{"id":"https://openalex.org/W2003536502","doi":"https://doi.org/10.1002/prot.23207","title":"Protein loop closure using orientational restraints from NMR data","display_name":"Protein loop closure using orientational restraints from NMR data","publication_year":2011,"publication_date":"2011-09-28","ids":{"openalex":"https://openalex.org/W2003536502","doi":"https://doi.org/10.1002/prot.23207","mag":"2003536502","pmid":"https://pubmed.ncbi.nlm.nih.gov/22161780","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3305838"},"language":"en","primary_location":{"id":"doi:10.1002/prot.23207","doi":"https://doi.org/10.1002/prot.23207","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prot.23207","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prot.23207","source":{"id":"https://openalex.org/S121161810","display_name":"Proteins Structure Function and Bioinformatics","issn_l":"0887-3585","issn":["0887-3585","1097-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins: Structure, Function, and Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prot.23207","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002496823","display_name":"Chittaranjan Tripathy","orcid":"https://orcid.org/0009-0006-7353-4793","observed_orcids":["https://orcid.org/0009-0006-7353-4793"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chittaranjan Tripathy","raw_affiliation_strings":["Department of Computer Science, Duke University, Durham, North Carolina 27708"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Duke University, Durham, North Carolina 27708","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009826239","display_name":"Jianyang Zeng","orcid":"https://orcid.org/0000-0003-0950-7716","observed_orcids":["https://orcid.org/0000-0003-0950-7716"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianyang Zeng","raw_affiliation_strings":["Department of Computer Science, Duke University, Durham, North Carolina 27708"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Duke University, Durham, North Carolina 27708","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003416661","display_name":"Pei Zhou","orcid":"https://orcid.org/0000-0002-7823-3416","observed_orcids":["https://orcid.org/0000-0002-7823-3416"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei Zhou","raw_affiliation_strings":["Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046723017","display_name":"Bruce Randall Donald","orcid":"https://orcid.org/0000-0001-6884-4398","observed_orcids":["https://orcid.org/0000-0001-6884-4398"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce Randall Donald","raw_affiliation_strings":["Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710","Department of Computer Science, Duke University, Durham, North Carolina 27708"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Computer Science, Duke University, Durham, North Carolina 27708","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046723017"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.7615,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.66469715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"80","issue":"2","first_page":"433","last_page":"453"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/residual-dipolar-couplings","display_name":"residual dipolar couplings","score":0.972000002861023},{"id":"https://openalex.org/keywords/analytical-solution","display_name":"analytical solution","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pruning-methods","display_name":"pruning techniques","score":0.8769999742507935},{"id":"https://openalex.org/keywords/human-ubiquitin","display_name":"human ubiquitin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/dini","display_name":"DINI","score":0.7699999809265137},{"id":"https://openalex.org/keywords/globotriaosylceramide","display_name":"globotriaosylceramide","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C150769733","wikidata":"https://www.wikidata.org/wiki/Q7315511","display_name":"Residual dipolar coupling","level":3,"score":0.7931339740753174},{"id":"https://openalex.org/C45475804","wikidata":"https://www.wikidata.org/wiki/Q6675846","display_name":"Loop modeling","level":4,"score":0.637151837348938},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.5216427445411682},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47387075424194336},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4708998501300812},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4424092173576355},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4140915870666504},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.39934468269348145},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.30614426732063293},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2505025267601013},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21382266283035278},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.16015595197677612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/prot.23207","doi":"https://doi.org/10.1002/prot.23207","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prot.23207","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prot.23207","source":{"id":"https://openalex.org/S121161810","display_name":"Proteins Structure Function and Bioinformatics","issn_l":"0887-3585","issn":["0887-3585","1097-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins: Structure, Function, and Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22161780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22161780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2603297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3305838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3305838","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3305838","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proteins","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.380.4997","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.380.4997","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.duke.edu/~zengjy/papers/recomb2011_pool.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1002/prot.23207","doi":"https://doi.org/10.1002/prot.23207","is_oa":true,"landing_page_url":"https://doi.org/10.1002/prot.23207","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/prot.23207","source":{"id":"https://openalex.org/S121161810","display_name":"Proteins Structure Function and Bioinformatics","issn_l":"0887-3585","issn":["0887-3585","1097-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteins: Structure, Function, and Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1911629827","display_name":"Automated NMR Assignment and Protein Structure Determination","funder_award_id":"R01GM065982","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5047192117","display_name":"Structural, Biochemical and Functional Studies of RNAPII CTD Interacting Proteins","funder_award_id":"R01GM079376","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003536502.pdf","grobid_xml":"https://content.openalex.org/works/W2003536502.grobid-xml"},"referenced_works_count":126,"referenced_works":["https://openalex.org/W208602951","https://openalex.org/W243990525","https://openalex.org/W271246402","https://openalex.org/W653555158","https://openalex.org/W656827624","https://openalex.org/W1561329317","https://openalex.org/W1564865013","https://openalex.org/W1589295940","https://openalex.org/W1813117265","https://openalex.org/W1825915940","https://openalex.org/W1969407832","https://openalex.org/W1972026510","https://openalex.org/W1974647057","https://openalex.org/W1977689937","https://openalex.org/W1979483545","https://openalex.org/W1980039387","https://openalex.org/W1980374511","https://openalex.org/W1980703922","https://openalex.org/W1982412826","https://openalex.org/W1982679430","https://openalex.org/W1984748711","https://openalex.org/W1986219298","https://openalex.org/W1987836768","https://openalex.org/W1990188813","https://openalex.org/W1997262127","https://openalex.org/W1997477098","https://openalex.org/W1998470735","https://openalex.org/W2000443388","https://openalex.org/W2000682550","https://openalex.org/W2000908837","https://openalex.org/W2000948557","https://openalex.org/W2002992883","https://openalex.org/W2003331005","https://openalex.org/W2003562204","https://openalex.org/W2004789768","https://openalex.org/W2007804411","https://openalex.org/W2009144168","https://openalex.org/W2009822822","https://openalex.org/W2010331070","https://openalex.org/W2011148270","https://openalex.org/W2018562664","https://openalex.org/W2019476648","https://openalex.org/W2022067264","https://openalex.org/W2027238103","https://openalex.org/W2029120587","https://openalex.org/W2036173433","https://openalex.org/W2036499039","https://openalex.org/W2037627497","https://openalex.org/W2039582903","https://openalex.org/W2042170152","https://openalex.org/W2042426030","https://openalex.org/W2043078269","https://openalex.org/W2046339334","https://openalex.org/W2047163848","https://openalex.org/W2047768577","https://openalex.org/W2049244367","https://openalex.org/W2052568123","https://openalex.org/W2062557777","https://openalex.org/W2063301255","https://openalex.org/W2065445396","https://openalex.org/W2067484689","https://openalex.org/W2067576503","https://openalex.org/W2067696548","https://openalex.org/W2069126311","https://openalex.org/W2070189028","https://openalex.org/W2071394854","https://openalex.org/W2073125464","https://openalex.org/W2073486807","https://openalex.org/W2074986801","https://openalex.org/W2076694118","https://openalex.org/W2080837519","https://openalex.org/W2082176639","https://openalex.org/W2085565764","https://openalex.org/W2092024874","https://openalex.org/W2096648003","https://openalex.org/W2097296296","https://openalex.org/W2099356919","https://openalex.org/W2100884728","https://openalex.org/W2102821177","https://openalex.org/W2105421919","https://openalex.org/W2107926260","https://openalex.org/W2109948087","https://openalex.org/W2110143908","https://openalex.org/W2111326643","https://openalex.org/W2112103709","https://openalex.org/W2112418305","https://openalex.org/W2115865752","https://openalex.org/W2119231936","https://openalex.org/W2119608369","https://openalex.org/W2122339645","https://openalex.org/W2125003003","https://openalex.org/W2130479394","https://openalex.org/W2130881584","https://openalex.org/W2137604324","https://openalex.org/W2142155807","https://openalex.org/W2145180780","https://openalex.org/W2146097584","https://openalex.org/W2147752484","https://openalex.org/W2149026172","https://openalex.org/W2149186423","https://openalex.org/W2149280798","https://openalex.org/W2149478651","https://openalex.org/W2154297157","https://openalex.org/W2154714625","https://openalex.org/W2154983943","https://openalex.org/W2154996409","https://openalex.org/W2159121958","https://openalex.org/W2159155807","https://openalex.org/W2164778451","https://openalex.org/W2166591715","https://openalex.org/W2166923082","https://openalex.org/W2167612644","https://openalex.org/W2168885089","https://openalex.org/W2169821755","https://openalex.org/W2170191635","https://openalex.org/W2170471837","https://openalex.org/W2170584833","https://openalex.org/W2170671445","https://openalex.org/W2171967381","https://openalex.org/W2201713963","https://openalex.org/W2317724673","https://openalex.org/W4229743141","https://openalex.org/W4236503766","https://openalex.org/W4243546559","https://openalex.org/W4248446246","https://openalex.org/W6667574570"],"related_works":["https://openalex.org/W271246402","https://openalex.org/W1780999417","https://openalex.org/W7096801018","https://openalex.org/W1510395959","https://openalex.org/W2085565764","https://openalex.org/W2157919982","https://openalex.org/W2102002759","https://openalex.org/W7098247991","https://openalex.org/W1982412826","https://openalex.org/W2000682550"],"abstract_inverted_index":{"Protein":[0],"loops":[1,10,49,173,208],"often":[2],"play":[3],"important":[4],"roles":[5],"in":[6,26,64,112,182,216,239],"biological":[7],"functions.":[8],"Modeling":[9],"accurately":[11],"is":[12,150],"crucial":[13],"to":[14,32,46,136,179,229],"determining":[15],"the":[16,23,38,84,95,119,131,146,194],"functional":[17],"specificity":[18],"of":[19,35,103,134,209],"a":[20,33,76,101,177],"protein.":[21],"Despite":[22],"recent":[24],"progress":[25],"loop":[27,96,142,232],"prediction":[28],"approaches,":[29],"which":[30,82,117],"led":[31],"number":[34],"algorithms":[36],"over":[37],"past":[39],"decade,":[40],"few":[41],"rigorous":[42],"algorithmic":[43],"approaches":[44],"exist":[45],"model":[47],"protein":[48,91,207,231,241],"using":[50,125],"global":[51],"orientational":[52],"restraints,":[53],"such":[54],"as":[55,100],"those":[56,186],"obtained":[57,187,201],"from":[58,247],"residual":[59],"dipolar":[60],"coupling":[61],"(RDC)":[62],"data":[63],"solution":[65],"nuclear":[66],"magnetic":[67],"resonance":[68],"(NMR)":[69],"spectroscopy.":[70],"In":[71],"this":[72],"article,":[73],"we":[74],"present":[75],"novel,":[77],"sparse":[78,248],"data,":[79],"RDC-based":[80],"algorithm,":[81],"exploits":[83],"mathematical":[85],"interplay":[86],"between":[87],"RDC-derived":[88],"sphero-conics":[89],"and":[90,93,165,213,234],"kinematics,":[92],"formulates":[94],"structure":[97,190,243],"determination":[98,191],"problem":[99],"system":[102],"low-degree":[104],"polynomial":[105,115],"equations":[106],"that":[107,129,168,222],"can":[108,171,225],"be":[109,226,237],"solved":[110],"exactly,":[111],"closed-form.":[113],"The":[114],"roots,":[116],"encode":[118],"candidate":[120],"conformations,":[121,135,233],"are":[122],"searched":[123],"systematically,":[124],"provable":[126],"pruning":[127],"strategies":[128],"triage":[130],"vast":[132],"majority":[133],"enumerate":[137],"or":[138],"prune":[139],"all":[140],"possible":[141],"conformations":[143],"consistent":[144],"with":[145,174],"data;":[147],"therefore,":[148],"completeness":[149],"ensured.":[151],"Results":[152],"on":[153,193,202],"experimental":[154],"RDC":[155,204],"datasets":[156,205],"for":[157,206],"four":[158],"proteins,":[159],"including":[160,245],"human":[161],"ubiquitin,":[162],"FF2,":[163],"DinI,":[164],"GB3,":[166],"demonstrate":[167],"our":[169,223],"algorithm":[170,224],"compute":[172],"higher":[175],"accuracy,":[176],"three-":[178],"six-fold":[180],"improvement":[181],"backbone":[183,242],"RMSD,":[184],"versus":[185],"by":[188],"traditional":[189],"protocols":[192],"same":[195],"data.":[196,250],"Excellent":[197],"results":[198,220],"were":[199],"also":[200],"synthetic":[203],"length":[210],"4,":[211],"8,":[212],"12":[214],"used":[215],"previous":[217],"studies.":[218],"These":[219],"suggest":[221],"successfully":[227],"applied":[228],"determine":[230],"hence,":[235],"will":[236],"useful":[238],"high-resolution":[240],"determination,":[244],"loops,":[246],"NMR":[249],"Proteins":[251],"2012.":[252],"\u00a9":[253],"2011":[254],"Wiley":[255],"Periodicals,":[256],"Inc.":[257]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}