{"id":"https://openalex.org/W2003706539","doi":"https://doi.org/10.1016/j.mehy.2006.10.066","title":"Free radical reactions might contribute to severe alpha amanitin hepatotoxicity \u2013 A hypothesis","display_name":"Free radical reactions might contribute to severe alpha amanitin hepatotoxicity \u2013 A hypothesis","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2003706539","doi":"https://doi.org/10.1016/j.mehy.2006.10.066","mag":"2003706539","pmid":"https://pubmed.ncbi.nlm.nih.gov/17336461"},"language":"en","primary_location":{"id":"doi:10.1016/j.mehy.2006.10.066","doi":"https://doi.org/10.1016/j.mehy.2006.10.066","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mehy.2006.10.066","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113726447","display_name":"Antoaneta M. Zheleva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Antoaneta Zheleva","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Thracian University, 6003 Stara Zagora, Bulgaria. azheleva@mf.uni-sz.bg <azheleva@mf.uni-sz.bg>","Department of Chemistry and Biochemistry, Thracian University, 6003 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Thracian University, 6003 Stara Zagora, Bulgaria. azheleva@mf.uni-sz.bg <azheleva@mf.uni-sz.bg>","institution_ids":["https://openalex.org/I173112312"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Thracian University, 6003 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039991242","display_name":"A. Tole\u043aova","orcid":"https://orcid.org/0000-0002-1692-0739","observed_orcids":["https://orcid.org/0000-0002-1692-0739"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Anna Tolekova","raw_affiliation_strings":["Department of Physiology, Pathophysiology and Pharmacology, Thracian University, 6003 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Pathophysiology and Pharmacology, Thracian University, 6003 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070948387","display_name":"Momchil Zhelev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Momchil Zhelev","raw_affiliation_strings":["Hospital of Mental Diseases, Shumen, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Mental Diseases, Shumen, Bulgaria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024479358","display_name":"Veselina P. Uzunova","orcid":"https://orcid.org/0000-0001-8770-2918","observed_orcids":["https://orcid.org/0000-0001-8770-2918"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Veselina Uzunova","raw_affiliation_strings":["Thracian University, 6003 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thracian University, 6003 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002949952","display_name":"Magdalena Platikanova","orcid":"https://orcid.org/0000-0002-5254-2229","observed_orcids":["https://orcid.org/0000-0002-5254-2229"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Magdalena Platikanova","raw_affiliation_strings":["Department of Hygiene, Epidemiology and Infectious disease, Thracian University, 6003 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, Epidemiology and Infectious disease, Thracian University, 6003 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024515024","display_name":"Vesselina Gadzheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Vesselina Gadzheva","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Thracian University, 6003 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Thracian University, 6003 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113726447"],"corresponding_institution_ids":["https://openalex.org/I173112312"],"apc_list":{"value":2820,"currency":"USD","value_usd":2820},"apc_paid":null,"fwci":1.2112,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.79409125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"2","first_page":"361","last_page":"367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-amanitin","display_name":"alpha-amanitin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/amatoxins","display_name":"amatoxins","score":0.8050000071525574},{"id":"https://openalex.org/keywords/amanita-phalloides","display_name":"Amanita phalloides","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mushroom-poisoning","display_name":"mushroom poisoning","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/radical-intermediates","display_name":"radical intermediates","score":0.7850000262260437},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/silibinin","display_name":"silibinin","score":0.7979999780654907},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8489999771118164},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.984000027179718},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.746999979019165},{"id":"https://openalex.org/keywords/rna-polymerase-ii-inhibition","display_name":"RNA polymerase II inhibition","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2780778100","wikidata":"https://www.wikidata.org/wiki/Q188643","display_name":"Amanita phalloides","level":2,"score":0.8965282440185547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5908158421516418},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.542936384677887},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5381980538368225},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5282444357872009},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5264076590538025},{"id":"https://openalex.org/C2992339995","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Free radical scavenger","level":3,"score":0.5170314908027649},{"id":"https://openalex.org/C149971331","wikidata":"https://www.wikidata.org/wiki/Q1444355","display_name":"Hepatotoxin","level":3,"score":0.5013432502746582},{"id":"https://openalex.org/C2779365888","wikidata":"https://www.wikidata.org/wiki/Q194168","display_name":"Antidote","level":3,"score":0.4840542674064636},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.47457292675971985},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4437459111213684},{"id":"https://openalex.org/C2778032725","wikidata":"https://www.wikidata.org/wiki/Q213938","display_name":"Amanita","level":2,"score":0.42944222688674927},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4231230318546295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31268370151519775},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.23304179310798645},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.06307083368301392},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000546","descriptor_name":"Amanitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000546","descriptor_name":"Amanitins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mehy.2006.10.066","doi":"https://doi.org/10.1016/j.mehy.2006.10.066","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mehy.2006.10.066","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},{"id":"pmid:17336461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17336461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical hypotheses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323573","display_name":"Ministry of Education and Science","ror":"https://ror.org/053pcb396"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W19086385","https://openalex.org/W19866120","https://openalex.org/W249221693","https://openalex.org/W256215270","https://openalex.org/W625127082","https://openalex.org/W632980832","https://openalex.org/W1967487924","https://openalex.org/W1970307477","https://openalex.org/W1972494513","https://openalex.org/W1979215811","https://openalex.org/W1979870994","https://openalex.org/W1981998984","https://openalex.org/W1982352870","https://openalex.org/W1984938903","https://openalex.org/W1986187834","https://openalex.org/W1997745709","https://openalex.org/W2003923040","https://openalex.org/W2025375675","https://openalex.org/W2027756656","https://openalex.org/W2031175788","https://openalex.org/W2045092678","https://openalex.org/W2062807444","https://openalex.org/W2082474224","https://openalex.org/W2091625038","https://openalex.org/W2117759403","https://openalex.org/W2126779719","https://openalex.org/W2153957570","https://openalex.org/W2159305277","https://openalex.org/W2168518837","https://openalex.org/W2229635092","https://openalex.org/W2250665134","https://openalex.org/W2307937492","https://openalex.org/W2408050718","https://openalex.org/W2469057522","https://openalex.org/W2894112559","https://openalex.org/W4255445553"],"related_works":["https://openalex.org/W7100647793","https://openalex.org/W3111145391","https://openalex.org/W2490605299","https://openalex.org/W2469057522","https://openalex.org/W3011184215","https://openalex.org/W2153957570","https://openalex.org/W2155046555","https://openalex.org/W2045092678","https://openalex.org/W2059040175","https://openalex.org/W3168157827"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
