{"id":"https://openalex.org/W200347340","doi":null,"title":"Neuroactive steroids and rat CNS","display_name":"Neuroactive steroids and rat CNS","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W200347340","mag":"200347340"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-296","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091896026","display_name":"Vita Birzniece","orcid":"https://orcid.org/0000-0003-1609-4358","observed_orcids":["https://orcid.org/0000-0003-1609-4358"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vita Birzniece","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1609-4358","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091896026"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.06809999793767929,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurosteroids","display_name":"neurosteroids","score":0.9919999837875366},{"id":"https://openalex.org/keywords/allopregnanolone","display_name":"allopregnanolone","score":0.9380000233650208},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8090000152587891},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/serotonin-receptors","display_name":"serotonin receptors","score":0.7239999771118164},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.9419999718666077},{"id":"https://openalex.org/keywords/gaba-a-receptor-subunits","display_name":"GABAA receptor subunits","score":0.8379999995231628},{"id":"https://openalex.org/keywords/acute-tolerance","display_name":"acute tolerance","score":0.7260000109672546},{"id":"https://openalex.org/keywords/spatial-learning","display_name":"spatial learning","score":0.703000009059906},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.5580000281333923},{"id":"https://openalex.org/keywords/ovariectomized-rats","display_name":"ovariectomized rats","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.6581048965454102},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41133901476860046},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3522030711174011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31672143936157227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3020045757293701},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2789115309715271},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10997703671455383},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-296","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:200347340","doi":null,"is_oa":false,"landing_page_url":"https://umu.diva-portal.org/smash/get/diva2:142981/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-296","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":367,"referenced_works":["https://openalex.org/W9065758","https://openalex.org/W265382647","https://openalex.org/W1492266111","https://openalex.org/W1493628203","https://openalex.org/W1502488470","https://openalex.org/W1507973104","https://openalex.org/W1516599165","https://openalex.org/W1522096759","https://openalex.org/W1524203275","https://openalex.org/W1536855017","https://openalex.org/W1564265454","https://openalex.org/W1602497443","https://openalex.org/W1647312149","https://openalex.org/W1655416104","https://openalex.org/W1659444689","https://openalex.org/W1684853394","https://openalex.org/W1724698019","https://openalex.org/W1790534678","https://openalex.org/W1834035763","https://openalex.org/W1845852481","https://openalex.org/W1881287185","https://openalex.org/W1912224219","https://openalex.org/W1915833704","https://openalex.org/W1916020852","https://openalex.org/W1932154717","https://openalex.org/W1940656453","https://openalex.org/W1957435031","https://openalex.org/W1963686445","https://openalex.org/W1964469142","https://openalex.org/W1964544239","https://openalex.org/W1965154263","https://openalex.org/W1966087738","https://openalex.org/W1966126679","https://openalex.org/W1967061503","https://openalex.org/W1967380120","https://openalex.org/W1968033928","https://openalex.org/W1968427184","https://openalex.org/W1968898388","https://openalex.org/W1969680120","https://openalex.org/W1971737428","https://openalex.org/W1974084625","https://openalex.org/W1974272664","https://openalex.org/W1974973093","https://openalex.org/W1975759742","https://openalex.org/W1976149644","https://openalex.org/W1976635326","https://openalex.org/W1977598790","https://openalex.org/W1977787204","https://openalex.org/W1980166775","https://openalex.org/W1980195431","https://openalex.org/W1980500956","https://openalex.org/W1981592369","https://openalex.org/W1981730561","https://openalex.org/W1983621709","https://openalex.org/W1984462265","https://openalex.org/W1984917548","https://openalex.org/W1985033275","https://openalex.org/W1985579395","https://openalex.org/W1988111959","https://openalex.org/W1988612597","https://openalex.org/W1988687093","https://openalex.org/W1989168929","https://openalex.org/W1990804897","https://openalex.org/W1991404313","https://openalex.org/W1991648062","https://openalex.org/W1992949123","https://openalex.org/W1993453646","https://openalex.org/W1994543595","https://openalex.org/W1996009982","https://openalex.org/W1996300933","https://openalex.org/W1996305854","https://openalex.org/W1996345484","https://openalex.org/W1996559187","https://openalex.org/W1996996773","https://openalex.org/W1997568797","https://openalex.org/W1997570708","https://openalex.org/W1999399598","https://openalex.org/W2000443525","https://openalex.org/W2000483250","https://openalex.org/W2000831869","https://openalex.org/W2000904191","https://openalex.org/W2001876739","https://openalex.org/W2001926934","https://openalex.org/W2001963326","https://openalex.org/W2002407300","https://openalex.org/W2002879969","https://openalex.org/W2003432290","https://openalex.org/W2003860461","https://openalex.org/W2004641165","https://openalex.org/W2006156983","https://openalex.org/W2006193334","https://openalex.org/W2006346377","https://openalex.org/W2007109865","https://openalex.org/W2008606615","https://openalex.org/W2009070251","https://openalex.org/W2009410204","https://openalex.org/W2010778459","https://openalex.org/W2012453718","https://openalex.org/W2014035121","https://openalex.org/W2014261005","https://openalex.org/W2014299343","https://openalex.org/W2014357483","https://openalex.org/W2015525713","https://openalex.org/W2015661750","https://openalex.org/W2015740286","https://openalex.org/W2015789469","https://openalex.org/W2016770736","https://openalex.org/W2017221228","https://openalex.org/W2017457726","https://openalex.org/W2017475039","https://openalex.org/W2017908901","https://openalex.org/W2017936386","https://openalex.org/W2018769555","https://openalex.org/W2019455802","https://openalex.org/W2020448764","https://openalex.org/W2020725121","https://openalex.org/W2021235911","https://openalex.org/W2021471098","https://openalex.org/W2022549781","https://openalex.org/W2022848383","https://openalex.org/W2022974549","https://openalex.org/W2023297756","https://openalex.org/W2023608920","https://openalex.org/W2024344189","https://openalex.org/W2024573722","https://openalex.org/W2024813908","https://openalex.org/W2025801062","https://openalex.org/W2027344841","https://openalex.org/W2027610787","https://openalex.org/W2027879303","https://openalex.org/W2028554478","https://openalex.org/W2028594041","https://openalex.org/W2029211334","https://openalex.org/W2029466154","https://openalex.org/W2029492792","https://openalex.org/W2030313035","https://openalex.org/W2030492864","https://openalex.org/W2031351244","https://openalex.org/W2031410274","https://openalex.org/W2031466548","https://openalex.org/W2034093770","https://openalex.org/W2034951640","https://openalex.org/W2036431222","https://openalex.org/W2036474396","https://openalex.org/W2036690788","https://openalex.org/W2036809519","https://openalex.org/W2038127485","https://openalex.org/W2038645070","https://openalex.org/W2039187716","https://openalex.org/W2040064014","https://openalex.org/W2040903359","https://openalex.org/W2041201203","https://openalex.org/W2041823889","https://openalex.org/W2042377179","https://openalex.org/W2043105055","https://openalex.org/W2045355683","https://openalex.org/W2045942675","https://openalex.org/W2046518068","https://openalex.org/W2047559848","https://openalex.org/W2047968184","https://openalex.org/W2049983745","https://openalex.org/W2050089594","https://openalex.org/W2050243692","https://openalex.org/W2051068515","https://openalex.org/W2052490837","https://openalex.org/W2052515926","https://openalex.org/W2052883666","https://openalex.org/W2053081316","https://openalex.org/W2053500820","https://openalex.org/W2054093934","https://openalex.org/W2054229812","https://openalex.org/W2054508155","https://openalex.org/W2054982643","https://openalex.org/W2055112994","https://openalex.org/W2056029795","https://openalex.org/W2056154551","https://openalex.org/W2057920317","https://openalex.org/W2058611708","https://openalex.org/W2058644057","https://openalex.org/W2059492003","https://openalex.org/W2059560647","https://openalex.org/W2059631233","https://openalex.org/W2060307846","https://openalex.org/W2060487112","https://openalex.org/W2061389597","https://openalex.org/W2061601865","https://openalex.org/W2062794515","https://openalex.org/W2063103922","https://openalex.org/W2063559733","https://openalex.org/W2064887450","https://openalex.org/W2065324325","https://openalex.org/W2065556700","https://openalex.org/W2065917785","https://openalex.org/W2066101401","https://openalex.org/W2067275030","https://openalex.org/W2067754245","https://openalex.org/W2068019080","https://openalex.org/W2068847189","https://openalex.org/W2069370117","https://openalex.org/W2069474577","https://openalex.org/W2069622944","https://openalex.org/W2070290419","https://openalex.org/W2071517246","https://openalex.org/W2072258938","https://openalex.org/W2072627631","https://openalex.org/W2072942450","https://openalex.org/W2073015466","https://openalex.org/W2073102858","https://openalex.org/W2073136637","https://openalex.org/W2073353512","https://openalex.org/W2073503722","https://openalex.org/W2073640827","https://openalex.org/W2073883348","https://openalex.org/W2074113629","https://openalex.org/W2074146462","https://openalex.org/W2074926791","https://openalex.org/W2075126584","https://openalex.org/W2075241114","https://openalex.org/W2075623469","https://openalex.org/W2076331767","https://openalex.org/W2077166589","https://openalex.org/W2077678165","https://openalex.org/W2078092192","https://openalex.org/W2078223791","https://openalex.org/W2078869741","https://openalex.org/W2078894227","https://openalex.org/W2079099498","https://openalex.org/W2079103153","https://openalex.org/W2079290416","https://openalex.org/W2079335790","https://openalex.org/W2080894710","https://openalex.org/W2081600480","https://openalex.org/W2082080730","https://openalex.org/W2082389353","https://openalex.org/W2083183508","https://openalex.org/W2083308326","https://openalex.org/W2083447043","https://openalex.org/W2083623577","https://openalex.org/W2083644914","https://openalex.org/W2084240947","https://openalex.org/W2084823166","https://openalex.org/W2085804096","https://openalex.org/W2085887859","https://openalex.org/W2086269846","https://openalex.org/W2087393295","https://openalex.org/W2087786917","https://openalex.org/W2088143216","https://openalex.org/W2088254156","https://openalex.org/W2088290994","https://openalex.org/W2088604715","https://openalex.org/W2088759212","https://openalex.org/W2088890382","https://openalex.org/W2089468765","https://openalex.org/W2090508525","https://openalex.org/W2092102996","https://openalex.org/W2092756373","https://openalex.org/W2093634879","https://openalex.org/W2094573117","https://openalex.org/W2094582467","https://openalex.org/W2094936308","https://openalex.org/W2096654038","https://openalex.org/W2097917275","https://openalex.org/W2099680004","https://openalex.org/W2101178259","https://openalex.org/W2101473364","https://openalex.org/W2102186066","https://openalex.org/W2102501457","https://openalex.org/W2104460069","https://openalex.org/W2109641935","https://openalex.org/W2110207143","https://openalex.org/W2110451811","https://openalex.org/W2110457784","https://openalex.org/W2110502449","https://openalex.org/W2110887671","https://openalex.org/W2111648388","https://openalex.org/W2112456808","https://openalex.org/W2113682171","https://openalex.org/W2115182798","https://openalex.org/W2115583232","https://openalex.org/W2115716954","https://openalex.org/W2115819312","https://openalex.org/W2116011820","https://openalex.org/W2117939235","https://openalex.org/W2118713264","https://openalex.org/W2119435034","https://openalex.org/W2120889805","https://openalex.org/W2121237571","https://openalex.org/W2121403142","https://openalex.org/W2122480302","https://openalex.org/W2123331750","https://openalex.org/W2124151108","https://openalex.org/W2125007857","https://openalex.org/W2125277337","https://openalex.org/W2125707003","https://openalex.org/W2127232583","https://openalex.org/W2127483997","https://openalex.org/W2128257083","https://openalex.org/W2128281042","https://openalex.org/W2128453973","https://openalex.org/W2129487001","https://openalex.org/W2129687735","https://openalex.org/W2129779698","https://openalex.org/W2129824932","https://openalex.org/W2130074917","https://openalex.org/W2130695898","https://openalex.org/W2131266318","https://openalex.org/W2131803903","https://openalex.org/W2132098297","https://openalex.org/W2133188546","https://openalex.org/W2134001901","https://openalex.org/W2134442832","https://openalex.org/W2134506701","https://openalex.org/W2136219580","https://openalex.org/W2136816138","https://openalex.org/W2138788537","https://openalex.org/W2140527803","https://openalex.org/W2140817543","https://openalex.org/W2141861222","https://openalex.org/W2141998004","https://openalex.org/W2142695282","https://openalex.org/W2142925815","https://openalex.org/W2143086898","https://openalex.org/W2143649581","https://openalex.org/W2145129394","https://openalex.org/W2145865543","https://openalex.org/W2146126584","https://openalex.org/W2147502381","https://openalex.org/W2147682916","https://openalex.org/W2148939305","https://openalex.org/W2149153246","https://openalex.org/W2149596824","https://openalex.org/W2149959738","https://openalex.org/W2152898418","https://openalex.org/W2153869185","https://openalex.org/W2158750650","https://openalex.org/W2159913137","https://openalex.org/W2160287478","https://openalex.org/W2161288077","https://openalex.org/W2162008670","https://openalex.org/W2162933869","https://openalex.org/W2163191129","https://openalex.org/W2163815564","https://openalex.org/W2165223719","https://openalex.org/W2167167124","https://openalex.org/W2167194856","https://openalex.org/W2169473035","https://openalex.org/W2170781458","https://openalex.org/W2171196764","https://openalex.org/W2171485428","https://openalex.org/W2186363591","https://openalex.org/W2331174375","https://openalex.org/W2340333303","https://openalex.org/W2342889336","https://openalex.org/W2402794981","https://openalex.org/W2409013290","https://openalex.org/W2413944511","https://openalex.org/W2414770207","https://openalex.org/W2418612983","https://openalex.org/W2442219175","https://openalex.org/W2616196046","https://openalex.org/W2911335841","https://openalex.org/W2924856415","https://openalex.org/W4232231542","https://openalex.org/W4323283900","https://openalex.org/W4405989182","https://openalex.org/W4406382368","https://openalex.org/W4407081069"],"related_works":["https://openalex.org/W3141471811","https://openalex.org/W2013589717","https://openalex.org/W639156220","https://openalex.org/W2036301383","https://openalex.org/W2004623377","https://openalex.org/W2042377179","https://openalex.org/W2965061036","https://openalex.org/W2028579013","https://openalex.org/W2090257440","https://openalex.org/W1993411585"],"abstract_inverted_index":{"Several":[0],"studies":[1],"suggest":[2],"profound":[3],"effects":[4,40,51,183,416],"on":[5,41,52,211],"mood":[6,29,42,115],"and":[7,43,71,99,116,264,272,281,322,380,395,411,419],"cognition":[8],"by":[9,58,205,347],"neuroactive":[10,375],"steroids.":[11],"Estrogen":[12],"alone":[13,131,141,180],"or":[14,132,137,227],"in":[15,68,109,133,153,165,174,251,279,284,308,342,356,383,393,417,420],"combination":[16,134,166],"with":[17,129,135,147,167,328],"antidepressant":[18],"drugs":[19],"affecting":[20],"the":[21,32,49,53,69,73,154,158,170,175,186,215,285,309,320,332,340,357,363,370,378],"serotonin":[22,107,429],"system":[23],"has":[24,181],"been":[25],"used":[26,120,201],"to":[27,38,82,185,195,262,290,331,399],"treat":[28],"disorders.":[30],"On":[31],"other":[33],"hand,":[34],"progesterone":[35,50,148,168],"is":[36,63,249,257],"related":[37,289,398],"negative":[39],"memory.":[44],"A":[45],"major":[46],"part":[47],"of":[48,79,97,127,214,230,244,253,259,267,292,353],"brain":[54,111,265,385],"can":[55,338,413],"be":[56,78],"mediated":[57],"its":[59],"metabolite":[60],"allopregnanolone,":[61,196,427],"which":[62],"also":[64],"de":[65],"novo":[66],"synthesized":[67],"brain,":[70],"affects":[72,106,305],"GABAA":[74,233,246,275,389,431],"receptors.":[75],"It":[76],"would":[77],"great":[80],"importance":[81,268],"find":[83],"a":[84,324,384],"substance":[85],"that":[86,374],"antagonize":[87],"allopregnanolone":[88,207,263,297,401],"adverse":[89],"effects.":[90],"To":[91,189],"investigate":[92],"how":[93,302],"long":[94],"term":[95],"supplementation":[96,128],"estradiol":[98,140,144,164,179],"progesterone,":[100,136,425],"resembling":[101],"postmenopausal":[102],"hormone":[103],"replacement":[104],"therapy,":[105],"receptors":[108],"different":[110,220],"areas":[112],"important":[113],"for":[114,239],"memory":[117],"functions,":[118],"we":[119,300],"ovariectomized":[121],"female":[122],"rats.":[123],"After":[124,219],"2":[125],"weeks":[126],"17\u03b2-estradiol":[130],"placebo":[138],"pellets,":[139],"decreases":[142,157,350],"but":[143],"supplemented":[145],"together":[146],"increases":[149,169],"5HT1A":[150],"mRNA":[151,172],"expression":[152,173,243],"hippocampus.":[155,177],"Estradiol":[156],"5HT2C":[159],"receptor":[160,234,247,276,390],"gene":[161],"expression,":[162],"while":[163],"5HT2A":[171],"ventral":[176],"Thus,":[178],"opposite":[182],"compared":[184],"estradiol/progesterone":[187],"combination.":[188],"detect":[190],"if":[191,241],"acute":[192,254,260,293,400],"tolerance":[193,261],"develops":[194],"an":[197],"EEG":[198],"method":[199],"was":[200],"where":[202],"male":[203],"rats":[204],"continuous":[206],"infusion":[208],"were":[209,237],"kept":[210],"anesthesia":[212],"level":[213],"silent":[216,437],"second":[217],"(SS).":[218],"time":[221],"intervals":[222],"(first":[223],"SS,":[224],"30":[225],"min":[226,229],"90":[228],"anesthesia)":[231],"several":[232],"subunit":[235,278,283,391],"mRNAs":[236],"measured":[238],"detecting":[240],"changed":[242],"any":[245],"subunits":[248],"involved":[250],"development":[252,258,291],"tolerance.":[255,294,402,439],"There":[256],"regions":[266],"are":[269,288,397],"hippocampus,":[270],"thalamus":[271,280,396],"hypothalamus.":[273],"The":[274,335],"alpha4":[277],"alpha2":[282],"dorsal":[286],"hippocampus":[287,394],"For":[295],"assessing":[296],"behavioral":[298,326,365],"effects,":[299],"studied":[301],"this":[303],"neurosteroid":[304],"spatial":[306,316,354,408],"learning":[307,317,355,409],"Morris":[310,434],"water":[311,358,435],"maze":[312],"task":[313],"Allopregnanolone":[314,403],"inhibits":[315],"short":[318],"after":[319],"injection":[321],"shows":[323],"specific":[325,364,387],"pattern":[327],"swimming":[329],"close":[330],"pool":[333],"wall.":[334],"steroid":[336],"UC1011":[337,349,412],"inhibit":[339,414],"increase":[341],"chloride":[343],"ion":[344],"uptake":[345],"induced":[346],"allopregnanolone.":[348],"allopregnanoloneinduced":[351],"impairment":[352,410],"maze,":[359,436],"as":[360,362],"well":[361],"swim":[366],"pattern.":[367],"In":[368],"conclusion,":[369],"present":[371],"work":[372],"demonstrates":[373],"steroids":[376],"affect":[377],"5HT":[379],"GABA":[381],"systems":[382],"region":[386],"way.":[388],"changes":[392],"induces":[404],"cognitive":[405],"deficits,":[406],"like":[407],"allopregnanolone-induced":[415],"vitro":[418],"vivo.":[421],"Key":[422],"words:":[423],"Estradiol,":[424],"HRT,":[426],"UC1011,":[428],"receptor,":[430,432],"mRNA,":[433],"second,":[438]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}