{"id":"https://openalex.org/W2004126648","doi":"https://doi.org/10.1172/jci118649","title":"Large scale isolation, growth, and function of porcine neonatal islet cells.","display_name":"Large scale isolation, growth, and function of porcine neonatal islet cells.","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2004126648","doi":"https://doi.org/10.1172/jci118649","mag":"2004126648","pmid":"https://pubmed.ncbi.nlm.nih.gov/8621802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507287"},"language":"en","primary_location":{"id":"doi:10.1172/jci118649","doi":"https://doi.org/10.1172/jci118649","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118649","pdf_url":"http://www.jci.org/articles/view/118649/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/118649/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111691559","display_name":"G S Korbutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G S Korbutt","raw_affiliation_strings":["Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J F Elliott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J F Elliott","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2N8 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2N8 Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109095607","display_name":"Z. Ao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Ao","raw_affiliation_strings":["Surgical-Medical Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical-Medical Research Institute and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000947925","display_name":"Dean K. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D K Smith","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2N8 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2N8 Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046141743","display_name":"Garth L. Warnock","orcid":"https://orcid.org/0000-0002-9005-746X","observed_orcids":["https://orcid.org/0000-0002-9005-746X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G L Warnock","raw_affiliation_strings":["Surgical-Medical Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical-Medical Research Institute and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111659869","display_name":"R. V. Rajotte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"R V Rajotte","raw_affiliation_strings":["Surgical-Medical Research Institute and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical-Medical Research Institute and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111659869"],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":4.8403,"has_fulltext":true,"cited_by_count":372,"citation_normalized_percentile":{"value":0.95580464,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"97","issue":"9","first_page":"2119","last_page":"2129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-cell-proliferation","display_name":"beta-cell proliferation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hyperglycemia-correction","display_name":"hyperglycemia correction","score":0.753000020980835},{"id":"https://openalex.org/keywords/nephrectomy","display_name":"nephrectomy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.45500001311302185},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.9850000143051147},{"id":"https://openalex.org/keywords/islet-cells","display_name":"pancreatic endocrine cells","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.7825305461883545},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7022110819816589},{"id":"https://openalex.org/C2778881546","wikidata":"https://www.wikidata.org/wiki/Q1752136","display_name":"Renal capsule","level":3,"score":0.6247810125350952},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5612173676490784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5497324466705322},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5436037182807922},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5271396636962891},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5137547254562378},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.507904589176178},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4735010266304016},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.46531322598457336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45780181884765625},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.43218743801116943},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.41827476024627686},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3694850206375122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3112383484840393},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1164843738079071},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0676259994506836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci118649","doi":"https://doi.org/10.1172/jci118649","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118649","pdf_url":"http://www.jci.org/articles/view/118649/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507287","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/507287","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:8621802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8621802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci118649","doi":"https://doi.org/10.1172/jci118649","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118649","pdf_url":"http://www.jci.org/articles/view/118649/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319946","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27"},{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004126648.pdf","grobid_xml":"https://content.openalex.org/works/W2004126648.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W38537514","https://openalex.org/W1589147909","https://openalex.org/W1669156028","https://openalex.org/W1979197288","https://openalex.org/W1983109849","https://openalex.org/W1985604928","https://openalex.org/W1997913235","https://openalex.org/W2006202151","https://openalex.org/W2011109619","https://openalex.org/W2015344124","https://openalex.org/W2024711583","https://openalex.org/W2029374135","https://openalex.org/W2036627417","https://openalex.org/W2037190164","https://openalex.org/W2047749768","https://openalex.org/W2053081561","https://openalex.org/W2053577320","https://openalex.org/W2054714044","https://openalex.org/W2060275191","https://openalex.org/W2063950583","https://openalex.org/W2075556162","https://openalex.org/W2081370531","https://openalex.org/W2083525730","https://openalex.org/W2090988549","https://openalex.org/W2092803859","https://openalex.org/W2109932464","https://openalex.org/W2116107973","https://openalex.org/W2116757200","https://openalex.org/W2116770225","https://openalex.org/W2123436766","https://openalex.org/W2132724553","https://openalex.org/W2138364349","https://openalex.org/W2140495641","https://openalex.org/W2170528653","https://openalex.org/W2171678230","https://openalex.org/W2317503901","https://openalex.org/W2326406503","https://openalex.org/W2409041319","https://openalex.org/W2410793168","https://openalex.org/W2413658028","https://openalex.org/W2440205628","https://openalex.org/W2461798727","https://openalex.org/W2468749345","https://openalex.org/W2473928111","https://openalex.org/W4230140532"],"related_works":["https://openalex.org/W2008437365","https://openalex.org/W91404273","https://openalex.org/W2808185578","https://openalex.org/W2053081561","https://openalex.org/W1991665275","https://openalex.org/W2167665968","https://openalex.org/W4367674440","https://openalex.org/W2015404859","https://openalex.org/W2265019028","https://openalex.org/W2000710839"],"abstract_inverted_index":{"Based":[0],"upon":[1],"existing":[2],"methods":[3],"of":[4,19,35,52,83,86,98,107,113,131,148,154,165,177,193,196],"isolating":[5],"fetal":[6],"porcine":[7,20,185],"islet":[8,22,48,198],"tissue,":[9],"a":[10,26,191],"simple,":[11],"reliable":[12],"procedure":[13],"was":[14,168],"developed":[15],"for":[16,204],"the":[17,63,66,95,108,132,149,152,175,183,202,214],"preparation":[18],"neonatal":[21,42,184],"cell":[23,49,69],"aggregates":[24],"with":[25,116],"reproducible":[27],"and":[28,57,80,146,158,209,212],"defined":[29],"cellular":[30,162],"composition.":[31],"After":[32],"9":[33],"d":[34],"in":[36,104,141,143,207,210,220],"vitro":[37,208],"culture,":[38],"tissue":[39],"from":[40],"one":[41],"pig":[43],"pancreas":[44],"yielded":[45],"approximately":[46],"50,000":[47],"aggregates,":[50],"consisting":[51,85],"primarily":[53],"epithelial":[54],"cells":[55,60,91,121],"(57%)":[56],"pancreatic":[58],"endocrine":[59],"(35%).":[61],"During":[62],"culture":[64],"period,":[65],"total":[67],"beta":[68,90,120],"mass":[70],"decreased":[71],"initially,":[72],"but":[73],"subsequently":[74],"increased":[75],"1.5-fold":[76],"between":[77],"days":[78],"3":[79,87],"9.":[81],"Transplantation":[82],"grafts":[84,150,167],"x":[88,118],"10(5)":[89,119],"(1,000":[92],"aggregated)":[93],"under":[94],"kidney":[96,135],"capsule":[97],"alloxan-diabetic":[99],"nude":[100,221],"mice":[101],"corrected":[102],"hyperglycemia":[103,142],"75%":[105],"(10/13)":[106],"animals,":[109],"whereas,":[110],"100%":[111],"(20/20)":[112],"recipients":[114],"implanted":[115],"6":[117],"(2,000":[122],"aggregates)":[123],"achieved":[124],"euglycemia":[125],"within":[126],"8":[127],"wk":[128,138],"posttransplantation.":[129],"Nephrectomy":[130],"graft":[133],"bearing":[134],"at":[136,174],"14":[137],"posttransplantation":[139],"resulted":[140],"all":[144],"recipients,":[145],"examination":[147],"revealed":[151],"presence":[153],"numerous":[155],"well-granulated":[156],"insulin-":[157],"glucagon-containing":[159],"cells.":[160],"The":[161],"insulin":[163],"content":[164],"these":[166],"20":[169],"to":[170,217],"30-fold":[171],"higher":[172],"than":[173],"time":[176],"transplantation.":[178],"These":[179],"results":[180],"indicate":[181],"that":[182],"pancrease":[186],"can":[187],"be":[188],"used":[189],"as":[190],"source":[192],"large":[194],"numbers":[195],"viable":[197],"cells,":[199],"which":[200],"have":[201],"potential":[203],"growth":[205],"both":[206],"vivo,":[211],"exhibit":[213],"metabolic":[215],"capacity":[216],"correct":[218],"diabetes":[219],"mice.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
