{"id":"https://openalex.org/W2003335129","doi":"https://doi.org/10.1016/j.mito.2012.10.013","title":"In Vitro assessment of the utility of stearyl triphenyl phosphonium modified liposomes in overcoming the resistance of ovarian carcinoma Ovcar-3 cells to paclitaxel","display_name":"In Vitro assessment of the utility of stearyl triphenyl phosphonium modified liposomes in overcoming the resistance of ovarian carcinoma Ovcar-3 cells to paclitaxel","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2003335129","doi":"https://doi.org/10.1016/j.mito.2012.10.013","mag":"2003335129","pmid":"https://pubmed.ncbi.nlm.nih.gov/23123917"},"language":"en","primary_location":{"id":"doi:10.1016/j.mito.2012.10.013","doi":"https://doi.org/10.1016/j.mito.2012.10.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mito.2012.10.013","pdf_url":null,"source":{"id":"https://openalex.org/S140584875","display_name":"Mitochondrion","issn_l":"1567-7249","issn":["1567-7249","1872-8278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mitochondrion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076543465","display_name":"Melani A. Solomon","orcid":"https://orcid.org/0000-0002-6604-049X","observed_orcids":["https://orcid.org/0000-0002-6604-049X"]},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melani A. Solomon","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA","institution_ids":["https://openalex.org/I165817395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002249454","display_name":"Anee Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anee A. Shah","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA","institution_ids":["https://openalex.org/I165817395"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090380505","display_name":"Gerard G. M. D\u2019Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gerard G.M. D'Souza","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA","institution_ids":["https://openalex.org/I165817395"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090380505"],"corresponding_institution_ids":["https://openalex.org/I165817395"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":1.3845,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.75614849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"13","issue":"5","first_page":"464","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.7369999885559082},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ovarian-carcinoma","display_name":"ovarian carcinoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/ovcar-3-cells","display_name":"OVCAR-3 cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mitochondrial-colocalization","display_name":"mitochondrial colocalization","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9549999833106995},{"id":"https://openalex.org/keywords/caspase-independent-cell-death","display_name":"caspase-independent cell death","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.6909999847412109},{"id":"https://openalex.org/keywords/three-dimensional-spheroid-culture","display_name":"three-dimensional spheroid culture","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.8649647235870361},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8272072076797485},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5533992052078247},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.51567542552948},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5132081508636475},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.5054721832275391},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.4785895347595215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4721408188343048},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.46320071816444397},{"id":"https://openalex.org/C2780707935","wikidata":"https://www.wikidata.org/wiki/Q907718","display_name":"Phosphonium","level":2,"score":0.43918564915657043},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.43554675579071045},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43444254994392395},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34543123841285706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3250812292098999},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32428643107414246},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29771536588668823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27956393361091614},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11568748950958252},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07380819320678711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mito.2012.10.013","doi":"https://doi.org/10.1016/j.mito.2012.10.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mito.2012.10.013","pdf_url":null,"source":{"id":"https://openalex.org/S140584875","display_name":"Mitochondrion","issn_l":"1567-7249","issn":["1567-7249","1872-8278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mitochondrion","raw_type":"journal-article"},{"id":"pmid:23123917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23123917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mitochondrion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W53566393","https://openalex.org/W117192623","https://openalex.org/W134791136","https://openalex.org/W1489105628","https://openalex.org/W1561391636","https://openalex.org/W1589515559","https://openalex.org/W1623861753","https://openalex.org/W1968507507","https://openalex.org/W1976033985","https://openalex.org/W1976881265","https://openalex.org/W1985970823","https://openalex.org/W1999086357","https://openalex.org/W2004411620","https://openalex.org/W2016603665","https://openalex.org/W2017695333","https://openalex.org/W2017836748","https://openalex.org/W2019346113","https://openalex.org/W2020552396","https://openalex.org/W2023062664","https://openalex.org/W2023300542","https://openalex.org/W2037895641","https://openalex.org/W2038695289","https://openalex.org/W2043425373","https://openalex.org/W2044901025","https://openalex.org/W2048912984","https://openalex.org/W2050301997","https://openalex.org/W2052795767","https://openalex.org/W2055904567","https://openalex.org/W2058785803","https://openalex.org/W2062552900","https://openalex.org/W2065612477","https://openalex.org/W2067299834","https://openalex.org/W2075206227","https://openalex.org/W2080344761","https://openalex.org/W2083160385","https://openalex.org/W2098854736","https://openalex.org/W2103379588","https://openalex.org/W2107436374","https://openalex.org/W2109129712","https://openalex.org/W2112237903","https://openalex.org/W2123575108","https://openalex.org/W2149797564","https://openalex.org/W2167044450","https://openalex.org/W2527721894","https://openalex.org/W4252941190","https://openalex.org/W7073699634"],"related_works":["https://openalex.org/W4214564051","https://openalex.org/W7084599643","https://openalex.org/W2021680808","https://openalex.org/W2885770323","https://openalex.org/W2891084049","https://openalex.org/W2360148484","https://openalex.org/W2004934153","https://openalex.org/W2078053367","https://openalex.org/W2021651355","https://openalex.org/W3187675304"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}