{"id":"https://openalex.org/W2003994256","doi":"https://doi.org/10.1002/(sici)1099-081x(199809)19:6<357::aid-bdd114>3.0.co;2-g","title":"Pharmacokinetic and pharmacodynamic changes of furosemide after intravenous and oral administration to rats with alloxan-induced diabetes mellitus","display_name":"Pharmacokinetic and pharmacodynamic changes of furosemide after intravenous and oral administration to rats with alloxan-induced diabetes mellitus","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2003994256","doi":"https://doi.org/10.1002/(sici)1099-081x(199809)19:6<357::aid-bdd114>3.0.co;2-g","mag":"2003994256","pmid":"https://pubmed.ncbi.nlm.nih.gov/9737816"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1099-081x(199809)19:6<357::aid-bdd114>3.0.co;2-g","doi":"https://doi.org/10.1002/(sici)1099-081x(199809)19:6<357::aid-bdd114>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199809)19:6<357::aid-bdd114>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034403201","display_name":"Joo H. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo H. Park","raw_affiliation_strings":["College of Pharmacy, Seoul National University, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Seoul National University, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Woo I. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo I. Lee","raw_affiliation_strings":["College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105892469","display_name":"Woo H. Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo H. Yoon","raw_affiliation_strings":["College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038937864","display_name":"Young-D. Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young-D. Park","raw_affiliation_strings":["Central-Research Institute, Dong Shin Pharmaceutical Company Ltd., 176-3 Kohyun Ri, Jinwee-Myun, Pyungtaek-Kun, Kyunggi-Do 451-860, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central-Research Institute, Dong Shin Pharmaceutical Company Ltd., 176-3 Kohyun Ri, Jinwee-Myun, Pyungtaek-Kun, Kyunggi-Do 451-860, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039800012","display_name":"Jung-S. Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jung-S. Lee","raw_affiliation_strings":["Central-Research Institute, Dong Shin Pharmaceutical Company Ltd., 176-3 Kohyun Ri, Jinwee-Myun, Pyungtaek-Kun, Kyunggi-Do 451-860, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central-Research Institute, Dong Shin Pharmaceutical Company Ltd., 176-3 Kohyun Ri, Jinwee-Myun, Pyungtaek-Kun, Kyunggi-Do 451-860, Republic of Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108426257","display_name":"Myung G. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Myung G. Lee","raw_affiliation_strings":["College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108426257"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"19","issue":"6","first_page":"357","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.4562999904155731,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.4562999904155731,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.15119999647140503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/furosemide","display_name":"furosemide","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.8019999861717224},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.8370000123977661},{"id":"https://openalex.org/keywords/diuretic-efficiency","display_name":"diuretic efficiency","score":0.7910000085830688},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.7009999752044678},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.6899999976158142},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5139999985694885},{"id":"https://openalex.org/keywords/drug-disease-interactions","display_name":"drug-disease interactions","score":0.453000009059906},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2777955127","wikidata":"https://www.wikidata.org/wiki/Q388801","display_name":"Furosemide","level":2,"score":0.8804771304130554},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.73288893699646},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6969490051269531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.634377658367157},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.5840202569961548},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5753291845321655},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5682838559150696},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5579062104225159},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5506030917167664},{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.5314775109291077},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4954906702041626},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.42872336506843567},{"id":"https://openalex.org/C2779547328","wikidata":"https://www.wikidata.org/wiki/Q584691","display_name":"Diuresis","level":3,"score":0.4162617325782776},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3679529130458832}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000496","descriptor_name":"Alloxan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005665","descriptor_name":"Furosemide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1099-081x(199809)19:6<357::aid-bdd114>3.0.co;2-g","doi":"https://doi.org/10.1002/(sici)1099-081x(199809)19:6<357::aid-bdd114>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199809)19:6<357::aid-bdd114>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},{"id":"pmid:9737816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9737816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics & drug disposition","raw_type":"Comparative Study"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/218275","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/218275","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031801165","https://openalex.org/W4232028077","https://openalex.org/W2068628316","https://openalex.org/W1971165336","https://openalex.org/W140270533","https://openalex.org/W2007441526","https://openalex.org/W2130234804","https://openalex.org/W2400647136","https://openalex.org/W2091428965","https://openalex.org/W2065514354"],"abstract_inverted_index":{"Because":[0],"some":[1],"physiological":[2],"changes":[3],"occurring":[4],"in":[5,70,114,160,164,168,181,216,255,285],"diabetes":[6,50],"mellitus":[7,51],"patients":[8],"could":[9],"alter":[10],"the":[11,16,20,22,37,57,88,121,140,169,184,201,204,240,256,273],"pharmacokinetics":[12,23],"and":[13,24,33,48,72,138,149],"pharmacodynamics":[14,25],"of":[15,26,36,96,103,155,196,230,235,266],"drugs":[17],"to":[18,45,76,117,211,226,259],"treat":[19],"disease,":[21],"furosemide":[27,104,231,267],"were":[28],"investigated":[29],"after":[30,105],"intravenous":[31],"(i.v.)":[32],"oral":[34,199,238],"administration":[35,107],"drug":[38],"(6":[39],"mg":[40,147],"per":[41,174,245],"whole":[42],"body":[43,59,156],"weight)":[44,157],"control":[46],"rats":[47,52],"alloxan-induced":[49],"(AIDRs).":[53],"After":[54,198,237],"i.v.":[55,106],"administration,":[56,200,239],"total":[58],"clearance":[60,80,90,128],"(5.47":[61],"versus":[62,82,111,133,145,153,178,219,249,269,281],"7.05":[63],"mL":[64,84,135,283],"min(-1)":[65,85,136],"kg(-1))":[66,86,137],"was":[67,74,91,129,189],"significantly":[68,77,109,130,159,191,215,254,260,279],"slower":[69,78,131],"AIDRs":[71,115,217,257],"this":[73],"due":[75,116,225,258],"renal":[79],"(2.35":[81],"4.33":[83,134],"because":[87],"nonrenal":[89],"comparable":[92],"between":[93,193],"two":[94,194],"groups":[95,195],"rats.":[97,197],"The":[98],"8":[99,170,185,212,241,262,274],"h":[100,171,186,213,242,263,275],"urinary":[101,264],"excretion":[102,265],"decreased":[108,214,228,253,261],"(2280":[110],"3760":[112],"microg)":[113],"impaired":[118],"kidney":[119,150,176,247],"function;":[120],"glomerular":[122],"filtration":[123],"rate":[124],"measured":[125],"by":[126],"creatinine":[127],"(2.86":[132],"both":[139],"plasma":[141,205],"urea":[142],"nitrogen":[143],"(43.5":[144],"17.3":[146],"dL(-1))":[148],"weight":[151],"(0.953":[152],"0.749%":[154],"increased":[158,278],"AIDRs.":[161,182,236,286],"This":[162],"resulted":[163],"a":[165],"significant":[166],"decrease":[167],"urine":[172,243],"output":[173,244],"g":[175,246],"(17.8":[177],"43.6":[179],"mL)":[180,251],"However,":[183],"diuretic":[187,276],"efficiency":[188,277],"not":[190],"different":[192],"area":[202],"under":[203],"concentration-time":[206],"curve":[207],"from":[208,232],"time":[209],"0":[210],"(1200":[218],"1910":[220],"microg":[221],"x":[222],"min":[223],"mL(-1))":[224],"considerably":[227],"absorption":[229],"gastrointestinal":[233],"tract":[234],"(18.6":[248],"36.4":[250],"also":[252],"(405":[268],"2210":[270],"microg),":[271],"however,":[272],"(127":[280],"35.2":[282],"mg(-1))":[284]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}