{"id":"https://openalex.org/W2003786243","doi":"https://doi.org/10.1097/00008571-199712000-00012","title":"Lack of association of tyrosine hydroxylase genetic polymorphism with cigarette smoking","display_name":"Lack of association of tyrosine hydroxylase genetic polymorphism with cigarette smoking","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2003786243","doi":"https://doi.org/10.1097/00008571-199712000-00012","mag":"2003786243","pmid":"https://pubmed.ncbi.nlm.nih.gov/9429239"},"language":"en","primary_location":{"id":"doi:10.1097/00008571-199712000-00012","doi":"https://doi.org/10.1097/00008571-199712000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00008571-199712000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S196130971","display_name":"Pharmacogenetics","issn_l":"0960-314X","issn":["0960-314X","1473-561X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020250839","display_name":"Caryn Lerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caryn Lerman","raw_affiliation_strings":["Lombardi Cancer Centre, Georgetown University Medical Centre, Washington, DC 20007-4104, USA. lermanc@gunet.georgetown.edu","Lombardi Cancer Centre, Georgetown University Medical Centre, 2233 Wisconsin Avenue, NW, Suite 535, Washington, DC 20007-4104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Cancer Centre, Georgetown University Medical Centre, Washington, DC 20007-4104, USA. lermanc@gunet.georgetown.edu","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Lombardi Cancer Centre, Georgetown University Medical Centre, 2233 Wisconsin Avenue, NW, Suite 535, Washington, DC 20007-4104, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079716545","display_name":"Peter G. Shields","orcid":"https://orcid.org/0000-0002-7404-217X","observed_orcids":["https://orcid.org/0000-0002-7404-217X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter G Shields","raw_affiliation_strings":["Molecular Epidemiology Section, Laboratory of Human Carcinogenesis, National Cancer Institute, National Cancer Institute, 37 Convent Drive, MSC 42 5 5, Bcthesda, MD 20892-42 5 5, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Epidemiology Section, Laboratory of Human Carcinogenesis, National Cancer Institute, National Cancer Institute, 37 Convent Drive, MSC 42 5 5, Bcthesda, MD 20892-42 5 5, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081249224","display_name":"David Main","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Main","raw_affiliation_strings":["Lombardi Cancer Centre, Georgetown University Medical Centre, 2233 Wisconsin Avenue, NW, Suite 535, Washington, DC 20007-4104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Cancer Centre, Georgetown University Medical Centre, 2233 Wisconsin Avenue, NW, Suite 535, Washington, DC 20007-4104, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090889648","display_name":"Janet E. Audrain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Audrain","raw_affiliation_strings":["Lombardi Cancer Centre, Georgetown University Medical Centre, 2233 Wisconsin Avenue, NW, Suite 535, Washington, DC 20007-4104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Cancer Centre, Georgetown University Medical Centre, 2233 Wisconsin Avenue, NW, Suite 535, Washington, DC 20007-4104, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068412773","display_name":"Joan Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Roth","raw_affiliation_strings":["Lombardi Cancer Centre, Georgetown University Medical Centre, 2233 Wisconsin Avenue, NW, Suite 535, Washington, DC 20007-4104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Cancer Centre, Georgetown University Medical Centre, 2233 Wisconsin Avenue, NW, Suite 535, Washington, DC 20007-4104, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022792236","display_name":"Neal Richard Boyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal R Boyd","raw_affiliation_strings":["Division of Population Science, Fox Chase Cancer Centre, 510 Township Line Road, Cheltenham, PA 1 9012, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Population Science, Fox Chase Cancer Centre, 510 Township Line Road, Cheltenham, PA 1 9012, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019329822","display_name":"Neil E. Caporaso","orcid":"https://orcid.org/0000-0001-7562-4609","observed_orcids":["https://orcid.org/0000-0001-7562-4609"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil E Caporaso","raw_affiliation_strings":["Pharmacogenetics Section, Genetic Epidemiology, National Cancer Institute, 6130 Executive Boulevard, Executive Plaza North, Rockville, MD 2OH52. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacogenetics Section, Genetic Epidemiology, National Cancer Institute, 6130 Executive Boulevard, Executive Plaza North, Rockville, MD 2OH52. USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4239,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.81286628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"6","first_page":"521","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0885000005364418,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gene-environment-association","display_name":"gene-environment association","score":0.6299999952316284},{"id":"https://openalex.org/keywords/catecholamine-metabolism","display_name":"catecholamine metabolism","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.569359302520752},{"id":"https://openalex.org/C2909129545","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine 3-Monooxygenase","level":4,"score":0.5209285616874695},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5064951181411743},{"id":"https://openalex.org/C3019085024","wikidata":"https://www.wikidata.org/wiki/Q7212330","display_name":"Cigarette smoking","level":2,"score":0.47293901443481445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4717355966567993},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3588082194328308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2962486743927002},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.2635543942451477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1734308898448944},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1594105064868927},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15839147567749023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07961371541023254}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004219","descriptor_name":"District of Columbia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015143","descriptor_name":"Philadelphia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00008571-199712000-00012","doi":"https://doi.org/10.1097/00008571-199712000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00008571-199712000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S196130971","display_name":"Pharmacogenetics","issn_l":"0960-314X","issn":["0960-314X","1473-561X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics","raw_type":"journal-article"},{"id":"pmid:9429239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9429239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2054759508","https://openalex.org/W2311626522","https://openalex.org/W2023786669","https://openalex.org/W7099853979","https://openalex.org/W3149478417","https://openalex.org/W7075644488","https://openalex.org/W2271419033","https://openalex.org/W2012145041","https://openalex.org/W2949411313","https://openalex.org/W3037600749"],"abstract_inverted_index":{"Lerman,":[0],"Caryn;":[1],"Shields,":[2],"Peter":[3],"G;":[4],"Main,":[5],"David;":[6],"Audrain,":[7],"Janet;":[8],"Roth,":[9],"Joan;":[10],"Boyd,":[11],"Neal":[12],"R;":[13],"Caporaso,":[14],"Neil":[15],"E":[16],"Author":[17],"Information":[18]},"counts_by_year":[{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}