{"id":"https://openalex.org/W2003999068","doi":"https://doi.org/10.1111/j.1365-2141.1994.tb04829.x","title":"Trisomy 8q due to i(8q) or der(8) t(8;8) is a frequent lesion in T\u2010prolymphocytic leukaemia: four new cases and a review of the literature","display_name":"Trisomy 8q due to i(8q) or der(8) t(8;8) is a frequent lesion in T\u2010prolymphocytic leukaemia: four new cases and a review of the literature","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W2003999068","doi":"https://doi.org/10.1111/j.1365-2141.1994.tb04829.x","mag":"2003999068","pmid":"https://pubmed.ncbi.nlm.nih.gov/7918072"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2141.1994.tb04829.x","doi":"https://doi.org/10.1111/j.1365-2141.1994.tb04829.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1994.tb04829.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062978849","display_name":"Hossain Mossafa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hossain Mossafa","raw_affiliation_strings":["Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109201512","display_name":"A. Brizard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Brizard","raw_affiliation_strings":["Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110394357","display_name":"J. L. Huret","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean\u2010Loup Huret","raw_affiliation_strings":["Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111507362","display_name":"Fran\u00e7oise Brizard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Brizard","raw_affiliation_strings":["Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112156004","display_name":"M Lessard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Lessard","raw_affiliation_strings":["Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079181777","display_name":"Fran\u00e7ois Guilhot","orcid":"https://orcid.org/0000-0001-7222-487X","observed_orcids":["https://orcid.org/0000-0001-7222-487X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Guilhot","raw_affiliation_strings":["Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017804017","display_name":"Joseph Tanzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph Tanzer","raw_affiliation_strings":["Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and Medical Oncology, Hospital Jean Bernard, Poitiers, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017804017"],"corresponding_institution_ids":[],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.4768,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.59917111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"86","issue":"4","first_page":"780","last_page":"785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.7919999957084656},{"id":"https://openalex.org/keywords/complex-karyotype","display_name":"complex karyotype","score":0.7329999804496765},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.8259999752044678},{"id":"https://openalex.org/keywords/misdiagnosis","display_name":"misdiagnosis","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C57269778","wikidata":"https://www.wikidata.org/wiki/Q900950","display_name":"Isochromosome","level":5,"score":0.8776512145996094},{"id":"https://openalex.org/C2775983024","wikidata":"https://www.wikidata.org/wiki/Q2112719","display_name":"Prolymphocytic leukemia","level":4,"score":0.7931660413742065},{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.6033931374549866},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.5376620888710022},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4555048942565918},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44094786047935486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36870622634887695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3661925792694092},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.3064003586769104},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2977980971336365},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.279853880405426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27335578203201294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17855587601661682},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014314","descriptor_name":"Trisomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015463","descriptor_name":"Leukemia, Prolymphocytic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015463","descriptor_name":"Leukemia, Prolymphocytic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2141.1994.tb04829.x","doi":"https://doi.org/10.1111/j.1365-2141.1994.tb04829.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1994.tb04829.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:7918072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7918072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W60627455","https://openalex.org/W97057411","https://openalex.org/W110182977","https://openalex.org/W1268837306","https://openalex.org/W1573670911","https://openalex.org/W1920736461","https://openalex.org/W1967392052","https://openalex.org/W1970260565","https://openalex.org/W1971838881","https://openalex.org/W1995713499","https://openalex.org/W1997401403","https://openalex.org/W2011394719","https://openalex.org/W2011878914","https://openalex.org/W2016402849","https://openalex.org/W2019777175","https://openalex.org/W2034672817","https://openalex.org/W2046459084","https://openalex.org/W2052186936","https://openalex.org/W2071051822","https://openalex.org/W2077514518","https://openalex.org/W2078126586","https://openalex.org/W2093266389","https://openalex.org/W2093497494","https://openalex.org/W2123515007","https://openalex.org/W2129856600","https://openalex.org/W2132024248","https://openalex.org/W2136524266","https://openalex.org/W2155644365","https://openalex.org/W2244191812","https://openalex.org/W2294256298","https://openalex.org/W2294844639","https://openalex.org/W2413156864","https://openalex.org/W2419362207","https://openalex.org/W2419497204","https://openalex.org/W2427875378","https://openalex.org/W2436372235","https://openalex.org/W2942665234","https://openalex.org/W4232211849","https://openalex.org/W4249790511","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2244191812","https://openalex.org/W2558628044","https://openalex.org/W2021692298","https://openalex.org/W3208728428","https://openalex.org/W2168689651","https://openalex.org/W2138330388","https://openalex.org/W2138275899","https://openalex.org/W1967689932","https://openalex.org/W2143234217","https://openalex.org/W2064935407"],"abstract_inverted_index":{"Cytogenetic":[0],"abnormalities":[1],"found":[2,17,88,100,163],"in":[3,18,24,59,75,89,164,181,184],"four":[4,28],"cases":[5,46,109,142],"of":[6,38,47,77,93,110,128,143,149,157,167,189,195],"T-cell":[7,126],"prolymphocytic":[8],"leukaemia":[9,114],"(T-PLL)":[10],"are":[11,61,161],"described.":[12],"An":[13],"isochromosome":[14],"8q":[15,160],"was":[16],"three":[19],"patients":[20,94],"and":[21,33,80,138,186],"a":[22,35],"t(8;8)":[23],"one.":[25],"In":[26,40],"the":[27,52,54,105,125,146,178,187,196],"cases,":[29],"karyotypes":[30],"were":[31,99],"complex":[32],"showed":[34],"high":[36],"degree":[37],"instability.":[39],"addition,":[41],"we":[42],"reviewed":[43],"27":[44],"published":[45],"cytogenetically":[48,107],"studied":[49,108],"T-PLL.":[50,158],"On":[51],"whole,":[53],"most":[55],"frequently":[56,103],"recurring":[57],"anomalies":[58,98],"T-PLL":[60,150,185],"14q":[62],"lesions":[63],"with":[64],"nonrandom":[65],"breakpoints,":[66],"inversion":[67],"(14)(q11q32)":[68],"or":[69,134],"tandem":[70],"translocations":[71],"(14;14)":[72],"(not":[73],"seen":[74],"any":[76,182],"our":[78],"cases)":[79],"trisomy":[81,190],"for":[82,191],"8q.":[83],"mainly":[84],"due":[85],"to":[86,118,176],"i(8q),":[87],"more":[90],"than":[91],"40%":[92],"each.":[95],"Similar":[96],"structural":[97],"almost":[101],"as":[102,193],"among":[104],"23":[106],"so-called":[111],"T-chronic":[112],"lymphocytic":[113],"(T-CLL)":[115],"reported":[116,141],"prior":[117],"1989.":[119],"It":[120],"is":[121,135,200],"now":[122],"accepted":[123],"that":[124],"counterpart":[127],"B-CLL":[129],"either":[130],"does":[131],"not":[132,173],"exist":[133],"exceedingly":[136],"rare":[137],"thus":[139],"previously":[140],"T-CLL":[144],"sharing":[145],"chromosomal":[147],"characteristics":[148],"may":[151],"well":[152,194],"have":[153],"been":[154],"misdiagnosed":[155],"examples":[156],"Isochromosomes":[159],"exceptionally":[162],"other":[165],"types":[166],"haematological":[168],"malignancies.":[169],"However,":[170],"i(8q)":[171],"could":[172],"be":[174,177],"shown":[175],"primary":[179],"lesion":[180],"case":[183],"role":[188],"8q,":[192],"associated":[197],"monosomy":[198],"8p,":[199],"entirely":[201],"unknown.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}