{"id":"https://openalex.org/W2003456330","doi":"https://doi.org/10.1242/dev.021493","title":"Targeted disruption of \u03b2-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex","display_name":"Targeted disruption of \u03b2-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex","publication_year":2008,"publication_date":"2008-07-04","ids":{"openalex":"https://openalex.org/W2003456330","doi":"https://doi.org/10.1242/dev.021493","mag":"2003456330","pmid":"https://pubmed.ncbi.nlm.nih.gov/18599507"},"language":"en","primary_location":{"id":"doi:10.1242/dev.021493","doi":"https://doi.org/10.1242/dev.021493","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.021493","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089030143","display_name":"Alex C. Kim","orcid":"https://orcid.org/0000-0003-3113-6560","observed_orcids":["https://orcid.org/0000-0003-3113-6560"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex C. Kim","raw_affiliation_strings":["Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678. USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015001192","display_name":"Anne L. Reuter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne L. Reuter","raw_affiliation_strings":["Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103383917","display_name":"Mohamad Zubair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamad Zubair","raw_affiliation_strings":["Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004009107","display_name":"Tobias Else","orcid":"https://orcid.org/0000-0002-2262-0011","observed_orcids":["https://orcid.org/0000-0002-2262-0011"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tobias Else","raw_affiliation_strings":["Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678. USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006462987","display_name":"Kerri A. Ohman","orcid":"https://orcid.org/0000-0001-7637-7339","observed_orcids":["https://orcid.org/0000-0001-7637-7339"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerri Serecky","raw_affiliation_strings":["Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678. USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048906240","display_name":"Nathan C. Bingham","orcid":"https://orcid.org/0000-0003-3343-0069","observed_orcids":["https://orcid.org/0000-0003-3343-0069"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan C. Bingham","raw_affiliation_strings":["Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058908918","display_name":"Gareth Geoffrey Lavery","orcid":"https://orcid.org/0000-0001-5794-748X","observed_orcids":["https://orcid.org/0000-0001-5794-748X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth G. Lavery","raw_affiliation_strings":["Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103395416","display_name":"Keith L. Parker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith L. Parker","raw_affiliation_strings":["Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-8857, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073697965","display_name":"Gary Douglas Hammer","orcid":"https://orcid.org/0000-0001-6843-3628","observed_orcids":["https://orcid.org/0000-0001-6843-3628"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary D. Hammer","raw_affiliation_strings":["Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678. USA","Cell and Developmental Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0678. USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Cell and Developmental Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073697965"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":5.0691,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.96471132,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"135","issue":"15","first_page":"2593","last_page":"2602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.094200000166893,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/steroidogenic-factor-1","display_name":"steroidogenic factor 1","score":0.953000009059906},{"id":"https://openalex.org/keywords/adrenal-cortex-development","display_name":"adrenal cortex development","score":0.8429999947547913},{"id":"https://openalex.org/keywords/conditional-gene-inactivation","display_name":"conditional gene inactivation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8954970836639404},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7961888313293457},{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.7653262615203857},{"id":"https://openalex.org/C2777703421","wikidata":"https://www.wikidata.org/wiki/Q15312538","display_name":"Steroidogenic factor 1","level":5,"score":0.6232682466506958},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5665565729141235},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5474886298179626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5072590708732605},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.48061293363571167},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.4675409197807312},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.46003565192222595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4546516239643097},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4325457811355591},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3523767590522766},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.31319305300712585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25616052746772766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23328155279159546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054339","descriptor_name":"Steroidogenic Factor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054339","descriptor_name":"Steroidogenic Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.021493","doi":"https://doi.org/10.1242/dev.021493","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.021493","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:18599507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18599507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1597840164","display_name":null,"funder_award_id":"DK062027","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3772003422","display_name":null,"funder_award_id":"HD046743","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G474905912","display_name":null,"funder_award_id":"DK-54480","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6022821159","display_name":"Steroidogenic Factor 1: Mediator of Gonadal Function","funder_award_id":"R01HD046743","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6910865047","display_name":"SF-1-Key Mediator of Endocrine Development and Function","funder_award_id":"R01DK054480","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000895316","display_name":"Mechanisms of Adrenal Differentiation","funder_award_id":"R01DK062027","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1498970130","https://openalex.org/W1504564486","https://openalex.org/W1551890621","https://openalex.org/W1590222977","https://openalex.org/W1886443720","https://openalex.org/W1967832920","https://openalex.org/W1971689970","https://openalex.org/W1975912195","https://openalex.org/W1977873240","https://openalex.org/W1978916626","https://openalex.org/W1985970079","https://openalex.org/W1996484852","https://openalex.org/W1996517697","https://openalex.org/W2002438570","https://openalex.org/W2011842366","https://openalex.org/W2011935366","https://openalex.org/W2014236527","https://openalex.org/W2022560804","https://openalex.org/W2029799875","https://openalex.org/W2042978848","https://openalex.org/W2044046815","https://openalex.org/W2058276161","https://openalex.org/W2074435588","https://openalex.org/W2078503449","https://openalex.org/W2081511864","https://openalex.org/W2086034924","https://openalex.org/W2095670260","https://openalex.org/W2098412813","https://openalex.org/W2103597610","https://openalex.org/W2106809514","https://openalex.org/W2107277218","https://openalex.org/W2110985070","https://openalex.org/W2111724542","https://openalex.org/W2119284420","https://openalex.org/W2126755481","https://openalex.org/W2130290296","https://openalex.org/W2135888028","https://openalex.org/W2137702233","https://openalex.org/W2140861044","https://openalex.org/W2149120477","https://openalex.org/W2149442523","https://openalex.org/W2153561951","https://openalex.org/W2155507705","https://openalex.org/W2157610967","https://openalex.org/W2162405918","https://openalex.org/W2166045505","https://openalex.org/W2169503556","https://openalex.org/W7073661393"],"related_works":["https://openalex.org/W2269945682","https://openalex.org/W7052252782","https://openalex.org/W2029992626","https://openalex.org/W2755301468","https://openalex.org/W2083777203","https://openalex.org/W7098516979","https://openalex.org/W1553955381","https://openalex.org/W2627039780","https://openalex.org/W1973773749","https://openalex.org/W1967832920"],"abstract_inverted_index":{"The":[0,21],"nuclear":[1],"receptor":[2],"steroidogenic":[3],"factor":[4],"1":[5],"(Sf1,":[6],"Nr5a1)":[7],"is":[8],"essential":[9],"for":[10,139],"adrenal":[11,58,83,91,125,154],"development":[12,92,151],"and":[13,156],"regulates":[14],"genes":[15],"that":[16,117],"specify":[17],"differentiated":[18],"adrenocortical":[19,48,102,122],"function.":[20],"transcriptional":[22],"coactivator":[23],"beta-catenin":[24,55,68,72,95,115],"reportedly":[25],"synergizes":[26],"with":[27,93],"Sf1":[28],"to":[29,65,127],"regulate":[30],"a":[31,76,111],"subset":[32],"of":[33,54,71,89,114,131,143,152,159],"these":[34],"target":[35],"genes;":[36],"moreover,":[37],"Wnt":[38,145],"family":[39],"members,":[40],"signaling":[41,147],"via":[42],"beta-catenin,":[43],"are":[44],"also":[45],"implicated":[46],"in":[47,56,85,100,157],"development.":[49],"To":[50],"investigate":[51],"the":[52,57,107,132,144,153,160],"role":[53],"cortex,":[59],"we":[60],"used":[61],"two":[62],"Sf1/Cre":[63],"transgenes":[64],"inactivate":[66],"conditional":[67],"alleles.":[69],"Inactivation":[70],"mediated":[73],"by":[74],"Sf1/Cre(high),":[75],"transgene":[77,109],"expressed":[78],"at":[79],"high":[80],"levels,":[81],"caused":[82],"aplasia":[84],"newborn":[86],"mice.":[87],"Analysis":[88],"fetal":[90],"Sf1/Cre(high)-mediated":[94],"inactivation":[96,116],"showed":[97],"decreased":[98],"proliferation":[99],"presumptive":[101],"precursor":[103],"cells.":[104],"By":[105],"contrast,":[106],"Sf1/Cre(low)":[108],"effected":[110],"lesser":[112],"degree":[113],"did":[118],"not":[119],"affect":[120],"all":[121],"cells,":[123],"permitting":[124],"survival":[126],"reveal":[128],"age-dependent":[129],"degeneration":[130],"cortex.":[133],"These":[134],"results":[135],"define":[136],"crucial":[137],"roles":[138],"beta-catenin--presumably":[140],"as":[141],"part":[142],"canonical":[146],"pathway--in":[148],"both":[149],"embryonic":[150],"cortex":[155],"maintenance":[158],"adult":[161],"organ.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}