{"id":"https://openalex.org/W2003585548","doi":"https://doi.org/10.1118/1.2761242","title":"MO\u2010D\u2010M100J\u201001: Dose Painting With Intensity Modulated Proton Therapy and Intensity Modulated X\u2010Ray Therapy: A Comparison","display_name":"MO\u2010D\u2010M100J\u201001: Dose Painting With Intensity Modulated Proton Therapy and Intensity Modulated X\u2010Ray Therapy: A Comparison","publication_year":2007,"publication_date":"2007-06-01","ids":{"openalex":"https://openalex.org/W2003585548","doi":"https://doi.org/10.1118/1.2761242","mag":"2003585548"},"language":"en","primary_location":{"id":"doi:10.1118/1.2761242","doi":"https://doi.org/10.1118/1.2761242","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.2761242","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016958000","display_name":"Ryan T. Flynn","orcid":"https://orcid.org/0000-0002-8604-6047","observed_orcids":["https://orcid.org/0000-0002-8604-6047"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Flynn","raw_affiliation_strings":["University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113558619","display_name":"David L. Barbee","orcid":"https://orcid.org/0000-0003-2065-9737","observed_orcids":["https://orcid.org/0000-0003-2065-9737"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Barbee","raw_affiliation_strings":["University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Bowen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Bowen","raw_affiliation_strings":["University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007947132","display_name":"Keisha C. McCall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K McCall","raw_affiliation_strings":["University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079940663","display_name":"S\u00f8ren M\u00f8ller Bentzen","orcid":"https://orcid.org/0000-0002-7444-7564","observed_orcids":["https://orcid.org/0000-0002-7444-7564"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Bentzen","raw_affiliation_strings":["University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110059213","display_name":"Thomas Rock Mackie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Mackie","raw_affiliation_strings":["TomoTherapy, Inc., Madison, WI","University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TomoTherapy, Inc., Madison, WI","institution_ids":[]},{"raw_affiliation_string":"University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030203098","display_name":"Robert Jeraj","orcid":"https://orcid.org/0000-0002-2192-2931","observed_orcids":["https://orcid.org/0000-0002-2192-2931"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Jeraj","raw_affiliation_strings":["University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.2871,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.67097172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"34","issue":"6Part15","first_page":"2522","last_page":"2523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dose-painting","display_name":"dose painting","score":0.984000027179718},{"id":"https://openalex.org/keywords/intensity-modulated-proton-therapy","display_name":"intensity-modulated proton therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tomotherapy","display_name":"helical tomotherapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pencil-beam-scanning","display_name":"pencil beam scanning","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hypoxia-imaging","display_name":"hypoxia imaging","score":0.8009999990463257},{"id":"https://openalex.org/keywords/18f-fluorodeoxyglucose","display_name":"18F-fluorodeoxyglucose","score":0.7089999914169312},{"id":"https://openalex.org/keywords/normal-tissue-dose","display_name":"normal tissue dose","score":0.4950000047683716},{"id":"https://openalex.org/keywords/critical-structure-sparing","display_name":"critical structure sparing","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2776713427","wikidata":"https://www.wikidata.org/wiki/Q174387","display_name":"Tomotherapy","level":3,"score":0.9212979674339294},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.8364375829696655},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6186352968215942},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.6057336330413818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5595946907997131},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.5302067995071411},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.48040035367012024},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.46256598830223083},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4511784315109253},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20816698670387268},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13737177848815918},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13528761267662048}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1118/1.2761242","doi":"https://doi.org/10.1118/1.2761242","is_oa":false,"landing_page_url":"https://doi.org/10.1118/1.2761242","pdf_url":null,"source":{"id":"https://openalex.org/S95522064","display_name":"Medical Physics","issn_l":"0094-2405","issn":["0094-2405","1522-8541","2473-4209"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Physics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043115868","https://openalex.org/W2001265272","https://openalex.org/W2130443041","https://openalex.org/W3020298154","https://openalex.org/W2094591030","https://openalex.org/W2896427127","https://openalex.org/W3194513416","https://openalex.org/W1855137148","https://openalex.org/W2029060561","https://openalex.org/W4410577380"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"compare":[2],"intensity":[3,9],"modulated":[4,10],"proton":[5,282],"therapy":[6,12],"(IMPT)":[7],"versus":[8,128],"x\u2010ray":[11],"(IMXT)":[13],"for":[14,79,145,189,245,275],"the":[15,63,107,117,185,208,212,216,243,278],"delivery":[16],"of":[17,70,82,121,175,236,257,270,281,291],"nonuniform":[18,118,141,224],"dose":[19,25,58,101,119,142,170,182,200,209,225,233,247,264],"prescriptions":[20,102],"based":[21,103],"on":[22,104,116,124],"hypoxia\u2010imaging,":[23],"so\u2010called":[24],"painting.":[26],"Materials":[27],"and":[28,45,148,161,201,220,234],"Methods:":[29],"IMXT":[30,219],"delivered":[31,40],"with":[32,41,86,98,106,277],"helical":[33],"tomotherapy":[34],"(HT)":[35],"was":[36,150,242],"compared":[37],"to":[38,158,179,261,294],"IMPT":[39,123,165,194,221,227,263],"spot":[42,283],"scanning":[43],"(SS)":[44],"distal":[46],"gradient":[47],"tracking":[48],"(DGT).":[49],"The":[50,114],"novel":[51],"DGT":[52,153,249],"method":[53],"places":[54],"beam":[55,65,252],"spots":[56,253],"where":[57],"prescription":[59,186],"gradients":[60],"occur":[61],"along":[62],"pencil":[64],"axis.":[66],"Fundamental":[67],"dosimetric":[68],"properties":[69],"each":[71],"modality":[72],"were":[73,112,134,155,187],"assessed":[74],"by":[75,171,254],"creating":[76],"optimized":[77],"plans":[78,154],"144":[80],"variations":[81],"a":[83,92,125,172,255,289],"cylindrical":[84],"phantom":[85,159],"six":[87],"boost":[88,162],"regions":[89],"embedded":[90],"inside":[91],"base":[93],"tumor":[94],"region.":[95],"Clinical":[96,181],"cases":[97],"biologically":[99],"conformal":[100],"PET":[105],"\u2010ATSM":[108],"hypoxia":[109],"imaging":[110],"radiopharmaceutical":[111],"planned.":[113],"effects":[115],"distribution":[120,210],"delivering":[122],"180\u00b0":[126],"arc":[127,193],"equi\u2010spaced":[129],"beams":[130],"spread":[131],"over":[132,239],"360\u00b0":[133],"investigated.":[135],"Results:":[136],"Phantom":[137],"studies":[138],"showed":[139],"that":[140],"plan":[143],"quality":[144],"tomotherapy,":[146],"SS,":[147],"DGT,":[149],"similar,":[151],"but":[152,192],"most":[156],"sensitive":[157],"size":[160],"region":[163],"proximity.":[164],"reduced":[166,197],"normal":[167,198,231],"tissue":[168,199,232],"integral":[169,230],"mean":[173],"factor":[174,256],"around":[176],"two":[177],"relative":[178,260],"IMXT.":[180],"deviations":[183],"from":[184],"comparable":[188,223],"all":[190],"modalities,":[191],"deliveries":[195],"markedly":[196],"improved":[202,229],"critical":[203,237],"structure":[204],"sparing":[205,235],"without":[206],"compromising":[207],"in":[211,297],"tumor.":[213],"Conclusions:":[214],"In":[215],"target":[217],"volume,":[218],"deliver":[222],"distributions.":[226],"offers":[228],"structures":[238],"IMXT,":[240,276],"as":[241,274],"case":[244],"uniform":[246],"deliveries.":[248],"reduces":[250],"required":[251],"about":[258],"three":[259],"SS.":[262],"painting":[265],"will":[266],"require":[267],"similar":[268],"management":[269],"intrafractional":[271],"patient":[272],"motion":[273],"additional":[279],"consideration":[280],"placement":[284],"uncertainty.":[285],"TR":[286],"Mackie":[287],"has":[288],"conflict":[290],"interest":[292,296],"due":[293],"financial":[295],"TomoTherapy,":[298],"Inc.":[299]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}