{"id":"https://openalex.org/W2003406245","doi":"https://doi.org/10.1073/pnas.96.12.6643","title":"Hemoglobin induction in mouse macrophages","display_name":"Hemoglobin induction in mouse macrophages","publication_year":1999,"publication_date":"1999-06-08","ids":{"openalex":"https://openalex.org/W2003406245","doi":"https://doi.org/10.1073/pnas.96.12.6643","mag":"2003406245","pmid":"https://pubmed.ncbi.nlm.nih.gov/10359765","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/21968"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.96.12.6643","doi":"https://doi.org/10.1073/pnas.96.12.6643","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.12.6643","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC21968","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100388544","display_name":"Limin Liu","orcid":"https://orcid.org/0000-0003-2527-7201","observed_orcids":["https://orcid.org/0000-0003-2527-7201"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Limin Liu","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Medicine, Pulmonary and Cardiology Divisions, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Medicine, Pulmonary and Cardiology Divisions, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zeng","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Medicine, Pulmonary and Cardiology Divisions, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Medicine, Pulmonary and Cardiology Divisions, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060088000","display_name":"Jonathan S. Stamler","orcid":"https://orcid.org/0000-0002-6866-1572","observed_orcids":["https://orcid.org/0000-0002-6866-1572"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Stamler","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Medicine, Pulmonary and Cardiology Divisions, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Medicine, Pulmonary and Cardiology Divisions, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5562,"has_fulltext":false,"cited_by_count":158,"citation_normalized_percentile":{"value":0.6159781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"96","issue":"12","first_page":"6643","last_page":"6647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.7549999952316284},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9210000038146973},{"id":"https://openalex.org/keywords/globin-gene-expression","display_name":"globin gene expression","score":0.5870000123977661},{"id":"https://openalex.org/keywords/flavohemoglobin","display_name":"flavohemoglobin","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.7710000276565552},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.8094154596328735},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.673130214214325},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.6377310752868652},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.606316089630127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48777681589126587},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46145758032798767},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.44331514835357666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3994506001472473},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3737490177154541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3693695068359375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1967654526233673},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08108189702033997}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.96.12.6643","doi":"https://doi.org/10.1073/pnas.96.12.6643","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.12.6643","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:179332","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC21968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:21968","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/21968","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10359765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10359765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:179332","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC21968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1480579987","https://openalex.org/W1525976258","https://openalex.org/W1580076592","https://openalex.org/W1662116282","https://openalex.org/W1944330918","https://openalex.org/W1965077361","https://openalex.org/W1978157745","https://openalex.org/W1978483415","https://openalex.org/W1998607972","https://openalex.org/W1999055162","https://openalex.org/W2000475723","https://openalex.org/W2007557612","https://openalex.org/W2011537701","https://openalex.org/W2013169303","https://openalex.org/W2022109900","https://openalex.org/W2028525826","https://openalex.org/W2029418997","https://openalex.org/W2030867249","https://openalex.org/W2033240573","https://openalex.org/W2034091834","https://openalex.org/W2035931854","https://openalex.org/W2044743938","https://openalex.org/W2055333718","https://openalex.org/W2061177902","https://openalex.org/W2062573914","https://openalex.org/W2069848230","https://openalex.org/W2071000969","https://openalex.org/W2095115132","https://openalex.org/W2095903306","https://openalex.org/W2109116927","https://openalex.org/W2110530182","https://openalex.org/W2110749080","https://openalex.org/W2115599755","https://openalex.org/W2132990783","https://openalex.org/W2133258970","https://openalex.org/W2133709520","https://openalex.org/W2148862069","https://openalex.org/W2156341767","https://openalex.org/W2162616695","https://openalex.org/W2417037728"],"related_works":["https://openalex.org/W90400019","https://openalex.org/W2153605615","https://openalex.org/W2021964855","https://openalex.org/W2467809618","https://openalex.org/W4396851650","https://openalex.org/W4295592714","https://openalex.org/W2127571730","https://openalex.org/W1996225545","https://openalex.org/W3145590376","https://openalex.org/W615901515"],"abstract_inverted_index":{"The":[0],"common":[1],"perception":[2],"that":[3,30,63,108],"hemoglobin":[4,47,77,90],"is":[5,116],"involved":[6],"solely":[7],"in":[8,56,99],"the":[9,31,57,75,105,109],"transport":[10],"of":[11,80,111],"oxygen":[12,54],"and":[13,72,102,113,119],"carbon":[14],"dioxide":[15],"has":[16],"been":[17],"challenged":[18],"by":[19,86,89],"recent":[20],"studies":[21,27],"with":[22,70],"nitric":[23],"oxide":[24],"(NO).":[25],"These":[26,92],"have":[28],"shown":[29],"primordial":[32],"bacterial":[33],"flavohemoglobin":[34],"functions":[35,48,96],"to":[36,49,67],"consume":[37],"NO":[38,51,69],"enzymatically":[39],"(to":[40],"protect":[41],"from":[42],"nitrosative":[43],"stress),":[44],"whereas":[45],"mammalian":[46,100],"deliver":[50],"(thus":[52],"maximizing":[53],"delivery":[55],"respiratory":[58],"cycle).":[59],"Here":[60],"we":[61],"report":[62],"murine":[64],"macrophages":[65],"stimulated":[66],"produce":[68],"lipopolysaccharide":[71],"interferon-gamma":[73],"express":[74],"betaminor":[76],"subunit.":[78],"Consumption":[79],"NO,":[81],"however,":[82],"was":[83],"not":[84],"increased":[85],"cytokines":[87],"or":[88],"expression.":[91],"data":[93],"suggest":[94],"alternative":[95],"for":[97],"globins":[98],"cells,":[101],"they":[103],"challenge":[104],"prevailing":[106],"view":[107],"expression":[110],"alpha-":[112],"beta-globin":[114],"genes":[115],"always":[117],"balanced":[118],"coordinated.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
