{"id":"https://openalex.org/W2003548745","doi":"https://doi.org/10.1002/jnr.10375","title":"Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF\u2010producing cells in a rat model of Parkinson's disease","display_name":"Neuroprotective and restorative effects of intrastriatal grafting of encapsulated GDNF\u2010producing cells in a rat model of Parkinson's disease","publication_year":2002,"publication_date":"2002-08-27","ids":{"openalex":"https://openalex.org/W2003548745","doi":"https://doi.org/10.1002/jnr.10375","mag":"2003548745","pmid":"https://pubmed.ncbi.nlm.nih.gov/12205688"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.10375","doi":"https://doi.org/10.1002/jnr.10375","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jnr.10375","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jnr.10375","source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jnr.10375","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111889099","display_name":"Tetsuro Shingo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsuro Shingo","raw_affiliation_strings":["Department of Neurological Surgery, Okayama University Medical School, Japan. teshingo@aol.com","Department of Neurological Surgery, Okayama University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Okayama University Medical School, Japan. teshingo@aol.com","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Neurological Surgery, Okayama University Medical School, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004595871","display_name":"Isao Date","orcid":"https://orcid.org/0000-0002-0218-2595","observed_orcids":["https://orcid.org/0000-0002-0218-2595"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isao Date","raw_affiliation_strings":["Department of Neurological Surgery, Okayama University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Okayama University Medical School, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hideyuki Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Yoshida","raw_affiliation_strings":["Department of Neurological Surgery, Okayama University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Okayama University Medical School, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110129563","display_name":"Takashi Ohmoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Ohmoto","raw_affiliation_strings":["Department of Neurological Surgery, Okayama University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Okayama University Medical School, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111889099"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":6.7308,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.97191489,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"69","issue":"6","first_page":"946","last_page":"954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-encapsulation","display_name":"cell encapsulation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hollow-fiber-bioreactor","display_name":"hollow fiber bioreactor","score":0.7369999885559082},{"id":"https://openalex.org/keywords/intrastriatal-transplantation","display_name":"intrastriatal transplantation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9330000281333923},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.8529999852180481},{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bhk-cells","display_name":"BHK cells","score":0.6079999804496765},{"id":"https://openalex.org/keywords/rotational-behavior","display_name":"rotational behavior","score":0.5210000276565552},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.9937682747840881},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.7962051630020142},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5840033292770386},{"id":"https://openalex.org/C33263850","wikidata":"https://www.wikidata.org/wiki/Q4838438","display_name":"Baby hamster kidney cell","level":3,"score":0.5805415511131287},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5763463973999023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41238224506378174},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40741121768951416},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3719748258590698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3339245617389679},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3220158815383911},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.23672175407409668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22034767270088196},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.20845210552215576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14080539345741272},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13743296265602112}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003337","descriptor_name":"Corpus Callosum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009414","descriptor_name":"Nerve Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jnr.10375","doi":"https://doi.org/10.1002/jnr.10375","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jnr.10375","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jnr.10375","source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:12205688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12205688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jnr.10375","doi":"https://doi.org/10.1002/jnr.10375","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jnr.10375","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jnr.10375","source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003548745.pdf","grobid_xml":"https://content.openalex.org/works/W2003548745.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1650719874","https://openalex.org/W1795898662","https://openalex.org/W1900535849","https://openalex.org/W1971025492","https://openalex.org/W1973061682","https://openalex.org/W1976110198","https://openalex.org/W1984349651","https://openalex.org/W1990131729","https://openalex.org/W1998885927","https://openalex.org/W1999128801","https://openalex.org/W2024454234","https://openalex.org/W2042162774","https://openalex.org/W2048162805","https://openalex.org/W2050636568","https://openalex.org/W2054810445","https://openalex.org/W2060154208","https://openalex.org/W2074432223","https://openalex.org/W2076204409","https://openalex.org/W2079378613","https://openalex.org/W2085304524","https://openalex.org/W2087262420","https://openalex.org/W2102284349","https://openalex.org/W2105310604","https://openalex.org/W2108724455","https://openalex.org/W2139661803","https://openalex.org/W2150857721","https://openalex.org/W2160073148","https://openalex.org/W2163815564","https://openalex.org/W2171584675","https://openalex.org/W2318463768","https://openalex.org/W4229557642","https://openalex.org/W4245890209"],"related_works":["https://openalex.org/W1991214068","https://openalex.org/W2396369348","https://openalex.org/W1967766664","https://openalex.org/W2205389607","https://openalex.org/W2041676728","https://openalex.org/W7208215550","https://openalex.org/W2076686536","https://openalex.org/W1992772507","https://openalex.org/W2088827109","https://openalex.org/W2383792566"],"abstract_inverted_index":{"Glial":[0],"cell":[1],"line-derived":[2],"neurotrophic":[3,12],"factor":[4],"(GDNF)":[5],"has":[6],"been":[7],"shown":[8],"to":[9,26,36,56,112,130],"possess":[10],"potent":[11],"effects":[13,41,178],"on":[14,179],"dopaminergic":[15],"(DA)":[16],"neurons.":[17,44,182],"We":[18,45],"attempted":[19],"the":[20,34,75,83,92,97,108,139,193],"transplantation":[21],"of":[22,31,85,94,138,195],"encapsulated":[23,70,77,101,163],"GDNF-producing":[24,164],"cells":[25,51,67,78,103,165],"generate":[27],"a":[28,119,123,134,149,157,170,186],"stable":[29,171],"supply":[30,167],"GDNF":[32,54,59,105,168],"in":[33,107,126,145,153,169,192],"brain":[35],"promote":[37],"neuroprotective":[38],"and":[39,52,74,173,176],"restorative":[40,177],"for":[42,110,188],"DA":[43,181],"established":[46],"baby":[47],"hamster":[48],"kidney":[49],"(BHK)":[50],"introduced":[53],"cDNA":[55],"produce":[57],"human":[58],"(BHK-GDNF).":[60],"These":[61],"BHK-GDNF":[62,102,120,150],"cells,":[63],"or":[64,90],"nontransfected":[65],"BHK":[66],"(BHK-Control),":[68],"were":[69,79],"into":[71,82,96],"hollow":[72],"fibers,":[73],"polymer":[76],"unilaterally":[80],"implanted":[81],"striatum":[84,109],"adult":[86],"rats,":[87],"either":[88],"before":[89],"after":[91],"administration":[93],"6-hydroxydopamine":[95],"same":[98],"striatum.":[99],"The":[100,115],"produced":[104],"continuously":[106],"up":[111],"6":[113],"months.":[114],"rats":[116],"that":[117,132,147,155,162],"received":[118,133,148,156],"capsule":[121,151],"showed":[122],"significant":[124],"decrease":[125],"rotational":[127],"behaviour":[128],"compared":[129],"those":[131,146,154],"BHK-control":[135,158],"capsule.":[136,159],"Preservation":[137],"nigrostriatal":[140],"pathway":[141],"was":[142],"significantly":[143],"greater":[144],"than":[152],"This":[160],"indicates":[161],"can":[166],"fashion":[172],"have":[174],"protective":[175],"host":[180],"Our":[183],"results":[184],"support":[185],"role":[187],"this":[189],"grafting":[190],"technique":[191],"treatment":[194],"Parkinson's":[196],"disease.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}