{"id":"https://openalex.org/W2004036163","doi":"https://doi.org/10.1046/j.1471-4159.1995.65031213.x","title":"Influence of Selective Inhibition of Monoamine Oxidase A or B on Striatal Metabolism of l \u2010DOPA in Hemiparkinsonian Rats","display_name":"Influence of Selective Inhibition of Monoamine Oxidase A or B on Striatal Metabolism of l \u2010DOPA in Hemiparkinsonian Rats","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2004036163","doi":"https://doi.org/10.1046/j.1471-4159.1995.65031213.x","mag":"2004036163","pmid":"https://pubmed.ncbi.nlm.nih.gov/7643100"},"language":"en","primary_location":{"id":"doi:10.1046/j.1471-4159.1995.65031213.x","doi":"https://doi.org/10.1046/j.1471-4159.1995.65031213.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1995.65031213.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083196590","display_name":"John P.M. Finberg","orcid":"https://orcid.org/0000-0003-3333-7606","observed_orcids":["https://orcid.org/0000-0003-3333-7606"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. P. M. Finberg","raw_affiliation_strings":["Clinical Neurosciences Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082791080","display_name":"Jixin Wang","orcid":"https://orcid.org/0000-0001-9285-1002","observed_orcids":["https://orcid.org/0000-0001-9285-1002"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Wang","raw_affiliation_strings":["Clinical Neurosciences and Surgical Neurology Branches, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences and Surgical Neurology Branches, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050003203","display_name":"David S. Goldstein","orcid":"https://orcid.org/0000-0002-5709-9940","observed_orcids":["https://orcid.org/0000-0002-5709-9940"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. S. Goldstein","raw_affiliation_strings":["Clinical Neurosciences and Surgical Neurology Branches, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences and Surgical Neurology Branches, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042995179","display_name":"Irwin J. Kopin","orcid":"https://orcid.org/0000-0002-8234-870X","observed_orcids":["https://orcid.org/0000-0002-8234-870X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. J. Kopin","raw_affiliation_strings":["Clinical Neurosciences and Surgical Neurology Branches, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences and Surgical Neurology Branches, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113631313","display_name":"Krys S. Bankiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. S. Bankiewicz","raw_affiliation_strings":["Clinical Neurosciences and Surgical Neurology Branches, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences and Surgical Neurology Branches, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083196590"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":2.3768,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.87948943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"65","issue":"3","first_page":"1213","last_page":"1220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.9539999961853027},{"id":"https://openalex.org/keywords/monoamine-oxidase-b","display_name":"monoamine oxidase B","score":1.0},{"id":"https://openalex.org/keywords/clorgyline","display_name":"clorgyline","score":0.8880000114440918},{"id":"https://openalex.org/keywords/selegiline","display_name":"selegiline","score":0.9919999837875366},{"id":"https://openalex.org/keywords/l-dopa-metabolism","display_name":"L-dopa metabolism","score":0.8309999704360962},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7929999828338623},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.7080000042915344},{"id":"https://openalex.org/keywords/dopac","display_name":"DOPAC","score":0.9049999713897705},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hemiparkinsonism","display_name":"hemiparkinsonism","score":0.8920000195503235},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/dopamine-efflux","display_name":"dopamine efflux","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.7853632569313049},{"id":"https://openalex.org/C39398028","wikidata":"https://www.wikidata.org/wiki/Q18028862","display_name":"Monoamine oxidase B","level":4,"score":0.6538453698158264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5635571479797363},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.553496778011322},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5203441977500916},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.5043376684188843},{"id":"https://openalex.org/C114461151","wikidata":"https://www.wikidata.org/wiki/Q14888415","display_name":"Monoamine oxidase A","level":4,"score":0.4833959639072418},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33070695400238037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3302467465400696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25409990549087524},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.23356670141220093},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23063498735427856},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09941646456718445}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003010","descriptor_name":"Clorgyline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003956","descriptor_name":"Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012642","descriptor_name":"Selegiline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1471-4159.1995.65031213.x","doi":"https://doi.org/10.1046/j.1471-4159.1995.65031213.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1995.65031213.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:7643100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7643100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090751730","https://openalex.org/W2117771667","https://openalex.org/W2029397070","https://openalex.org/W2033301784","https://openalex.org/W2104795285","https://openalex.org/W2089016654","https://openalex.org/W2055515863","https://openalex.org/W2045404004","https://openalex.org/W1496632093","https://openalex.org/W1999014193"],"abstract_inverted_index":{"The":[0,61,179],"effect":[1,160],"of":[2,5,16,41,46,53,69,97,103,137,161,166],"selective":[3,82,88],"inhibition":[4,163],"monoamine":[6],"oxidase":[7],"(MAO)":[8],"subtypes":[9],"A":[10],"and":[11,24,58,106,128,140,192],"B":[12],"on":[13,56,111,125,164],"striatal":[14,75],"metabolism":[15,189],"DOPA":[17,62,98],"to":[18],"dopamine":[19],"(DA),":[20],"3,4-dihydroxyphenylacetic":[21],"acid":[22,26],"(DOPAC),":[23],"4-hydroxy-3-methoxyphenylacetic":[25],"(homovanillic":[27],"acid;":[28],"HVA)":[29],"was":[30,63,109,154],"studied":[31],"in":[32,73,170,187,194],"halothane-anesthetized":[33],"rats":[34],"3":[35],"weeks":[36],"after":[37],"unilateral":[38],"6-hydroxydopamine":[39],"lesion":[40],"the":[42,74,81,87,112,150,171,176,195],"substantia":[43],"nigra.":[44],"Implantation":[45],"bilateral":[47],"microdialysis":[48],"probes":[49],"allowed":[50],"simultaneous":[51],"quantitation":[52],"metabolite":[54],"production":[55],"lesioned":[57,129,172],"control":[59,177],"sides.":[60,130],"administered":[64],"as":[65,173],"a":[66,134,158,182],"15-min":[67],"bolus":[68],"1":[70],"mM":[71],"solution":[72],"microdialysate.":[76],"Rats":[77],"were":[78,147],"pretreated":[79],"with":[80,175],"MAO-A":[83,186],"inhibitor":[84],"clorgyline,":[85],"or":[86,92,119,168],"MAO-B":[89,151,162],"inhibitors":[90],"deprenyl":[91,118],"TVP-101":[93],"[2,3-dihydro-N-2-propynyl-1H-inden-1-amine-(1R)-hydrochloride].":[94],"Intrastriatal":[95],"infusion":[96],"caused":[99,133],"an":[100],"increased":[101,121],"efflux":[102,124,165],"DA,":[104],"DOPAC,":[105],"HVA,":[107],"which":[108],"greater":[110],"intact":[113,127],"side.":[114],"Clorgyline,":[115],"but":[116],"not":[117],"TVP-101,":[120],"post-DOPA":[122,138],"DA":[123,167,188],"both":[126,190],"Clorgyline":[131],"also":[132],"marked":[135],"suppression":[136],"DOPAC":[139],"HVA":[141],"effluxes,":[142],"whereas":[143],"only":[144],"mild":[145],"effects":[146],"produced":[148],"by":[149],"inhibitors.":[152],"There":[153],"no":[155],"evidence":[156],"for":[157,185],"differential":[159],"metabolites":[169],"compared":[174],"striatum.":[178,197],"results":[180],"indicate":[181],"major":[183],"role":[184],"intra-":[191],"extraneuronally":[193],"rat":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}