{"id":"https://openalex.org/W2004141058","doi":"https://doi.org/10.1080/01635581.2015.1029638","title":"Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats","display_name":"Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats","publication_year":2015,"publication_date":"2015-04-16","ids":{"openalex":"https://openalex.org/W2004141058","doi":"https://doi.org/10.1080/01635581.2015.1029638","mag":"2004141058","pmid":"https://pubmed.ncbi.nlm.nih.gov/25879155"},"language":"en","primary_location":{"id":"doi:10.1080/01635581.2015.1029638","doi":"https://doi.org/10.1080/01635581.2015.1029638","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01635581.2015.1029638","pdf_url":null,"source":{"id":"https://openalex.org/S105083709","display_name":"Nutrition and Cancer","issn_l":"0163-5581","issn":["0163-5581","1532-7914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/en/publications/0bb2a29f-0239-4391-8ab3-e590f50fd8d1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004521656","display_name":"Nikki Buijs","orcid":"https://orcid.org/0000-0002-0256-9597","observed_orcids":["https://orcid.org/0000-0002-0256-9597"]},"institutions":[{"id":"https://openalex.org/I4210157913","display_name":"Medisch Centrum Alkmaar","ror":"https://ror.org/04vccmr34","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210157913"]},{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nikki Buijs","raw_affiliation_strings":["a Department of Surgery , VU University Medical Center , Amsterdam , The Netherlands and Department of Surgery , Medical Center Alkmaar, Trial Center Holland Health , Alkmaar , The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Department of Surgery , VU University Medical Center , Amsterdam , The Netherlands and Department of Surgery , Medical Center Alkmaar, Trial Center Holland Health , Alkmaar , The Netherlands","institution_ids":["https://openalex.org/I4210157913","https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043228883","display_name":"Mechteld A. R. Vermeulen","orcid":"https://orcid.org/0000-0002-5776-6117","observed_orcids":["https://orcid.org/0000-0002-5776-6117"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mechteld A. R. Vermeulen","raw_affiliation_strings":["Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands","Internal medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Internal medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039567972","display_name":"V\u00edola B. Weeda","orcid":"https://orcid.org/0000-0002-0618-3632","observed_orcids":["https://orcid.org/0000-0002-0618-3632","https://orcid.org/0000-0002-6531-2588"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viola B. Weeda","raw_affiliation_strings":["Department of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109917933","display_name":"James R. Bading","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Bading","raw_affiliation_strings":["Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute/City of Hope, Duarte, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute/City of Hope, Duarte, California, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088723020","display_name":"Alexander P. J. Houdijk","orcid":"https://orcid.org/0000-0002-7851-9043","observed_orcids":["https://orcid.org/0000-0002-7851-9043"]},"institutions":[{"id":"https://openalex.org/I4210157913","display_name":"Medisch Centrum Alkmaar","ror":"https://ror.org/04vccmr34","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210157913"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alexander P. J. Houdijk","raw_affiliation_strings":["Department of Surgery, Medical Center Alkmaar, Trial Center Holland Health, Alkmaar, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medical Center Alkmaar, Trial Center Holland Health, Alkmaar, The Netherlands","institution_ids":["https://openalex.org/I4210157913"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110005419","display_name":"Paul A.M. van Leeuwen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Paul A. M. van Leeuwen","raw_affiliation_strings":["Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5110005419"],"corresponding_institution_ids":["https://openalex.org/I911458345"],"apc_list":null,"apc_paid":null,"fwci":0.5456,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66758719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"67","issue":"5","first_page":"713","last_page":"720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.323199987411499,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.323199987411499,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.23010000586509705,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glutamine-supplementation","display_name":"glutamine supplementation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glutamine-uptake","display_name":"glutamine uptake","score":0.6600000262260437},{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-bearing-rats","display_name":"tumor-bearing rats","score":0.8519999980926514},{"id":"https://openalex.org/keywords/amino-acid-flux","display_name":"amino acid flux","score":0.8399999737739563},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.9444708228111267},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.8694513440132141},{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.8270503282546997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7625651359558105},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7491214275360107},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5694612860679626},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.5688747763633728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5004899501800537},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48517948389053345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34885525703430176},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3079637885093689},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1742824912071228},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17298632860183716},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16952240467071533}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008748","descriptor_name":"Methylcholanthrene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010288","descriptor_name":"Parenteral Nutrition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012513","descriptor_name":"Sarcoma, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012513","descriptor_name":"Sarcoma, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/01635581.2015.1029638","doi":"https://doi.org/10.1080/01635581.2015.1029638","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01635581.2015.1029638","pdf_url":null,"source":{"id":"https://openalex.org/S105083709","display_name":"Nutrition and Cancer","issn_l":"0163-5581","issn":["0163-5581","1532-7914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and Cancer","raw_type":"journal-article"},{"id":"pmid:25879155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25879155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/0bb2a29f-0239-4391-8ab3-e590f50fd8d1","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/0bb2a29f-0239-4391-8ab3-e590f50fd8d1","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Buijs, N, Vermeulen, M A R, Weeda, V B, Bading, J R, Houdijk, A P J & van Leeuwen, P A M 2015, 'Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats', Nutrition and cancer, vol. 67, no. 5, pp. 713-720. https://doi.org/10.1080/01635581.2015.1029638","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/4fa100f0-2398-46c5-a44d-2c37086ea581","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/4fa100f0-2398-46c5-a44d-2c37086ea581","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrition and Cancer, 67(5), 713 - 720. Routledge","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/0bb2a29f-0239-4391-8ab3-e590f50fd8d1","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/0bb2a29f-0239-4391-8ab3-e590f50fd8d1","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Buijs, N, Vermeulen, M A R, Weeda, V B, Bading, J R, Houdijk, A P J & van Leeuwen, P A M 2015, 'Adaptations of Arginine's Intestinal-Renal Axis in Cachectic Tumor-Bearing Rats', Nutrition and cancer, vol. 67, no. 5, pp. 713-720. https://doi.org/10.1080/01635581.2015.1029638","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327317","display_name":"Kom op tegen Kanker","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1479784763","https://openalex.org/W1601375885","https://openalex.org/W1908510719","https://openalex.org/W1913354205","https://openalex.org/W1964996260","https://openalex.org/W1971512865","https://openalex.org/W1972157068","https://openalex.org/W1973214694","https://openalex.org/W1974423646","https://openalex.org/W1981022377","https://openalex.org/W1984990706","https://openalex.org/W1989927214","https://openalex.org/W1990205291","https://openalex.org/W1993657967","https://openalex.org/W1995490493","https://openalex.org/W2007837142","https://openalex.org/W2024745914","https://openalex.org/W2027362748","https://openalex.org/W2040319474","https://openalex.org/W2041898452","https://openalex.org/W2044116574","https://openalex.org/W2044170656","https://openalex.org/W2045330664","https://openalex.org/W2060727628","https://openalex.org/W2074674694","https://openalex.org/W2090862497","https://openalex.org/W2092956233","https://openalex.org/W2099894956","https://openalex.org/W2124881271","https://openalex.org/W2134401635","https://openalex.org/W2156106286","https://openalex.org/W2170244178","https://openalex.org/W2171005463","https://openalex.org/W2179506076","https://openalex.org/W2218611209","https://openalex.org/W2302544927","https://openalex.org/W2394606541","https://openalex.org/W2414773820","https://openalex.org/W2419604885","https://openalex.org/W4241060332"],"related_works":["https://openalex.org/W2159360103","https://openalex.org/W2124881271","https://openalex.org/W2516122773","https://openalex.org/W1996944178","https://openalex.org/W2598054442","https://openalex.org/W4297977759","https://openalex.org/W2044170656","https://openalex.org/W2058386311","https://openalex.org/W2519032821","https://openalex.org/W1488480231"],"abstract_inverted_index":{"Malignancies":[0],"induce":[1],"disposal":[2],"of":[3,48,64,74,80,134],"arginine,":[4],"an":[5,175,185],"important":[6],"substrate":[7],"for":[8,68],"the":[9,16,46,61,65,72,77,84,131,152,172,195],"immune":[10,14],"system.":[11],"To":[12],"sustain":[13],"function,":[15],"tumor-bearing":[17,94,105,135,154,197],"host":[18],"accelerates":[19],"arginine's":[20],"intestinal-renal":[21,43],"axis":[22,44],"by":[23,184],"glutamine":[24,49,81,141,179,203],"mobilization":[25],"from":[26],"skeletal":[27],"muscle":[28],"and":[29,45,76,104,117,124,142,166],"this":[30],"may":[31],"promote":[32],"cachexia.":[33],"Glutamine":[34,159],"supplementation":[35,50,82,160],"stimulates":[36],"argi-nine":[37],"production":[38,70],"in":[39,51,83,151,171,177,187,194],"healthy":[40],"subjects.":[41],"Arginine's":[42],"effect":[47,79],"cancer":[52],"cach-exia":[53],"have":[54],"not":[55,182,200],"been":[56],"investigated.":[57],"This":[58],"study":[59],"evaluated":[60],"long-term":[62],"adaptations":[63,192],"interorgan":[66],"pathway":[67],"arginine":[69,189],"following":[71],"onset":[73],"cachexia":[75],"metabolic":[78],"cachectic":[85,153,173],"state.":[86],"Fischer-344":[87],"rats":[88,136,155],"were":[89,126],"randomly":[90],"divided":[91],"into":[92],"a":[93,108],"group":[95,100,106],"(n":[96,101,111],"=":[97,102,112],"12),":[98],"control":[99],"7)":[103],"receiving":[107],"glutamine-enriched":[109],"diet":[110],"9).":[113],"Amino":[114],"acid":[115],"fluxes":[116],"net":[118],"fractional":[119],"extractions":[120],"across":[121],"intestine,":[122],"kidneys,":[123],"liver":[125],"studied.":[127],"Compared":[128],"to":[129],"controls,":[130],"portal-drained":[132],"viscera":[133],"took":[137],"up":[138],"significantly":[139,144],"more":[140],"released":[143],"less":[145],"citrulline.":[146],"Renal":[147],"metabolism":[148],"was":[149],"unchanged":[150],"compared":[156],"with":[157],"controls.":[158],"had":[161],"no":[162],"effects":[163],"on":[164,202],"intestinal":[165,178],"renal":[167,188],"adaptations.":[168],"In":[169],"conclusion,":[170],"state,":[174],"increase":[176,186],"uptake":[180],"is":[181],"accompanied":[183],"production.":[190],"The":[191],"found":[193],"cachectic,":[196],"rat":[198],"do":[199],"depend":[201],"availability.":[204]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}