{"id":"https://openalex.org/W2004121271","doi":"https://doi.org/10.1248/bpb.28.1762","title":"Neurotrophic Effect of Magnolol in the Hippocampal CA1 Region of Senescence-Accelerated Mice (SAMP1)","display_name":"Neurotrophic Effect of Magnolol in the Hippocampal CA1 Region of Senescence-Accelerated Mice (SAMP1)","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2004121271","doi":"https://doi.org/10.1248/bpb.28.1762","mag":"2004121271","pmid":"https://pubmed.ncbi.nlm.nih.gov/16141555"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.28.1762","doi":"https://doi.org/10.1248/bpb.28.1762","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.1762","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/9/28_9_1762/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb/28/9/28_9_1762/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037951576","display_name":"Nobuaki Matsui","orcid":"https://orcid.org/0000-0002-4252-2072","observed_orcids":["https://orcid.org/0000-0002-4252-2072"]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuaki Matsui","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054093764","display_name":"Hiroshi Nakashima","orcid":"https://orcid.org/0000-0001-9678-9234","observed_orcids":["https://orcid.org/0000-0001-9678-9234"]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Nakashima","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020427411","display_name":"Yuki Ushio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Ushio","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028071408","display_name":"Toshimasa Tada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshimasa Tada","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069972635","display_name":"Akiko Shirono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Shirono","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062126268","display_name":"Yoshiyasu Fukuyama","orcid":"https://orcid.org/0000-0003-0989-172X","observed_orcids":["https://orcid.org/0000-0003-0989-172X"]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyasu Fukuyama","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032003005","display_name":"Kousuke Nakade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kousuke Nakade","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015922793","display_name":"Haifeng Zhai","orcid":"https://orcid.org/0000-0002-4965-6989","observed_orcids":["https://orcid.org/0000-0002-4965-6989"]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haifeng Zhai","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yumiko Yasui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yumiko Yasui","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070302842","display_name":"Nobuyuki Fukuishi","orcid":"https://orcid.org/0000-0002-9315-6121","observed_orcids":["https://orcid.org/0000-0002-9315-6121"]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Fukuishi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048719914","display_name":"Reiko Akagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193620225","display_name":"Okayama Prefectural University","ror":"https://ror.org/038bgk418","country_code":"JP","type":"education","lineage":["https://openalex.org/I193620225"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Akagi","raw_affiliation_strings":["Faculty of Health and Welfare Science, Okayama Prefectural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Welfare Science, Okayama Prefectural University","institution_ids":["https://openalex.org/I193620225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108391922","display_name":"Masaaki Akagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89098413","display_name":"Tokushima Bunri University","ror":"https://ror.org/00smwky98","country_code":"JP","type":"education","lineage":["https://openalex.org/I89098413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Akagi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Tokushima Bunri University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Tokushima Bunri University","institution_ids":["https://openalex.org/I89098413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.406,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80896272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"9","first_page":"1762","last_page":"1765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnolol","display_name":"magnolol","score":1.0},{"id":"https://openalex.org/keywords/neurotrophic-effects","display_name":"neurotrophic effects","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.8539999723434448},{"id":"https://openalex.org/keywords/senescence-accelerated-mouse","display_name":"senescence-accelerated mice","score":0.8610000014305115},{"id":"https://openalex.org/keywords/samp1","display_name":"SAMP1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/age-related-neuronal-loss","display_name":"age-related neuronal loss","score":0.9440000057220459},{"id":"https://openalex.org/keywords/stratum-radiatum","display_name":"stratum radiatum","score":0.9419999718666077},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neurodegeneration-prevention","display_name":"neurodegeneration prevention","score":0.5929999947547913},{"id":"https://openalex.org/keywords/timing-of-drug-administration","display_name":"timing of drug administration","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2781009524","wikidata":"https://www.wikidata.org/wiki/Q6732002","display_name":"Magnolol","level":2,"score":0.9507651925086975},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7858526706695557},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6860874891281128},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6502460241317749},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5955474376678467},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.575157880783081},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.5319281816482544},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4637048840522766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3942945599555969},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3905259966850281},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37955623865127563},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3227512836456299},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08766645193099976},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08587431907653809},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009454","descriptor_name":"Neurofibrils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016610","descriptor_name":"Tissue Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017705","descriptor_name":"Lignans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.28.1762","doi":"https://doi.org/10.1248/bpb.28.1762","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.1762","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/9/28_9_1762/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:16141555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16141555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.28.1762","doi":"https://doi.org/10.1248/bpb.28.1762","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.1762","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/9/28_9_1762/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004121271.pdf","grobid_xml":"https://content.openalex.org/works/W2004121271.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W175721692","https://openalex.org/W230657648","https://openalex.org/W1598800837","https://openalex.org/W1966927218","https://openalex.org/W1967676622","https://openalex.org/W1971135597","https://openalex.org/W1971776625","https://openalex.org/W1977647185","https://openalex.org/W1983607733","https://openalex.org/W1985468502","https://openalex.org/W1992736931","https://openalex.org/W1994392702","https://openalex.org/W2012834750","https://openalex.org/W2015759422","https://openalex.org/W2021354710","https://openalex.org/W2023543550","https://openalex.org/W2033089072","https://openalex.org/W2041224852","https://openalex.org/W2075529771","https://openalex.org/W2088038548","https://openalex.org/W2090261512","https://openalex.org/W2091659696","https://openalex.org/W2095797798","https://openalex.org/W2121785931","https://openalex.org/W2135638671","https://openalex.org/W2411072273","https://openalex.org/W2413677453","https://openalex.org/W3190169566"],"related_works":["https://openalex.org/W2067207644","https://openalex.org/W2008253137","https://openalex.org/W2416478556","https://openalex.org/W4293734991","https://openalex.org/W7160262436","https://openalex.org/W2896130532","https://openalex.org/W2380858859","https://openalex.org/W6903617032","https://openalex.org/W2012587061","https://openalex.org/W4376598458"],"abstract_inverted_index":{"Magnolol":[0,43],"has":[1],"neurotrophic":[2],"effects":[3],"in":[4,36,82,90,106,113,125,145,149],"primary":[5],"cultured":[6],"rat":[7],"cortical":[8],"neurons,":[9],"which":[10],"are":[11],"expressed":[12],"as":[13],"the":[14,27,37,67,83,87,91,102,107,133,138,150],"promotion":[15],"of":[16,30,77,86,93,104,120,135,140],"neurite":[17],"outgrowth":[18],"and":[19,61],"neuronal":[20,34,141],"survival.":[21],"In":[22],"this":[23],"study,":[24],"we":[25],"investigated":[26],"protective":[28,147],"effect":[29,148],"magnolol":[31,99,136],"against":[32],"age-related":[33],"loss":[35,142],"hippocampus":[38,92],"using":[39],"senescence-accelerated":[40],"mouse":[41],"(SAMP1).":[42],"(5,":[44],"10":[45],"mg/kg)":[46],"was":[47,63,111],"orally":[48],"administered":[49,112],"once":[50],"a":[51,126,146],"day":[52],"for":[53],"14":[54],"d":[55],"to":[56],"2-":[57],"or":[58,71],"4-month-old":[59],"mice,":[60],"evaluation":[62],"carried":[64],"out":[65],"when":[66,109],"mice":[68],"were":[69],"4":[70,118],"6":[72],"months":[73,119],"old.":[74],"The":[75],"density":[76],"neurofibrils":[78,105],"decreased":[79],"with":[80,98],"aging":[81],"stratum":[84],"radiatum":[85],"CA1":[88],"region":[89],"SAMP1,":[94],"not":[95,123],"SAMR1.":[96],"Treatment":[97],"significantly":[100],"prevented":[101],"decrease":[103],"CA1,":[108],"it":[110],"2-month-olds.":[114],"However,":[115],"administration":[116,134],"at":[117],"age":[121],"did":[122],"result":[124,144],"preventive":[127],"effect.":[128],"These":[129],"findings":[130],"suggest":[131],"that":[132],"before":[137],"initiation":[139],"may":[143],"hippocampus.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}