{"id":"https://openalex.org/W2003420932","doi":"https://doi.org/10.1158/0008-5472.can-06-1182","title":"PIK3CA Mutations Are an Early Genetic Alteration Associated with FGFR3 Mutations in Superficial Papillary Bladder Tumors","display_name":"PIK3CA Mutations Are an Early Genetic Alteration Associated with FGFR3 Mutations in Superficial Papillary Bladder Tumors","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2003420932","doi":"https://doi.org/10.1158/0008-5472.can-06-1182","mag":"2003420932","pmid":"https://pubmed.ncbi.nlm.nih.gov/16885334"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-06-1182","doi":"https://doi.org/10.1158/0008-5472.can-06-1182","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-1182","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/66/15/7401/2551707/7401.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/66/15/7401/2551707/7401.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062099405","display_name":"Elena L\u00f3pez\u2010Knowles","orcid":"https://orcid.org/0000-0002-0893-3361","observed_orcids":["https://orcid.org/0000-0002-0893-3361"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Lo\u0301pez-Knowles","raw_affiliation_strings":["1Institut Municipal d'Investigacio\u0301 Me\u0300dica;","Institut Municipal d'Investigaci\u00f3 M\u00e8dica, Universitat Pompeu Fabra, Carrer del Dr. Aiguader 80, 08003 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut Municipal d'Investigacio\u0301 Me\u0300dica;","institution_ids":["https://openalex.org/I4210136145"]},{"raw_affiliation_string":"Institut Municipal d'Investigaci\u00f3 M\u00e8dica, Universitat Pompeu Fabra, Carrer del Dr. Aiguader 80, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013180518","display_name":"Silvia F. Hernandez","orcid":"https://orcid.org/0000-0002-7973-2620","observed_orcids":["https://orcid.org/0000-0002-7973-2620"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia Herna\u0301ndez","raw_affiliation_strings":["2Universitat Pompeu Fabra;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Universitat Pompeu Fabra;","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037804113","display_name":"N\u00faria Malats","orcid":"https://orcid.org/0000-0003-2538-3784","observed_orcids":["https://orcid.org/0000-0003-2538-3784"]},"institutions":[{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nu\u0301ria Malats","raw_affiliation_strings":["1Institut Municipal d'Investigacio\u0301 Me\u0300dica;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut Municipal d'Investigacio\u0301 Me\u0300dica;","institution_ids":["https://openalex.org/I4210136145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025023257","display_name":"Manolis Kogevinas","orcid":"https://orcid.org/0000-0002-9605-0461","observed_orcids":["https://orcid.org/0000-0002-9605-0461"]},"institutions":[{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manolis Kogevinas","raw_affiliation_strings":["1Institut Municipal d'Investigacio\u0301 Me\u0300dica;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut Municipal d'Investigacio\u0301 Me\u0300dica;","institution_ids":["https://openalex.org/I4210136145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036947619","display_name":"Josep Lloreta","orcid":"https://orcid.org/0000-0003-1644-9470","observed_orcids":["https://orcid.org/0000-0003-1644-9470"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep Lloreta","raw_affiliation_strings":["2Universitat Pompeu Fabra;","3Hospital del Mar, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Universitat Pompeu Fabra;","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"3Hospital del Mar, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073682977","display_name":"Alfredo Carrato","orcid":"https://orcid.org/0000-0001-7749-8140","observed_orcids":["https://orcid.org/0000-0001-7749-8140"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]},{"id":"https://openalex.org/I4210115956","display_name":"Hospital General Universitario de Elche","ror":"https://ror.org/01jmsem62","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115956"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alfredo Carrato","raw_affiliation_strings":["4Hospital General Universitario, Instituto Biologi\u0301a Molecular y Celular, Universidad Miguel Herna\u0301ndez, Elche, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Hospital General Universitario, Instituto Biologi\u0301a Molecular y Celular, Universidad Miguel Herna\u0301ndez, Elche, Spain;","institution_ids":["https://openalex.org/I111262870","https://openalex.org/I4210115956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002857362","display_name":"Adonina Tard\u00f3n","orcid":"https://orcid.org/0000-0001-5150-1209","observed_orcids":["https://orcid.org/0000-0001-5150-1209"]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adonina Tardo\u0301n","raw_affiliation_strings":["5Universidad de Oviedo, Oviedo, Spain; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Universidad de Oviedo, Oviedo, Spain; and","institution_ids":["https://openalex.org/I165339363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053507664","display_name":"C\u00f2nsol Serra","orcid":"https://orcid.org/0000-0001-8337-8356","observed_orcids":["https://orcid.org/0000-0001-8337-8356"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210115578","display_name":"Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed","ror":"https://ror.org/02pg81z63","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210115578"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Consol Serra","raw_affiliation_strings":["2Universitat Pompeu Fabra;","6Consorci Hospitalari Parc Tauli, Sabadell, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Universitat Pompeu Fabra;","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"6Consorci Hospitalari Parc Tauli, Sabadell, Spain","institution_ids":["https://openalex.org/I4210115578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060086359","display_name":"Francisco X. Real","orcid":"https://orcid.org/0000-0001-9501-498X","observed_orcids":["https://orcid.org/0000-0001-9501-498X"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco X. Real","raw_affiliation_strings":["1Institut Municipal d'Investigacio\u0301 Me\u0300dica;","2Universitat Pompeu Fabra;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institut Municipal d'Investigacio\u0301 Me\u0300dica;","institution_ids":["https://openalex.org/I4210136145"]},{"raw_affiliation_string":"2Universitat Pompeu Fabra;","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"last","author":{"id":null,"display_name":"EPICURO Study Group Investigators","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EPICURO Study Group Investigators","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.3757,"has_fulltext":true,"cited_by_count":217,"citation_normalized_percentile":{"value":0.98599082,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"66","issue":"15","first_page":"7401","last_page":"7404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fgfr3-mutation","display_name":"FGFR3 mutation","score":1.0},{"id":"https://openalex.org/keywords/superficial-bladder-cancer","display_name":"superficial bladder cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.6980000138282776},{"id":"https://openalex.org/keywords/bladder-carcinogenesis","display_name":"bladder carcinogenesis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.550542950630188},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4921950399875641},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4919726550579071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4874251186847687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48109740018844604},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.47838178277015686},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4446975886821747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3068969249725342},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26178738474845886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21748435497283936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17042478919029236}],"mesh":[{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-06-1182","doi":"https://doi.org/10.1158/0008-5472.can-06-1182","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-1182","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/66/15/7401/2551707/7401.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:16885334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16885334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-06-1182","doi":"https://doi.org/10.1158/0008-5472.can-06-1182","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-1182","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/66/15/7401/2551707/7401.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1409166086","display_name":null,"funder_award_id":"C03/010","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2066181179","display_name":null,"funder_award_id":"00/0745","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G827871650","display_name":null,"funder_award_id":"G03/174","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003420932.pdf","grobid_xml":"https://content.openalex.org/works/W2003420932.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1563019250","https://openalex.org/W1971843650","https://openalex.org/W1987057033","https://openalex.org/W1995308076","https://openalex.org/W2002714006","https://openalex.org/W2014031706","https://openalex.org/W2033096588","https://openalex.org/W2054937850","https://openalex.org/W2078821211","https://openalex.org/W2078932376","https://openalex.org/W2085483616","https://openalex.org/W2096477951","https://openalex.org/W2099900006","https://openalex.org/W2102894828","https://openalex.org/W2129172946","https://openalex.org/W2132016433","https://openalex.org/W2140178932","https://openalex.org/W2142024983","https://openalex.org/W2143033064","https://openalex.org/W2167010784","https://openalex.org/W2275614507"],"related_works":["https://openalex.org/W2321353030","https://openalex.org/W2031541885","https://openalex.org/W2160129064","https://openalex.org/W3104279036","https://openalex.org/W2100910581","https://openalex.org/W2401652829","https://openalex.org/W2101106357","https://openalex.org/W2028435559","https://openalex.org/W2972931911","https://openalex.org/W1964934512"],"abstract_inverted_index":{"Bladder":[0],"tumors":[1,8,25,50,77,137,187,196,225],"constitute":[2,233],"a":[3,12,46,207,234,243],"very":[4],"heterogeneous":[5],"disease.":[6,57],"Superficial":[7],"are":[9,26,206],"characterized":[10,27],"by":[11,28,66],"high":[13],"prevalence":[14,85],"of":[15,38,43,48,55,76,79,89,116,122,127,132,139,154,160,167,183,192],"FGFR3":[16,180],"mutations":[17,30,175,205],"and":[18,23,31,41,68,103,135,163,217,223,237],"chromosome":[19],"9":[20,40],"alterations.":[21],"High-grade":[22],"muscle-invasive":[24,136,224],"Tp53":[29],"aneuploidy.":[32],"We":[33],"have":[34],"analyzed":[35],"the":[36,52,56,80,82,95,219],"sequence":[37],"exons":[39],"20":[42],"PIK3CA":[44,83,174,204,231],"in":[45,214,246],"panel":[47,75],"bladder":[49,215,247],"covering":[51],"whole":[53],"spectrum":[54],"DNA":[58],"from":[59],"formalin-fixed,":[60],"paraffin-embedded":[61],"tumor":[62],"sections":[63],"was":[64,86,110],"amplified":[65],"PCR":[67],"products":[69],"were":[70,146,176,188],"sequenced.":[71],"In":[72],"an":[73],"unselected":[74],"representative":[78],"disease,":[81],"mutation":[84],"13%":[87],"(11":[88],"87).":[90],"Mutations":[91,145],"occurred":[92],"mainly":[93],"at":[94],"previously":[96],"identified":[97],"hotspots":[98],"(codons":[99],"542,":[100],"545,":[101],"1007,":[102],"1047).":[104],"The":[105],"distribution":[106],"according":[107],"to":[108],"stage":[109],"as":[111,240,242],"follows:":[112],"papillary":[113,222],"urothelial":[114],"neoplasms":[115],"uncertain":[117],"malignant":[118],"potential":[119],"(PUNLMP;":[120],"11":[121],"43,":[123],"25.6%),":[124],"T(a)":[125],"(9":[126],"57,":[128],"16%),":[129],"T(1)":[130],"(2":[131,166],"10,":[133],"20%),":[134],"(0":[138],"20,":[140],"0%;":[141],"P":[142,170],"=":[143,171,198],"0.019).":[144],"associated":[147,178],"with":[148,179],"low-grade":[149],"tumors:":[150],"grade":[151,157,164],"1":[152],"(6":[153],"27,":[155],"22.2%),":[156],"2":[158],"(3":[159],"23,":[161],"13%),":[162],"3":[165],"37,":[168],"5.4%;":[169],"0.047).":[172],"Overall,":[173],"strongly":[177],"mutations:":[181],"18":[182],"69":[184],"(26%)":[185],"FGFR3(mut)":[186],"PIK3CA(mut),":[189],"versus":[190],"4":[191],"58":[193],"(6.9%)":[194],"FGFR3(wt)":[195],"(P":[197],"0.005).":[199],"Our":[200],"findings":[201],"indicate":[202],"that":[203,210,221],"common":[208],"event":[209],"can":[211],"occur":[212],"early":[213],"carcinogenesis":[216],"support":[218],"notion":[220],"arise":[226],"through":[227],"different":[228],"molecular":[229],"pathways.":[230],"may":[232],"novel":[235],"diagnostic":[236],"prognostic":[238],"tool,":[239],"well":[241],"therapeutic":[244],"target,":[245],"cancer.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}