{"id":"https://openalex.org/W2004149336","doi":"https://doi.org/10.1152/ajpregu.00196.2004","title":"Standing up to the challenge of standing: a siphon does not support cerebral blood flow in humans","display_name":"Standing up to the challenge of standing: a siphon does not support cerebral blood flow in humans","publication_year":2004,"publication_date":"2004-06-15","ids":{"openalex":"https://openalex.org/W2004149336","doi":"https://doi.org/10.1152/ajpregu.00196.2004","mag":"2004149336","pmid":"https://pubmed.ncbi.nlm.nih.gov/15191903"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00196.2004","doi":"https://doi.org/10.1152/ajpregu.00196.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00196.2004","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078425072","display_name":"Ellen A. Dawson","orcid":"https://orcid.org/0000-0002-5958-267X","observed_orcids":["https://orcid.org/0000-0002-5958-267X"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"E. A. Dawson","raw_affiliation_strings":["Dept. of Anesthesia, Rigshospitalet, Section 2041, Blegdamsvej 9, DK-2100 Copenhagen \u00d8, Denmark. ellendawson@hotmail.com","Dept. of Anesthesia, Rigshospitalet, Section 2041, Blegdamsvej 9, DK-2100 Copenhagen \u00d8, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anesthesia, Rigshospitalet, Section 2041, Blegdamsvej 9, DK-2100 Copenhagen \u00d8, Denmark. ellendawson@hotmail.com","institution_ids":["https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Dept. of Anesthesia, Rigshospitalet, Section 2041, Blegdamsvej 9, DK-2100 Copenhagen \u00d8, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050361725","display_name":"Niels Henry Secher","orcid":"https://orcid.org/0000-0002-5207-9932","observed_orcids":["https://orcid.org/0000-0002-5207-9932","https://orcid.org/0000-0001-7972-9731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. H. Secher","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111480743","display_name":"Morten Dalsgaard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. K. Dalsgaard","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034606638","display_name":"Shigehiko Ogoh","orcid":"https://orcid.org/0000-0001-5297-6468","observed_orcids":["https://orcid.org/0000-0001-5297-6468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Ogoh","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043469467","display_name":"Chie C. Yoshiga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. C. Yoshiga","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015138528","display_name":"Jos\u00e9 Gonz\u00e1lez\u2010Alonso","orcid":"https://orcid.org/0000-0002-8205-3311","observed_orcids":["https://orcid.org/0000-0002-8205-3311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Gonz\u00e1lez-Alonso","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008622478","display_name":"Adam Steensberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Steensberg","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113593886","display_name":"P. B. Raven","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. B. Raven","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9364,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.937842,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"287","issue":"4","first_page":"R911","last_page":"R914"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.7820000052452087},{"id":"https://openalex.org/keywords/head-up-tilt-test","display_name":"head-up tilt","score":0.7559999823570251},{"id":"https://openalex.org/keywords/siphon","display_name":"siphon","score":0.5720000267028809},{"id":"https://openalex.org/keywords/internal-jugular-vein","display_name":"internal jugular vein","score":0.7879999876022339},{"id":"https://openalex.org/keywords/venous-drainage","display_name":"venous drainage","score":0.6399999856948853},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-pressure","display_name":"cerebrospinal fluid pressure","score":0.8389999866485596},{"id":"https://openalex.org/keywords/central-venous-pressure","display_name":"central venous pressure","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hydrostatic-pressure","display_name":"hydrostatic pressure","score":0.5910000205039978},{"id":"https://openalex.org/keywords/upright-posture","display_name":"upright posture","score":0.8299999833106995},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C35207712","wikidata":"https://www.wikidata.org/wiki/Q190402","display_name":"Central venous pressure","level":4,"score":0.6844020485877991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5646764039993286},{"id":"https://openalex.org/C163629137","wikidata":"https://www.wikidata.org/wiki/Q1276903","display_name":"Siphon (mollusc)","level":2,"score":0.5476521253585815},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.5460065603256226},{"id":"https://openalex.org/C2776370487","wikidata":"https://www.wikidata.org/wiki/Q1144593","display_name":"Sitting","level":2,"score":0.5450790524482727},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5024731159210205},{"id":"https://openalex.org/C2775856269","wikidata":"https://www.wikidata.org/wiki/Q540598","display_name":"Internal jugular vein","level":2,"score":0.4663991332054138},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.44016844034194946},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4385179579257965},{"id":"https://openalex.org/C2910081258","wikidata":"https://www.wikidata.org/wiki/Q177807","display_name":"Hydrostatic pressure","level":2,"score":0.4213578999042511},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4121495485305786},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4056278467178345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3481943607330322},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.3443388044834137},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20368418097496033},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.11644947528839111},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06930062174797058},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007601","descriptor_name":"Jugular Veins","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007601","descriptor_name":"Jugular Veins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007839","descriptor_name":"Functional Laterality","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015170","descriptor_name":"Cerebrospinal Fluid Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015656","descriptor_name":"Respiratory Mechanics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016683","descriptor_name":"Supine Position","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.00196.2004","doi":"https://doi.org/10.1152/ajpregu.00196.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00196.2004","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:15191903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15191903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W3536694","https://openalex.org/W1898215286","https://openalex.org/W1936461591","https://openalex.org/W1968656500","https://openalex.org/W1986311299","https://openalex.org/W2003657321","https://openalex.org/W2003773468","https://openalex.org/W2016154792","https://openalex.org/W2031434296","https://openalex.org/W2054964487","https://openalex.org/W2080616233","https://openalex.org/W2084292310","https://openalex.org/W2110687281","https://openalex.org/W2114919659","https://openalex.org/W2138669309","https://openalex.org/W2149019868","https://openalex.org/W2173135046","https://openalex.org/W2260591796","https://openalex.org/W2272540276","https://openalex.org/W2799153656"],"related_works":["https://openalex.org/W2121883372","https://openalex.org/W1565894869","https://openalex.org/W2042059843","https://openalex.org/W1993500011","https://openalex.org/W82880034","https://openalex.org/W2110558176","https://openalex.org/W2625042505","https://openalex.org/W2965743262","https://openalex.org/W2767603353","https://openalex.org/W2124274882"],"abstract_inverted_index":{"Model":[0],"studies":[1],"have":[2],"been":[3],"advanced":[4],"to":[5,109,133,200],"suggest":[6],"both":[7,215],"that":[8,35,214,243],"a":[9,24,244],"siphon":[10,25,245],"does":[11,13],"and":[12,62,74,77,162,167,222],"not":[14,174],"support":[15],"cerebral":[16,247],"blood":[17,248],"flow":[18],"in":[19,56,71,146],"an":[20],"upright":[21,58],"position.":[22],"If":[23],"is":[26],"established":[27],"with":[28],"the":[29,44,48,57,60,63,67,72,78,87,95,98,149,191,206,209,220,226,232,235],"head":[30,88],"raised,":[31],"it":[32],"would":[33],"mean":[34],"internal":[36,68,79,100,154,177],"jugular":[37,69,80,101,178],"pressure":[38,42,55,61,82,103,127,189,228],"reflects":[39],"right":[40,153],"atrium":[41],"minus":[43],"hydrostatic":[45],"difference":[46],"from":[47,105,129,219],"brain.":[49,210],"This":[50],"study":[51],"measured":[52],"spinal":[53,187,224],"fluid":[54,188],"position,":[59],"ultrasound-determined":[64],"size":[65],"of":[66,97,148,208,234],"vein":[70],"supine":[73],"sitting":[75,185],"positions,":[76],"venous":[81,102,126,179,217],"during":[83],"seated":[84],"exercise.":[85],"When":[86],"was":[89,144,194],"elevated":[90],"approximately":[91],"25":[92],"cm":[93],"above":[94],"level":[96,193],"heart,":[99],"decreased":[104,128],"9.5":[106],"(SD":[107,111,131,135,196,202],"2.8)":[108],"0.2":[110],"1.0)":[112],"mmHg":[113,137,198,204],"[n":[114],"=":[115,165,171],"15;":[116],"values":[117],"are":[118,239],"means":[119],"(SD);":[120],"P":[121],"<":[122,139],"0.01].":[123],"Similarly,":[124],"central":[125],"6.2":[130],"1.8)":[132],"0.6":[134],"2.6)":[136],"(P":[138],"0.05).":[140],"No":[141],"apparent":[142],"lumen":[143],"detected":[145],"any":[147],"31":[150],"left":[151],"or":[152],"veins":[155],"imaged":[156],"at":[157,190,205,231],"40":[158],"degrees":[159],"head-up":[160],"tilt,":[161],"submaximal":[163],"(n":[164,170],"7)":[166],"maximal":[168],"exercise":[169],"4)":[172,197],"did":[173],"significantly":[175],"affect":[176],"pressure.":[180],"While":[181],"seven":[182],"subjects":[183],"were":[184],"up,":[186],"lumbar":[192],"26":[195],"corresponding":[199],"0.1":[201],"4.1)":[203],"base":[207,233],"These":[211],"results":[212],"demonstrate":[213],"for":[216,223],"outflow":[218],"brain":[221,236],"fluid,":[225],"prevailing":[227],"approaches":[229],"zero":[230],"when":[237],"humans":[238],"upright,":[240],"which":[241],"negates":[242],"supports":[246],"flow.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
