{"id":"https://openalex.org/W2004019018","doi":"https://doi.org/10.1016/s0022-5347(05)00163-1","title":"North American White Mitochondrial Haplogroups in Prostate and Renal Cancer","display_name":"North American White Mitochondrial Haplogroups in Prostate and Renal Cancer","publication_year":2006,"publication_date":"2006-01-08","ids":{"openalex":"https://openalex.org/W2004019018","doi":"https://doi.org/10.1016/s0022-5347(05)00163-1","mag":"2004019018","pmid":"https://pubmed.ncbi.nlm.nih.gov/16406974"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(05)00163-1","doi":"https://doi.org/10.1016/s0022-5347(05)00163-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(05)00163-1","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036037696","display_name":"Lyra M. Booker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lyra M. Booker","raw_affiliation_strings":["Department of Urology, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046704088","display_name":"Geoffrey M. Habermacher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey M. Habermacher","raw_affiliation_strings":["Department of Urology, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021538109","display_name":"Benjamin C. Jessie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin C. Jessie","raw_affiliation_strings":["Department of Urology, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109966957","display_name":"Qi Carrie Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Carrie Sun","raw_affiliation_strings":["Department of Urology, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081358653","display_name":"Amanda K. Baumann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda K. Baumann","raw_affiliation_strings":["Department of Urology, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102981230","display_name":"Mahul B. Amin","orcid":"https://orcid.org/0000-0001-5943-3634","observed_orcids":["https://orcid.org/0000-0001-5943-3634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahul Amin","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011562609","display_name":"So Dug Lim","orcid":"https://orcid.org/0000-0003-2036-0313","observed_orcids":["https://orcid.org/0000-0003-2036-0313"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"So Dug Lim","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075604590","display_name":"Carina P. Fernandez-Golarz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carina Fernandez-Golarz","raw_affiliation_strings":["Department of Urology, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006024935","display_name":"Robert H. Lyles","orcid":"https://orcid.org/0000-0001-7883-6404","observed_orcids":["https://orcid.org/0000-0001-7883-6404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert H. Lyles","raw_affiliation_strings":["School of Public Health, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Macon, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael D. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150149174","display_name":"Mercer University","ror":"https://ror.org/04bk7v425","country_code":"US","type":"education","lineage":["https://openalex.org/I150149174"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Brown","raw_affiliation_strings":["Atlanta and Mercer University School of Medicine, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta and Mercer University School of Medicine, Macon, Georgia","institution_ids":["https://openalex.org/I150149174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020818394","display_name":"Fray F. Marshall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fray F. Marshall","raw_affiliation_strings":["Department of Urology, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Macon, Georgia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057088967","display_name":"John A. Petros","orcid":"https://orcid.org/0000-0002-4472-6335","observed_orcids":["https://orcid.org/0000-0002-4472-6335"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Petros","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Macon, Georgia","Department of Urology, Macon, Georgia","Emory University and Atlanta Veterans Affairs Medical Center, Macon, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Macon, Georgia","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, Macon, Georgia","institution_ids":[]},{"raw_affiliation_string":"Emory University and Atlanta Veterans Affairs Medical Center, Macon, Georgia","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":5.7857,"has_fulltext":false,"cited_by_count":141,"citation_normalized_percentile":{"value":0.96916536,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"175","issue":"2","first_page":"468","last_page":"473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.30809998512268066,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9330000281333923},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mitochondrial-inheritance","display_name":"mitochondrial inheritance","score":0.699999988079071},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5239999890327454},{"id":"https://openalex.org/keywords/white-men","display_name":"white men","score":0.6800000071525574},{"id":"https://openalex.org/keywords/north-american-populations","display_name":"North American populations","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.942116379737854},{"id":"https://openalex.org/C56273599","wikidata":"https://www.wikidata.org/wiki/Q3122841","display_name":"White (mutation)","level":3,"score":0.6137048602104187},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.543419599533081},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.49057167768478394},{"id":"https://openalex.org/C201526758","wikidata":"https://www.wikidata.org/wiki/Q80686","display_name":"Haplogroup","level":5,"score":0.4684448540210724},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4221354126930237},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3600916564464569},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30002549290657043},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.07475385069847107},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.059871017932891846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(05)00163-1","doi":"https://doi.org/10.1016/s0022-5347(05)00163-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(05)00163-1","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:16406974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16406974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G280284612","display_name":"Prostate Cancer Bone Metastasis Biology and Targeting","funder_award_id":"P01CA098912","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3401050234","display_name":null,"funder_award_id":"CA98912","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6010327929","display_name":"Mitochondrial DNA in Mutations in Prostate Cancer","funder_award_id":"R01CA096994","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G871452396","display_name":null,"funder_award_id":"CA96994","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1483242733","https://openalex.org/W1549290306","https://openalex.org/W1553373033","https://openalex.org/W1917926680","https://openalex.org/W1973653736","https://openalex.org/W1979970299","https://openalex.org/W1980684918","https://openalex.org/W1989519508","https://openalex.org/W1990839388","https://openalex.org/W2005758857","https://openalex.org/W2009829901","https://openalex.org/W2022650434","https://openalex.org/W2035499008","https://openalex.org/W2052703170","https://openalex.org/W2069931604","https://openalex.org/W2072451938","https://openalex.org/W2075132593","https://openalex.org/W2095915630","https://openalex.org/W2141371533","https://openalex.org/W2163069284","https://openalex.org/W2167438676","https://openalex.org/W2986272972","https://openalex.org/W3209992856","https://openalex.org/W4251955174"],"related_works":["https://openalex.org/W2027050653","https://openalex.org/W2332911585","https://openalex.org/W1972263098","https://openalex.org/W7096740158","https://openalex.org/W2009834416","https://openalex.org/W2053450004","https://openalex.org/W7097506239","https://openalex.org/W2796685665","https://openalex.org/W2321893712","https://openalex.org/W2031273586"],"abstract_inverted_index":{"PURPOSE:":[0],"While":[1],"the":[2,19,30,72,234],"mitochondrion":[3],"is":[4,48,190,229],"known":[5],"to":[6,40,44],"be":[7],"a":[8,104,124,221],"key":[9,68],"mediator":[10],"of":[11,22,67,77,94,106,170,178,186,198,205,233],"apoptosis,":[12],"there":[13,47,239],"has":[14],"been":[15],"little":[16],"inquiry":[17],"into":[18],"inheritance":[20,185],"pattern":[21],"mitochondria":[23],"in":[24,33,42,71,155,208,220,231,246],"patients":[25,34],"with":[26,35,83,192,215],"cancer.":[27,55,182],"We":[28],"compared":[29],"mtDNA":[31],"haplotype":[32,218],"prostate":[36,86,130,173,199],"and":[37,54,79,85,115,131,137,147,175,201],"renal":[38,84,132,156,181,206],"cancer":[39,133,157,174,200,207],"that":[41],"controls":[43,99,135],"determine":[45],"if":[46],"an":[49,168,176,193],"association":[50,151],"between":[51],"mitochondrial":[52,73,187,217,226],"genotype":[53],"MATERIALS":[56],"AND":[57],"METHODS:":[58],"Haplotyping":[59],"was":[60,113,123],"performed":[61,114],"using":[62],"polymerase":[63],"chain":[64],"reaction/digest":[65],"identification":[66],"polymorphic":[69],"sites":[70],"genome.":[74],"A":[75],"total":[76],"121":[78],"221":[80],"white":[81,98,209,235],"men":[82],"cancer,":[87,95],"respectively,":[88],"were":[89,100,117],"identified":[90],"following":[91],"pathological":[92],"confirmation":[93],"while":[96],"246":[97],"selected":[101],"randomly":[102],"from":[103],"bank":[105],"cadaveric":[107],"organ":[108],"donor":[109],"DNA.":[110],"Statistical":[111],"analysis":[112],"ORs":[116],"calculated.":[118],"RESULTS:":[119],"Mitochondrial":[120],"haplogroup":[121,188,227],"U":[122,166,189,228],"highly":[125],"significant":[126,154],"risk":[127,197,204,223,249],"factor":[128],"for":[129,162,172,180],"vs":[134,139],"(16.74%":[136],"20.66%":[138],"9.35%,":[140],"Fisher's":[141],"exact":[142],"test":[143],"p":[144],"=":[145],"0.019":[146],"0.005,":[148],"respectively).":[149],"The":[150,184],"remained":[152],"statistically":[153],"even":[158],"after":[159],"Bonferroni":[160],"adjustment":[161],"multiple":[163],"comparisons.":[164],"Haplogroup":[165],"carried":[167],"OR":[169,177],"1.95":[171],"2.52":[179],"CONCLUSIONS:":[183],"associated":[191],"approximately":[194],"2-fold":[195],"increased":[196,203],"2.5-fold":[202],"North":[210],"American":[211],"individuals.":[212],"Therefore,":[213],"individuals":[214,245],"this":[216,247],"are":[219,240],"high":[222,248],"group.":[224,250],"Because":[225],"found":[230],"9.35%":[232],"United":[236],"States":[237],"population,":[238],"more":[241],"than":[242],"20":[243],"million":[244]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
