{"id":"https://openalex.org/W2004077302","doi":"https://doi.org/10.1093/ajh/hps052","title":"The Effects of Short Term L-Citrulline Supplementation on Wave Reflection Responses to Cold Exposure With Concurrent Isometric Exercise","display_name":"The Effects of Short Term L-Citrulline Supplementation on Wave Reflection Responses to Cold Exposure With Concurrent Isometric Exercise","publication_year":2012,"publication_date":"2012-12-27","ids":{"openalex":"https://openalex.org/W2004077302","doi":"https://doi.org/10.1093/ajh/hps052","mag":"2004077302","pmid":"https://pubmed.ncbi.nlm.nih.gov/23467207"},"language":"en","primary_location":{"id":"doi:10.1093/ajh/hps052","doi":"https://doi.org/10.1093/ajh/hps052","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/hps052","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090804516","display_name":"Marcos A. Sanchez\u2010Gonzalez","orcid":"https://orcid.org/0000-0002-7585-708X","observed_orcids":["https://orcid.org/0000-0002-7585-708X"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. Sanchez-Gonzalez","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, The Florida State University, Tallahassee, FL, USA. mas08u@my.fsu.edu","Department of Biomedical Sciences, College of Medicine, The Florida State University, Tallahassee, FL","Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, The Florida State University, Tallahassee, FL, USA. mas08u@my.fsu.edu","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, The Florida State University, Tallahassee, FL","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055031138","display_name":"Andrew Paul Koutnik","orcid":"https://orcid.org/0000-0002-5491-3919","observed_orcids":["https://orcid.org/0000-0002-5491-3919"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. P. Koutnik","raw_affiliation_strings":["Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111858189","display_name":"K. Ramirez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Ramirez","raw_affiliation_strings":["Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018287061","display_name":"Alexei Wong","orcid":"https://orcid.org/0000-0003-2695-8850","observed_orcids":["https://orcid.org/0000-0003-2695-8850"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Wong","raw_affiliation_strings":["Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030577554","display_name":"Arturo Figueroa","orcid":"https://orcid.org/0000-0001-9710-038X","observed_orcids":["https://orcid.org/0000-0001-9710-038X"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Figueroa","raw_affiliation_strings":["Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Food and Exercise Sciences, College of Human Sciences, The Florida State University, Tallahassee, FL","institution_ids":["https://openalex.org/I103163165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I103163165"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":0.7896,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.76239253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"26","issue":"4","first_page":"518","last_page":"526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.9459999799728394},{"id":"https://openalex.org/keywords/isometric-handgrip-exercise","display_name":"isometric handgrip exercise","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pulse-wave-analysis","display_name":"pulse wave analysis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/augmentation-index","display_name":"augmentation index","score":0.9909999966621399},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/wave-reflection","display_name":"wave reflection","score":0.847000002861023},{"id":"https://openalex.org/keywords/applanation-tonometry","display_name":"applanation tonometry","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8290190696716309},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.7021380662918091},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6300374269485474},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.5931182503700256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5037311911582947},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4989051818847656},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4842934012413025},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.48256316781044006},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4373505711555481},{"id":"https://openalex.org/C2775976690","wikidata":"https://www.wikidata.org/wiki/Q1660241","display_name":"Impedance cardiography","level":5,"score":0.4134773910045624},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3324873447418213},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.18999311327934265},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001916","descriptor_name":"Brachial Artery","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002956","descriptor_name":"Citrulline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018737","descriptor_name":"Hand Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059289","descriptor_name":"Vascular Stiffness","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D063177","descriptor_name":"Pulse Wave Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajh/hps052","doi":"https://doi.org/10.1093/ajh/hps052","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/hps052","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:23467207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23467207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1963988487","https://openalex.org/W1969860218","https://openalex.org/W1971539237","https://openalex.org/W1975519941","https://openalex.org/W1991509594","https://openalex.org/W2002954459","https://openalex.org/W2004839224","https://openalex.org/W2008170985","https://openalex.org/W2010799584","https://openalex.org/W2011837293","https://openalex.org/W2016913364","https://openalex.org/W2016917904","https://openalex.org/W2024145756","https://openalex.org/W2035838413","https://openalex.org/W2044915048","https://openalex.org/W2045644663","https://openalex.org/W2046187414","https://openalex.org/W2051954005","https://openalex.org/W2052898997","https://openalex.org/W2054436086","https://openalex.org/W2056899774","https://openalex.org/W2058826415","https://openalex.org/W2063034416","https://openalex.org/W2066442598","https://openalex.org/W2095330684","https://openalex.org/W2102301398","https://openalex.org/W2106414226","https://openalex.org/W2107943950","https://openalex.org/W2110035614","https://openalex.org/W2120171412","https://openalex.org/W2133882991","https://openalex.org/W2134638296","https://openalex.org/W2138131313","https://openalex.org/W2138138135","https://openalex.org/W2146427379","https://openalex.org/W2159157497","https://openalex.org/W2160333702","https://openalex.org/W2162463567","https://openalex.org/W2165301844","https://openalex.org/W2170547362","https://openalex.org/W2270287237","https://openalex.org/W2401227225","https://openalex.org/W2405887519"],"related_works":["https://openalex.org/W7113537230","https://openalex.org/W2467311557","https://openalex.org/W2286565410","https://openalex.org/W2416265766","https://openalex.org/W1971539237","https://openalex.org/W7112316713","https://openalex.org/W2991594772","https://openalex.org/W3182232557","https://openalex.org/W4386496413","https://openalex.org/W6893629162"],"abstract_inverted_index":{"BACKGROUND:":[0],"Supplementation":[1],"with":[2,35,64,248,268],"L-citrulline":[3,285],"(L-cit)":[4],"has":[5],"shown":[6],"attenuating":[7],"effects":[8,28],"on":[9,80,315],"blood":[10],"pressure":[11],"(BP)":[12],"and":[13,49,55,83,89,110,179,219,240,259,296,313],"pulse-wave-reflection":[14],"responses":[15,51,85,275,298],"(augmentation":[16],"index":[17],"(AIx))":[18],"to":[19,22,52,86,160,306],"local":[20],"exposure":[21,34,54,88,312],"cold,":[23],"but":[24,273],"the":[25,47,76,81,124,129,132,135,146,149,185,253,281,294,308],"potential":[26],"cardioprotective":[27],"of":[29,68,75,78,118,131,184,280,310],"L-cit":[30,44,79,168,226],"during":[31],"whole-body":[32],"cold":[33,53,87,100,155,311],"concurrent":[36],"exercise":[37,133,141,314],"are":[38],"poorly":[39],"understood.":[40],"We":[41],"hypothesized":[42],"that":[43,143,225],"would":[45],"attenuate":[46],"BP":[48,82,207,214,295],"AIx":[50,84,220,241,260,297],"isometric":[56],"handgrip":[57],"(IHG)":[58],"exercise.":[59,91],"METHODS:":[60],"Sixteen":[61],"healthy":[62],"males":[63],"a":[65,73,163,175,181,200,288],"mean":[66],"age":[67],"23\u00b13":[69],"years":[70],"volunteered":[71],"for":[72,170,204,292],"study":[74,282],"effect":[77],"IHG":[90],"Experiments":[92],"were":[93,106,137,144,158,189,261,276],"conducted":[94],"inside":[95],"an":[96],"environmental":[97],"chamber":[98],"in":[99,108,123,139,154,318],"conditions":[101],"(4":[102],"\u00baC).":[103],"Radial":[104],"waveforms":[105],"obtained":[107],"duplicates":[109],"averaged":[111],"through":[112],"applanation":[113],"tonometry.":[114],"After":[115,151],"5":[116],"minutes":[117],"measurements":[119,153],"made":[120],"at":[121,271],"rest":[122],"supine":[125],"position":[126],"(RES),":[127],"after":[128,191],"finalization":[130],"about":[134],"subjects":[136,157],"evaluated":[138],"non":[140],"condition":[142],"basically":[145],"same":[147],"as":[148,246,266],"RES.":[150],"initial":[152],"conditions,":[156],"randomized":[159],"receive":[161],"either":[162,279],"placebo":[164],"(Maltodextrin,":[165],"PL)":[166],"or":[167],"(100mg/kg)":[169],"14":[171],"days,":[172],"followed":[173],"by":[174,278,300],"14-day":[176,182],"washout":[177],"period":[178],"then":[180],"regimen":[183],"other":[186],"agent.":[187],"Subjects":[188],"re-evaluated":[190],"each":[192],"treatment":[193,291],"period.":[194],"RESULTS:":[195],"At":[196],"RES,":[197,272],"there":[198],"was":[199],"significant":[201],"treatment-by-time":[202],"interaction":[203],"brachial":[205],"systolic":[206,213],"(BSBP;":[208],"P":[209,216,231,237,243],"<":[210,217,222,232,238,244,264],"0.01),":[211,218,233],"aortic":[212],"(ASBP;":[215],"(P":[221,263],"0.05),":[223,239],"such":[224],"decreased":[227],"BSBP":[228],"(-11\u00b12mm":[229],"Hg;":[230,236],"ASBP":[234],"(-10\u00b12mm":[235],"(-2\u00b12%;":[242],"0.05)":[245,265],"compared":[247,267],"their":[249,269],"respective":[250],"values":[251,270],"before":[252],"intervention.":[254],"During":[255],"IHG,":[256],"BSBP,":[257],"ASBP,":[258],"increased":[262],"these":[274],"unaffected":[277],"treatments.":[283],"CONCLUSIONS:":[284],"may":[286],"be":[287],"feasible":[289],"adjuvant":[290],"decrease":[293],"induced":[299],"cold.":[301],"Further":[302],"research":[303],"is":[304],"warranted":[305],"evaluate":[307],"impact":[309],"cardiovascular":[316],"risk":[317],"clinical":[319],"populations.":[320]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
