{"id":"https://openalex.org/W2004012343","doi":"https://doi.org/10.1210/me.2008-0300","title":"Loss of Betaglycan Contributes to the Malignant Properties of Human Granulosa Tumor Cells","display_name":"Loss of Betaglycan Contributes to the Malignant Properties of Human Granulosa Tumor Cells","publication_year":2009,"publication_date":"2009-01-23","ids":{"openalex":"https://openalex.org/W2004012343","doi":"https://doi.org/10.1210/me.2008-0300","mag":"2004012343","pmid":"https://pubmed.ncbi.nlm.nih.gov/19164448","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5419273"},"language":"en","primary_location":{"id":"doi:10.1210/me.2008-0300","doi":"https://doi.org/10.1210/me.2008-0300","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2008-0300","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5419273","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045883594","display_name":"Maree Bilandzic","orcid":"https://orcid.org/0000-0002-6319-1153","observed_orcids":["https://orcid.org/0000-0002-6319-1153","https://orcid.org/0000-0002-9457-4333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maree Bilandzic","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013915903","display_name":"Simon Chu","orcid":"https://orcid.org/0000-0003-4658-215X","observed_orcids":["https://orcid.org/0000-0003-4658-215X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Chu","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088213224","display_name":"Paul G. Farnworth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul G. Farnworth","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079892976","display_name":"Craig A. Harrison","orcid":"https://orcid.org/0000-0003-1059-3682","observed_orcids":["https://orcid.org/0000-0003-1059-3682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig Harrison","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040427992","display_name":"Peter K. Nicholls","orcid":"https://orcid.org/0000-0002-5540-442X","observed_orcids":["https://orcid.org/0000-0002-5540-442X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Nicholls","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613706","display_name":"Yao Wang","orcid":"https://orcid.org/0009-0000-9141-9891","observed_orcids":["https://orcid.org/0009-0000-9141-9891","https://orcid.org/0000-0001-9578-9128","https://orcid.org/0000-0001-8927-6588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yao Wang","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088204119","display_name":"Ruth M. Escalona","orcid":"https://orcid.org/0000-0002-7070-7728","observed_orcids":["https://orcid.org/0000-0002-7070-7728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth M. Escalona","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046419066","display_name":"Peter J. Fuller","orcid":"https://orcid.org/0000-0002-0948-2072","observed_orcids":["https://orcid.org/0000-0002-0948-2072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J. Fuller","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107484284","display_name":"Jock K. Findlay","orcid":"https://orcid.org/0000-0001-8025-5799","observed_orcids":["https://orcid.org/0000-0001-8025-5799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jock K. Findlay","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034848117","display_name":"Kaye L. Stenvers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaye L. Stenvers","raw_affiliation_strings":["Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince Henry\u2019s Institute of Medical Research, Clayton, Victoria 3168, Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.8396,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.97099511,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"4","first_page":"539","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.27469998598098755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betaglycan","display_name":"betaglycan","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ovarian-granulosa-cell-tumor","display_name":"ovarian granulosa cell tumor","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.7400000095367432},{"id":"https://openalex.org/keywords/inhibin-a","display_name":"inhibin A","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.878000020980835},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8009999990463257},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9890000224113464},{"id":"https://openalex.org/keywords/kgn-cells","display_name":"KGN cells","score":0.6069999933242798},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6190363764762878},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5879396200180054},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5253238677978516},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4744642376899719},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4255122244358063},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42360424995422363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.379149854183197},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3489546775817871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2185496687889099},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19614818692207336},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0856783390045166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05773240327835083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006106","descriptor_name":"Granulosa Cell Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006106","descriptor_name":"Granulosa Cell Tumor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/me.2008-0300","doi":"https://doi.org/10.1210/me.2008-0300","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2008-0300","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5419273","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5419273","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Endocrinol","raw_type":"Text"},{"id":"pmid:19164448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19164448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5419273","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5419273","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Endocrinol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W207785097","https://openalex.org/W1966123943","https://openalex.org/W1969619516","https://openalex.org/W1972535443","https://openalex.org/W1980615784","https://openalex.org/W1987544972","https://openalex.org/W1987705769","https://openalex.org/W1993800649","https://openalex.org/W1997096869","https://openalex.org/W1998106693","https://openalex.org/W2007019698","https://openalex.org/W2008702706","https://openalex.org/W2017799047","https://openalex.org/W2019998854","https://openalex.org/W2026463198","https://openalex.org/W2029515001","https://openalex.org/W2035066075","https://openalex.org/W2037038224","https://openalex.org/W2037472243","https://openalex.org/W2042183080","https://openalex.org/W2046446541","https://openalex.org/W2050007095","https://openalex.org/W2061564388","https://openalex.org/W2062960630","https://openalex.org/W2069117573","https://openalex.org/W2078977017","https://openalex.org/W2088721663","https://openalex.org/W2093016551","https://openalex.org/W2094579915","https://openalex.org/W2103484049","https://openalex.org/W2106487699","https://openalex.org/W2106876536","https://openalex.org/W2111949892","https://openalex.org/W2112548808","https://openalex.org/W2123761761","https://openalex.org/W2129072528","https://openalex.org/W2134659127","https://openalex.org/W2135153712","https://openalex.org/W2136856538","https://openalex.org/W2145870562","https://openalex.org/W2148734937","https://openalex.org/W2154564110","https://openalex.org/W2156345810","https://openalex.org/W2158403875","https://openalex.org/W2162203291","https://openalex.org/W2164615751","https://openalex.org/W2165769086","https://openalex.org/W2165927567","https://openalex.org/W2167185127","https://openalex.org/W2170563954","https://openalex.org/W2186618994","https://openalex.org/W4285719527","https://openalex.org/W6663240408","https://openalex.org/W6676783725"],"related_works":["https://openalex.org/W1981085847","https://openalex.org/W2595243635","https://openalex.org/W2595380812","https://openalex.org/W2593663184","https://openalex.org/W2104557772","https://openalex.org/W2536566900","https://openalex.org/W2170563954","https://openalex.org/W2029515001","https://openalex.org/W2031850977","https://openalex.org/W4391844014"],"abstract_inverted_index":{"Betaglycan":[0,148],"is":[1],"a":[2,23,97],"type":[3],"III":[4],"TGFbeta":[5,131,183,232],"receptor":[6,65],"that":[7,19,94,179,193,245],"modulates":[8],"cellular":[9,165],"sensitivity":[10],"to":[11,51,74,130,206,240,250],"inhibins":[12],"and":[13,84,121,127,132,158,169,225,231],"TGFbeta.":[14],"Previous":[15],"studies":[16],"have":[17],"suggested":[18],"betaglycan":[20,35,57,76,102,125,178,198,248],"acts":[21],"as":[22,105],"tumor":[24,68],"suppressor":[25],"in":[26,36,78,135,182,187,238],"certain":[27],"human":[28,54,79,116],"epithelial":[29],"cancers.":[30],"However,":[31],"the":[32,108,151,194,207,219,235,251],"roles":[33],"of":[34,47,145,153,174,177,197,210,214,222,247,253],"ovarian":[37],"granulosa":[38],"cell":[39,118,190],"tumors":[40],"(GCTs)":[41],"are":[42,180],"poorly":[43],"understood.":[44],"The":[45],"objective":[46],"this":[48,64],"study":[49],"was":[50,72,140],"determine":[52],"whether":[53],"GCTs":[55,80,95],"exhibit":[56],"expression":[58,126,217],"and,":[59],"if":[60],"so,":[61],"what":[62],"impact":[63],"has":[66],"on":[67,199],"biology.":[69],"Real-time":[70],"PCR":[71],"used":[73],"quantify":[75],"transcripts":[77],"(n":[81,88],"=":[82,89],"17)":[83],"normal":[85,109],"premenopausal":[86],"ovaries":[87],"11).":[90],"This":[91],"analysis":[92],"established":[93],"exhibited":[96,123],"significant":[98],"2-fold":[99],"lower":[100],"mean":[101],"mRNA":[103,216],"level":[104],"compared":[106],"with":[107],"ovary":[110],"(P":[111,155,160],"<":[112,156,161],"0.05).":[113],"Similarly,":[114],"two":[115],"GCT":[117,189],"lines,":[119],"KGN":[120,159],"COV434,":[122],"low":[124],"poor":[128],"responsiveness":[129],"inhibin":[133,185],"A":[134],"luciferase":[136],"reporter":[137],"assays,":[138],"which":[139],"restored":[141],"by":[142],"stable":[143],"transfection":[144],"wild-type":[146],"betaglycan.":[147,211],"significantly":[149],"increased":[150],"adhesion":[152,239],"COV434":[154],"0.05)":[157],"0.0001)":[162],"cells,":[163],"decreased":[164],"invasion":[166],"through":[167],"Matrigel,":[168],"inhibited":[170],"wound":[171,200,223],"healing.":[172],"Expression":[173],"mutant":[175],"forms":[176],"defective":[181],"and/or":[184],"binding":[186],"each":[188],"line":[191],"revealed":[192],"inhibitory":[195],"effects":[196],"healing":[201,224],"were":[202],"most":[203],"strongly":[204],"linked":[205],"inhibin-binding":[208],"region":[209],"Furthermore,":[212],"knockdown":[213],"INHA":[215,229],"abrogated":[218],"betaglycan-mediated":[220,236],"inhibition":[221],"invasion,":[226],"whereas":[227],"both":[228],"silencing":[230],"neutralization":[233],"abolished":[234],"increase":[237],"substrate.":[241],"These":[242],"data":[243],"suggest":[244],"loss":[246],"contributes":[249],"pathogenesis":[252],"GCTs.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}