{"id":"https://openalex.org/W2003705524","doi":"https://doi.org/10.1016/j.humimm.2005.03.007","title":"Persistence of Herpes Simplex Virus Type 2 VP16-Specific CD4+ T Cells","display_name":"Persistence of Herpes Simplex Virus Type 2 VP16-Specific CD4+ T Cells","publication_year":2005,"publication_date":"2005-04-30","ids":{"openalex":"https://openalex.org/W2003705524","doi":"https://doi.org/10.1016/j.humimm.2005.03.007","mag":"2003705524","pmid":"https://pubmed.ncbi.nlm.nih.gov/16112025"},"language":"en","primary_location":{"id":"doi:10.1016/j.humimm.2005.03.007","doi":"https://doi.org/10.1016/j.humimm.2005.03.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.humimm.2005.03.007","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053576798","display_name":"Nancy A. Danke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy A. Danke","raw_affiliation_strings":["Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA","Benaroya Research Institute at Virginia Mason Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA","institution_ids":["https://openalex.org/I4391012615"]},{"raw_affiliation_string":"Benaroya Research Institute at Virginia Mason Seattle, WA, USA","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014605629","display_name":"David M. Koelle","orcid":"https://orcid.org/0000-0003-1255-9023","observed_orcids":["https://orcid.org/0000-0003-1255-9023"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Koelle","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, USA","Dept. of Medicine, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Dept. of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090475940","display_name":"William W. Kwok","orcid":"https://orcid.org/0000-0003-4843-4599","observed_orcids":["https://orcid.org/0000-0003-4843-4599"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William W. Kwok","raw_affiliation_strings":["Benaroya Research Institute at Virginia Mason, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Benaroya Research Institute at Virginia Mason, Seattle, WA, USA","institution_ids":["https://openalex.org/I4391012615"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090475940"],"corresponding_institution_ids":["https://openalex.org/I4391012615"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.239,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6372782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"66","issue":"7","first_page":"777","last_page":"787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vp16","display_name":"VP16","score":0.9089999794960022},{"id":"https://openalex.org/keywords/tegument-proteins","display_name":"tegument proteins","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/t-cell-memory","display_name":"T cell memory","score":0.6629999876022339},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.6759999990463257},{"id":"https://openalex.org/keywords/t-cell-receptor-v-beta-usage","display_name":"T cell receptor V beta usage","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7833267450332642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6729230880737305},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6659846305847168},{"id":"https://openalex.org/C146998594","wikidata":"https://www.wikidata.org/wiki/Q7933625","display_name":"Viral tegument","level":2,"score":0.5482632517814636},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5218650102615356},{"id":"https://openalex.org/C2778498788","wikidata":"https://www.wikidata.org/wiki/Q7476596","display_name":"Genital herpes","level":4,"score":0.5168188214302063},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.5160388946533203},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5066107511520386},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4973635971546173},{"id":"https://openalex.org/C36372059","wikidata":"https://www.wikidata.org/wiki/Q376492","display_name":"HSL and HSV","level":3,"score":0.47337502241134644},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.402823805809021},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23144015669822693},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006558","descriptor_name":"Herpes Genitalis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017405","descriptor_name":"Herpes Simplex Virus Protein Vmw65","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018258","descriptor_name":"Herpesvirus 2, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.humimm.2005.03.007","doi":"https://doi.org/10.1016/j.humimm.2005.03.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.humimm.2005.03.007","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Immunology","raw_type":"journal-article"},{"id":"pmid:16112025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16112025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.75}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G2767126187","display_name":null,"funder_award_id":"AI 30731","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2986588876","display_name":"Clinical Epidemiology and Pathogenesis of Asymptomatic HSV","funder_award_id":"P01AI030731","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G537845991","display_name":null,"funder_award_id":"AI 50132","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320314903","display_name":"Immune Tolerance Network","ror":"https://ror.org/00pjnm784"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1482928030","https://openalex.org/W1507160172","https://openalex.org/W1603918837","https://openalex.org/W1607982202","https://openalex.org/W1612656617","https://openalex.org/W1908906651","https://openalex.org/W1919804251","https://openalex.org/W1931750338","https://openalex.org/W1969530715","https://openalex.org/W1975832142","https://openalex.org/W1977739694","https://openalex.org/W1981663428","https://openalex.org/W1995332511","https://openalex.org/W2006645462","https://openalex.org/W2007048801","https://openalex.org/W2009905888","https://openalex.org/W2024909307","https://openalex.org/W2040032860","https://openalex.org/W2049432379","https://openalex.org/W2058001723","https://openalex.org/W2097230911","https://openalex.org/W2099648098","https://openalex.org/W2102944336","https://openalex.org/W2131748930","https://openalex.org/W2142377571","https://openalex.org/W2143873960","https://openalex.org/W2153293687","https://openalex.org/W2167295408","https://openalex.org/W2310632873","https://openalex.org/W2319146475","https://openalex.org/W2616864849","https://openalex.org/W4234329713"],"related_works":["https://openalex.org/W2155252245","https://openalex.org/W2167295408","https://openalex.org/W2130766119","https://openalex.org/W4313385529","https://openalex.org/W1605851537","https://openalex.org/W2057838101","https://openalex.org/W2086797918","https://openalex.org/W2052596145","https://openalex.org/W2160949272","https://openalex.org/W1531124155"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}