{"id":"https://openalex.org/W2003677831","doi":"https://doi.org/10.1186/1742-4690-6-36","title":"Conservation of Nef function across highly diverse lineages of SIVsmm","display_name":"Conservation of Nef function across highly diverse lineages of SIVsmm","publication_year":2009,"publication_date":"2009-04-09","ids":{"openalex":"https://openalex.org/W2003677831","doi":"https://doi.org/10.1186/1742-4690-6-36","mag":"2003677831","pmid":"https://pubmed.ncbi.nlm.nih.gov/19358735","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2678078"},"language":"en","primary_location":{"id":"doi:10.1186/1742-4690-6-36","doi":"https://doi.org/10.1186/1742-4690-6-36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-6-36","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-6-36","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-6-36","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003656228","display_name":"Jan Schm\u00f6kel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Schm\u00f6kel","raw_affiliation_strings":["Institute of Virology, University of Ulm, 89081 Ulm, Germany. jan.schmoekel@uniklinik-ulm.de","Institute of Virology, University of Ulm, 89081 Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Ulm, 89081 Ulm, Germany. jan.schmoekel@uniklinik-ulm.de","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Virology, University of Ulm, 89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041039715","display_name":"Hui Li","orcid":"https://orcid.org/0000-0001-6282-5559","observed_orcids":["https://orcid.org/0000-0001-6282-5559"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA","Departments of Medicine & Microbiology, University of Alabama at Birmingham, Birmingham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Departments of Medicine & Microbiology, University of Alabama at Birmingham, Birmingham, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003431778","display_name":"Elizabeth Bailes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Bailes","raw_affiliation_strings":["Institute of Genetics, University of Nottingham, Queens Medical Centre, NH7 2UH, Nottingham, UK","Institute of Genetics University of Nottingham Nottingham UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, University of Nottingham, Queens Medical Centre, NH7 2UH, Nottingham, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]},{"raw_affiliation_string":"Institute of Genetics University of Nottingham Nottingham UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020673989","display_name":"Michael Schindler","orcid":"https://orcid.org/0000-0001-8989-5813","observed_orcids":["https://orcid.org/0000-0001-8989-5813","https://orcid.org/0000-0001-7665-0040"]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schindler","raw_affiliation_strings":["Heinrich-Pette-Institut, 20251, Hamburg, Germany","Institute of Virology, University of Ulm, 89081, Ulm, Germany","Institute of Virology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich-Pette-Institut, 20251, Hamburg, Germany","institution_ids":["https://openalex.org/I137251492"]},{"raw_affiliation_string":"Institute of Virology, University of Ulm, 89081, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Virology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074424857","display_name":"Guido Silvestri","orcid":"https://orcid.org/0000-0001-6602-2470","observed_orcids":["https://orcid.org/0000-0001-6602-2470","https://orcid.org/0000-0001-5505-7467"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guido Silvestri","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19107, USA","Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA","Yerkes Regional Primate Research Center, Emory University, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19107, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Yerkes Regional Primate Research Center, Emory University, Atlanta, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043461622","display_name":"Beatrice H. Hahn","orcid":"https://orcid.org/0000-0002-9400-9887","observed_orcids":["https://orcid.org/0000-0002-9400-9887"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatrice H Hahn","raw_affiliation_strings":["Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA","Departments of Medicine & Microbiology, University of Alabama at Birmingham, Birmingham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Departments of Medicine & Microbiology, University of Alabama at Birmingham, Birmingham, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019370510","display_name":"Cristian Apetrei","orcid":"https://orcid.org/0000-0002-0322-7185","observed_orcids":["https://orcid.org/0000-0002-0322-7185"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristian Apetrei","raw_affiliation_strings":["Division of Microbiology, Tulane National Primate Research Center, Covington, LA, 70433, USA","Division of Microbiology, Tulane National Primate Research Center, Covington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Tulane National Primate Research Center, Covington, LA, 70433, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Division of Microbiology, Tulane National Primate Research Center, Covington, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075006919","display_name":"Frank Kirchhoff","orcid":"https://orcid.org/0000-0002-7052-2360","observed_orcids":["https://orcid.org/0000-0002-7052-2360"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank Kirchhoff","raw_affiliation_strings":["Institute of Virology, University of Ulm, 89081, Ulm, Germany","Institute of Virology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Ulm, 89081, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Institute of Virology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5075006919"],"corresponding_institution_ids":["https://openalex.org/I196349391"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.5727,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.63267998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"1","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sivsmm","display_name":"SIVsmm","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nef-protein","display_name":"Nef protein","score":0.8209999799728394},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.8259999752044678},{"id":"https://openalex.org/keywords/sooty-mangabey","display_name":"sooty mangabey","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cd4-downregulation","display_name":"CD4 downregulation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mhc-class-i-downregulation","display_name":"MHC class I downregulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.828000009059906},{"id":"https://openalex.org/keywords/cd74","display_name":"CD74","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.9110000133514404},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.765999972820282},{"id":"https://openalex.org/keywords/virus-infectivity","display_name":"viral infectivity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.515999972820282},{"id":"https://openalex.org/keywords/cross-species-transmission","display_name":"interspecies transmission","score":0.8309999704360962},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.6240000128746033},{"id":"https://openalex.org/keywords/viral-fitness","display_name":"viral fitness","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8580043315887451},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.6252385377883911},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.5944167375564575},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5935381650924683},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5425835251808167},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5028080940246582},{"id":"https://openalex.org/C2778950215","wikidata":"https://www.wikidata.org/wiki/Q177601","display_name":"Macaque","level":2,"score":0.4805793762207031},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.471832811832428},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46125543117523193},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4559422731399536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.445403516292572},{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.4435540437698364},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.43845927715301514},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36272403597831726},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33100128173828125},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015498","descriptor_name":"HIV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015498","descriptor_name":"HIV-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1742-4690-6-36","doi":"https://doi.org/10.1186/1742-4690-6-36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-6-36","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-6-36","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1440536","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2678078","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2678078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2678078","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Text"},{"id":"pmid:19358735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19358735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:64c98c8fcb0441fcaea0c4c41d2272ac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/64c98c8fcb0441fcaea0c4c41d2272ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Retrovirology, Vol 6, Iss 1, p 36 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1742-4690-6-36","doi":"https://doi.org/10.1186/1742-4690-6-36","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-6-36","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-6-36","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G222498484","display_name":"Role of specific Nef functions in AIDS pathogenesis","funder_award_id":"R01AI067057","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G306992018","display_name":"Center for Experimental Infectious Disease Research","funder_award_id":"P20RR020159","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5100847444","display_name":"Natural SIV Reservoirs and Human Zoonotic Risk","funder_award_id":"R37AI050529","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6013628594","display_name":"Tulane National Primate Research Center","funder_award_id":"P51RR000164","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8405283442","display_name":"Pathogenesis of New SIVsm Lineages in Rhesus Macaques","funder_award_id":"R01AI065325","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003677831.pdf","grobid_xml":"https://content.openalex.org/works/W2003677831.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1581934447","https://openalex.org/W1582855350","https://openalex.org/W1615389848","https://openalex.org/W1764504318","https://openalex.org/W1764550320","https://openalex.org/W1854844842","https://openalex.org/W1905921278","https://openalex.org/W1911317520","https://openalex.org/W1952459954","https://openalex.org/W1972190162","https://openalex.org/W1976298092","https://openalex.org/W1981298192","https://openalex.org/W1983002447","https://openalex.org/W2002432452","https://openalex.org/W2009596137","https://openalex.org/W2011837950","https://openalex.org/W2013362242","https://openalex.org/W2014818809","https://openalex.org/W2021906926","https://openalex.org/W2031728418","https://openalex.org/W2036433468","https://openalex.org/W2045106722","https://openalex.org/W2050786152","https://openalex.org/W2054395379","https://openalex.org/W2061114508","https://openalex.org/W2061805840","https://openalex.org/W2061872921","https://openalex.org/W2063465748","https://openalex.org/W2064557078","https://openalex.org/W2068233660","https://openalex.org/W2086795078","https://openalex.org/W2091841156","https://openalex.org/W2096071832","https://openalex.org/W2105021838","https://openalex.org/W2105935286","https://openalex.org/W2106558937","https://openalex.org/W2106882534","https://openalex.org/W2110447839","https://openalex.org/W2111080140","https://openalex.org/W2112612176","https://openalex.org/W2116575078","https://openalex.org/W2117154978","https://openalex.org/W2119327257","https://openalex.org/W2124790653","https://openalex.org/W2126255146","https://openalex.org/W2127234024","https://openalex.org/W2127310510","https://openalex.org/W2127930176","https://openalex.org/W2128720756","https://openalex.org/W2129579037","https://openalex.org/W2130874555","https://openalex.org/W2137381957","https://openalex.org/W2137418694","https://openalex.org/W2142574667","https://openalex.org/W2143661142","https://openalex.org/W2146478787","https://openalex.org/W2146998119","https://openalex.org/W2147258683","https://openalex.org/W2147312754","https://openalex.org/W2148697792","https://openalex.org/W2148930709","https://openalex.org/W2151024978","https://openalex.org/W2153976288","https://openalex.org/W2153978383","https://openalex.org/W2154963941","https://openalex.org/W2158029570","https://openalex.org/W2160483300","https://openalex.org/W2161444534","https://openalex.org/W2162863369","https://openalex.org/W2163644060","https://openalex.org/W2165895151","https://openalex.org/W2167788081","https://openalex.org/W2168541231","https://openalex.org/W2168578033","https://openalex.org/W2168706854","https://openalex.org/W2169657665","https://openalex.org/W2342220526","https://openalex.org/W2588405359","https://openalex.org/W2765963705"],"related_works":["https://openalex.org/W2096071832","https://openalex.org/W2146998119","https://openalex.org/W2045106722","https://openalex.org/W2082477478","https://openalex.org/W2160483300","https://openalex.org/W2081785115","https://openalex.org/W7097942117","https://openalex.org/W2013362242","https://openalex.org/W2103423598","https://openalex.org/W2106558937"],"abstract_inverted_index":{"BACKGROUND:":[0],"SIVsmm":[1,34,53,77,90,121,186,207,236],"is":[2],"a":[3,37],"simian":[4],"immunodeficiency":[5],"virus":[6,161],"that":[7,33,43,116],"persists":[8],"efficiently":[9],"without":[10],"causing":[11],"disease":[12],"in":[13,76,94,107,140,163,176,197,217,225,237,246],"naturally":[14],"infected":[15,151],"sooty":[16],"mangabeys":[17],"(SMs)":[18],"but":[19,187],"induces":[20],"AIDS":[21],"upon":[22],"cross-species":[23],"transmission":[24,110],"to":[25,61,154,213],"humans":[26,62],"and":[27,63,111,127,129,159,232,239,244,248],"macaques.":[28],"Current":[29],"phylogenetic":[30],"data":[31],"indicate":[32],"strains":[35,54,184],"comprise":[36],"highly":[38],"diverse":[39],"group":[40],"of":[41,87,97,149,172,185,206,235],"viruses":[42],"can":[44],"be":[45,214],"subdivided":[46],"into":[47],"different":[48,89,183,204],"lineages.":[49],"Since":[50],"only":[51],"certain":[52],"have":[55],"successfully":[56],"crossed":[57],"the":[58,65,80,95,98,131,147,177,230],"species":[59],"barrier":[60],"macaques,":[64],"question":[66],"has":[67],"been":[68],"raised":[69],"whether":[70,85],"there":[71],"are":[72],"lineage":[73],"specific":[74],"differences":[75,93,196,224],"biology.":[78],"In":[79],"present":[81],"study":[82],"we":[83],"examined":[84],"representatives":[86],"five":[88],"lineages":[91,122,205],"show":[92],"function":[96,227],"accessory":[99],"Nef":[100,198,201,226],"protein,":[101],"which":[102],"plays":[103],"an":[104],"important":[105],"role":[106],"viral":[108,242],"persistence,":[109],"pathogenesis.":[112],"RESULTS:":[113],"We":[114],"found":[115],"nef":[117,174],"alleles":[118,175,202],"from":[119,203],"all":[120],"down-modulated":[123],"CD4,":[124],"MHC-I,":[125],"CD28":[126],"CD3":[128],"up-regulated":[130],"invariant":[132],"chain":[133],"(Ii)":[134],"associated":[135],"with":[136],"immature":[137],"MHC-II":[138],"molecules":[139],"human-derived":[141],"cells.":[142,168,219],"Moreover,":[143],"they":[144],"generally":[145],"suppressed":[146],"responsiveness":[148],"virally":[150],"T":[152],"cells":[153],"activation,":[155],"enhanced":[156],"virion":[157],"infectivity":[158],"promoted":[160],"replication":[162],"human":[164,218,247],"peripheral":[165],"blood":[166],"mononuclear":[167],"The":[169],"functional":[170],"activity":[171],"these":[173],"various":[178],"assays":[179],"varied":[180],"substantially":[181],"between":[182],"quantitative":[188],"analyses":[189],"did":[190],"not":[191,209],"reveal":[192],"any":[193],"significant":[194],"lineage-specific":[195,223],"function.":[199],"CONCLUSION:":[200],"do":[208],"require":[210],"adaptive":[211],"changes":[212],"functionally":[215],"active":[216],"Strain":[220],"rather":[221],"than":[222],"may":[228],"impact":[229],"virological":[231],"immunological":[233],"feature":[234],"SMs":[238],"possibly":[240],"affected":[241],"fitness":[243],"pathogenicity":[245],"macaque":[249],"hosts.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
