{"id":"https://openalex.org/W2003407117","doi":"https://doi.org/10.2174/157339609788185703","title":"Mechanistic Approach to Understanding Psychosis Risk in Velocardiofacial Syndrome","display_name":"Mechanistic Approach to Understanding Psychosis Risk in Velocardiofacial Syndrome","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2003407117","doi":"https://doi.org/10.2174/157339609788185703","mag":"2003407117"},"language":"en","primary_location":{"id":"doi:10.2174/157339609788185703","doi":"https://doi.org/10.2174/157339609788185703","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157339609788185703","pdf_url":null,"source":{"id":"https://openalex.org/S61482747","display_name":"Current Pediatric Reviews","issn_l":"1573-3963","issn":["1573-3963","1875-6336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pediatric Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084740808","display_name":"Vandana Shashi","orcid":"https://orcid.org/0000-0002-5011-7501","observed_orcids":["https://orcid.org/0000-0002-5011-7501","https://orcid.org/0000-0002-3763-4643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vandana Shashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111961706","display_name":"Margaret N. Berry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margaret Berry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000706062","display_name":"Matcheri S. Keshavan","orcid":"https://orcid.org/0000-0002-5945-888X","observed_orcids":["https://orcid.org/0000-0002-5945-888X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matcheri Keshavan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.14669063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"5","issue":"2","first_page":"89","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.8457000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.1509999930858612,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/22q11-2-deletion-syndrome","display_name":"22q11.2 deletion syndrome","score":0.9580000042915344},{"id":"https://openalex.org/keywords/22q11-2-deletion","display_name":"22q11.2 deletion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/psychosis-risk","display_name":"psychosis risk","score":0.9340000152587891},{"id":"https://openalex.org/keywords/schizophrenia-spectrum-disorders","display_name":"schizophrenia spectrum disorders","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neurodevelopmental-theory","display_name":"neurodevelopmental theory","score":0.7239999771118164},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7329999804496765},{"id":"https://openalex.org/keywords/brain-morphometry","display_name":"brain morphometry","score":0.8169999718666077},{"id":"https://openalex.org/keywords/genetic-markers","display_name":"genetic markers","score":0.6420000195503235},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.675000011920929},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.6959999799728394},{"id":"https://openalex.org/keywords/hypoparathyroidism","display_name":"hypoparathyroidism","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.7712194919586182},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.751725435256958},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.727318286895752},{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.596049964427948},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5099457502365112},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.5095725059509277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5066643357276917},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.46307671070098877},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3584102988243103},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.24540314078330994},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.21344029903411865},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10739150643348694}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/157339609788185703","doi":"https://doi.org/10.2174/157339609788185703","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157339609788185703","pdf_url":null,"source":{"id":"https://openalex.org/S61482747","display_name":"Current Pediatric Reviews","issn_l":"1573-3963","issn":["1573-3963","1875-6336"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pediatric Reviews","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149372360","https://openalex.org/W4231630215","https://openalex.org/W1999115255","https://openalex.org/W2335779600","https://openalex.org/W4299411796","https://openalex.org/W2073210673","https://openalex.org/W2996185699","https://openalex.org/W1975090276","https://openalex.org/W4251142597","https://openalex.org/W879975035"],"abstract_inverted_index":{"Velocardiofacial":[0],"syndrome":[1,8],"(VCFS),":[2],"the":[3,50,59,84,118,151,186,190,193,196,222,226,249,284,287,295,299],"most":[4],"common":[5],"chromosomal":[6],"microdeletion":[7],"in":[9,58,76,81,92,173,269,310],"humans,":[10],"is":[11,26],"caused":[12],"by":[13],"a":[14,29,64,97,101,137,216,234,243],"heterozygous":[15],"deletion":[16],"of":[17,23,32,70,88,96,100,107,153,189,192,201,208,215,225,233,245,256,286,298],"chromosome":[18],"22q11.2.":[19],"With":[20],"an":[21,108,125,280],"incidence":[22,67],"1/2000-1/6000,":[24],"it":[25,273],"associated":[27],"with":[28,83,103,110,113],"vast":[30],"array":[31],"abnormalities":[33,148,306],"such":[34],"as":[35,136],"congenital":[36],"heart":[37],"disease,":[38],"palatal":[39],"dysfunction,":[40],"immune":[41],"deficiency,":[42],"hypoparathyroidism":[43],"and":[44,53,74,79,124,146,195,247,252,301,307,312],"cognitive":[45],"impairment.":[46],"In":[47,129],"addition":[48],"to":[49,160,163,170,185,229,254,259,263,267,290,315],"numerous":[51],"medical":[52],"developmental":[54],"problems,":[55],"retrospective":[56],"studies":[57,309],"last":[60],"decade":[61],"have":[62],"reported":[63],"markedly":[65],"high":[66],"(\u223c":[68],"40%)":[69],"schizophrenia,":[71,104],"bipolar":[72],"disorder":[73],"depression":[75],"late":[77],"adolescence":[78],"adulthood":[80],"individuals":[82],"deletion.":[85],"This":[86,140,292],"risk":[87],"schizophrenia":[89,132,174,257,316],"spectrum":[90,175,317],"disorders":[91],"VCFS":[93,260,278,311],"approaches":[94],"that":[95,106,144,167,198,219,238,268,277],"monozygotic":[98],"twin":[99],"patient":[102],"or":[105],"individual":[109,202],"both":[111],"parents":[112],"schizophrenia.":[114,291],"These":[115],"observations":[116],"provide":[117],"strongest":[119],"known":[120,235],"link":[121],"between":[122],"psychosis":[123,246],"identified":[126],"genetic":[127,210,236,308],"condition.":[128],"recent":[130],"years,":[131],"has":[133,180,274],"been":[134,182,275],"viewed":[135],"neurodevelopmental":[138,141,165,240],"disorder.":[139],"theory":[142],"suggests":[143],"neurocognitive":[145],"neuroanatomical":[147],"often":[149],"precede":[150],"development":[152],"overt":[154],"psychosis.":[155,230],"Genetic":[156],"factors":[157,227,288],"are":[158,168,205,261],"thought":[159,169,262],"be":[161,264],"contributory":[162],"these":[164],"anomalies":[166],"ultimately":[171],"culminate":[172],"disorders.":[176,318],"However,":[177],"gene":[178],"identification":[179,214],"largely":[181],"unsuccessful,":[183],"due":[184],"complex":[187],"nature":[188],"inheritance":[191],"genes":[194,200],"probability":[197],"multiple":[199],"modest":[203],"effect":[204],"involved.":[206],"Identification":[207],"predisposing":[209],"markers":[211],"would":[212,220],"enable":[213,221],"high-risk":[217,244],"group":[218],"prospective":[223],"study":[224,285],"contributing":[228,289],"The":[231],"presence":[232],"abnormality":[237],"causes":[239],"deficits,":[241],"confers":[242],"since":[248],"signs,":[250],"symptoms":[251],"response":[253],"treatment":[255],"secondary":[258],"no":[265],"different":[266],"primary":[270],"schizophrenic":[271],"illness,":[272],"suggested":[276],"represents":[279],"ideal":[281],"model":[282],"for":[283],"article":[293],"delineates":[294],"current":[296],"understanding":[297],"psychological":[300],"psychiatric":[302],"findings,":[303],"brain":[304],"morphometric":[305],"their":[313],"relevance":[314]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
