{"id":"https://openalex.org/W2004140063","doi":"https://doi.org/10.1016/s0939-6411(03)00046-8","title":"Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines","display_name":"Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines","publication_year":2003,"publication_date":"2003-06-02","ids":{"openalex":"https://openalex.org/W2004140063","doi":"https://doi.org/10.1016/s0939-6411(03)00046-8","mag":"2004140063","pmid":"https://pubmed.ncbi.nlm.nih.gov/12837490"},"language":"en","primary_location":{"id":"doi:10.1016/s0939-6411(03)00046-8","doi":"https://doi.org/10.1016/s0939-6411(03)00046-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0939-6411(03)00046-8","pdf_url":null,"source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110245279","display_name":"Katarina Hostanska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Katarina Hostanska","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland. katarina.hostanska@access.unizh.ch","Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland. katarina.hostanska@access.unizh.ch","institution_ids":["https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056393496","display_name":"Juergen Reichling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Juergen Reichling","raw_affiliation_strings":["Institute of Biology, Institute for Pharmacy & Molecular Biotechnology, University Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology, Institute for Pharmacy & Molecular Biotechnology, University Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042936706","display_name":"Silvia Bommer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267908","display_name":"A. Vogel AG (Switzerland)","ror":"https://ror.org/04z1mz580","country_code":"CH","type":"company","lineage":["https://openalex.org/I4405267908"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Silvia Bommer","raw_affiliation_strings":["Department of Medicine, Bioforce AG, Roggwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bioforce AG, Roggwil, Switzerland","institution_ids":["https://openalex.org/I4405267908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michel Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267908","display_name":"A. Vogel AG (Switzerland)","ror":"https://ror.org/04z1mz580","country_code":"CH","type":"company","lineage":["https://openalex.org/I4405267908"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michel Weber","raw_affiliation_strings":["Department of Medicine, Bioforce AG, Roggwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Bioforce AG, Roggwil, Switzerland","institution_ids":["https://openalex.org/I4405267908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037325494","display_name":"Reinhard Saller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Reinhard Saller","raw_affiliation_strings":["Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110245279"],"corresponding_institution_ids":["https://openalex.org/I4210100468"],"apc_list":{"value":4210,"currency":"USD","value_usd":4210},"apc_paid":null,"fwci":11.3978,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.98423404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"56","issue":"1","first_page":"121","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperforin","display_name":"hyperforin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypericum-perforatum","display_name":"Hypericum perforatum","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hypericin","display_name":"hypericin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/procyanidin-b2","display_name":"procyanidin B2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9200000166893005},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9160000085830688},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.6140000224113464},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8399999737739563},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7710000276565552},{"id":"https://openalex.org/keywords/synergistic-cytotoxicity","display_name":"synergistic cytotoxicity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/phosphatidylserine-exposure","display_name":"phosphatidylserine exposure","score":0.949999988079071},{"id":"https://openalex.org/keywords/membrane-phospholipid-asymmetry","display_name":"membrane phospholipid asymmetry","score":0.9290000200271606},{"id":"https://openalex.org/keywords/z-vad-fmk","display_name":"z-VAD-fmk","score":0.781000018119812},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2778350159","wikidata":"https://www.wikidata.org/wiki/Q412742","display_name":"Hyperforin","level":3,"score":0.8745595812797546},{"id":"https://openalex.org/C2776651039","wikidata":"https://www.wikidata.org/wiki/Q158289","display_name":"Hypericum perforatum","level":2,"score":0.7829949855804443},{"id":"https://openalex.org/C2778432610","wikidata":"https://www.wikidata.org/wiki/Q425409","display_name":"Hypericin","level":2,"score":0.7608954906463623},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.713363766670227},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.6232219338417053},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.6199190020561218},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5592714548110962},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5142571330070496},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4894646406173706},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4830111265182495},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.475104421377182},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.46472790837287903},{"id":"https://openalex.org/C108634530","wikidata":"https://www.wikidata.org/wiki/Q7863610","display_name":"U937 cell","level":3,"score":0.4556456506252289},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.4109012484550476},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38055187463760376},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34142082929611206},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3303667902946472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3236877918243408},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.2229909896850586},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000873","descriptor_name":"Anthracenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001643","descriptor_name":"Bridged Bicyclo Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010569","descriptor_name":"Perylene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010696","descriptor_name":"Phloroglucinol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017304","descriptor_name":"Annexin A5","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020902","descriptor_name":"Hypericum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044945","descriptor_name":"Proanthocyanidins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044946","descriptor_name":"Biflavonoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0939-6411(03)00046-8","doi":"https://doi.org/10.1016/s0939-6411(03)00046-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0939-6411(03)00046-8","pdf_url":null,"source":{"id":"https://openalex.org/S122302516","display_name":"European Journal of Pharmaceutics and Biopharmaceutics","issn_l":"0939-6411","issn":["0939-6411","1873-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutics and Biopharmaceutics","raw_type":"journal-article"},{"id":"pmid:12837490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12837490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W39324834","https://openalex.org/W403527634","https://openalex.org/W1498486272","https://openalex.org/W1503002499","https://openalex.org/W1523826811","https://openalex.org/W1636279715","https://openalex.org/W1775749144","https://openalex.org/W1879559146","https://openalex.org/W1926202956","https://openalex.org/W1965776209","https://openalex.org/W1969345055","https://openalex.org/W1979684530","https://openalex.org/W1979973303","https://openalex.org/W1981258134","https://openalex.org/W1983584933","https://openalex.org/W1985848091","https://openalex.org/W1990771160","https://openalex.org/W1991227280","https://openalex.org/W1994245797","https://openalex.org/W1997005484","https://openalex.org/W2000216883","https://openalex.org/W2000780867","https://openalex.org/W2012048832","https://openalex.org/W2019500797","https://openalex.org/W2020831335","https://openalex.org/W2025608123","https://openalex.org/W2028272823","https://openalex.org/W2030693662","https://openalex.org/W2037781464","https://openalex.org/W2048903451","https://openalex.org/W2051658124","https://openalex.org/W2056510708","https://openalex.org/W2056743160","https://openalex.org/W2059029852","https://openalex.org/W2061497413","https://openalex.org/W2076104235","https://openalex.org/W2078532650","https://openalex.org/W2080818089","https://openalex.org/W2090674998","https://openalex.org/W2093322721","https://openalex.org/W2094774861","https://openalex.org/W2119214100","https://openalex.org/W2137165155","https://openalex.org/W2138322954","https://openalex.org/W2157999078","https://openalex.org/W2172071325","https://openalex.org/W2189148829","https://openalex.org/W2219711995","https://openalex.org/W2404089574","https://openalex.org/W2409129531","https://openalex.org/W2410423766","https://openalex.org/W2415910168","https://openalex.org/W2418281831","https://openalex.org/W2464987254","https://openalex.org/W2472474998","https://openalex.org/W6636857024","https://openalex.org/W6656683383","https://openalex.org/W6680682335","https://openalex.org/W6688875241"],"related_works":["https://openalex.org/W2080409396","https://openalex.org/W2077422696","https://openalex.org/W1969345055","https://openalex.org/W2404089574","https://openalex.org/W2513743962","https://openalex.org/W3007874163","https://openalex.org/W2130057537","https://openalex.org/W2004185410","https://openalex.org/W2313080906","https://openalex.org/W2052037946"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
