{"id":"https://openalex.org/W2003563768","doi":"https://doi.org/10.1016/j.cellbi.2006.12.003","title":"Evaluation of rabbit auricular chondrocyte isolation and growth parameters in cell culture","display_name":"Evaluation of rabbit auricular chondrocyte isolation and growth parameters in cell culture","publication_year":2006,"publication_date":"2006-12-31","ids":{"openalex":"https://openalex.org/W2003563768","doi":"https://doi.org/10.1016/j.cellbi.2006.12.003","mag":"2003563768","pmid":"https://pubmed.ncbi.nlm.nih.gov/17293128"},"language":"en","primary_location":{"id":"doi:10.1016/j.cellbi.2006.12.003","doi":"https://doi.org/10.1016/j.cellbi.2006.12.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cellbi.2006.12.003","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016275334","display_name":"Mirjam Fr\u00f6hlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148909","display_name":"Educell","ror":"https://ror.org/03yajhg79","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210148909"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"M. Fr\u00f6hlich","raw_affiliation_strings":["Educell d.o.o., Letaliska cesta 33, SI-1000 Ljubljana, Slovenia. mirjam.froehlich@educell.si"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Educell d.o.o., Letaliska cesta 33, SI-1000 Ljubljana, Slovenia. mirjam.froehlich@educell.si","institution_ids":["https://openalex.org/I4210148909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035906557","display_name":"Elvira Mali\u010dev","orcid":"https://orcid.org/0000-0001-8312-1331","observed_orcids":["https://orcid.org/0000-0001-8312-1331"]},"institutions":[{"id":"https://openalex.org/I4210148909","display_name":"Educell","ror":"https://ror.org/03yajhg79","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210148909"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"E. Mali\u010dev","raw_affiliation_strings":["Educell d.o.o., Letalis\u030cka cesta 33, SI-1000 Ljubljana, Slovenia","Educell d.o.o., Letali\u0161ka cesta 33, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Educell d.o.o., Letalis\u030cka cesta 33, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210148909"]},{"raw_affiliation_string":"Educell d.o.o., Letali\u0161ka cesta 33, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210148909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110055618","display_name":"Miro Goren\u0161ek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148909","display_name":"Educell","ror":"https://ror.org/03yajhg79","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210148909"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"M. Goren\u0161ek","raw_affiliation_strings":["Educell d.o.o., Letalis\u030cka cesta 33, SI-1000 Ljubljana, Slovenia","Educell d.o.o., Letali\u0161ka cesta 33, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Educell d.o.o., Letalis\u030cka cesta 33, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210148909"]},{"raw_affiliation_string":"Educell d.o.o., Letali\u0161ka cesta 33, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210148909"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Kne\u017eevi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086542","display_name":"Blood Transfusion Centre of Slovenia","ror":"https://ror.org/001s05659","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I4210086542"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"M. Kne\u017eevi\u0107","raw_affiliation_strings":["Blood Transfusion Centre of Slovenia, S\u030clajmerjeva 6, SI-1000 Ljubljana, Slovenia","Blood Transfusion Centre of Slovenia, \u0160lajmerjeva 6, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Transfusion Centre of Slovenia, S\u030clajmerjeva 6, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210086542"]},{"raw_affiliation_string":"Blood Transfusion Centre of Slovenia, \u0160lajmerjeva 6, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210086542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053085666","display_name":"Nevenka Kregar Velikonja","orcid":"https://orcid.org/0000-0002-0479-3779","observed_orcids":["https://orcid.org/0000-0002-0479-3779"]},"institutions":[{"id":"https://openalex.org/I4210148909","display_name":"Educell","ror":"https://ror.org/03yajhg79","country_code":"SI","type":"facility","lineage":["https://openalex.org/I4210148909"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"N. Kregar Velikonja","raw_affiliation_strings":["Educell d.o.o., Letalis\u030cka cesta 33, SI-1000 Ljubljana, Slovenia","Educell d.o.o., Letali\u0161ka cesta 33, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Educell d.o.o., Letalis\u030cka cesta 33, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210148909"]},{"raw_affiliation_string":"Educell d.o.o., Letali\u0161ka cesta 33, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I4210148909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016275334"],"corresponding_institution_ids":["https://openalex.org/I4210148909"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.8752,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.75090797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"6","first_page":"620","last_page":"625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/auricular-chondrocytes","display_name":"auricular chondrocytes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/chondrocyte-isolation","display_name":"chondrocyte isolation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/extracellular-matrix-gene-expression","display_name":"extracellular matrix gene expression","score":0.8100000023841858},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.996999979019165},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.996999979019165},{"id":"https://openalex.org/keywords/cartilage-tissue-engineering","display_name":"cartilage tissue engineering","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.765999972820282},{"id":"https://openalex.org/keywords/subculture","display_name":"subculture","score":0.44699999690055847},{"id":"https://openalex.org/keywords/cell-phenotype","display_name":"cell phenotype","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.8890973329544067},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7283007502555847},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.7166880369186401},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.7162845134735107},{"id":"https://openalex.org/C2781013607","wikidata":"https://www.wikidata.org/wiki/Q14877666","display_name":"Type II collagen","level":3,"score":0.7076823711395264},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6350491642951965},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.605330228805542},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5040990114212036},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4528820812702179},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4208534061908722},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.4141808748245239},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3410797119140625},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32104742527008057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3089304566383362},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2434416115283966},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16412201523780823},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.1619688868522644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13575753569602966},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.12113571166992188},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09445106983184814},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004425","descriptor_name":"Ear Cartilage","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cellbi.2006.12.003","doi":"https://doi.org/10.1016/j.cellbi.2006.12.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cellbi.2006.12.003","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},{"id":"pmid:17293128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17293128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology international","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W42830026","https://openalex.org/W113459969","https://openalex.org/W116245827","https://openalex.org/W141802151","https://openalex.org/W1584652055","https://openalex.org/W1967269017","https://openalex.org/W1968298531","https://openalex.org/W1968608285","https://openalex.org/W1974384763","https://openalex.org/W1995201420","https://openalex.org/W2001705654","https://openalex.org/W2004288873","https://openalex.org/W2010691434","https://openalex.org/W2016412871","https://openalex.org/W2018143964","https://openalex.org/W2023633302","https://openalex.org/W2036156799","https://openalex.org/W2042559686","https://openalex.org/W2045852515","https://openalex.org/W2073812004","https://openalex.org/W2074223337","https://openalex.org/W2089229619","https://openalex.org/W2090521085","https://openalex.org/W2176300883","https://openalex.org/W4211147424","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2353518379","https://openalex.org/W2051568366","https://openalex.org/W2166246170","https://openalex.org/W2379017845","https://openalex.org/W2411042777","https://openalex.org/W2365827996","https://openalex.org/W2119331267","https://openalex.org/W1968298531","https://openalex.org/W1995201420","https://openalex.org/W2110837546"],"abstract_inverted_index":{"Auricular":[0],"cartilage":[1,44,92,153,162],"is":[2],"an":[3],"attractive":[4],"potential":[5,78],"source":[6],"of":[7,43,60,80,102,126,137,152,192,206,220],"cells":[8,104],"for":[9,39,66,83,156,172,218],"many":[10],"tissue":[11,30,84,222],"engineering":[12,223],"applications.":[13],"However,":[14],"there":[15,199],"are":[16,231],"several":[17],"requirements":[18],"that":[19],"have":[20],"to":[21,26,75,113],"be":[22],"fulfilled":[23],"in":[24,73,95,119,144,179,204,225],"order":[25,74],"develop":[27],"a":[28,215],"suitable":[29],"engineered":[31],"implant.":[32],"Animal":[33],"experiments":[34],"serve":[35],"as":[36,233],"important":[37],"tools":[38],"validating":[40],"novel":[41],"concepts":[42],"regeneration;":[45],"therefore":[46],"rabbit":[47,90,226],"auricular":[48,229],"chondrocytes":[49,82,230],"were":[50,71,87,107,121,176,200],"studied.":[51],"Various":[52],"parameters":[53],"including":[54],"isolation":[55],"procedures,":[56],"passage":[57],"number,":[58],"rate":[59],"proliferation":[61,106,124],"and":[62,93,105,117,132,147,161,208],"gene":[63],"expression":[64,151,191,205],"profile":[65],"major":[67],"extracellular":[68],"matrix":[69],"components":[70],"evaluated":[72],"assess":[76],"the":[77,110,114,145,180,190],"use":[79],"elastic":[81],"engineering.":[85],"Chondrocytes":[86],"isolated":[88],"from":[89,109],"ear":[91],"grown":[94],"monolayer":[96],"cultures":[97,128],"over":[98],"four":[99],"passages.":[100,149],"Yields":[101],"harvested":[103],"analysed":[108],"digestion":[111],"step":[112],"fourth":[115,148],"passage,":[116],"changes":[118,203],"phenotype":[120],"monitored.":[122],"The":[123,150,169],"capacity":[125],"cell":[127,234],"decreased":[129,196],"during":[130],"cultivation":[131,189],"was":[133,167],"accompanied":[134],"by":[135],"enlargement":[136],"cells,":[138],"this":[139],"phenomenon":[140],"being":[141],"especially":[142],"evident":[143],"third":[146],"specific":[154],"genes":[155,175],"collagen":[157,164,193,209],"type":[158,165,194,210],"II,":[159],"aggrecan":[160,207],"non-specific":[163],"I":[166],"determined.":[168],"mRNA":[170],"levels":[171],"all":[173],"three":[174],"obviously":[177],"lower":[178],"primo":[181],"culture":[182],"than":[183],"immediately":[184],"after":[185],"isolation.":[186],"During":[187],"subsequent":[188],"II":[195],"further,":[197],"while":[198],"only":[201],"slight":[202],"I.":[211],"This":[212],"study":[213],"provides":[214],"valuable":[216],"basis":[217],"testing":[219],"different":[221],"applications":[224],"model,":[227],"where":[228],"considered":[232],"source.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
