{"id":"https://openalex.org/W2004090970","doi":"https://doi.org/10.1128/aac.36.8.1614","title":"Evaluation of cefuroxime axetil and cefadroxil suspensions for treatment of pediatric skin infections","display_name":"Evaluation of cefuroxime axetil and cefadroxil suspensions for treatment of pediatric skin infections","publication_year":1992,"publication_date":"1992-08-01","ids":{"openalex":"https://openalex.org/W2004090970","doi":"https://doi.org/10.1128/aac.36.8.1614","mag":"2004090970","pmid":"https://pubmed.ncbi.nlm.nih.gov/1416842","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/192018"},"language":"en","primary_location":{"id":"doi:10.1128/aac.36.8.1614","doi":"https://doi.org/10.1128/aac.36.8.1614","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.36.8.1614","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/192018","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108194724","display_name":"Richard F. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R F Jacobs","raw_affiliation_strings":["Arkansas Children's Hospital, Little Rock 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital, Little Rock 72202","institution_ids":["https://openalex.org/I1301864278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059415649","display_name":"William D. Brown","orcid":"https://orcid.org/0000-0003-0830-8889","observed_orcids":["https://orcid.org/0000-0003-0830-8889","https://orcid.org/0000-0002-6148-290X"]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W D Brown","raw_affiliation_strings":["Arkansas Children's Hospital, Little Rock 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital, Little Rock 72202","institution_ids":["https://openalex.org/I1301864278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020663851","display_name":"Stephen A. Chartrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Chartrand","raw_affiliation_strings":["Arkansas Children's Hospital, Little Rock 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital, Little Rock 72202","institution_ids":["https://openalex.org/I1301864278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055986139","display_name":"Paul M. Darden","orcid":"https://orcid.org/0000-0003-2298-4306","observed_orcids":["https://orcid.org/0000-0003-2298-4306"]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Darden","raw_affiliation_strings":["Arkansas Children's Hospital, Little Rock 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital, Little Rock 72202","institution_ids":["https://openalex.org/I1301864278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032535811","display_name":"Margaret Drehobl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Drehobl","raw_affiliation_strings":["Arkansas Children's Hospital, Little Rock 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital, Little Rock 72202","institution_ids":["https://openalex.org/I1301864278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073880645","display_name":"Robert J. Yetman","orcid":"https://orcid.org/0000-0003-2703-2283","observed_orcids":["https://orcid.org/0000-0003-2703-2283"]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Yetman","raw_affiliation_strings":["Arkansas Children's Hospital, Little Rock 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital, Little Rock 72202","institution_ids":["https://openalex.org/I1301864278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073764334","display_name":"Michael J. Ossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Ossi","raw_affiliation_strings":["Arkansas Children's Hospital, Little Rock 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital, Little Rock 72202","institution_ids":["https://openalex.org/I1301864278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1301864278"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.09150327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"36","issue":"8","first_page":"1614","last_page":"1618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.2502000033855438,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.11749999970197678,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefuroxime-axetil","display_name":"cefuroxime axetil","score":1.0},{"id":"https://openalex.org/keywords/cefadroxil","display_name":"cefadroxil","score":1.0},{"id":"https://openalex.org/keywords/pediatric-skin-infection","display_name":"pediatric skin infection","score":0.8849999904632568},{"id":"https://openalex.org/keywords/skin-and-skin-structure-infections","display_name":"skin and skin structure infections","score":0.9710000157356262},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/streptococcus-pyogenes","display_name":"Streptococcus pyogenes","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-efficacy","display_name":"antibiotic efficacy","score":0.5569999814033508},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6890000104904175},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.699999988079071},{"id":"https://openalex.org/keywords/treatment-refusal","display_name":"treatment refusal","score":0.4259999990463257},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2780131815","wikidata":"https://www.wikidata.org/wiki/Q2319020","display_name":"Cefadroxil","level":4,"score":0.9939362406730652},{"id":"https://openalex.org/C2777514703","wikidata":"https://www.wikidata.org/wiki/Q413728","display_name":"Cefuroxime","level":3,"score":0.9883801937103271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7836141586303711},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6119844913482666},{"id":"https://openalex.org/C2775983603","wikidata":"https://www.wikidata.org/wiki/Q2458539","display_name":"Skin infection","level":4,"score":0.5714637041091919},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5247069597244263},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.4096093475818634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3784797489643097},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3226704001426697},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.2834690511226654},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.19031530618667603},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06602504849433899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0568595826625824},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002434","descriptor_name":"Cefadroxil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002434","descriptor_name":"Cefadroxil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002444","descriptor_name":"Cefuroxime","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002444","descriptor_name":"Cefuroxime","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002444","descriptor_name":"Cefuroxime","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012874","descriptor_name":"Skin Diseases, Infectious","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012874","descriptor_name":"Skin Diseases, Infectious","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013535","descriptor_name":"Suspensions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.36.8.1614","doi":"https://doi.org/10.1128/aac.36.8.1614","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.36.8.1614","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:12122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/192018","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:192018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/192018","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:1416842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1416842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:12122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/192018","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1581962345","https://openalex.org/W1965843928","https://openalex.org/W1977728203","https://openalex.org/W1996167188","https://openalex.org/W2006175369","https://openalex.org/W2029820126","https://openalex.org/W2057623780","https://openalex.org/W2081200134","https://openalex.org/W2150000105","https://openalex.org/W2237977417","https://openalex.org/W2409429019","https://openalex.org/W2611591252"],"related_works":["https://openalex.org/W7096269551","https://openalex.org/W1769422801","https://openalex.org/W2043422420","https://openalex.org/W7098990342","https://openalex.org/W2057623780","https://openalex.org/W1996167188","https://openalex.org/W2106238491","https://openalex.org/W192769413","https://openalex.org/W39524724","https://openalex.org/W2070842494"],"abstract_inverted_index":{"A":[0,70],"randomized,":[1],"single-blind,":[2],"multicenter":[3],"study":[4],"was":[5,33,78,172,184],"conducted":[6],"to":[7,107,151,163],"evaluate":[8],"the":[9,20,59,62,87,170],"safety":[10],"and":[11,16,52,82,90,136,141,194],"efficacy":[12],"of":[13,22,38,41,58,84,138,156,167],"cefuroxime":[14,88,110,139,153,182],"axetil":[15,89,111,140,154,183],"cefadroxil":[17,91,115,142,165,190],"suspensions":[18],"for":[19],"treatment":[21],"skin":[23,25,68,193,195],"or":[24,55,75,102],"structure":[26,196],"infections":[27,197],"in":[28,46,80,86,109,114,134,191,198],"287":[29],"children.":[30,199],"Each":[31],"drug":[32],"given":[34],"at":[35,185],"a":[36,56],"dosage":[37],"30":[39],"mg/kg":[40],"body":[42],"weight":[43],"per":[44],"day":[45],"two":[47],"divided":[48],"doses.":[49],"Staphylococcus":[50],"aureus":[51],"Streptococcus":[53],"pyogenes,":[54],"combination":[57],"two,":[60],"were":[61,104,126,146,160],"primary":[63],"pathogens":[64],"isolated":[65],"from":[66],"infected":[67],"lesions.":[69],"satisfactory":[71],"bacteriological":[72],"response":[73],"(cure":[74,101],"presumed":[76],"cure)":[77],"obtained":[79],"97.1":[81],"94.3%":[83],"children":[85],"groups,":[92],"respectively":[93],"(P":[94,176],"greater":[95],"than":[96,113,122,158],"0.05).":[97,123],"Satisfactory":[98],"clinical":[99],"responses":[100],"improvement)":[103],"more":[105,147],"likely":[106],"occur":[108],"recipients":[112,116],"(97.8":[117],"versus":[118],"90.3%;":[119],"P":[120],"less":[121],"Both":[124],"regimens":[125],"equally":[127],"well":[128],"tolerated,":[129],"with":[130],"adverse":[131],"events":[132],"occurring":[133],"7.9":[135],"6.1%":[137],"recipients,":[143],"respectively.":[144],"There":[145],"patients":[148],"who":[149,161],"refused":[150,162],"take":[152,164],"(7":[155],"189)":[157],"there":[159],"(0":[166],"98),":[168],"but":[169],"difference":[171],"not":[173],"statistically":[174],"significant":[175],"=":[177],"0.1).":[178],"In":[179],"this":[180],"study,":[181],"least":[186],"as":[187,189],"effective":[188],"resolving":[192]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
