{"id":"https://openalex.org/W2003671495","doi":"https://doi.org/10.1038/35018119","title":"A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits","display_name":"A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2003671495","doi":"https://doi.org/10.1038/35018119","mag":"2003671495","pmid":"https://pubmed.ncbi.nlm.nih.gov/10910363"},"language":"en","primary_location":{"id":"doi:10.1038/35018119","doi":"https://doi.org/10.1038/35018119","is_oa":false,"landing_page_url":"https://doi.org/10.1038/35018119","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2003671495"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101597564","display_name":"Hiroshi Okamoto","orcid":"https://orcid.org/0000-0002-9042-7096","observed_orcids":["https://orcid.org/0000-0002-9042-7096"]},"institutions":[{"id":"https://openalex.org/I4210108598","display_name":"Japan Tobacco (Japan)","ror":"https://ror.org/01xdq1k91","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210108598"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Okamoto","raw_affiliation_strings":["Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., Takatsuki, Osaka, Japan. ye6h-okmt@asahi-net.or.jp","Biological/Pharmacological Research Laboratories,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., Takatsuki, Osaka, Japan. ye6h-okmt@asahi-net.or.jp","institution_ids":["https://openalex.org/I4210108598"]},{"raw_affiliation_string":"Biological/Pharmacological Research Laboratories,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041229162","display_name":"Fumihiko Yonemori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumihiko Yonemori","raw_affiliation_strings":["Biological/Pharmacological Research Laboratories,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological/Pharmacological Research Laboratories,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110182654","display_name":"Korekiyo Wakitani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Korekiyo Wakitani","raw_affiliation_strings":["Biological/Pharmacological Research Laboratories,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological/Pharmacological Research Laboratories,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032403727","display_name":"Takashi Minowa","orcid":"https://orcid.org/0000-0003-0046-5230","observed_orcids":["https://orcid.org/0000-0003-0046-5230"]},"institutions":[{"id":"https://openalex.org/I4210108598","display_name":"Japan Tobacco (Japan)","ror":"https://ror.org/01xdq1k91","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210108598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Minowa","raw_affiliation_strings":["Pharmaceutical Frontier Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., 13-2 Fukuura 1-chome, Kanazawa-ku, Yokohama,  236-0004, Kanagawa, Japan","Pharmaceutical Frontier Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., Kanazawa-ku, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Frontier Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., 13-2 Fukuura 1-chome, Kanazawa-ku, Yokohama,  236-0004, Kanagawa, Japan","institution_ids":["https://openalex.org/I4210108598"]},{"raw_affiliation_string":"Pharmaceutical Frontier Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., Kanazawa-ku, Yokohama, Japan","institution_ids":["https://openalex.org/I4210108598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112444430","display_name":"Kimiya Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108598","display_name":"Japan Tobacco (Japan)","ror":"https://ror.org/01xdq1k91","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210108598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimiya Maeda","raw_affiliation_strings":["Chemical Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., 1-1 Murasaki-cho,  Takatsuki, 569-1125, Osaka, Japan","Chemical Research Laboratories, Central Pharmaceutical Research Institute, JT Inc.,  Takatsuki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., 1-1 Murasaki-cho,  Takatsuki, 569-1125, Osaka, Japan","institution_ids":["https://openalex.org/I4210108598"]},{"raw_affiliation_string":"Chemical Research Laboratories, Central Pharmaceutical Research Institute, JT Inc.,  Takatsuki, Japan","institution_ids":["https://openalex.org/I4210108598"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113561140","display_name":"Hisashi Shinkai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108598","display_name":"Japan Tobacco (Japan)","ror":"https://ror.org/01xdq1k91","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210108598"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Shinkai","raw_affiliation_strings":["Chemical Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., 1-1 Murasaki-cho,  Takatsuki, 569-1125, Osaka, Japan","Chemical Research Laboratories, Central Pharmaceutical Research Institute, JT Inc.,  Takatsuki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Research Laboratories, Central Pharmaceutical Research Institute, JT Inc., 1-1 Murasaki-cho,  Takatsuki, 569-1125, Osaka, Japan","institution_ids":["https://openalex.org/I4210108598"]},{"raw_affiliation_string":"Chemical Research Laboratories, Central Pharmaceutical Research Institute, JT Inc.,  Takatsuki, Japan","institution_ids":["https://openalex.org/I4210108598"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101597564"],"corresponding_institution_ids":["https://openalex.org/I4210108598"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":9.9186,"has_fulltext":false,"cited_by_count":532,"citation_normalized_percentile":{"value":0.99193548,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"406","issue":"6792","first_page":"203","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesteryl-ester-transfer-protein","display_name":"cholesteryl ester transfer protein","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cetp-inhibitors","display_name":"CETP inhibitors","score":0.8569999933242798},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9110000133514404},{"id":"https://openalex.org/keywords/reverse-cholesterol-transport","display_name":"reverse cholesterol transport","score":0.9150000214576721},{"id":"https://openalex.org/keywords/non-hdl-cholesterol","display_name":"non-HDL cholesterol","score":0.8849999904632568},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C45505151","wikidata":"https://www.wikidata.org/wiki/Q424706","display_name":"Cholesterylester transfer protein","level":4,"score":0.9801201820373535},{"id":"https://openalex.org/C110459506","wikidata":"https://www.wikidata.org/wiki/Q7318217","display_name":"Reverse cholesterol transport","level":4,"score":0.7190334796905518},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.7120968699455261},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.7006492614746094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6486576199531555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6213030815124512},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5750213265419006},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5738376975059509},{"id":"https://openalex.org/C2776448209","wikidata":"https://www.wikidata.org/wiki/Q415555","display_name":"Cholesteryl ester","level":4,"score":0.5100892186164856},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.5097379088401794},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.497969388961792},{"id":"https://openalex.org/C8004288","wikidata":"https://www.wikidata.org/wiki/Q2619230","display_name":"Intermediate-density lipoprotein","level":5,"score":0.47177743911743164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25931626558303833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1851942539215088}],"mesh":[{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002788","descriptor_name":"Cholesterol Esters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004952","descriptor_name":"Esters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053480","descriptor_name":"Cholesterol Ester Transfer Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/35018119","doi":"https://doi.org/10.1038/35018119","is_oa":false,"landing_page_url":"https://doi.org/10.1038/35018119","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:10910363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10910363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:406:y:2000:i:6792:d:10.1038_35018119","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/35018119","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1495393871","https://openalex.org/W1528960277","https://openalex.org/W1702543376","https://openalex.org/W1947043095","https://openalex.org/W1975103250","https://openalex.org/W1977321522","https://openalex.org/W1984154504","https://openalex.org/W1988448764","https://openalex.org/W1991272474","https://openalex.org/W1998091483","https://openalex.org/W1998187767","https://openalex.org/W2012613681","https://openalex.org/W2026530829","https://openalex.org/W2035973872","https://openalex.org/W2036931150","https://openalex.org/W2043154979","https://openalex.org/W2048360969","https://openalex.org/W2060593271","https://openalex.org/W2068939714","https://openalex.org/W2079281998","https://openalex.org/W2083930160","https://openalex.org/W2125757745","https://openalex.org/W2148398727","https://openalex.org/W2165387431","https://openalex.org/W2166606079","https://openalex.org/W2317841552","https://openalex.org/W2336122760","https://openalex.org/W2339504049"],"related_works":["https://openalex.org/W818906334","https://openalex.org/W4249719469","https://openalex.org/W2053540100","https://openalex.org/W2148609678","https://openalex.org/W2117416880","https://openalex.org/W2419255189","https://openalex.org/W2362162009","https://openalex.org/W2029253708","https://openalex.org/W2071087311","https://openalex.org/W2492479006"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
