{"id":"https://openalex.org/W2003558751","doi":"https://doi.org/10.1371/journal.pone.0049291","title":"Role of PheE15 Gate in Ligand Entry and Nitric Oxide Detoxification Function of Mycobacterium tuberculosis Truncated Hemoglobin N","display_name":"Role of PheE15 Gate in Ligand Entry and Nitric Oxide Detoxification Function of Mycobacterium tuberculosis Truncated Hemoglobin N","publication_year":2012,"publication_date":"2012-11-08","ids":{"openalex":"https://openalex.org/W2003558751","doi":"https://doi.org/10.1371/journal.pone.0049291","mag":"2003558751","pmid":"https://pubmed.ncbi.nlm.nih.gov/23145144","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493545"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0049291","doi":"https://doi.org/10.1371/journal.pone.0049291","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049291","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049291&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049291&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076069892","display_name":"Ana L. Novo de Oliveira","orcid":"https://orcid.org/0000-0001-6594-6022","observed_orcids":["https://orcid.org/0000-0001-6594-6022"]},"institutions":[{"id":"https://openalex.org/I4388891874","display_name":"Institut de Biomedicina de la Universitat de Barcelona","ror":"https://ror.org/01y43zx14","country_code":"ES","type":"education","lineage":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Oliveira","raw_affiliation_strings":["Department of Physical Chemistry and Institute of Biomedicine, IBUB, Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry and Institute of Biomedicine, IBUB, Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain","institution_ids":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071711307","display_name":"Sandeep Singh","orcid":"https://orcid.org/0000-0001-9322-2929","observed_orcids":["https://orcid.org/0000-0001-9322-2929"]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep Singh","raw_affiliation_strings":["CSIR-Institute of Microbial Technology, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Institute of Microbial Technology, Chandigarh, India","institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019643670","display_name":"Axel Bidon\u2010Chanal","orcid":"https://orcid.org/0000-0002-1666-1490","observed_orcids":["https://orcid.org/0000-0002-1666-1490"]},"institutions":[{"id":"https://openalex.org/I4388891874","display_name":"Institut de Biomedicina de la Universitat de Barcelona","ror":"https://ror.org/01y43zx14","country_code":"ES","type":"education","lineage":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Axel Bidon-Chanal","raw_affiliation_strings":["Department of Physical Chemistry and Institute of Biomedicine, IBUB, Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry and Institute of Biomedicine, IBUB, Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain","institution_ids":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031320885","display_name":"Flavio Forti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891874","display_name":"Institut de Biomedicina de la Universitat de Barcelona","ror":"https://ror.org/01y43zx14","country_code":"ES","type":"education","lineage":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Flavio Forti","raw_affiliation_strings":["Department of Physical Chemistry and Institute of Biomedicine, IBUB, Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry and Institute of Biomedicine, IBUB, Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain","institution_ids":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089022257","display_name":"Marcelo Adrian Marti","orcid":"https://orcid.org/0000-0002-7911-9340","observed_orcids":["https://orcid.org/0000-0002-7911-9340"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4405263323","display_name":"Instituto de Qu\u00edmica-F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda","ror":"https://ror.org/057xgqr91","country_code":"AR","type":"facility","lineage":["https://openalex.org/I24354313","https://openalex.org/I4405263323"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marcelo A. Mart\u00ed","raw_affiliation_strings":["Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/Instituto de Qu\u00edmica F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/Instituto de Qu\u00edmica F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4405263323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019388904","display_name":"Leonardo Boechi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4405263323","display_name":"Instituto de Qu\u00edmica-F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda","ror":"https://ror.org/057xgqr91","country_code":"AR","type":"facility","lineage":["https://openalex.org/I24354313","https://openalex.org/I4405263323"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Leonardo Boechi","raw_affiliation_strings":["Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/Instituto de Qu\u00edmica F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/Instituto de Qu\u00edmica F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4405263323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027457760","display_name":"Dario Ariel Estrin","orcid":"https://orcid.org/0000-0002-5006-7225","observed_orcids":["https://orcid.org/0000-0002-5006-7225"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4405263323","display_name":"Instituto de Qu\u00edmica-F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda","ror":"https://ror.org/057xgqr91","country_code":"AR","type":"facility","lineage":["https://openalex.org/I24354313","https://openalex.org/I4405263323"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Dario A. Estrin","raw_affiliation_strings":["Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/Instituto de Qu\u00edmica F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica/Instituto de Qu\u00edmica F\u00edsica de los Materiales, Medio Ambiente y Energ\u00eda (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4405263323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066733001","display_name":"Kanak Lata Dikshit","orcid":"https://orcid.org/0000-0003-0154-0431","observed_orcids":["https://orcid.org/0000-0003-0154-0431"]},"institutions":[{"id":"https://openalex.org/I4210147764","display_name":"Institute of Microbial Technology","ror":"https://ror.org/055rjs771","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210147764","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kanak L. Dikshit","raw_affiliation_strings":["CSIR-Institute of Microbial Technology, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Institute of Microbial Technology, Chandigarh, India","institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I66760702"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058817123","display_name":"Francisco Javier Luque","orcid":"https://orcid.org/0000-0002-8049-3567","observed_orcids":["https://orcid.org/0000-0002-8049-3567","https://orcid.org/0000-0002-8476-2728"]},"institutions":[{"id":"https://openalex.org/I4388891874","display_name":"Institut de Biomedicina de la Universitat de Barcelona","ror":"https://ror.org/01y43zx14","country_code":"ES","type":"education","lineage":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"F. Javier Luque","raw_affiliation_strings":["Department of Physical Chemistry and Institute of Biomedicine, IBUB, Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry and Institute of Biomedicine, IBUB, Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain","institution_ids":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058817123","https://openalex.org/A5066733001"],"corresponding_institution_ids":["https://openalex.org/I4210147764","https://openalex.org/I4388891874","https://openalex.org/I66760702","https://openalex.org/I71999127"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.2551,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.72565585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"11","first_page":"e49291","last_page":"e49291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nitric-oxide-dioxygenase","display_name":"nitric oxide dioxygenase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nitric-oxide-detoxification","display_name":"nitric oxide detoxification","score":0.8539999723434448},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.6309999823570251},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.6456770896911621},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5766709446907043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5452218651771545},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5409160852432251},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.4821490943431854},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.47775617241859436},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.47331225872039795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44759777188301086},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.42656418681144714},{"id":"https://openalex.org/C2780227090","wikidata":"https://www.wikidata.org/wiki/Q2636892","display_name":"Alanine scanning","level":5,"score":0.41499030590057373},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2712680697441101},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2422131896018982},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":15,"locations":[{"id":"doi:10.1371/journal.pone.0049291","doi":"https://doi.org/10.1371/journal.pone.0049291","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049291","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049291&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:snrd:HASHb0ce468f213deca606d810","doi":null,"is_oa":true,"landing_page_url":"http://digital.bl.fcen.uba.ar/Download/paper/paper_19326203_v7_n11_p_Oliveira.pdf","pdf_url":"http://digital.bl.fcen.uba.ar/Download/paper/paper_19326203_v7_n11_p_Oliveira.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE 2012;7(11)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:23145144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23145144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:RDI UBA:artiaex:paper_19326203_v7_n11_p_Oliveira_oai","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12110/paper_19326203_v7_n11_p_Oliveira","pdf_url":null,"source":{"id":"https://openalex.org/S4306402562","display_name":"Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24354313","host_organization_name":"Universidad de Buenos Aires","host_organization_lineage":["https://openalex.org/I24354313"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE 2012;7(11)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:diposit.ub.edu:2445/62426","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/62426","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Articles publicats en revistes (Farm\u00e0cia, Tecnologia Farmac\u00e8utica i Fisicoqu\u00edmica)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3493545","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3493545/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:www.recercat.cat:2072/264567","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/62426","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:paperaa:paper_19326203_v7_n11_p_Oliveira","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12110/paper_19326203_v7_n11_p_Oliveira","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE 2012;7(11)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.791.4320","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.791.4320","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/28/73/pone.0049291.PMC3493545.pdf","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:3891014","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3891014","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:d4fa0b2d6d6c4787a9cfc4e8faf134e9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d4fa0b2d6d6c4787a9cfc4e8faf134e9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 11, p e49291 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/117476","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Role_of_PheE15_Gate_in_Ligand_Entry_and_Nitric_Oxide_Detoxification_Function_of_Mycobacterium_tuberculosis_Truncated_Hemoglobin_N__/117476","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/83863","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/83863","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"doi:10.60692/9z0hx-3pe20","doi":"https://doi.org/10.60692/9z0hx-3pe20","is_oa":true,"landing_page_url":"https://doi.org/10.60692/9z0hx-3pe20","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/fzmpk-e7863","doi":"https://doi.org/10.60692/fzmpk-e7863","is_oa":true,"landing_page_url":"https://doi.org/10.60692/fzmpk-e7863","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0049291","doi":"https://doi.org/10.1371/journal.pone.0049291","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049291","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049291&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2439265903","display_name":null,"funder_award_id":"CONICET","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G3148950119","display_name":null,"funder_award_id":"SAF2011-27642","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"}],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320323257","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513"},{"id":"https://openalex.org/F4320324131","display_name":"University of Delhi","ror":"https://ror.org/04gzb2213"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003558751.pdf","grobid_xml":"https://content.openalex.org/works/W2003558751.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W966671179","https://openalex.org/W1601173997","https://openalex.org/W1942505014","https://openalex.org/W1964135072","https://openalex.org/W1976499671","https://openalex.org/W1984698654","https://openalex.org/W2001773296","https://openalex.org/W2005755199","https://openalex.org/W2011842508","https://openalex.org/W2020017486","https://openalex.org/W2027685125","https://openalex.org/W2034807847","https://openalex.org/W2042430880","https://openalex.org/W2052773830","https://openalex.org/W2063750781","https://openalex.org/W2065568568","https://openalex.org/W2067174909","https://openalex.org/W2077547350","https://openalex.org/W2081299490","https://openalex.org/W2089654452","https://openalex.org/W2106140689","https://openalex.org/W2112880344","https://openalex.org/W2126110146","https://openalex.org/W2130746911","https://openalex.org/W2132589721","https://openalex.org/W2133709520","https://openalex.org/W2143498389","https://openalex.org/W2144288821","https://openalex.org/W2149801992","https://openalex.org/W2158076215","https://openalex.org/W2164088236","https://openalex.org/W2168327701","https://openalex.org/W2742505748"],"related_works":["https://openalex.org/W2034807847","https://openalex.org/W1553259954","https://openalex.org/W2168327701","https://openalex.org/W2005755199","https://openalex.org/W2065568568","https://openalex.org/W7006202463","https://openalex.org/W1984698654","https://openalex.org/W1976213145","https://openalex.org/W2070105650","https://openalex.org/W2147477198"],"abstract_inverted_index":{"The":[0],"truncated":[1],"hemoglobin":[2],"N,":[3],"HbN,":[4],"of":[5,30,40,47,73,96,134,139,182,190,197,213],"Mycobacterium":[6],"tuberculosis":[7],"is":[8],"endowed":[9],"with":[10,141],"a":[11,43,90,104,111],"potent":[12],"nitric":[13],"oxide":[14],"dioxygenase":[15],"(NOD)":[16],"activity":[17],"that":[18,53,108,163],"allows":[19],"it":[20],"to":[21,59,70,77,121],"relieve":[22],"nitrosative":[23],"stress":[24],"and":[25,50,75,115,145,176,208],"enhance":[26],"in":[27,129,156,172,193,204],"vivo":[28],"survival":[29],"its":[31,34],"host.":[32],"Despite":[33],"small":[35],"size,":[36],"the":[37,55,60,78,87,97,123,131,166,173,180,187,195,200,205,210],"protein":[38,61],"matrix":[39],"HbN":[41],"hosts":[42],"two-branched":[44],"tunnel,":[45,175],"consisting":[46],"orthogonal":[48],"short":[49,88],"long":[51,98,174,201],"channels,":[52],"connects":[54],"heme":[56,80],"active":[57],"site":[58],"surface.":[62],"A":[63],"novel":[64],"dual-path":[65],"mechanism":[66],"has":[67],"been":[68,119],"suggested":[69],"drive":[71],"migration":[72,181],"O(2)":[74],"NO":[76,198],"distal":[79],"cavity.":[81],"While":[82],"oxygen":[83],"migrates":[84],"mainly":[85],"by":[86,127],"path,":[89],"ligand-induced":[91],"conformational":[92],"change":[93],"regulates":[94],"opening":[95],"tunnel":[99,202],"branch":[100,203],"for":[101],"NO,":[102],"via":[103,199],"phenylalanine":[105],"(PheE15)":[106],"residue":[107],"acts":[109],"as":[110],"gate.":[112],"Site-directed":[113],"mutagenesis":[114],"molecular":[116],"simulations":[117,161],"have":[118,147],"used":[120],"examine":[122],"gating":[124],"role":[125,189],"played":[126],"PheE15":[128,140,167,191],"modulating":[130,194],"NOD":[132,158,211],"function":[133,212],"HbN.":[135,214],"Mutants":[136],"carrying":[137],"replacement":[138],"alanine,":[142],"isoleucine,":[143],"tyrosine":[144],"tryptophan":[146],"similar":[148],"O(2)/CO":[149],"association":[150],"kinetics,":[151],"but":[152],"display":[153],"significant":[154,170],"reduction":[155],"their":[157],"function.":[159],"Molecular":[160],"substantiated":[162],"mutation":[164],"at":[165],"gate":[168,192],"confers":[169],"changes":[171],"therefore":[177],"may":[178],"affect":[179],"ligands.":[183],"These":[184],"results":[185],"support":[186],"pivotal":[188],"diffusion":[196],"oxygenated":[206],"protein,":[207],"hence":[209]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
