{"id":"https://openalex.org/W200349053","doi":"https://doi.org/10.1182/blood.v90.4.1508","title":"Human Kininogens Regulate Thrombin Binding to Platelets Through the Glycoprotein Ib-IX-V Complex","display_name":"Human Kininogens Regulate Thrombin Binding to Platelets Through the Glycoprotein Ib-IX-V Complex","publication_year":1997,"publication_date":"1997-08-15","ids":{"openalex":"https://openalex.org/W200349053","doi":"https://doi.org/10.1182/blood.v90.4.1508","mag":"200349053","pmid":"https://pubmed.ncbi.nlm.nih.gov/9269768"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v90.4.1508","doi":"https://doi.org/10.1182/blood.v90.4.1508","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v90.4.1508","pdf_url":"https://ashpublications.org/blood/article-pdf/90/4/1508/1040290/1508.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/90/4/1508/1040290/1508.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087529422","display_name":"Harlan N. Bradford","orcid":"https://orcid.org/0000-0001-5582-278X","observed_orcids":["https://orcid.org/0000-0001-5582-278X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harlan N. Bradford","raw_affiliation_strings":["From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111826851","display_name":"Raul A. DeLa Cadena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raul A. Dela Cadena","raw_affiliation_strings":["From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053757739","display_name":"Satya P. Kunapuli","orcid":"https://orcid.org/0000-0002-1298-3214","observed_orcids":["https://orcid.org/0000-0002-1298-3214"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satya P. Kunapuli","raw_affiliation_strings":["From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110468927","display_name":"Jing-fei Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing-Fei Dong","raw_affiliation_strings":["From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105936287","display_name":"Jos\u00e9 A. L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose\u0301 A. Lo\u0301pez","raw_affiliation_strings":["From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Sol Sherry Thrombosis Research Center and Departments of Medicine, Pathology, and Physiology, Temple University School of Medicine, Philadelphia, PA; and The Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Veterans Affairs Medical Center and Hematology-Oncology Section, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.8446,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93345847,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"90","issue":"4","first_page":"1508","last_page":"1515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kininogen","display_name":"kininogen","score":0.8330000042915344},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bernard-soulier-syndrome","display_name":"Bernard-Soulier syndrome","score":0.8489999771118164},{"id":"https://openalex.org/keywords/thrombin-binding","display_name":"thrombin binding","score":0.5360000133514404},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/platelet-receptors","display_name":"platelet receptors","score":0.5239999890327454},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.7553048729896545},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.630198061466217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5956175327301025},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.583827018737793},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5280923247337341},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.48887985944747925},{"id":"https://openalex.org/C26828662","wikidata":"https://www.wikidata.org/wiki/Q7202248","display_name":"Platelet membrane glycoprotein","level":3,"score":0.48332786560058594},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4647839069366455},{"id":"https://openalex.org/C2910597130","wikidata":"https://www.wikidata.org/wiki/Q17156451","display_name":"Platelet Glycoprotein GPIb-IX Complex","level":4,"score":0.460027813911438},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4441976845264435},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4392316937446594},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.41134849190711975},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3906213641166687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2542428970336914},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.17237809300422668},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07162299752235413}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001606","descriptor_name":"Bernard-Soulier Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019038","descriptor_name":"Platelet Glycoprotein GPIb-IX Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v90.4.1508","doi":"https://doi.org/10.1182/blood.v90.4.1508","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v90.4.1508","pdf_url":"https://ashpublications.org/blood/article-pdf/90/4/1508/1040290/1508.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v90.4.1508.1508_1508_1515","doi":"https://doi.org/10.1182/blood.v90.4.1508.1508_1508_1515","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v90.4.1508.1508_1508_1515","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:9269768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9269768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v90.4.1508","doi":"https://doi.org/10.1182/blood.v90.4.1508","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v90.4.1508","pdf_url":"https://ashpublications.org/blood/article-pdf/90/4/1508/1040290/1508.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2412388860","display_name":null,"funder_award_id":"HL02681","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G402531770","display_name":null,"funder_award_id":"HL-02463","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4421370787","display_name":"ANTIADHESIVE AND ANTICOAGULANT ACTIVITY OF KININOGENS","funder_award_id":"1r01hl054894-01a2","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4554742491","display_name":"PLATELET THROMBOSPONDIN BINDING DOMAINS","funder_award_id":"5k08hl002681-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G85206700","display_name":null,"funder_award_id":"HL54894","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G988595684","display_name":"STRUCTURE &FUNCTION OF THE PLATELET GP IB-IX COMPLEX","funder_award_id":"5k08hl002463-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W200349053.pdf","grobid_xml":"https://content.openalex.org/works/W200349053.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W57636002","https://openalex.org/W1492746912","https://openalex.org/W1533112727","https://openalex.org/W1535032041","https://openalex.org/W1548847180","https://openalex.org/W1553583401","https://openalex.org/W1570407438","https://openalex.org/W1604352043","https://openalex.org/W1685438413","https://openalex.org/W1734562766","https://openalex.org/W1831777278","https://openalex.org/W1964456661","https://openalex.org/W1981890152","https://openalex.org/W1983827472","https://openalex.org/W2002882141","https://openalex.org/W2003100667","https://openalex.org/W2011165507","https://openalex.org/W2028687062","https://openalex.org/W2032030691","https://openalex.org/W2042843704","https://openalex.org/W2047985607","https://openalex.org/W2053125166","https://openalex.org/W2065543620","https://openalex.org/W2066149593","https://openalex.org/W2080580789","https://openalex.org/W2086427528","https://openalex.org/W2088302978","https://openalex.org/W2089865447","https://openalex.org/W2155911050","https://openalex.org/W2195745009","https://openalex.org/W2292419927","https://openalex.org/W2333195072","https://openalex.org/W2395363260","https://openalex.org/W2404081591","https://openalex.org/W2410107450","https://openalex.org/W2411122919","https://openalex.org/W2416367333","https://openalex.org/W2438199954","https://openalex.org/W2463468240"],"related_works":["https://openalex.org/W2088302978","https://openalex.org/W1533112727","https://openalex.org/W2292419927","https://openalex.org/W2417204277","https://openalex.org/W1604352043","https://openalex.org/W2042553339","https://openalex.org/W2889373171","https://openalex.org/W2121844388","https://openalex.org/W2411238771","https://openalex.org/W2025505638"],"abstract_inverted_index":{"We":[0,123,170],"and":[1,8,55,78,114,162,178,207,218,279],"others":[2],"have":[3],"shown":[4,100],"that":[5,24,152,160,173,266],"both":[6,174],"high":[7,185],"low":[9],"molecular":[10,84,186,224],"mass":[11,187,225],"kininogens":[12,88],"are":[13],"able":[14],"to":[15,43,76,101,103,120,167,192,198,201,228,251,269,277],"inhibit":[16,73,80,89,138,222],"the":[17,25,31,44,48,56,107,115,139,147,179,234,245,259,270,280,293],"thrombin-induced":[18,81,90,140],"aggregation":[19,91,141],"of":[20,47,92,142,209,236,240,247,292,296],"gel-filtered":[21],"platelets,":[22,132,144],"indicating":[23],"locus":[26],"for":[27],"inhibition":[28],"resides":[29],"in":[30,39,194],"heavy":[32],"chain.":[33],"The":[34,83,212],"inhibitory":[35],"site":[36],"is":[37,60,94],"present":[38],"domain":[40],"3,":[41],"confined":[42],"C-terminal":[45],"portion":[46],"region":[49],"encoded":[50],"by":[51,86,165,299],"exon":[52],"7":[53],"(K270-G292),":[54],"minimal":[57],"effective":[58],"sequence":[59],"a":[61,195,252],"heptapeptide":[62],"(L271-A277;":[63],"Kunapuli":[64],"et":[65],"al,":[66],"J":[67],"Biol":[68],"Chem":[69],"271:11228,":[70],"1996).":[71],"Kininogens":[72],"thrombin":[74,166,190,249,275],"binding":[75,191,227,235,246,276],"platelets":[77,93,193,278],"thus":[79,286],"aggregation.":[82,283],"mechanism":[85],"which":[87,145],"unknown.":[95],"Thrombin":[96],"has":[97],"previously":[98],"been":[99],"bind":[102],"two":[104],"receptors":[105],"on":[106,130],"platelet":[108,282,297],"surface,":[109],"glycoprotein":[110],"(GP)":[111],"Ib-IX-V":[112,149,214,261,272],"complex":[113,161,215,273],"hepta-spanning":[116],"transmembrane":[117],"receptor":[118],"coupled":[119],"G":[121],"protein(s).":[122],"now":[124],"show":[125,172],"that,":[126],"unlike":[127],"its":[128],"effect":[129],"normal":[131],"kininogen":[133,153,188,226,231,267],"(2":[134],"micromol/L)":[135],"did":[136],"not":[137],"Bernard-Soulier":[143],"lack":[146],"GP":[148,210,260,271],"complex,":[150],"suggesting":[151],"interacts":[154],"either":[155],"directly":[156],"or":[157,202,239],"indirectly":[158],"with":[159,258],"restricts":[163],"access":[164],"this":[168],"receptor.":[169],"further":[171],"recombinant":[175],"K270-G292":[176],"polypeptide":[177],"synthetic":[180],"peptide":[181],"L271-A277":[182],"derived":[183],"from":[184],"lower":[189],"manner":[196],"similar":[197],"monoclonal":[199],"antibodies":[200],"ligands":[203],"(von":[204],"Willebrand":[205],"factor":[206],"echicetin)":[208],"Ib-IX.":[211],"anti-GP":[213],"antibodies,":[216],"TM-60":[217,238],"SZ":[219],"2,":[220],"can":[221,285],"125I-high":[223],"platelets.":[229],"Conversely,":[230],"could":[232],"block":[233],"biotinylated":[237,248],"125I-SZ":[241],"2.":[242],"Kininogen":[243,284],"inhibited":[244],"bound":[250],"mouse":[253],"fibroblast":[254],"cell":[255],"line":[256],"transfected":[257],"complex.":[262],"These":[263],"results":[264],"indicated":[265],"binds":[268],"modulating":[274],"consequent":[281],"serve":[287],"as":[288],"an":[289],"important":[290],"regulator":[291],"early":[294],"stages":[295],"stimulation":[298],"thrombin.":[300]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
