{"id":"https://openalex.org/W2004135232","doi":"https://doi.org/10.1113/jphysiol.1986.sp016102","title":"Effects of mono and divalent cations on total and partial reactions catalysed by pig kidney Na,K\u2010ATPase.","display_name":"Effects of mono and divalent cations on total and partial reactions catalysed by pig kidney Na,K\u2010ATPase.","publication_year":1986,"publication_date":"1986-06-01","ids":{"openalex":"https://openalex.org/W2004135232","doi":"https://doi.org/10.1113/jphysiol.1986.sp016102","mag":"2004135232","pmid":"https://pubmed.ncbi.nlm.nih.gov/3025425","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1182744"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1986.sp016102","doi":"https://doi.org/10.1113/jphysiol.1986.sp016102","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1986.sp016102","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1182744","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109156996","display_name":"Luis Beaug\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Beaug\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085508307","display_name":"Marta Campos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Campos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":1.2955,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.79857762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"375","issue":"1","first_page":"1","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.1200999990105629,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/sodium","display_name":"sodium","score":0.8399999737739563},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.8989999890327454},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adp-atp-exchange","display_name":"ADP/ATP exchange","score":0.8479999899864197},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ouabain","display_name":"ouabain","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.7160000205039978},{"id":"https://openalex.org/keywords/phosphatase-activity","display_name":"phosphatase activity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.38100001215934753},{"id":"https://openalex.org/keywords/pig-kidney","display_name":"pig kidney","score":0.5789999961853027},{"id":"https://openalex.org/keywords/divalent-cations","display_name":"divalent cations","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cation-binding-sites","display_name":"cation binding sites","score":0.5709999799728394},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.7917715311050415},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6916729211807251},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5499937534332275},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4700305163860321},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3598567843437195},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3402532935142517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29275405406951904},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2111072540283203},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18853455781936646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15799155831336975},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09967440366744995}],"mesh":[{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1986.sp016102","doi":"https://doi.org/10.1113/jphysiol.1986.sp016102","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1986.sp016102","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1182744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1182744","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:3025425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3025425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1182744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1182744","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1238743721","https://openalex.org/W1480144064","https://openalex.org/W1482850475","https://openalex.org/W1493572762","https://openalex.org/W1495162468","https://openalex.org/W1554161190","https://openalex.org/W1577410692","https://openalex.org/W1606821594","https://openalex.org/W1775749144","https://openalex.org/W1971519888","https://openalex.org/W1979845718","https://openalex.org/W1980095753","https://openalex.org/W1994946211","https://openalex.org/W1998043540","https://openalex.org/W2012837315","https://openalex.org/W2014532846","https://openalex.org/W2014959863","https://openalex.org/W2022834506","https://openalex.org/W2031423487","https://openalex.org/W2036334309","https://openalex.org/W2042326757","https://openalex.org/W2051588281","https://openalex.org/W2054238787","https://openalex.org/W2055652819","https://openalex.org/W2063182196","https://openalex.org/W2068868021","https://openalex.org/W2078898428","https://openalex.org/W2079710184","https://openalex.org/W2080057691","https://openalex.org/W2084075562","https://openalex.org/W2087584121","https://openalex.org/W2088777284","https://openalex.org/W2089867911","https://openalex.org/W2104184940","https://openalex.org/W2112214832","https://openalex.org/W2116489549","https://openalex.org/W2126379961","https://openalex.org/W2137157986","https://openalex.org/W2230924357","https://openalex.org/W2409836313","https://openalex.org/W3165208394"],"related_works":["https://openalex.org/W2010265945","https://openalex.org/W2001787886","https://openalex.org/W7100616111","https://openalex.org/W1862853453","https://openalex.org/W3023331724","https://openalex.org/W2082169180","https://openalex.org/W1930263167","https://openalex.org/W2065177443","https://openalex.org/W2063182196","https://openalex.org/W2068868021"],"abstract_inverted_index":{"Interactions":[0],"of":[1,23,40,94,126,133,185,194,216,238,251,257,261,274,280,283,303],"Na,":[2],"K,":[3,127],"Ca":[4,180,229],"and":[5,30,43,57,73,77,83,97,109,114,137,153,222,240,268,285,294,306,334,354],"Mg":[6,298,315,339],"ions":[7,162,230],"with":[8,63,69,203,211,345],"partially":[9],"purified":[10],"Na,K-ATPase":[11,98],"from":[12,102],"pig":[13],"kidneys":[14],"were":[15,80,100,117,131,208,231,317],"investigated":[16],"using":[17],"as":[18,271,273],"a":[19,300,347,356],"tool":[20],"simultaneous":[21],"determinations":[22],"adenosine":[24],"5'-triphosphate":[25],"(ATP)-adenosine":[26],"5'-diphosphate":[27],"(ADP)":[28],"exchange":[29,52,96,136,159,196,242,286,330],"ATPase":[31,138,174,239,246,269,284,305,335],"activity":[32,99,247],"catalysed":[33],"by":[34,120],"the":[35,38,46,55,124,158,177,183,192,195,206,214,249,258,262,278,309,351,361],"enzyme.":[36],"In":[37,123,213,288],"presence":[39,215,250],"120":[41,110],"mM-NaCl":[42],"0.5":[44,292],"mM-MgCl2,":[45],"effects":[47],"12":[48],"mM-KCl":[49],"on":[50,54,173,176],"ATP-ADP":[51,95,135,178,189,241,307,329],"depended":[53],"ATP":[56,76],"ADP":[58,78],"concentrations:":[59],"stimulation":[60,93],"(about":[61],"10-fold)":[62],"3":[64],"mM-ATP-0.75":[65],"mM-ADP,":[66],"no":[67],"effect":[68],"0.04":[70],"mM-ATP-0.01":[71],"mM-ADP":[72],"inhibition":[74,142,237,282],"when":[75],"concentrations":[79,130,224,316],"0.003":[81],"mM":[82,85],"0.001":[84],"respectively.":[86],"The":[87],"apparent":[88],"affinities":[89],"(K0.5)":[90],"for":[91,277,319],"K":[92,161,263],"indistinguishable":[101],"each":[103],"other":[104],"both":[105,320],"at":[106,146,149,218,223,350],"20":[107],"mM-":[108],"mM-Na.":[111],"All":[112],"Na":[113,129,141,165,236,281,323],"Na+K-dependent":[115],"exchanges":[116],"completely":[118],"abolished":[119],"10(-4)":[121],"M-ouabain.":[122],"absence":[125,184],"intermediate":[128],"inhibitory":[132],"ouabain-sensitive":[134,304],"activity.":[139],"This":[140,253],"was":[143,154,170,198,299,324],"more":[144,155,171,332,336],"pronounced":[145],"low":[147,219,295],"than":[148,175],"high":[150],"ionic":[151,220,296],"strength":[152,221],"noticeable":[156],"in":[157,182,248,266,359],"reaction.":[160,287],"antagonized":[163],"these":[164],"effects;":[166],"this":[167],"K-Na":[168],"antagonism":[169,349],"effective":[172],"exchange.":[179,190],"ions,":[181],"Mg,":[186,217],"could":[187],"sustain":[188],"Qualitatively":[191],"behaviour":[193],"reaction":[197],"similar":[199],"to":[200,234,244,314,326,338],"that":[201],"observed":[202],"Mg.":[204],"Quantitatively":[205],"rates":[207],"always":[209],"lower":[210],"Ca.":[212],"which":[225],"stimulated":[226],"phosphatase":[227,267],"activity,":[228],"not":[232],"able":[233],"counteract":[235],"or":[243],"stimulate":[245],"Na.":[252],"is":[254],"another":[255],"indication":[256],"different":[259],"reactivity":[260],"sites":[264],"involved":[265],"activities":[270,313],"well":[272],"those":[275],"responsible":[276],"release":[279],"K-free":[289],"solutions":[290],"containing":[291],"mM-Na":[293],"strength,":[297],"powerful":[301],"inhibitor":[302],"exchange;":[308],"curves":[310],"relating":[311],"remaining":[312],"identical":[318],"reactions.":[321],"When":[322],"increased":[325],"5":[327],"mM,":[328],"became":[331],"sensitive":[333],"resistant":[337],"inhibition.":[340],"These":[341],"data":[342],"are":[343],"consistent":[344],"(i)":[346],"Na-Mg":[348,357],"phosphorylation":[352],"step,":[353],"(ii)":[355],"synergism":[358],"blocking":[360],"E2PNa-E1PNa":[362],"transformation.(ABSTRACT":[363],"TRUNCATED":[364],"AT":[365],"400":[366],"WORDS)":[367]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}