{"id":"https://openalex.org/W2003989159","doi":"https://doi.org/10.1016/s0196-9781(97)00178-2","title":"Decreases in Systemic Arterial and Hindquarters Perfusion Pressure in Response to Nociceptin Are Not Inhibited by Naloxone in the Rat","display_name":"Decreases in Systemic Arterial and Hindquarters Perfusion Pressure in Response to Nociceptin Are Not Inhibited by Naloxone in the Rat","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2003989159","doi":"https://doi.org/10.1016/s0196-9781(97)00178-2","mag":"2003989159","pmid":"https://pubmed.ncbi.nlm.nih.gov/9396061"},"language":"en","primary_location":{"id":"doi:10.1016/s0196-9781(97)00178-2","doi":"https://doi.org/10.1016/s0196-9781(97)00178-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0196-9781(97)00178-2","pdf_url":null,"source":{"id":"https://openalex.org/S120382301","display_name":"Peptides","issn_l":"0196-9781","issn":["0196-9781","1873-5169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007746995","display_name":"Marc A. Czapla","orcid":"https://orcid.org/0009-0008-3291-6028","observed_orcids":["https://orcid.org/0009-0008-3291-6028"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.A Czapla","raw_affiliation_strings":["Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA","Departments of Pharmacology and Physiology, Tulane University School of Medicine, New Orleans, LA 70112USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Departments of Pharmacology and Physiology, Tulane University School of Medicine, New Orleans, LA 70112USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109278846","display_name":"Hunter C. Champion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.C Champion","raw_affiliation_strings":["Departments of Pharmacology and Physiology, Tulane University School of Medicine, New Orleans, LA 70112USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Physiology, Tulane University School of Medicine, New Orleans, LA 70112USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108535774","display_name":"Philip J. Kadowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P.J Kadowitz","raw_affiliation_strings":["Departments of Pharmacology and Physiology, Tulane University School of Medicine, New Orleans, LA 70112USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Physiology, Tulane University School of Medicine, New Orleans, LA 70112USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108535774"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":1.2815,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.77781666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"8","first_page":"1197","last_page":"1200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nociceptin","display_name":"nociceptin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/orl1-receptor","display_name":"ORL1 receptor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.7409999966621399},{"id":"https://openalex.org/keywords/systemic-blood-pressure","display_name":"systemic blood pressure","score":0.7509999871253967},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.5049999952316284},{"id":"https://openalex.org/keywords/met-enkephalin","display_name":"met-enkephalin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dea-no","display_name":"DEA/NO","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.972000002861023},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C125439840","wikidata":"https://www.wikidata.org/wiki/Q14911984","display_name":"Nociceptin receptor","level":5,"score":0.9220031499862671},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.6851742267608643},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6684557795524597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6441265344619751},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5528978109359741},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5176680088043213},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.4682261645793915},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.4533585011959076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45031052827835083},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.44000113010406494},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.42632395029067993},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4141434133052826},{"id":"https://openalex.org/C3017995582","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Endogenous opioid","level":4,"score":0.41034409403800964},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.3784528374671936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36188897490501404},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2556609511375427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14546233415603638},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.10713276267051697},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000097629","descriptor_name":"Nociceptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018847","descriptor_name":"Opioid Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0196-9781(97)00178-2","doi":"https://doi.org/10.1016/s0196-9781(97)00178-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0196-9781(97)00178-2","pdf_url":null,"source":{"id":"https://openalex.org/S120382301","display_name":"Peptides","issn_l":"0196-9781","issn":["0196-9781","1873-5169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"journal-article"},{"id":"pmid:9396061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9396061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Peptides","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4580082933","display_name":"HUMORAL CONTROL OF PULMONARY AND SYSTEMIC CIRCULATION","funder_award_id":"R01HL015580","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1598044684","https://openalex.org/W1976325021","https://openalex.org/W1988185716","https://openalex.org/W1991377640","https://openalex.org/W1992685840","https://openalex.org/W2011885458","https://openalex.org/W2016562510","https://openalex.org/W2016960897","https://openalex.org/W2027884975","https://openalex.org/W2030381973","https://openalex.org/W2047345012","https://openalex.org/W2055246318","https://openalex.org/W2066624199","https://openalex.org/W2073314491","https://openalex.org/W2077530921","https://openalex.org/W2083920808","https://openalex.org/W2093513199","https://openalex.org/W2166290059","https://openalex.org/W2397252797","https://openalex.org/W2407372133","https://openalex.org/W6635671486"],"related_works":["https://openalex.org/W1983906384","https://openalex.org/W2164524573","https://openalex.org/W2093513199","https://openalex.org/W1996184752","https://openalex.org/W2159677072","https://openalex.org/W2056245975","https://openalex.org/W2002640022","https://openalex.org/W1992685840","https://openalex.org/W2083920808","https://openalex.org/W1989521646"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}