{"id":"https://openalex.org/W2003408346","doi":"https://doi.org/10.1111/j.1600-0773.1988.tb00966.x","title":"Changes in Renal Function in Cadmium\u2010Intoxicated Rats","display_name":"Changes in Renal Function in Cadmium\u2010Intoxicated Rats","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2003408346","doi":"https://doi.org/10.1111/j.1600-0773.1988.tb00966.x","mag":"2003408346","pmid":"https://pubmed.ncbi.nlm.nih.gov/2853338"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0773.1988.tb00966.x","doi":"https://doi.org/10.1111/j.1600-0773.1988.tb00966.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1988.tb00966.x","pdf_url":null,"source":{"id":"https://openalex.org/S62051601","display_name":"Pharmacology & Toxicology","issn_l":"0901-9928","issn":["0901-9928","1600-0773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology &amp; Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033871355","display_name":"Y. K. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Y. K. Kim","raw_affiliation_strings":["Department of Physiology, Kosin Medical College, Pusan, Korea","Department of Physiology, Kosin Medical College, Pusan 602\u2010030, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Kosin Medical College, Pusan, Korea","institution_ids":["https://openalex.org/I90735388"]},{"raw_affiliation_string":"Department of Physiology, Kosin Medical College, Pusan 602\u2010030, Korea","institution_ids":["https://openalex.org/I90735388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082801151","display_name":"Jongsoon Choi","orcid":"https://orcid.org/0000-0001-8356-1919","observed_orcids":["https://orcid.org/0000-0001-8356-1919"]},"institutions":[{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"J. K. Choi","raw_affiliation_strings":["Department of Physiology, Kosin Medical College, Pusan 602-030, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Kosin Medical College, Pusan 602-030, Korea","institution_ids":["https://openalex.org/I90735388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084196439","display_name":"J. S. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"J. S. Kim","raw_affiliation_strings":["Department of Physiology, Kosin Medical College, Pusan 602-030, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Kosin Medical College, Pusan 602-030, Korea","institution_ids":["https://openalex.org/I90735388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046098060","display_name":"Y. S. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Y. S. Park","raw_affiliation_strings":["Department of Physiology, Kosin Medical College, Pusan 602-030, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Kosin Medical College, Pusan 602-030, Korea","institution_ids":["https://openalex.org/I90735388"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I90735388"],"apc_list":null,"apc_paid":null,"fwci":2.1305,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.83396985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"63","issue":"5","first_page":"342","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadmium-toxicity","display_name":"cadmium toxicity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.9240000247955322},{"id":"https://openalex.org/keywords/polyuria","display_name":"polyuria","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hyposthenuria","display_name":"hyposthenuria","score":0.9890000224113464},{"id":"https://openalex.org/keywords/osmotic-diuresis","display_name":"osmotic diuresis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/na-k-atpase-inhibition","display_name":"Na+/K+-ATPase inhibition","score":0.9509999752044678},{"id":"https://openalex.org/keywords/renal-cortex","display_name":"renal cortex","score":0.8939999938011169},{"id":"https://openalex.org/keywords/para-aminohippurate","display_name":"para-aminohippurate","score":0.7820000052452087},{"id":"https://openalex.org/keywords/organic-anion-transport","display_name":"organic anion transport","score":0.7850000262260437},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.9449999928474426},{"id":"https://openalex.org/keywords/basolateral-membrane","display_name":"basolateral membrane","score":0.7639999985694885},{"id":"https://openalex.org/keywords/renal-tubular-proteinuria","display_name":"renal tubular proteinuria","score":0.42100000381469727},{"id":"https://openalex.org/keywords/renal-tubular-dysfunction","display_name":"renal tubular dysfunction","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7931729555130005},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7356967329978943},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6969377398490906},{"id":"https://openalex.org/C2778577996","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Renal cortex","level":3,"score":0.6711654663085938},{"id":"https://openalex.org/C2780180277","wikidata":"https://www.wikidata.org/wiki/Q1124286","display_name":"Polyuria","level":3,"score":0.6509298086166382},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.6122052669525146},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5533846020698547},{"id":"https://openalex.org/C2779547328","wikidata":"https://www.wikidata.org/wiki/Q584691","display_name":"Diuresis","level":3,"score":0.5104226469993591},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4929637908935547},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.4722810685634613},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16312840580940247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13081997632980347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10366243124008179},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002105","descriptor_name":"Cadmium Poisoning","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002105","descriptor_name":"Cadmium Poisoning","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002105","descriptor_name":"Cadmium Poisoning","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007672","descriptor_name":"Kidney Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010130","descriptor_name":"p-Aminohippuric Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011141","descriptor_name":"Polyuria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011141","descriptor_name":"Polyuria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0773.1988.tb00966.x","doi":"https://doi.org/10.1111/j.1600-0773.1988.tb00966.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1988.tb00966.x","pdf_url":null,"source":{"id":"https://openalex.org/S62051601","display_name":"Pharmacology & Toxicology","issn_l":"0901-9928","issn":["0901-9928","1600-0773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology &amp; Toxicology","raw_type":"journal-article"},{"id":"pmid:2853338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2853338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W364559441","https://openalex.org/W1501263184","https://openalex.org/W1775749144","https://openalex.org/W1966391556","https://openalex.org/W1969934425","https://openalex.org/W1978209221","https://openalex.org/W1981575872","https://openalex.org/W1992728927","https://openalex.org/W1995456301","https://openalex.org/W2011270327","https://openalex.org/W2012019970","https://openalex.org/W2030637900","https://openalex.org/W2037907049","https://openalex.org/W2045487885","https://openalex.org/W2058130938","https://openalex.org/W2063841724","https://openalex.org/W2072682349","https://openalex.org/W2076785584","https://openalex.org/W2076975501","https://openalex.org/W2078068094","https://openalex.org/W2078530597","https://openalex.org/W2082958416","https://openalex.org/W2089351912","https://openalex.org/W2093205087","https://openalex.org/W2093745121","https://openalex.org/W2144016017","https://openalex.org/W2146351587","https://openalex.org/W2153435210","https://openalex.org/W2154523593","https://openalex.org/W2169934140","https://openalex.org/W2216072203","https://openalex.org/W2266564283","https://openalex.org/W2272287996","https://openalex.org/W2331550739","https://openalex.org/W2344199028","https://openalex.org/W2346015101","https://openalex.org/W2396956162","https://openalex.org/W2599507859","https://openalex.org/W2767416337","https://openalex.org/W4300280269"],"related_works":["https://openalex.org/W2808090295","https://openalex.org/W2059721847","https://openalex.org/W2069243920","https://openalex.org/W2120235475","https://openalex.org/W2409240058","https://openalex.org/W1976821118","https://openalex.org/W2000436821","https://openalex.org/W2021400290","https://openalex.org/W2256731089","https://openalex.org/W2073665991"],"abstract_inverted_index":{"Changes":[0],"in":[1,10,15,43,56,64,98,137,173,183],"renal":[2,84,92,129,170],"function,":[3],"Na+-K+-ATPase":[4,82],"activity":[5],"and":[6,34,51,71,119,127,150,164],"PAH":[7,89,105,122,171],"transport":[8],"system":[9],"kidney":[11],"cortex":[12,85],"were":[13,39,133],"studied":[14],"rats":[16],"treated":[17],"with":[18],"cadmium.":[19],"Subcutaneous":[20],"injections":[21],"of":[22,83,121,147,161,168,179],"CdCl2":[23],"(2":[24],"mg":[25],"Cd/kg.day)":[26],"for":[27,103],"16":[28],"days":[29],"induced":[30,156],"a":[31,35,177],"marked":[32],"polyuria":[33,149],"hyposthenuria.":[36],"These":[37,140],"changes":[38],"accompanied":[40],"by":[41,91,157],"increase":[42],"urinary":[44],"protein,":[45],"glucose,":[46],"urea,":[47],"calcium,":[48],"phosphate,":[49],"chloride":[50],"potassium":[52],"excretions.":[53],"The":[54,101,116],"change":[55,63],"urine":[57],"flow":[58],"was":[59,77,86,95,107,113],"proportional":[60],"to":[61],"the":[62,81,111,124,128,145,166],"total":[65],"osmotic":[66,154],"solute":[67],"excretion.":[68],"Creatinine":[69],"excretion":[70,76,172],"TcH2O":[72],"remained":[73],"unchanged.":[74],"Na+":[75],"not":[78,114,134],"increased,":[79],"but":[80,110],"significantly":[87],"inhibited.":[88],"uptake":[90],"cortical":[93],"slices":[94],"markedly":[96],"attenuated":[97],"Cd-treated":[99,138,174],"rats.":[100],"Vmax":[102],"active":[104],"influx":[106,118],"drastically":[108],"reduced,":[109],"Km":[112],"changed.":[115],"passive":[117],"efflux":[120],"across":[123],"basolateral":[125,186],"membrane":[126],"tissue":[130],"oxygen":[131],"consumption":[132],"apparently":[135],"altered":[136],"animals.":[139],"results":[141],"indicate":[142],"that":[143],"1)":[144],"nature":[146],"Cd-induced":[148],"hyposthenuria":[151],"is":[152,176],"an":[153],"diuresis":[155],"proximal":[158,184],"tubular":[159,185],"rejection":[160],"various":[162],"substances,":[163],"2)":[165],"mechanism":[167],"impaired":[169],"animals":[175],"loss":[178],"organic":[180],"anion":[181],"carriers":[182],"membranes.":[187]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
