{"id":"https://openalex.org/W2004025152","doi":"https://doi.org/10.1080/01483918808067207","title":"Measurement of Nicotine in Plasma by High-Performance Liquid Chromatography","display_name":"Measurement of Nicotine in Plasma by High-Performance Liquid Chromatography","publication_year":1988,"publication_date":"1988-09-01","ids":{"openalex":"https://openalex.org/W2004025152","doi":"https://doi.org/10.1080/01483918808067207","mag":"2004025152"},"language":"en","primary_location":{"id":"doi:10.1080/01483918808067207","doi":"https://doi.org/10.1080/01483918808067207","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01483918808067207","pdf_url":null,"source":{"id":"https://openalex.org/S4210197900","display_name":"Journal of Liquid Chromatography","issn_l":"0148-3919","issn":["0148-3919","2331-0413"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liquid Chromatography","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063631826","display_name":"Jaye E. Hefner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaye E. Hefner","raw_affiliation_strings":["Department of Physiology, Texas College of Osteopathic Medicine Fort Worth, Texas, 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Texas College of Osteopathic Medicine Fort Worth, Texas, 76107","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074670029","display_name":"Arthur G. Williams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arthur G. Williams","raw_affiliation_strings":["Department of Physiology, Texas College of Osteopathic Medicine Fort Worth, Texas, 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Texas College of Osteopathic Medicine Fort Worth, Texas, 76107","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012015185","display_name":"Esther J. Robinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esther J. Robinson","raw_affiliation_strings":["Department of Physiology, Texas College of Osteopathic Medicine Fort Worth, Texas, 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Texas College of Osteopathic Medicine Fort Worth, Texas, 76107","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024850921","display_name":"H. Fred Downey","orcid":"https://orcid.org/0000-0002-7280-1021","observed_orcids":["https://orcid.org/0000-0002-7280-1021"]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Fred Downey","raw_affiliation_strings":["Department of Physiology, Texas College of Osteopathic Medicine Fort Worth, Texas, 76107; Department of Internal Medicine, University of Texas, Health Science Center at Dallas, Dallas, Texas, 75235","Department of Internal Medicine , University of Texas , Health Science Center at Dallas, Dallas, Texas, 75235","Department of Physiology , Texas College of Osteopathic Medicine Fort Worth , Texas, 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Texas College of Osteopathic Medicine Fort Worth, Texas, 76107; Department of Internal Medicine, University of Texas, Health Science Center at Dallas, Dallas, Texas, 75235","institution_ids":["https://openalex.org/I4210094379"]},{"raw_affiliation_string":"Department of Internal Medicine , University of Texas , Health Science Center at Dallas, Dallas, Texas, 75235","institution_ids":["https://openalex.org/I4210094379"]},{"raw_affiliation_string":"Department of Physiology , Texas College of Osteopathic Medicine Fort Worth , Texas, 76107","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8181,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64267405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"11","first_page":"2375","last_page":"2389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.41110000014305115,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.41110000014305115,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.3481000065803528,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.17649999260902405,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.949999988079071},{"id":"https://openalex.org/keywords/blood-plasma","display_name":"blood plasma","score":0.7070000171661377},{"id":"https://openalex.org/keywords/nicotine-extraction","display_name":"nicotine extraction","score":0.5410000085830688},{"id":"https://openalex.org/keywords/chloroform-extraction","display_name":"chloroform extraction","score":0.9129999876022339},{"id":"https://openalex.org/keywords/silica-gel-column","display_name":"silica gel column","score":0.5109999775886536},{"id":"https://openalex.org/keywords/uv-detection","display_name":"UV detection","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hplc-analysis","display_name":"HPLC assay","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.86055588722229},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8186218738555908},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.8045377731323242},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6763700842857361},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.615402102470398},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.4255075454711914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.047121286392211914},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/01483918808067207","doi":"https://doi.org/10.1080/01483918808067207","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01483918808067207","pdf_url":null,"source":{"id":"https://openalex.org/S4210197900","display_name":"Journal of Liquid Chromatography","issn_l":"0148-3919","issn":["0148-3919","2331-0413"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315681","host_organization_name":"Marcel Dekker","host_organization_lineage":["https://openalex.org/P4310315681"],"host_organization_lineage_names":["Marcel Dekker"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liquid Chromatography","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1965447052","https://openalex.org/W1981399097","https://openalex.org/W1998601349","https://openalex.org/W2015736627","https://openalex.org/W2022612951","https://openalex.org/W2033817042","https://openalex.org/W2034452624","https://openalex.org/W2040605981","https://openalex.org/W2056703445","https://openalex.org/W2069714933","https://openalex.org/W2070220826","https://openalex.org/W2074772928","https://openalex.org/W2083900701","https://openalex.org/W2090191580","https://openalex.org/W2100620365"],"related_works":["https://openalex.org/W2026254424","https://openalex.org/W2076181113","https://openalex.org/W2597716306","https://openalex.org/W3121783629","https://openalex.org/W2353497846","https://openalex.org/W7100028556","https://openalex.org/W2039331791","https://openalex.org/W2005600582","https://openalex.org/W1869971420","https://openalex.org/W3196678410"],"abstract_inverted_index":{"A":[0],"new":[1],"procedure":[2,61],"has":[3],"been":[4],"developed":[5],"to":[6,64,81,94],"measure":[7],"nicotine":[8,68,91,99],"in":[9],"blood":[10],"plasma":[11,21,39,72],"by":[12,22,30],"high-performance":[13],"liquid":[14],"chromatography":[15],"(HPLC).":[16],"Nicotine":[17],"is":[18,28,41,62,74],"extracted":[19],"from":[20],"elution":[23],"with":[24,33,54],"cholorform.":[25],"Final":[26],"determination":[27],"achieved":[29],"isocratic":[31],"HPLC":[32],"ultraviolet":[34],"detection.":[35],"Twenty":[36],"microliters":[37],"of":[38,51,67,71,79,84,90,98,106,113],"extract":[40],"deluted":[42],"over":[43],"a":[44,48,55,87],"silica":[45],"column":[46],"at":[47],"flow":[49],"rate":[50],"1.0":[52],"ml/min":[53],"dioxane:isopropanol:NH4OH":[56],"(80:3.0:0.4)":[57],"mobile":[58],"phase.":[59],"The":[60,110],"sensitive":[63],"0.05":[65,80],"ug":[66],"per":[69],"ml":[70],"and":[73],"linear":[75],"within":[76],"the":[77,96,107],"range":[78],"10.0":[82],"ug/ml":[83],"plasma.":[85],"When":[86],"known":[88,108],"amount":[89],"was":[92,115],"added":[93],"plasma,":[95],"concentration":[97],"measured":[100],"averaged":[101],"99.9":[102],"+":[103],"3.9":[104],"(S.D.)%":[105],"concentration.":[109],"within-sample":[111],"coefficient":[112],"variation":[114],"3.9%":[116]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}