{"id":"https://openalex.org/W2003709806","doi":"https://doi.org/10.1097/fpc.0b013e328349daa1","title":"Beta2-adrenergic receptor polymorphisms as a determinant of preferential bronchodilator responses to \u03b22-agonist and anticholinergic agents in Japanese patients with chronic obstructive pulmonary disease","display_name":"Beta2-adrenergic receptor polymorphisms as a determinant of preferential bronchodilator responses to \u03b22-agonist and anticholinergic agents in Japanese patients with chronic obstructive pulmonary disease","publication_year":2011,"publication_date":"2011-10-04","ids":{"openalex":"https://openalex.org/W2003709806","doi":"https://doi.org/10.1097/fpc.0b013e328349daa1","mag":"2003709806","pmid":"https://pubmed.ncbi.nlm.nih.gov/21881540"},"language":"en","primary_location":{"id":"doi:10.1097/fpc.0b013e328349daa1","doi":"https://doi.org/10.1097/fpc.0b013e328349daa1","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fpc.0b013e328349daa1","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025695892","display_name":"Satoshi Konno","orcid":"https://orcid.org/0000-0001-6439-2443","observed_orcids":["https://orcid.org/0000-0001-6439-2443"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Konno","raw_affiliation_strings":["First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068638978","display_name":"Hironi Makita","orcid":"https://orcid.org/0000-0002-4208-8982","observed_orcids":["https://orcid.org/0000-0002-4208-8982"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironi Makita","raw_affiliation_strings":["First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016648286","display_name":"Masaru Hasegawa","orcid":"https://orcid.org/0000-0002-8731-949X","observed_orcids":["https://orcid.org/0000-0002-8731-949X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Hasegawa","raw_affiliation_strings":["First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036442562","display_name":"Yasuyuki Nasuhara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Nasuhara","raw_affiliation_strings":["First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037650","display_name":"Katsura Nagai","orcid":"https://orcid.org/0000-0002-1257-9844","observed_orcids":["https://orcid.org/0000-0002-1257-9844"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsura Nagai","raw_affiliation_strings":["First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072440708","display_name":"Tomoko Betsuyaku","orcid":"https://orcid.org/0000-0001-8807-5645","observed_orcids":["https://orcid.org/0000-0001-8807-5645"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Betsuyaku","raw_affiliation_strings":["First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","Department of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Department of Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112013626","display_name":"Nobuyuki Hizawa","orcid":"https://orcid.org/0000-0003-1822-2448","observed_orcids":["https://orcid.org/0000-0003-1822-2448"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4210114927","display_name":"University of Tsukuba Hospital","ror":"https://ror.org/028fz3b89","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114927"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Hizawa","raw_affiliation_strings":["Department of Pulmonary Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, Tsukuba, Ibaraki, Japan","university of Tsukuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4210114927"]},{"raw_affiliation_string":"university of Tsukuba","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081243390","display_name":"Masaharu Nishimura","orcid":"https://orcid.org/0000-0002-6456-4361","observed_orcids":["https://orcid.org/0000-0002-6456-4361"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaharu Nishimura","raw_affiliation_strings":["First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","to Dr Masaharu Nishimura, First Department of Medicine, Hokkaido University School of Medicine, Kita-15 Nishi-7 Kita-Ku, Sapporo 060\u20138638, Japan Tel: +81 11 716 1161\u00d75911; fax: +81 11 706 7899; e-mail: [email\u00a0protected]","Hokkaido University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"to Dr Masaharu Nishimura, First Department of Medicine, Hokkaido University School of Medicine, Kita-15 Nishi-7 Kita-Ku, Sapporo 060\u20138638, Japan Tel: +81 11 716 1161\u00d75911; fax: +81 11 706 7899; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Hokkaido University","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081243390"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":null,"apc_paid":null,"fwci":2.233,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.87754435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"21","issue":"11","first_page":"687","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.878000020980835},{"id":"https://openalex.org/keywords/adrb2-polymorphisms","display_name":"ADRB2 polymorphisms","score":0.9359999895095825},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bronchodilator-response","display_name":"bronchodilator response","score":0.9929999709129333},{"id":"https://openalex.org/keywords/beta-2-adrenergic-agonists","display_name":"beta2-adrenergic agonists","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anticholinergic-drugs","display_name":"anticholinergic agents","score":0.9409999847412109},{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.984000027179718},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.7260000109672546},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.6700000166893005},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.842577338218689},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.8153610229492188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7603211402893066},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7242635488510132},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6016559600830078},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5402542948722839},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5188269019126892},{"id":"https://openalex.org/C2909548125","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator Agents","level":4,"score":0.4731612801551819},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.4645293653011322},{"id":"https://openalex.org/C3017940444","wikidata":"https://www.wikidata.org/wiki/Q287961","display_name":"B2 receptor","level":4,"score":0.4458343982696533},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42604056000709534},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41870272159576416},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4121881425380707},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2441093623638153},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012602","descriptor_name":"Scopolamine Derivatives","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018680","descriptor_name":"Cholinergic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058666","descriptor_name":"Adrenergic beta-2 Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/fpc.0b013e328349daa1","doi":"https://doi.org/10.1097/fpc.0b013e328349daa1","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fpc.0b013e328349daa1","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"},{"id":"pmid:21881540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21881540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and genomics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320317302","display_name":"Boehringer Ingelheim Japan","ror":"https://ror.org/02r1d7x68"},{"id":"https://openalex.org/F4320333002","display_name":"Pfizer Japan","ror":"https://ror.org/05pm71w80"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1967567932","https://openalex.org/W1973954620","https://openalex.org/W1978801965","https://openalex.org/W2003293665","https://openalex.org/W2017014359","https://openalex.org/W2051159483","https://openalex.org/W2066166144","https://openalex.org/W2076107981","https://openalex.org/W2084894893","https://openalex.org/W2090430326","https://openalex.org/W2094495786","https://openalex.org/W2097845477","https://openalex.org/W2101612379","https://openalex.org/W2101932319","https://openalex.org/W2103038852","https://openalex.org/W2109006492","https://openalex.org/W2112278267","https://openalex.org/W2113096218","https://openalex.org/W2121774438","https://openalex.org/W2134436842","https://openalex.org/W2143454168","https://openalex.org/W2145322825","https://openalex.org/W2150103375","https://openalex.org/W2160092183","https://openalex.org/W2164405525","https://openalex.org/W2178027278","https://openalex.org/W4255337810","https://openalex.org/W4405992955"],"related_works":["https://openalex.org/W2097845477","https://openalex.org/W1521573673","https://openalex.org/W2277920461","https://openalex.org/W2089611746","https://openalex.org/W1862378926","https://openalex.org/W6885091418","https://openalex.org/W2596020814","https://openalex.org/W2075103724","https://openalex.org/W2017014359","https://openalex.org/W2187820162"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"studies":[2],"have":[3],"shown":[4],"that":[5,37],"polymorphisms":[6,51,67],"in":[7,28,31,52,75,87,126,130,226,231,251],"the":[8,32,38,63,88,113,135,147,153,156,196,200,209,212,227,232],"\u03b22-adrenergic":[9],"receptor":[10],"gene":[11],"(ADRB2)":[12],"may":[13,239],"influence":[14],"bronchodilator":[15,210],"response":[16,40,214],"(BDR)":[17],"to":[18,41,71,94,178,181,193,246],"both":[19],"\u03b22-agonists":[20,72,248],"and":[21,68,73,118,180,217],"anticholinergics,":[22],"possibly":[23],"by":[24,49],"intracellular":[25],"cross-talk,":[26],"but":[27],"opposite":[29],"ways,":[30],"Japanese":[33],"population.":[34],"We":[35],"hypothesized":[36],"preferential":[39,69,244],"either":[42,95,247],"class":[43,96],"of":[44,65,97,115,123,155,195,243],"bronchodilators":[45,98],"might":[46],"be":[47,240],"determined":[48],"ADRB2":[50,66,237],"patients":[53,76,252],"with":[54,77,253],"chronic":[55],"obstructive":[56],"pulmonary":[57],"disease":[58],"(COPD).":[59],"OBJECTIVE:":[60],"To":[61,151],"examine":[62],"association":[64],"BDR":[70,93,116,245],"anticholinergics":[74,250],"COPD.":[78,254],"DESIGN":[79],"AND":[80],"PARTICIPANTS:":[81],"The":[82],"participants":[83,201],"had":[84],"been":[85],"enrolled":[86],"Hokkaido":[89],"COPD":[90],"cohort":[91],"study.":[92],"(salbutamol":[99],"or":[100,249],"oxytropium,":[101],"0.4":[102],"mg)":[103],"was":[104,165,183,222],"measured":[105,138,160],"every":[106],"6":[107],"months":[108],"for":[109,134,146,168],"2":[110],"years.":[111],"Considering":[112],"variation":[114],"within":[117],"between":[119,176],"days,":[120],"mean":[121],"values":[122],"postbronchodilator":[124],"increases":[125],"forced":[127],"expiratory":[128],"volume":[129],"1":[131],"s":[132],"(\u0394FEV\u2081)":[133],"two":[136,140,197,205],"agents":[137],"at":[139,161],"different":[141],"visits":[142],"were":[143,188,202],"initially":[144],"used":[145,167],"primary":[148,157],"analysis":[149],"(N=189).":[150],"confirm":[152],"results":[154],"analysis,":[158],"\u0394FEV\u2081":[159],"a":[162,173,241],"single":[163],"visit":[164],"also":[166],"secondary":[169],"analyses.":[170],"RESULTS:":[171],"Although":[172],"significant":[174],"correlation":[175],"BDRs":[177],"salbutamol":[179],"oxytropium":[182],"observed":[184],"(P<0.001,":[185],"r=0.36),":[186],"there":[187],"individuals":[189],"who":[190],"responded":[191],"preferentially":[192],"one":[194],"agents.":[198],"When":[199],"classified":[203],"into":[204],"groups":[206],"based":[207],"on":[208],"causing":[211],"better":[213],"(salbutamol-dominant":[215],"group":[216,229,234],"oxytropium-dominant":[218,228],"group),":[219],"Arg":[220],"allele":[221],"significantly":[223],"more":[224],"common":[225],"than":[230],"salbutamol-dominant":[233],"(0.001<P<0.05).":[235],"CONCLUSION:":[236],"polymorphism":[238],"determinant":[242]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
