{"id":"https://openalex.org/W2004064512","doi":"https://doi.org/10.1016/j.juro.2014.02.1252","title":"MP37-15 APPLICATION OF LONG-ACTING PAI-1 DURING SUTURELESS PARTIAL NEPHRECTOMY IN MICE","display_name":"MP37-15 APPLICATION OF LONG-ACTING PAI-1 DURING SUTURELESS PARTIAL NEPHRECTOMY IN MICE","publication_year":2014,"publication_date":"2014-03-28","ids":{"openalex":"https://openalex.org/W2004064512","doi":"https://doi.org/10.1016/j.juro.2014.02.1252","mag":"2004064512"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2014.02.1252","doi":"https://doi.org/10.1016/j.juro.2014.02.1252","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2014.02.1252","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018887050","display_name":"Khaled Shahrour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khaled Shahrour","raw_affiliation_strings":["Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toledo, OH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111452586","display_name":"Rick W. Keck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rick Keck","raw_affiliation_strings":["Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toledo, OH","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079636370","display_name":"Jerzy Jankun","orcid":"https://orcid.org/0000-0003-2354-4046","observed_orcids":["https://orcid.org/0000-0003-2354-4046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerzy Jankun","raw_affiliation_strings":["Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toledo, OH","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09907351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"191","issue":"4S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.21150000393390656,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/intraoperative-blood-loss","display_name":"intraoperative blood loss","score":0.6800000071525574},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.8849999904632568},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/renal-resection","display_name":"renal resection","score":0.3449999988079071},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.4690000116825104},{"id":"https://openalex.org/keywords/hemostatic-agents","display_name":"hemostatic agents","score":0.5429999828338623},{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.5180000066757202},{"id":"https://openalex.org/keywords/renal-function-after-nephrectomy","display_name":"renal function after nephrectomy","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.8751821517944336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8542371988296509},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.7750951647758484},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.5618844628334045},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.5446450710296631},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.49860692024230957},{"id":"https://openalex.org/C2777956836","wikidata":"https://www.wikidata.org/wiki/Q749592","display_name":"Jugular vein","level":2,"score":0.4300159811973572},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42739319801330566},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4147317111492157},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24400466680526733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.juro.2014.02.1252","doi":"https://doi.org/10.1016/j.juro.2014.02.1252","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2014.02.1252","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099993901","https://openalex.org/W2017331675","https://openalex.org/W1561170777","https://openalex.org/W2606035621","https://openalex.org/W1992938475","https://openalex.org/W2102547497","https://openalex.org/W1985844444","https://openalex.org/W2441865746","https://openalex.org/W2417505803","https://openalex.org/W2322630429"],"abstract_inverted_index":{"You":[0],"have":[1],"accessJournal":[2],"of":[3,79,93,183,246,294,302,312,314,379,408,425,483],"UrologyTechnology":[4],"&":[5,10,84,305,332,345,358,374,391,410,491,503],"Instruments:":[6],"Robotics":[7],"-":[8],"Benign":[9],"Malignant":[11],"Disease1":[12],"Apr":[13],"2014MP37-15":[14],"APPLICATION":[15],"OF":[16],"LONG-ACTING":[17],"PAI-1":[18,114,133,247,337,363,461,484],"DURING":[19],"SUTURELESS":[20],"PARTIAL":[21],"NEPHRECTOMY":[22],"IN":[23],"MICE":[24],"Khaled":[25,32,507],"Shahrour,":[26],"Rick":[27,41,514],"Keck,":[28],"and":[29,50,162,201,219,404,420,431],"Jerzy":[30,51,521],"Jankun":[31,53,522],"ShahrourKhaled":[33],"Shahrour":[34,508],"More":[35,44,54,509,516,523],"articles":[36,45,55,510,517,524],"by":[37,46,56,89,95,290,377,511,518,525],"this":[38,47,57,512,519,526],"author":[39,48,58,513,520,527],",":[40,49],"KeckRick":[42],"Keck":[43,515],"JankunJerzy":[52],"View":[59],"All":[60,529],"Author":[61],"Informationhttps://doi.org/10.1016/j.juro.2014.02.1252AboutPDF":[62],"ToolsAdd":[63],"to":[64,81,86,102,106,131,211,215,253,277,336,349,362,382,399,460,485],"favoritesDownload":[65],"CitationsTrack":[66],"CitationsPermissionsReprints":[67],"ShareFacebookTwitterLinked":[68],"InEmail":[69],"INTRODUCTION":[70],"AND":[71],"OBJECTIVES":[72],"Plasminogen":[73],"activator":[74],"inhibitor-1":[75],"(PAI-1)":[76],"inhibits":[77],"converters":[78],"plasminogen":[80],"plasmin":[82],"(urokinase":[83],"tPA)":[85],"regulate":[87],"fibrinolysis":[88],"preventing":[90],"premature":[91],"lysis":[92],"clot":[94],"plasmin.":[96],"Several":[97],"mutant":[98],"proteins":[99],"were":[100,170,308,319,417,428],"created":[101],"extend":[103],"half-life":[104],"up":[105],"700":[107],"hours":[108],"with":[109,271,330,343,356,467,473],"full":[110],"activity.":[111],"Potentially,":[112],"long-acting":[113],"can":[115,122],"be":[116,123,477,486],"used":[117,276],"in":[118,140,147,152,282,388,414],"limiting":[119],"bleeding":[120,136],"that":[121],"encountered":[124],"during":[125,137,462],"extensive":[126],"partial":[127,138,463],"nephrectomy.":[128],"Objective":[129],"is":[130,263],"test":[132],"effect":[134],"on":[135],"nephrectomy":[139,464],"mice.":[141],"METHODS":[142],"Long-acting":[143],"PAI":[144],"was":[145,178,199,204,209,225,234,250,267,288,328,334,341,347,354,360,367,395,436],"produced":[146],"our":[148],"laboratory":[149],"as":[150,370],"described":[151],"prior":[153],"studies.":[154],"After":[155],"obtaining":[156],"approval":[157],"from":[158,296],"institutional":[159],"animal":[160],"care":[161],"use":[163],"committee,":[164],"11":[165],"week":[166],"old":[167],"male":[168],"mice":[169],"used.":[171],"The":[172,265,300,317],"left":[173,202],"or":[174,187,248],"right":[175],"jugular":[176],"vein":[177],"cannulated":[179],"for":[180,227,256,310],"intravenous":[181],"infusion":[182,195],"tPA":[184,344,357],"(30":[185],"\u03bcg)":[186],"saline":[188,249,331,350],"at":[189],"1.2":[190],"cc/hr.":[191],"Fifteen":[192],"minutes":[193],"after":[194],"start,":[196],"midline":[197],"incision":[198],"done":[200,396],"kidney":[203,214,255,262,307,333,346,359,381,384],"exposed.":[205],"Clear":[206],"plastic":[207,284],"wrap":[208],"placed":[210],"isolate":[212],"the":[213,231,254,260,283,292,297,441],"contain":[216],"blood":[217,280,368,386,412,443,451,469],"loss":[218,287,369,413,444,452],"prevent":[220],"any":[221,279],"moisture":[222],"evaporation.":[223],"Hilum":[224],"clamped":[226],"30":[228,257],"seconds":[229],"while":[230,423],"lower":[232],"third":[233],"resected.":[235],"Previously":[236],"weighted":[237],"gauze":[238,266,275],"(5":[239],"x":[240],"2":[241,340,390,403,416],"cm)":[242],"containing":[243],"0.25":[244],"cc":[245,419,430],"then":[251,268],"applied":[252],"minutes.":[258],"Then,":[259],"whole":[261,383],"excised.":[264],"weighed":[269,411,442],"along":[270],"an":[272,371],"additional":[273],"pre-weighed":[274],"absorb":[278],"remaining":[281,306],"wrap.":[285],"Blood":[286],"measured":[289],"subtracting":[291],"pre-weight":[293],"gauzes":[295],"final":[298],"weight.":[299],"weight":[301],"resected":[303,380],"piece":[304],"recorded":[309],"analysis":[311,394],"variability":[313],"resection":[315],"size.":[316],"animals":[318,475],"divided":[320],"into":[321],"three":[322],"groups.":[323],"Group":[324,339,352],"1":[325],"(procedure":[326],"control)":[327],"infused":[329,342,355],"exposed":[335,348,361,459],"(n1=3).":[338],"(n2=8).":[351],"3":[353,427],"(n3=10).":[364],"Primary":[365],"outcome":[366],"absolute":[372,409,450],"value":[373],"when":[375],"standardized":[376],"ratio":[378],"(weighed":[385],"loss)":[387],"groups":[389],"3.":[392,405],"Statistical":[393],"using":[397],"t-test":[398],"compare":[400],"between":[401,440,449],"group":[402,415,426],"RESULTS":[406],"Means":[407],"0.2125":[418],"0.0552":[421],"cc/g":[422,433],"those":[424],"0.0737":[429],"0.0084":[432],"respectively.":[434],"There":[435],"statistically":[437],"significant":[438],"difference":[439],"means":[445,453],"(p=0.0177)":[446],"but":[447],"not":[448],"(p":[454],"=":[455],"0.0519).":[456],"CONCLUSIONS":[457],"Kidneys":[458],"are":[465],"associated":[466],"less":[468],"loss.":[470],"Further":[471],"experimentation":[472],"larger":[474],"should":[476],"pursued.":[478],"Other":[479],"potential":[480],"urologic":[481],"applications":[482],"studied":[487],"include":[488],"intractable":[489],"hematuria":[490],"percutaneous":[492],"nephrolithotomy.":[493],"\u00a9":[494],"2014FiguresReferencesRelatedDetails":[495],"Volume":[496],"191Issue":[497],"4SApril":[498],"2014Page:":[499],"e397-e398":[500],"Advertisement":[501,530,531],"Copyright":[502],"Permissions\u00a9":[504],"2014MetricsAuthor":[505],"Information":[506],"Expand":[528],"PDF":[532],"downloadLoading":[533],"...":[534]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
