{"id":"https://openalex.org/W2003641257","doi":"https://doi.org/10.1016/s0021-9673(99)00827-4","title":"Preparative isolation and purification of hydroxyanthraquinones from Rheum officinale Baill by high-speed counter-current chromatography using pH-modulated stepwise elution","display_name":"Preparative isolation and purification of hydroxyanthraquinones from Rheum officinale Baill by high-speed counter-current chromatography using pH-modulated stepwise elution","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2003641257","doi":"https://doi.org/10.1016/s0021-9673(99)00827-4","mag":"2003641257","pmid":"https://pubmed.ncbi.nlm.nih.gov/10544895"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9673(99)00827-4","doi":"https://doi.org/10.1016/s0021-9673(99)00827-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0021-9673(99)00827-4","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111872254","display_name":"Fuquan Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fuquan Yang","raw_affiliation_strings":["Beijing Institute of New Technology Application, China","Beijing Institute of New Technology Application, Beijing 100035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of New Technology Application, China","institution_ids":[]},{"raw_affiliation_string":"Beijing Institute of New Technology Application, Beijing 100035, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015554057","display_name":"Tianyou Zhang","orcid":"https://orcid.org/0000-0001-8032-1071","observed_orcids":["https://orcid.org/0000-0001-8032-1071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianyou Zhang","raw_affiliation_strings":["Beijing Institute of New Technology Application, Beijing 100035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of New Technology Application, Beijing 100035, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101174220","display_name":"Guilian Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guilian Tian","raw_affiliation_strings":["Beijing Institute of New Technology Application, Beijing 100035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of New Technology Application, Beijing 100035, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haifeng Cao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haifeng Cao","raw_affiliation_strings":["Beijing Institute of New Technology Application, Beijing 100035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of New Technology Application, Beijing 100035, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101525437","display_name":"Qinhui Liu","orcid":"https://orcid.org/0000-0001-9510-3704","observed_orcids":["https://orcid.org/0000-0001-9510-3704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qinhui Liu","raw_affiliation_strings":["Beijing Institute of New Technology Application, Beijing 100035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of New Technology Application, Beijing 100035, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029128268","display_name":"Yoichiro Ito","orcid":"https://orcid.org/0000-0001-9018-295X","observed_orcids":["https://orcid.org/0000-0001-9018-295X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yoichiro Ito","raw_affiliation_strings":["Laboratory of Biophysical Chemistry, Bldg. 10, Rm. 7N322, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biophysical Chemistry, Bldg. 10, Rm. 7N322, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029128268"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":null,"fwci":3.123,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.8976863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"858","issue":"1","first_page":"103","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheum-officinale","display_name":"Rheum officinale","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hydroxyanthraquinones","display_name":"hydroxyanthraquinones","score":0.9779999852180481},{"id":"https://openalex.org/keywords/high-speed-countercurrent-chromatography","display_name":"high-speed countercurrent chromatography","score":0.8799999952316284},{"id":"https://openalex.org/keywords/preparative-isolation","display_name":"preparative isolation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/chrysophanol","display_name":"chrysophanol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/emodin","display_name":"emodin","score":1.0},{"id":"https://openalex.org/keywords/physcion","display_name":"physcion","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aloe-emodin","display_name":"aloe-emodin","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8674910068511963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8556313514709473},{"id":"https://openalex.org/C2778248515","wikidata":"https://www.wikidata.org/wiki/Q4348178","display_name":"Emodin","level":2,"score":0.8427843451499939},{"id":"https://openalex.org/C2777412654","wikidata":"https://www.wikidata.org/wiki/Q3533249","display_name":"Aloe emodin","level":3,"score":0.6780611276626587},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.6272386312484741},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.5308084487915039},{"id":"https://openalex.org/C63258622","wikidata":"https://www.wikidata.org/wiki/Q1498317","display_name":"Countercurrent chromatography","level":3,"score":0.4556884467601776},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.42369344830513},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.043816179037094116},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000880","descriptor_name":"Anthraquinones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012250","descriptor_name":"Rheum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9673(99)00827-4","doi":"https://doi.org/10.1016/s0021-9673(99)00827-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0021-9673(99)00827-4","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},{"id":"pmid:10544895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10544895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2001949663","https://openalex.org/W2003518178","https://openalex.org/W2085424795","https://openalex.org/W4244455167"],"related_works":["https://openalex.org/W2147832091","https://openalex.org/W1978933449","https://openalex.org/W2045698723","https://openalex.org/W1980800627","https://openalex.org/W2023327978","https://openalex.org/W1997719701","https://openalex.org/W2008517204","https://openalex.org/W2016129203","https://openalex.org/W2378782348","https://openalex.org/W2031248762"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}