{"id":"https://openalex.org/W2003395343","doi":"https://doi.org/10.1016/j.jalz.2012.05.817","title":"P2\u2010112: The role of potassium channel Kv1.3 in A\u00df\u2010induced microglia activation","display_name":"P2\u2010112: The role of potassium channel Kv1.3 in A\u00df\u2010induced microglia activation","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2003395343","doi":"https://doi.org/10.1016/j.jalz.2012.05.817","mag":"2003395343"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2012.05.817","doi":"https://doi.org/10.1016/j.jalz.2012.05.817","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.817","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070072260","display_name":"Izumi Maezawa","orcid":"https://orcid.org/0000-0002-8666-3520","observed_orcids":["https://orcid.org/0000-0002-8666-3520"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Izumi Maezawa","raw_affiliation_strings":["University of California Davis, Sacramento, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Davis, Sacramento, California, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089285751","display_name":"Paul David Jenkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul David Jenkins","raw_affiliation_strings":["University of California, Davis Davis California United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Davis Davis California United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jessica Sexton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Sexton","raw_affiliation_strings":["University of California Davis, Sacramento, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Davis, Sacramento, California, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026660883","display_name":"Heike Wulff","orcid":"https://orcid.org/0000-0003-4437-5763","observed_orcids":["https://orcid.org/0000-0003-4437-5763"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heike Wulff","raw_affiliation_strings":["University of California, Davis Davis California United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Davis Davis California United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022477562","display_name":"Lee\u2010Way Jin","orcid":"https://orcid.org/0000-0001-9729-1032","observed_orcids":["https://orcid.org/0000-0001-9729-1032"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee\u2010Way Jin","raw_affiliation_strings":["University of California Davis, Sacramento, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Davis, Sacramento, California, United States","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09357278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"4S_Part_8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.21789999306201935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kv1-3","display_name":"Kv1.3 potassium channel","score":0.8799999952316284},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.945628821849823},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6900346875190735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6074075698852539},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5981913805007935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5247226357460022},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.47384172677993774},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.45803311467170715},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.44304805994033813},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4424499273300171},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4357791244983673},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.4188106656074524},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3781697750091553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35558563470840454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2579105496406555},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2461962103843689},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.24333858489990234},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.23676863312721252},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20295444130897522},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19923388957977295},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12563586235046387},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2012.05.817","doi":"https://doi.org/10.1016/j.jalz.2012.05.817","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.817","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093561765","https://openalex.org/W2780797805","https://openalex.org/W2535272252","https://openalex.org/W2583469177","https://openalex.org/W3133755251","https://openalex.org/W4390195637","https://openalex.org/W1718126001","https://openalex.org/W1855654763","https://openalex.org/W7117321989","https://openalex.org/W4224290092"],"abstract_inverted_index":{"Microglia":[0,224],"play":[1],"a":[2,49,334],"pivotal":[3],"role":[4,71],"in":[5,28,79,122,134,215,218,250,256,272,304],"the":[6,55,70,103,148,171,198,227,338],"initiation":[7],"and":[8,72,88,101,114,136,164,175,186,192,275,287,319],"progression":[9],"of":[10,75,105,151,173,200,229,236,258,281,299,337],"Alzheimer's":[11],"disease":[12],"(AD)":[13],"by":[14,24,32,107,141,190,208,302],"either":[15],"clearing":[16],"A":[17],"b":[18],"deposits":[19],"through":[20],"phagocytic":[21],"activity":[22,310],"or":[23,125],"releasing":[25],"cytotoxic":[26],"substances":[27],"response":[29,219],"to":[30,97,204,220,306,315],"activation":[31,100,163,185,286,314],"various":[33],"stimuli":[34],"including":[35],"A\u00df":[36,94,300,329],"aggregates.":[37],"By":[38],"mediating":[39],"membrane":[40,51],"potential-activated":[41],"K":[42],"+":[43],"efflux,":[44],"Kv1.3":[45,77,106,119,123,143,211,237,248,291,309,339],"channels":[46,78,120],"help":[47],"maintain":[48],"negative":[50],"potential,":[52],"which":[53],"provides":[54],"driving":[56],"force":[57],"for":[58,63],"Ca":[59],"2+":[60],"entry":[61],"required":[62],"sustained":[64],"immune":[65],"cell":[66],"activation.":[67,82],"We":[68,83,166,195,244],"study":[69],"therapeutic":[73,335],"significance":[74,150],"microglial":[76,81,86,99,118,162,184,273,285,313,317,324],"A\u00df-induced":[80,161,284],"treated":[84],"primary":[85],"cultures":[87,274],"hippocamopal":[89],"slices":[90],"with":[91,158,222,253,293],"10-50":[92],"nM":[93],"oligomers":[95],"(A\u00dfO)":[96],"induce":[98],"determined":[102,155,176],"expression":[104,212],"whole-cell":[108],"patch":[109],"clamp,":[110],"qPCR,":[111],"Western":[112],"blotting":[113],"immunohistochemistry.":[115],"In":[116,278],"brain,":[117],"exist":[121],"homotetramers":[124],"Kv1.3/Kv1.5":[126],"heterotetramers;":[127],"they":[128],"are":[129],"pharmacologically":[130],"distinct":[131],"from":[132,226,241],"those":[133],"neurons":[135],"can":[137],"be":[138],"specifically":[139],"inhibited":[140,160,262],"our":[142],"blocker":[144,340],"PAP-1.":[145,341],"To":[146],"test":[147],"functional":[149],"Kv1.3,":[152],"we":[153],"therefore":[154],"if":[156,177],"co-treatment":[157],"PAP-1":[159,180,261,282,294],"neurotoxicity.":[165],"also":[167,196],"injected":[168,179],"A\u00dfO":[169,207],"into":[170],"hippocampus":[172],"rats":[174],"intraperitoneally":[178],"could":[181,311],"ameliorate":[182],"hippocampal":[183,276],"associated":[187,252],"dendritic":[188,289],"damage,":[189],"immunohistochemistry":[191],"Golgi":[193],"stain.":[194],"tested":[197],"ability":[199],"PAP-1-treated,":[201],"cultured":[202,216],"microglia":[203,217,239,251],"uptake":[205],"fluorescence-labeled":[206],"flow":[209],"cytometry.":[210],"was":[213],"increased":[214],"stimulation":[221],"A\u03b2O.":[223],"isolated":[225,240],"brains":[228,257],"adult":[230],"5xFAD":[231,259],"mice":[232],"expressed":[233],"higher":[234],"levels":[235],"than":[238],"non-transgenic":[242],"mice.":[243,260],"further":[245],"observed":[246],"strong":[247],"immunoreactivities":[249],"amyloid":[254],"plaques":[255],"A\u00dfO-stimulated":[263],"nitric":[264],"oxide":[265],"production":[266],"as":[267,269,328],"well":[268],"microglia-mediated":[270],"neurotoxicity":[271,318],"slices.":[277],"vivo,":[279],"administration":[280],"blocked":[283],"preserved":[288],"integrity.":[290],"blockade":[292],"did":[295],"not":[296],"affect":[297],"phagocytosis":[298],"aggregates":[301],"microglia,":[303],"contrast":[305],"doxycyclin.":[307],"Modulating":[308],"\u201cfine-tune\u201d":[312],"block":[316],"at":[320],"least":[321],"partially":[322],"preserve":[323],"neuroprotective":[325],"actions":[326],"such":[327],"clearance.":[330],"Our":[331],"results":[332],"suggest":[333],"potential":[336]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}