,246],"cells.":[100],"Laser":[101],"confocal":[102,171],"micrographs":[103],"wild":[105],"type":[106],"(WT)":[107],"mouse":[108],"slices":[110],"treated":[111],"with":[112],"fluorescein":[113],"labeled":[114],"Abeta40":[115,241],"(F-Abeta40)":[116],"demonstrated":[117,180],"selective":[118],"protein":[122,224],"a":[124,182,234],"subpopulation":[125],"cortical":[127,268],"hippocampal":[129,166,270],"via":[131,153],"nonsaturable,":[132],"energy":[133,216],"independent,":[134],"nonendocytotic":[136],"pathways.":[137],"This":[138],"groundbreaking":[139],"finding,":[140],"which":[141,206],"challenges":[142],"conventional":[144],"belief":[145],"are":[149],"internalized":[150,189],"receptor":[154],"mediated":[155],"endocytosis,":[156],"was":[157],"verified":[158],"differentiated":[160,191],"PC12":[161,192],"cells":[162,193,214,247,256],"rat":[164],"primary":[165],"(RPH)":[167],"through":[169],"laser":[170],"microscopy":[172],"flow":[174],"cytometry":[175],"studies.":[176],"Microscopy":[177],"studies":[178],"have":[179],"proportion":[184],"F-Abeta40":[186],"or":[187,194,203],"F-Abeta42":[188],"RPH":[195],"located":[198],"outside":[199],"endosomal":[202],"lysosomal":[204],"compartments,":[205],"may":[207,248],"accumulate":[208,222],"without":[209],"degradation.":[210],"In":[211],"contrast,":[212],"BBME":[213],"exhibit":[215],"dependent":[217],"uptake":[218],"F-Abeta40,":[220],"acidic":[226],"cell":[227],"organelle,":[228],"indicative":[229],"endocytotic":[231],"uptake.":[232],"Such":[233],"phenomenal":[235],"difference":[236],"between":[242],"provide":[249],"essential":[250],"clues":[251],"how":[254],"various":[255],"can":[257],"differentially":[258],"regulate":[259],"help":[263],"explain":[264],"vulnerability":[266],"toxicity.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
