{"id":"https://openalex.org/W2003445065","doi":"https://doi.org/10.1073/pnas.0909333107","title":"Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival","display_name":"Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival","publication_year":2009,"publication_date":"2009-12-28","ids":{"openalex":"https://openalex.org/W2003445065","doi":"https://doi.org/10.1073/pnas.0909333107","mag":"2003445065","pmid":"https://pubmed.ncbi.nlm.nih.gov/20080645","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2824310"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0909333107","doi":"https://doi.org/10.1073/pnas.0909333107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0909333107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2824310/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082482645","display_name":"Christine Gjerdrum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Gjerdrum","raw_affiliation_strings":["Department of Biomedicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079979338","display_name":"Crina Elena Tiron","orcid":"https://orcid.org/0000-0002-1469-9153","observed_orcids":["https://orcid.org/0000-0002-1469-9153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Crina Tiron","raw_affiliation_strings":["Department of Biomedicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072662202","display_name":"Torill H\u00f8iby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Torill H\u00f8iby","raw_affiliation_strings":["Department of Biomedicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038328067","display_name":"Ingunn M. Stefansson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingunn Stefansson","raw_affiliation_strings":["Department of Pathology","The Gade Institute, Pathology Section","Department of Pathology; The Gade Institute, Pathology Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"The Gade Institute, Pathology Section","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology; The Gade Institute, Pathology Section","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052105924","display_name":"Hallvard Haugen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hallvard Haugen","raw_affiliation_strings":["Department of Biomedicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081617275","display_name":"Tone Sandal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tone Sandal","raw_affiliation_strings":["The Gade Institute, Pathology Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Gade Institute, Pathology Section","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084493797","display_name":"Karin Collett","orcid":"https://orcid.org/0000-0003-0101-356X","observed_orcids":["https://orcid.org/0000-0003-0101-356X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karin Collett","raw_affiliation_strings":["Department of Pathology","The Gade Institute, Pathology Section","Department of Pathology; The Gade Institute, Pathology Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"The Gade Institute, Pathology Section","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology; The Gade Institute, Pathology Section","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324733","display_name":"Shan Li","orcid":"https://orcid.org/0000-0003-4446-2218","observed_orcids":["https://orcid.org/0000-0003-4446-2218"]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shan Li","raw_affiliation_strings":["Beckman Research Institute of the City of Hope, Duarte, CA 91010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Research Institute of the City of Hope, Duarte, CA 91010","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006949480","display_name":"Emmet McCormack","orcid":"https://orcid.org/0000-0002-7621-4625","observed_orcids":["https://orcid.org/0000-0002-7621-4625"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Emmet McCormack","raw_affiliation_strings":["Department of Medicine, Hematology Section, Haukeland University Hospital, N-5021, Bergen, Norway","Institute of Medicine, University of Bergen, N-5009 Bergen, Norway","Department of Medicine, Hematology Section, Haukeland University Hospital, N-5021, Bergen, Norway; Institute of Medicine, University of Bergen, N-5009 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology Section, Haukeland University Hospital, N-5021, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]},{"raw_affiliation_string":"Institute of Medicine, University of Bergen, N-5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Department of Medicine, Hematology Section, Haukeland University Hospital, N-5021, Bergen, Norway; Institute of Medicine, University of Bergen, N-5009 Bergen, Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057088387","display_name":"Bj\u00f8rn Tore Gjertsen","orcid":"https://orcid.org/0000-0001-9358-9704","observed_orcids":["https://orcid.org/0000-0001-9358-9704"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Bj\u00f8rn Tore Gjertsen","raw_affiliation_strings":["Department of Medicine, Hematology Section, Haukeland University Hospital, N-5021, Bergen, Norway","Institute of Medicine, University of Bergen, N-5009 Bergen, Norway","Department of Medicine, Hematology Section, Haukeland University Hospital, N-5021, Bergen, Norway; Institute of Medicine, University of Bergen, N-5009 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology Section, Haukeland University Hospital, N-5021, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]},{"raw_affiliation_string":"Institute of Medicine, University of Bergen, N-5009 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Department of Medicine, Hematology Section, Haukeland University Hospital, N-5021, Bergen, Norway; Institute of Medicine, University of Bergen, N-5009 Bergen, Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013499544","display_name":"David Micklem","orcid":"https://orcid.org/0000-0003-2756-2591","observed_orcids":["https://orcid.org/0000-0003-2756-2591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R. Micklem","raw_affiliation_strings":["Department of Biomedicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068445062","display_name":"Lars A. Akslen","orcid":"https://orcid.org/0000-0003-2710-9543","observed_orcids":["https://orcid.org/0000-0003-2710-9543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lars A. Akslen","raw_affiliation_strings":["Department of Pathology","The Gade Institute, Pathology Section","Department of Pathology; The Gade Institute, Pathology Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology","institution_ids":[]},{"raw_affiliation_string":"The Gade Institute, Pathology Section","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology; The Gade Institute, Pathology Section","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064008571","display_name":"Carlotta A. Glackin","orcid":"https://orcid.org/0000-0003-2009-3518","observed_orcids":["https://orcid.org/0000-0003-2009-3518"]},"institutions":[{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlotta Glackin","raw_affiliation_strings":["Beckman Research Institute of the City of Hope, Duarte, CA 91010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Research Institute of the City of Hope, Duarte, CA 91010","institution_ids":["https://openalex.org/I4387156432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010590862","display_name":"James B. Lorens","orcid":"https://orcid.org/0000-0002-6782-3349","observed_orcids":["https://orcid.org/0000-0002-6782-3349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James B. Lorens","raw_affiliation_strings":["Department of Biomedicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.518,"has_fulltext":false,"cited_by_count":607,"citation_normalized_percentile":{"value":0.99098126,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"107","issue":"3","first_page":"1124","last_page":"1129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axl","display_name":"AXL","score":0.7649999856948853},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9890000224113464},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.996999979019165},{"id":"https://openalex.org/keywords/gas6","display_name":"Gas6","score":0.9139999747276306},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5950000286102295},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6420000195503235},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7222002744674683},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6990078687667847},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6632377505302429},{"id":"https://openalex.org/C172811965","wikidata":"https://www.wikidata.org/wiki/Q21110911","display_name":"GAS6","level":4,"score":0.6300867199897766},{"id":"https://openalex.org/C5364575","wikidata":"https://www.wikidata.org/wiki/Q17836543","display_name":"AXL receptor tyrosine kinase","level":5,"score":0.5784437656402588},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5709624290466309},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5364921689033508},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.488489031791687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48129287362098694},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4609909653663635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32706353068351746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2762066125869751},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18663129210472107},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000094963","descriptor_name":"Axl Receptor Tyrosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0909333107","doi":"https://doi.org/10.1073/pnas.0909333107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0909333107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:20080645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20080645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2824310","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2824310/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2824310","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2824310/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3605261935","display_name":"Molecular Interactions of TWIST and Wnt in Breast Cancer","funder_award_id":"R21CA107245","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320322496","display_name":"Helse Vest","ror":"https://ror.org/001212e83"},{"id":"https://openalex.org/F4320323078","display_name":"Universitetet i Bergen","ror":"https://ror.org/03zga2b32"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W275110452","https://openalex.org/W1497663772","https://openalex.org/W1607701774","https://openalex.org/W1971801942","https://openalex.org/W2012634952","https://openalex.org/W2013107571","https://openalex.org/W2014691022","https://openalex.org/W2025647419","https://openalex.org/W2036008499","https://openalex.org/W2040167467","https://openalex.org/W2042198997","https://openalex.org/W2046142904","https://openalex.org/W2076583198","https://openalex.org/W2086811477","https://openalex.org/W2106382644","https://openalex.org/W2114154136","https://openalex.org/W2116141084","https://openalex.org/W2117716725","https://openalex.org/W2122483745","https://openalex.org/W2122917672","https://openalex.org/W2126073113","https://openalex.org/W2132089284","https://openalex.org/W2140551998","https://openalex.org/W2142739240","https://openalex.org/W2146012957","https://openalex.org/W2152387535","https://openalex.org/W2156323704","https://openalex.org/W2159490365","https://openalex.org/W2170253702"],"related_works":["https://openalex.org/W2134409397","https://openalex.org/W2333797329","https://openalex.org/W2020694732","https://openalex.org/W2313604544","https://openalex.org/W2800659548","https://openalex.org/W3006490798","https://openalex.org/W2885061945","https://openalex.org/W2149542744","https://openalex.org/W3083195530","https://openalex.org/W4253885390"],"abstract_inverted_index":{"Metastasis":[0],"underlies":[1],"the":[2,12,61,64,161,170,194,206],"majority":[3],"of":[4,11,42,63,127,138,163,193,211],"cancer-related":[5],"deaths.":[6],"Thus,":[7,205],"furthering":[8],"our":[9],"understanding":[10],"molecular":[13],"mechanisms":[14],"that":[15,37,60,81,92,104,187,198],"enable":[16],"tumor":[17,195],"cell":[18,134,196],"dissemination":[19],"is":[20,45,94,199],"a":[21,124,190],"vital":[22],"health":[23],"issue.":[24],"Epithelial-to-mesenchymal":[25],"transitions":[26],"(EMTs)":[27],"endow":[28],"carcinoma":[29,167],"cells":[30,103,122,168],"with":[31,110],"enhanced":[32,87],"migratory":[33],"and":[34,53,80,136,142,176,180,208],"survival":[35],"attributes":[36],"facilitate":[38],"malignant":[39],"progression.":[40],"Characterization":[41],"EMT":[43,98,197],"effectors":[44],"likely":[46],"to":[47,173],"yield":[48],"new":[49,217],"insights":[50],"into":[51],"metastasis":[52],"novel":[54],"avenues":[55],"for":[56,130,201,220],"treatment.":[57],"We":[58,90],"show":[59,86],"presence":[62],"receptor":[65],"tyrosine":[66],"kinase":[67],"Axl":[68,88,93,128,157,188],"in":[69,99,118,132,140,145,148],"primary":[70],"breast":[71,120,154,166,202,221],"cancers":[72],"independently":[73],"predicts":[74],"strongly":[75,95],"reduced":[76],"overall":[77,182],"patient":[78,83],"survival,":[79],"matched":[82],"metastatic":[84,119,165],"lesions":[85],"expression.":[89],"demonstrate":[91],"induced":[96],"by":[97],"immortalized":[100],"mammary":[101,171],"epithelial":[102],"establishes":[105],"an":[106,215],"autocrine":[107],"signaling":[108],"loop":[109],"its":[111],"ligand,":[112],"Gas6.":[113],"Epiallelic":[114],"RNA":[115],"interference":[116],"analysis":[117],"cancer":[121,155,203],"delineated":[123],"distinct":[125],"threshold":[126],"expression":[129],"mesenchymal-like":[131],"vitro":[133],"invasiveness":[135],"formation":[137],"tumors":[139,213],"foreign":[141],"tissue-engineered":[143],"microenvironments":[144],"vivo.":[146],"Importantly,":[147],"two":[149],"different":[150],"optical":[151],"imaging-based":[152],"experimental":[153],"models,":[156],"knockdown":[158],"completely":[159],"prevented":[160],"spread":[162],"highly":[164],"from":[169],"gland":[172],"lymph":[174],"nodes":[175],"several":[177],"major":[178],"organs":[179],"increased":[181],"survival.":[183],"These":[184],"findings":[185],"suggest":[186],"represents":[189,214],"downstream":[191],"effector":[192],"required":[200],"metastasis.":[204],"detection":[207],"targeted":[209],"treatment":[210],"Axl-expressing":[212],"important":[216],"therapeutic":[218],"strategy":[219],"cancer.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":46},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":57},{"year":2019,"cited_by_count":40},{"year":2018,"cited_by_count":38},{"year":2017,"cited_by_count":44},{"year":2016,"cited_by_count":52},{"year":2015,"cited_by_count":44},{"year":2014,"cited_by_count":40},{"year":2013,"cited_by_count":29},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
