{"id":"https://openalex.org/W2003647237","doi":"https://doi.org/10.1007/s00431-008-0828-5","title":"Clinical implications and prognostic value of EMMPRIN/CD147 and MMP2 expression in pediatric gliomas","display_name":"Clinical implications and prognostic value of EMMPRIN/CD147 and MMP2 expression in pediatric gliomas","publication_year":2008,"publication_date":"2008-09-15","ids":{"openalex":"https://openalex.org/W2003647237","doi":"https://doi.org/10.1007/s00431-008-0828-5","mag":"2003647237","pmid":"https://pubmed.ncbi.nlm.nih.gov/18795327"},"language":"en","primary_location":{"id":"doi:10.1007/s00431-008-0828-5","doi":"https://doi.org/10.1007/s00431-008-0828-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00431-008-0828-5","pdf_url":null,"source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2003647237"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049385499","display_name":"Jian Ping Gu","orcid":"https://orcid.org/0000-0001-8606-0618","observed_orcids":["https://orcid.org/0000-0001-8606-0618"]},"institutions":[{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Gu","raw_affiliation_strings":["Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","institution_ids":["https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China","institution_ids":["https://openalex.org/I4210117378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045260031","display_name":"Che Zhang","orcid":"https://orcid.org/0000-0001-6757-4306","observed_orcids":["https://orcid.org/0000-0001-6757-4306"]},"institutions":[{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Che Zhang","raw_affiliation_strings":["Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","institution_ids":["https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China","institution_ids":["https://openalex.org/I4210117378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006426834","display_name":"Rongguang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongguang Chen","raw_affiliation_strings":["Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","institution_ids":["https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China","institution_ids":["https://openalex.org/I4210117378"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Pan","raw_affiliation_strings":["Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","institution_ids":["https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China","institution_ids":["https://openalex.org/I4210117378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424447","display_name":"Yong Wang","orcid":"https://orcid.org/0000-0002-4905-4195","observed_orcids":["https://orcid.org/0000-0002-4905-4195"]},"institutions":[{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Wang","raw_affiliation_strings":["Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","institution_ids":["https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China","institution_ids":["https://openalex.org/I4210117378"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Meng Ming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Ming","raw_affiliation_strings":["Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","institution_ids":["https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China","institution_ids":["https://openalex.org/I4210117378"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weixing Gui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixing Gui","raw_affiliation_strings":["Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","institution_ids":["https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China","institution_ids":["https://openalex.org/I4210117378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102842764","display_name":"Dabin Wang","orcid":"https://orcid.org/0000-0001-9377-5830","observed_orcids":["https://orcid.org/0000-0001-9377-5830"]},"institutions":[{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dabin Wang","raw_affiliation_strings":["Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China","institution_ids":["https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, China","institution_ids":["https://openalex.org/I4210117378"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102842764"],"corresponding_institution_ids":["https://openalex.org/I4210117378"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":null,"fwci":1.1049,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.78484555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"168","issue":"6","first_page":"705","last_page":"710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pediatric-glioma","display_name":"pediatric glioma","score":0.8240000009536743},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/low-grade-astrocytoma","display_name":"low-grade astrocytoma","score":0.7839999794960022},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.7900000214576721},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7229999899864197},{"id":"https://openalex.org/keywords/extracellular-matrix-metalloproteinase-inducer","display_name":"extracellular matrix metalloproteinase inducer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9421038627624512},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.5970810055732727},{"id":"https://openalex.org/C2780699576","wikidata":"https://www.wikidata.org/wiki/Q15327913","display_name":"MMP2","level":4,"score":0.584020733833313},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5144348740577698},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.47553300857543945},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42728424072265625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41040295362472534},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3855987787246704},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22561383247375488},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12051346898078918},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.11320242285728455},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051926","descriptor_name":"Basigin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00431-008-0828-5","doi":"https://doi.org/10.1007/s00431-008-0828-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00431-008-0828-5","pdf_url":null,"source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:18795327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18795327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W18911010","https://openalex.org/W1565387552","https://openalex.org/W1635873859","https://openalex.org/W1963681491","https://openalex.org/W1966315696","https://openalex.org/W1970002473","https://openalex.org/W1975288990","https://openalex.org/W1983219998","https://openalex.org/W1996541578","https://openalex.org/W1998057081","https://openalex.org/W2015660037","https://openalex.org/W2022687069","https://openalex.org/W2029368519","https://openalex.org/W2042915356","https://openalex.org/W2054084446","https://openalex.org/W2065569711","https://openalex.org/W2078241670","https://openalex.org/W2080644116","https://openalex.org/W2087233429","https://openalex.org/W2096287682","https://openalex.org/W2108234265","https://openalex.org/W2111058811","https://openalex.org/W2164756915","https://openalex.org/W2168369189"],"related_works":["https://openalex.org/W1028100036","https://openalex.org/W2083900400","https://openalex.org/W2021196979","https://openalex.org/W2903011464","https://openalex.org/W2269903829","https://openalex.org/W2365801088","https://openalex.org/W2385972154","https://openalex.org/W2589701735"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}