{"id":"https://openalex.org/W2003459185","doi":"https://doi.org/10.1016/j.jalz.2008.05.1655","title":"P3\u2010091: Specific conformational detection of beta\u2010sheet rich amyloid beta proteins using conformationally dynamic Pronucleon\u2122 peptides","display_name":"P3\u2010091: Specific conformational detection of beta\u2010sheet rich amyloid beta proteins using conformationally dynamic Pronucleon\u2122 peptides","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W2003459185","doi":"https://doi.org/10.1016/j.jalz.2008.05.1655","mag":"2003459185"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2008.05.1655","doi":"https://doi.org/10.1016/j.jalz.2008.05.1655","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2008.05.1655","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050980294","display_name":"Gretchen L. Schieber","orcid":"https://orcid.org/0000-0002-1024-6050","observed_orcids":["https://orcid.org/0000-0002-1024-6050"]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gretchen L. Schieber","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060408204","display_name":"Roxanne Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roxanne Duan","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082386681","display_name":"Jonathan R. Moll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Moll","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010188932","display_name":"Craig Nelsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Nelsen","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040856063","display_name":"Andrew C. Nyborg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Nyborg","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101086","display_name":"Alan S. Rudolph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Rudolph","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049888868","display_name":"Shankaramma Shivaprasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shankaramma Shivaprasad","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022682916","display_name":"Serguei Soukharev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serguei Soukharev","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039535686","display_name":"Renee D. Wegrzyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee Wegrzyn","raw_affiliation_strings":["Adlyfe, Inc., Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe, Inc., Rockville, MD, USA","institution_ids":["https://openalex.org/I4210125368"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050980294"],"corresponding_institution_ids":["https://openalex.org/I4210125368"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15653034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"4S_Part_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8349999785423279},{"id":"https://openalex.org/keywords/beta-sheet-conformation","display_name":"\u03b2-sheet conformation","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7214512228965759},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.6594822406768799},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6194620132446289},{"id":"https://openalex.org/C159547669","wikidata":"https://www.wikidata.org/wiki/Q283449","display_name":"Beta sheet","level":3,"score":0.6009275317192078},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5563185811042786},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.5321580171585083},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5090277194976807},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.48950016498565674},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44215163588523865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43897590041160583},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4122445285320282},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.28842052817344666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21413737535476685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1416352093219757},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10462945699691772},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10402625799179077},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2008.05.1655","doi":"https://doi.org/10.1016/j.jalz.2008.05.1655","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2008.05.1655","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2117873636","https://openalex.org/W2582547315","https://openalex.org/W2085068166","https://openalex.org/W2055730197","https://openalex.org/W4233270448","https://openalex.org/W2004329147","https://openalex.org/W2113386925","https://openalex.org/W1571888941","https://openalex.org/W2600248198","https://openalex.org/W2471951344"],"abstract_inverted_index":{"The":[0,118,316],"pathogenesis":[1],"of":[2,11,26,31,46,56,77,88,111,115,140,160,178,194,233,240,272,279,287,297,323,340],"many":[3],"protein":[4,15,35,59,211],"disorders":[5],"is":[6,39],"characterized":[7],"by":[8],"the":[9,24,57,69,75,86,109,112,125,137,226,234,238,270,273,295,329,337],"conversion":[10],"a":[12,17,43,63,104,122,158,221,333],"constitutive":[13],"soluble":[14,19,195,262],"into":[16,36,168],"less":[18],"beta-sheet":[20,113,324],"rich":[21,325],"conformation.":[22],"In":[23,243,254],"case":[25],"Alzheimer's":[27],"disease":[28,96],"(AD),":[29],"assembly":[30],"amyloid":[32,91,163],"beta":[33,89],"(Abeta)":[34],"neurotoxic":[37],"oligomers":[38],"reported":[40,74],"to":[41,68,261,300,331],"be":[42,62,130],"likely":[44],"cause":[45],"disease.":[47],"Diagnostic":[48],"tools":[49],"that":[50,84,128,147],"can":[51,129],"distinguish":[52],"between":[53],"different":[54],"conformations":[55],"Abeta":[58,116,196,241,251,263,280,326],"biomarker":[60],"would":[61],"unique":[64],"and":[65,97,165,182,217,224,282,291,328],"valuable":[66],"contribution":[67],"field.":[70],"We":[71,175,189,265,284],"have":[72,190,266],"previously":[73],"use":[76],"small":[78],"conformationally":[79],"dynamic":[80],"peptides":[81,102],"(Pronucleon\u2122":[82],"peptides),":[83],"enable":[85],"detection":[87,286],"sheet":[90],"proteins":[92],"both":[93],"in":[94,98,108,121,124,143,154,185,220,237,269],"prion":[95],"AD.":[99,341],"These":[100],"fluorescently-labeled":[101],"undergo":[103],"sequence-specific":[105],"conformational":[106,231],"rearrangement":[107,119],"presence":[110,239],"structure":[114],"aggregates.":[117,242,264],"results":[120],"change":[123],"fluorescence":[126,227],"profile":[127],"monitored":[131],"using":[132,207],"standard":[133],"laboratory":[134],"instrumentation.":[135],"Toward":[136],"overall":[138],"goal":[139],"creating":[141],"an":[142],"vitro":[144],"diagnostic":[145,334],"test":[146,335],"directly":[148],"measures":[149],"peptide":[150,219,236,318,338],"molecular":[151],"structures":[152],"implicated":[153],"AD,":[155],"we":[156,246,257],"tested":[157],"system":[159],"specifically":[161],"defined":[162],"aggregates":[164,197,327],"spiked":[166],"these":[167],"clinical":[169,301],"matrices":[170],"including":[171],"cerebrospinal":[172],"fluid":[173],"(CSF).":[174],"addressed":[176],"issues":[177],"assay":[179,213,260,298],"design,":[180],"dose-response,":[181],"target":[183],"availability":[184],"this":[186,255],"biological":[187],"matrix.":[188],"created":[191],"controlled":[192],"populations":[193],"prepared":[198],"from":[199,305],"purchased":[200],"recombinant":[201],"Abeta.":[202],"Assay":[203],"studies":[204],"were":[205],"performed":[206],"Adlyfe's":[208],"MPD":[209],"(\u201cmisfolded\u201d":[210],"detection)":[212],"which":[214],"combines":[215],"sample":[216],"Pronucleon":[218,235,274,317],"96-well":[222],"plate":[223],"follows":[225],"transition":[228],"associated":[229],"with":[230,249,307],"changes":[232],"previous":[244],"studies,":[245],"demonstrated":[247],"reactivity":[248],"insoluble":[250],"\u201cfiber\u201d":[252],"aggregate.":[253],"work,":[256],"extend":[258],"our":[259],"evaluated":[267],"variations":[268],"sequence":[271],"peptides,":[275],"considering":[276],"structural":[277],"regions":[278],"folding":[281],"aggregation.":[283],"demonstrate":[285],"synthetic":[288],"aggregate":[289],"forms":[290],"present":[292],"data":[293],"on":[294],"translation":[296],"conditions":[299],"samples":[302],"representing":[303],"cohorts":[304],"subjects":[306],"AD":[308],"or":[309],"mild":[310],"cognitive":[311],"impairment":[312],"versus":[313],"age-matched":[314],"controls.":[315],"technology":[319],"demonstrates":[320],"specific":[321],"recognition":[322],"potential":[330],"create":[332],"for":[336],"biomarkers":[339]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
