{"id":"https://openalex.org/W2003727255","doi":"https://doi.org/10.1210/en.140.3.1294","title":"Role of Signal Transduction in Internalization of the G Protein-Coupled Receptor for Parathyroid Hormone (PTH) and PTH-Related Protein","display_name":"Role of Signal Transduction in Internalization of the G Protein-Coupled Receptor for Parathyroid Hormone (PTH) and PTH-Related Protein","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2003727255","doi":"https://doi.org/10.1210/en.140.3.1294","mag":"2003727255","pmid":"https://pubmed.ncbi.nlm.nih.gov/10067856"},"language":"en","primary_location":{"id":"doi:10.1210/en.140.3.1294","doi":"https://doi.org/10.1210/en.140.3.1294","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.140.3.1294","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072904368","display_name":"Zhengmin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengmin Huang","raw_affiliation_strings":["Endocrine Research Unit (Z.H., T.B., Y.C., R.A.N.), Veterans\u2019 Affairs Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, California 94121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit (Z.H., T.B., Y.C., R.A.N.), Veterans\u2019 Affairs Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, California 94121;","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029762083","display_name":"Tom Bambino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Bambino","raw_affiliation_strings":["Endocrine Research Unit (Z.H., T.B., Y.C., R.A.N.), Veterans\u2019 Affairs Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, California 94121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit (Z.H., T.B., Y.C., R.A.N.), Veterans\u2019 Affairs Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, California 94121;","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100383000","display_name":"Ying Chen","orcid":"https://orcid.org/0000-0001-6303-5858","observed_orcids":["https://orcid.org/0000-0001-6303-5858","https://orcid.org/0000-0001-6180-1600"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Chen","raw_affiliation_strings":["Endocrine Research Unit (Z.H., T.B., Y.C., R.A.N.), Veterans\u2019 Affairs Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, California 94121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit (Z.H., T.B., Y.C., R.A.N.), Veterans\u2019 Affairs Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, California 94121;","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005645056","display_name":"Jelveh Lameh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jelveh Lameh","raw_affiliation_strings":["Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry (J.L.), School of Pharmacy, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry (J.L.), School of Pharmacy, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067422009","display_name":"Robert A. Nissenson","orcid":"https://orcid.org/0000-0002-0701-0151","observed_orcids":["https://orcid.org/0000-0002-0701-0151"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert A. Nissenson","raw_affiliation_strings":["Endocrine Research Unit (Z.H., T.B., Y.C., R.A.N.), Veterans\u2019 Affairs Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, California 94121;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit (Z.H., T.B., Y.C., R.A.N.), Veterans\u2019 Affairs Medical Center and Departments of Medicine and Physiology, University of California, San Francisco, California 94121;","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067422009"],"corresponding_institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.0536,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.73025584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"140","issue":"3","first_page":"1294","last_page":"1300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pth-pthrp-receptor","display_name":"PTH/PTHrP receptor","score":0.8059999942779541},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-internalization","display_name":"G protein-coupled receptor internalization","score":0.8289999961853027},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9909999966621399},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.878000020980835},{"id":"https://openalex.org/keywords/opossum","display_name":"Didelphidae","score":0.6209999918937683},{"id":"https://openalex.org/keywords/agonist-binding","display_name":"agonist binding","score":0.7310000061988831},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7919999957084656},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9890000224113464},{"id":"https://openalex.org/keywords/second-messenger-signaling","display_name":"second messenger signaling","score":0.5879999995231628},{"id":"https://openalex.org/keywords/receptor-conformational-change","display_name":"receptor conformational change","score":0.7360000014305115},{"id":"https://openalex.org/keywords/teriparatide","display_name":"teriparatide","score":0.7580000162124634},{"id":"https://openalex.org/keywords/pthrp-1-34","display_name":"PTHrP(1-34)","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.7872055768966675},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6118085384368896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6074585318565369},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.5759807229042053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5693946480751038},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.5593953728675842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5303977727890015},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5203968286514282},{"id":"https://openalex.org/C75184817","wikidata":"https://www.wikidata.org/wiki/Q5381540","display_name":"Enzyme-linked receptor","level":3,"score":0.47880277037620544},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.44464248418807983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4298170804977417},{"id":"https://openalex.org/C116016267","wikidata":"https://www.wikidata.org/wiki/Q18039826","display_name":"Interleukin-21 receptor","level":3,"score":0.4165347218513489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15286040306091309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09436598420143127},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.06006637215614319}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018016","descriptor_name":"Receptors, Parathyroid Hormone","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044162","descriptor_name":"Parathyroid Hormone-Related Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044168","descriptor_name":"Receptor, Parathyroid Hormone, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.140.3.1294","doi":"https://doi.org/10.1210/en.140.3.1294","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.140.3.1294","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.140.3.6584","doi":"https://doi.org/10.1210/endo.140.3.6584","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.140.3.6584","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:10067856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10067856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3732051043","display_name":"PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE","funder_award_id":"R01DK035323","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6871328031","display_name":"MECHANISM OF PTH/PTHRP RECEPTOR MEDIATED ENDOCYTOSIS","funder_award_id":"F32DK009187","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1954929088","https://openalex.org/W1965382934","https://openalex.org/W1965963242","https://openalex.org/W1966525626","https://openalex.org/W1967194189","https://openalex.org/W1968093456","https://openalex.org/W1968950287","https://openalex.org/W1969557235","https://openalex.org/W1973852009","https://openalex.org/W1976455796","https://openalex.org/W1976820979","https://openalex.org/W1977826459","https://openalex.org/W1986929579","https://openalex.org/W1989899477","https://openalex.org/W2011456572","https://openalex.org/W2014237427","https://openalex.org/W2025472785","https://openalex.org/W2028672563","https://openalex.org/W2035192379","https://openalex.org/W2046813958","https://openalex.org/W2059536365","https://openalex.org/W2060594505","https://openalex.org/W2063513614","https://openalex.org/W2066715966","https://openalex.org/W2067698573","https://openalex.org/W2078762652","https://openalex.org/W2080273350","https://openalex.org/W2080697422","https://openalex.org/W2085530184","https://openalex.org/W2090845744","https://openalex.org/W2092827299","https://openalex.org/W2094892613","https://openalex.org/W2096160632","https://openalex.org/W2111211256","https://openalex.org/W2119705421","https://openalex.org/W2125111388","https://openalex.org/W2134344512","https://openalex.org/W2135319033","https://openalex.org/W2147590428","https://openalex.org/W2149305593","https://openalex.org/W2151074506","https://openalex.org/W2153523264","https://openalex.org/W2165244186","https://openalex.org/W2169295770","https://openalex.org/W2414697249","https://openalex.org/W4231136244","https://openalex.org/W4232524111","https://openalex.org/W6715635827"],"related_works":["https://openalex.org/W1969557235","https://openalex.org/W2096160632","https://openalex.org/W2129979663","https://openalex.org/W1974662997","https://openalex.org/W2034919163","https://openalex.org/W2132762811","https://openalex.org/W1979950308","https://openalex.org/W1973852009","https://openalex.org/W96144113","https://openalex.org/W4289341937"],"abstract_inverted_index":{"For":[0],"G":[1,40,284],"protein-coupled":[2,41],"receptors,":[3],"limited":[4],"information":[5],"is":[6,264,300],"available":[7],"on":[8,22],"the":[9,16,30,51,58,86,118,133,161,171,178,196,229,252,267,271],"role":[10,119,289],"of":[11,15,19,54,57,120,132,148,163,209,228,247,270,296],"agonist":[12,262],"binding":[13,263],"or":[14,175],"second-messenger":[17,121],"products":[18],"receptor":[20,23,61,95,135,164,172,179,193,224,241,249,255,275,278,291,307],"signaling":[21,76,96,110],"endocytosis.":[24,206,242],"We":[25],"explored":[26],"this":[27],"problem":[28],"using":[29,254],"opossum":[31,59],"PTH/PTH-related":[32],"protein":[33,197],"(PTHrP)":[34],"receptor,":[35,42],"a":[36,44,125,155,188,219,235,287],"prototypical":[37],"Class":[38],"II":[39],"as":[43],"model.":[45],"In":[46],"one":[47],"approach,":[48],"we":[49,63,123],"evaluated":[50],"endocytic":[52],"properties":[53],"mutated":[55],"forms":[56],"PTH/PTHrP":[60,94,248,272],"that":[62,91,104],"had":[64,182],"previously":[65],"shown":[66],"to":[67,73,129,203,238,283],"be":[68],"impaired":[69],"in":[70,79,85,109,138,191,222,290],"their":[71],"ability":[72],"initiate":[74],"agonist-induced":[75,240],"when":[77],"expressed":[78,137],"COS-7":[80],"cells.":[81,144],"A":[82,145],"point":[83],"mutation":[84],"third":[87],"cytoplasmic":[88],"loop":[89],"(K382A)":[90],"severely":[92],"impairs":[93],"significantly":[97],"reduced":[98],"internalization,":[99],"whereas":[100,177],"two":[101],"mutant":[102],"receptors":[103],"displayed":[105],"only":[106,218],"partial":[107],"defects":[108],"were":[111],"internalized":[112],"normally.":[113],"To":[114],"explore":[115],"more":[116],"directly":[117],"pathways,":[122],"used":[124],"cleavable":[126],"biotinylation":[127],"method":[128],"assess":[130],"endocytosis":[131,269],"wild-type":[134],"stably":[136],"human":[139],"embryonic":[140],"kidney":[141],"(HEK)":[142],"293":[143],"low":[146],"rate":[147,162],"constitutive":[149,192,223],"internalization":[150,165,250],"was":[151,166],"detected":[152],"(<5%":[153],"over":[154],"30-min":[156],"incubation":[157],"at":[158],"37":[159],"C);":[160],"enhanced":[167],"about":[168],"10-fold":[169],"by":[170,211,232],"agonists":[173],"PTH(1-34)":[174],"PTHrP(1-34),":[176],"antagonist":[180],"PTH(7-34)":[181],"no":[183],"effect.":[184],"Forskolin":[185],"treatment":[186,212,233],"produced":[187],"minimal":[189,220],"increase":[190,221],"endocytosis,":[194],"and":[195,226,293,298],"kinase":[198],"(PK)-A":[199],"inhibitor":[200],"H-89":[201],"failed":[202,237],"block":[204],"agonist-stimulated":[205,306],"Similarly,":[207],"activation":[208,276,295],"PK-C,":[210],"with":[213,234],"phorbol":[214],"12-myristate":[215],"13-acetate,":[216],"elicited":[217],"endocytosis;":[225],"blockade":[227],"PK-C":[230,299],"pathway,":[231],"bisindolylmaleimide,":[236],"inhibit":[239],"Immunofluorescence":[243],"confocal":[244],"microscopic":[245],"studies":[246],"confirmed":[251],"results":[253],"biotinylation.":[256],"These":[257],"findings":[258],"suggest":[259],"that:":[260],"1)":[261],"required":[265],"for":[266,305],"efficient":[268],"receptor;":[273],"2)":[274],"(agonist-induced":[277],"conformational":[279],"change)":[280],"and/or":[281],"coupling":[282],"proteins":[285],"plays":[286],"critical":[288],"internalization;":[292],"3)":[294],"PK-A":[297],"neither":[301],"necessary":[302],"nor":[303],"sufficient":[304],"internalization.":[308]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
