{"id":"https://openalex.org/W2003753489","doi":"https://doi.org/10.1016/j.tox.2006.11.002","title":"Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties","display_name":"Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties","publication_year":2006,"publication_date":"2006-11-14","ids":{"openalex":"https://openalex.org/W2003753489","doi":"https://doi.org/10.1016/j.tox.2006.11.002","mag":"2003753489","pmid":"https://pubmed.ncbi.nlm.nih.gov/17196727"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2006.11.002","doi":"https://doi.org/10.1016/j.tox.2006.11.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2006.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2003753489"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044206554","display_name":"David B. Warheit","orcid":"https://orcid.org/0000-0002-9780-4704","observed_orcids":["https://orcid.org/0000-0002-9780-4704"]},"institutions":[{"id":"https://openalex.org/I1316910977","display_name":"DuPont (United States)","ror":"https://ror.org/03g3m1w62","country_code":"US","type":"company","lineage":["https://openalex.org/I1316910977"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David B. Warheit","raw_affiliation_strings":["DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA. david.b.warheit@usa.dupont.com","DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA. david.b.warheit@usa.dupont.com","institution_ids":["https://openalex.org/I1316910977"]},{"raw_affiliation_string":"DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA","institution_ids":["https://openalex.org/I1316910977"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas R. Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316910977","display_name":"DuPont (United States)","ror":"https://ror.org/03g3m1w62","country_code":"US","type":"company","lineage":["https://openalex.org/I1316910977"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Webb","raw_affiliation_strings":["DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA","institution_ids":["https://openalex.org/I1316910977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111511287","display_name":"Kenneth L. Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316910977","display_name":"DuPont (United States)","ror":"https://ror.org/03g3m1w62","country_code":"US","type":"company","lineage":["https://openalex.org/I1316910977"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth L. Reed","raw_affiliation_strings":["DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA","institution_ids":["https://openalex.org/I1316910977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111626378","display_name":"Scott Frerichs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316910977","display_name":"DuPont (United States)","ror":"https://ror.org/03g3m1w62","country_code":"US","type":"company","lineage":["https://openalex.org/I1316910977"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Frerichs","raw_affiliation_strings":["DuPont Titanium Technologies, Wilmington, DE 19803, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DuPont Titanium Technologies, Wilmington, DE 19803, USA","institution_ids":["https://openalex.org/I1316910977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079022942","display_name":"Christie Maria Sayes","orcid":"https://orcid.org/0000-0002-5529-4101","observed_orcids":["https://orcid.org/0000-0002-5529-4101"]},"institutions":[{"id":"https://openalex.org/I1316910977","display_name":"DuPont (United States)","ror":"https://ror.org/03g3m1w62","country_code":"US","type":"company","lineage":["https://openalex.org/I1316910977"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christie M. Sayes","raw_affiliation_strings":["DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, DE 19714-0050, USA","institution_ids":["https://openalex.org/I1316910977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044206554"],"corresponding_institution_ids":["https://openalex.org/I1316910977"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":22.2753,"has_fulltext":false,"cited_by_count":661,"citation_normalized_percentile":{"value":0.9980464,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"230","issue":"1","first_page":"90","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.4092000126838684,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.4092000126838684,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.36059999465942383,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.1023000031709671,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-toxicity","display_name":"pulmonary toxicity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/surface-properties","display_name":"surface properties","score":0.7009999752044678},{"id":"https://openalex.org/keywords/rutile-tio2","display_name":"rutile TiO2","score":0.8100000023841858},{"id":"https://openalex.org/keywords/quartz","display_name":"quartz","score":0.4050000011920929},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.718999981880188},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.753000020980835},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.5669999718666077},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.921999990940094},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8610000014305115},{"id":"https://openalex.org/keywords/alpha-quartz","display_name":"alpha-quartz","score":0.609000027179718},{"id":"https://openalex.org/keywords/intratracheal-instillation","display_name":"intratracheal instillation","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C150032891","wikidata":"https://www.wikidata.org/wiki/Q7880535","display_name":"Ultrafine particle","level":2,"score":0.8370300531387329},{"id":"https://openalex.org/C2777889555","wikidata":"https://www.wikidata.org/wiki/Q320603","display_name":"Rutile","level":2,"score":0.7966044545173645},{"id":"https://openalex.org/C2777402863","wikidata":"https://www.wikidata.org/wiki/Q413357","display_name":"Anatase","level":4,"score":0.7183985710144043},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.6011120676994324},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5289145708084106},{"id":"https://openalex.org/C2781047374","wikidata":"https://www.wikidata.org/wiki/Q2100012","display_name":"Pulmonary toxicity","level":3,"score":0.4786180853843689},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.46540623903274536},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42278552055358887},{"id":"https://openalex.org/C2777593239","wikidata":"https://www.wikidata.org/wiki/Q193521","display_name":"Titanium dioxide","level":2,"score":0.4227394461631775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4077310562133789},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.37049204111099243},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3201996684074402},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2461501955986023},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.21663635969161987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1906464397907257},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.16144531965255737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08590367436408997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06599453091621399},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06181901693344116},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007507","descriptor_name":"Therapeutic Irrigation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011791","descriptor_name":"Quartz","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tox.2006.11.002","doi":"https://doi.org/10.1016/j.tox.2006.11.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2006.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:17196727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17196727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W81369347","https://openalex.org/W166321423","https://openalex.org/W643602444","https://openalex.org/W1984142674","https://openalex.org/W1988888066","https://openalex.org/W1996838083","https://openalex.org/W2011254969","https://openalex.org/W2032953614","https://openalex.org/W2035054419","https://openalex.org/W2039935804","https://openalex.org/W2049641678","https://openalex.org/W2053119528","https://openalex.org/W2054684604","https://openalex.org/W2059536479","https://openalex.org/W2075791335","https://openalex.org/W2077699069","https://openalex.org/W2084183600","https://openalex.org/W2095285770","https://openalex.org/W2099191918","https://openalex.org/W2113637303","https://openalex.org/W2122021233","https://openalex.org/W2134896722","https://openalex.org/W2135980592","https://openalex.org/W2136587232","https://openalex.org/W2140720810","https://openalex.org/W2149848619","https://openalex.org/W2155118487","https://openalex.org/W2159364645","https://openalex.org/W2164752041","https://openalex.org/W2165418613","https://openalex.org/W2170488399","https://openalex.org/W4248285292","https://openalex.org/W4285719527","https://openalex.org/W4300503711"],"related_works":["https://openalex.org/W2785874289","https://openalex.org/W2160920388","https://openalex.org/W2135980592","https://openalex.org/W2149848619","https://openalex.org/W2101829025","https://openalex.org/W1984124225","https://openalex.org/W2058527061","https://openalex.org/W1967627528","https://openalex.org/W1981332418"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":47},{"year":2015,"cited_by_count":49},{"year":2014,"cited_by_count":47},{"year":2013,"cited_by_count":52},{"year":2012,"cited_by_count":55}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}