{"id":"https://openalex.org/W2003320353","doi":"https://doi.org/10.4236/health.2013.55a004","title":"CGH-based microarray detection of cryptic and novel copy number alterations and balanced translocations in cytogenetically abnormal cases of b-cell all","display_name":"CGH-based microarray detection of cryptic and novel copy number alterations and balanced translocations in cytogenetically abnormal cases of b-cell all","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2003320353","doi":"https://doi.org/10.4236/health.2013.55a004","mag":"2003320353"},"language":"en","primary_location":{"id":"doi:10.4236/health.2013.55a004","doi":"https://doi.org/10.4236/health.2013.55a004","is_oa":true,"landing_page_url":"https://doi.org/10.4236/health.2013.55a004","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=31998","source":{"id":"https://openalex.org/S4210222741","display_name":"Health","issn_l":"1949-4998","issn":["1949-4998","1949-5005"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=31998","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020033287","display_name":"Roger Alan Schultz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Roger A. Schultz","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058581049","display_name":"Karen D. Tsuchiya","orcid":"https://orcid.org/0000-0003-1406-5000","observed_orcids":["https://orcid.org/0000-0003-1406-5000"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Tsuchiya","raw_affiliation_strings":["Seattle Children's Hospital, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Hospital, Seattle, USA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028766011","display_name":"Aubry Furrow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aubry Furrow","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103602458","display_name":"Marilyn L. Slovak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marilyn L. Slovak","raw_affiliation_strings":["Sonora Quest Laboratories, Tempe, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sonora Quest Laboratories, Tempe, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112247354","display_name":"Lisa D. McDaniel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa D. McDaniel","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064752314","display_name":"Meaghan Wall","orcid":"https://orcid.org/0000-0001-9711-0705","observed_orcids":["https://orcid.org/0000-0001-9711-0705"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Meaghan Wall","raw_affiliation_strings":["Victorian Cancer Cytogenetics Service, St. Vincent's Hospital Melbourne, Fitzroy, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victorian Cancer Cytogenetics Service, St. Vincent's Hospital Melbourne, Fitzroy, Australia","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102164330","display_name":"Eric C. Crawford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Crawford","raw_affiliation_strings":["Genetics Associates, Inc., Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Associates, Inc., Nashville, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055756816","display_name":"Yi Ning","orcid":"https://orcid.org/0000-0002-7737-580X","observed_orcids":["https://orcid.org/0000-0002-7737-580X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Ning","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011997896","display_name":"Reza Saleki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reza Saleki","raw_affiliation_strings":["Pathology Associates Medical Laboratories (PAML), Spokane, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Associates Medical Laboratories (PAML), Spokane, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045975673","display_name":"Min Fang","orcid":"https://orcid.org/0000-0001-6688-437X","observed_orcids":["https://orcid.org/0000-0001-6688-437X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Fang","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021979198","display_name":"Victoria Cawich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria Cawich","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042826046","display_name":"Caitlin E. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caitlin E. Johnson","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045329291","display_name":"Sara L. Minier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara L. Minier","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023682372","display_name":"Nicholas J. Neill","orcid":"https://orcid.org/0000-0003-4205-3488","observed_orcids":["https://orcid.org/0000-0003-4205-3488"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Neill","raw_affiliation_strings":["Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014768583","display_name":"S. Annie Morton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Annie Morton","raw_affiliation_strings":["Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signature Genomic Laboratories, PerkinElmer, Inc., Spokane, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045118780","display_name":"Steve Byerly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Byerly","raw_affiliation_strings":["Paw Print Genetics, Genetic Veterinary Sciences, Inc., Spokane, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paw Print Genetics, Genetic Veterinary Sciences, Inc., Spokane, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054573446","display_name":"Urvashi Surti","orcid":"https://orcid.org/0000-0003-4283-9018","observed_orcids":["https://orcid.org/0000-0003-4283-9018"]},"institutions":[{"id":"https://openalex.org/I4210106153","display_name":"Magee-Womens Hospital","ror":"https://ror.org/01fbdn283","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210106153","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Urvashi Surti","raw_affiliation_strings":["Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, USA","institution_ids":["https://openalex.org/I4210106153","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Theresa C. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159616","display_name":"Empire Genomics (United States)","ror":"https://ror.org/04wts6j28","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa C. Brown","raw_affiliation_strings":["Empire Genomics, Buffalo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Empire Genomics, Buffalo, USA","institution_ids":["https://openalex.org/I4210159616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018127934","display_name":"Blake C. Ballif","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Blake C. Ballif","raw_affiliation_strings":["Paw Print Genetics, Genetic Veterinary Sciences, Inc., Spokane, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paw Print Genetics, Genetic Veterinary Sciences, Inc., Spokane, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070769975","display_name":"Lisa G. Shaffer","orcid":"https://orcid.org/0000-0002-2848-8103","observed_orcids":["https://orcid.org/0000-0002-2848-8103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa G. Shaffer","raw_affiliation_strings":["Paw Print Genetics, Genetic Veterinary Sciences, Inc., Spokane, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paw Print Genetics, Genetic Veterinary Sciences, Inc., Spokane, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5020033287"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13313349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"05","issue":"05","first_page":"23","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3589000105857849,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.9359999895095825},{"id":"https://openalex.org/keywords/balanced-translocation","display_name":"balanced translocation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.7129999995231628},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/etv6-runx1","display_name":"ETV6-RUNX1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/translocation-breakpoints","display_name":"translocation breakpoints","score":0.7770000100135803},{"id":"https://openalex.org/keywords/prognostic-value","display_name":"prognostic value","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.8193328976631165},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.7276535034179688},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.673820972442627},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5733075141906738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5267271995544434},{"id":"https://openalex.org/C166608930","wikidata":"https://www.wikidata.org/wiki/Q5169175","display_name":"Copy number analysis","level":5,"score":0.5151849985122681},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.49715331196784973},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4727811813354492},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4605395793914795},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45787355303764343},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4203590750694275},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3607769012451172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35613346099853516},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.35187461972236633},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32287973165512085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19524919986724854},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1525651216506958},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.06336626410484314}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4236/health.2013.55a004","doi":"https://doi.org/10.4236/health.2013.55a004","is_oa":true,"landing_page_url":"https://doi.org/10.4236/health.2013.55a004","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=31998","source":{"id":"https://openalex.org/S4210222741","display_name":"Health","issn_l":"1949-4998","issn":["1949-4998","1949-5005"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4236/health.2013.55a004","doi":"https://doi.org/10.4236/health.2013.55a004","is_oa":true,"landing_page_url":"https://doi.org/10.4236/health.2013.55a004","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=31998","source":{"id":"https://openalex.org/S4210222741","display_name":"Health","issn_l":"1949-4998","issn":["1949-4998","1949-5005"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003320353.pdf","grobid_xml":"https://content.openalex.org/works/W2003320353.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W36485510","https://openalex.org/W43555878","https://openalex.org/W200907363","https://openalex.org/W225957511","https://openalex.org/W1534965621","https://openalex.org/W1750225402","https://openalex.org/W1964693797","https://openalex.org/W1968184308","https://openalex.org/W1973850616","https://openalex.org/W1976888332","https://openalex.org/W1977380325","https://openalex.org/W1979699800","https://openalex.org/W1984065010","https://openalex.org/W1984183164","https://openalex.org/W1987361685","https://openalex.org/W1987446594","https://openalex.org/W1995460052","https://openalex.org/W1996600754","https://openalex.org/W2004237422","https://openalex.org/W2004652425","https://openalex.org/W2006120252","https://openalex.org/W2016124708","https://openalex.org/W2030592620","https://openalex.org/W2037037639","https://openalex.org/W2040329520","https://openalex.org/W2042177615","https://openalex.org/W2044499590","https://openalex.org/W2044952574","https://openalex.org/W2047328042","https://openalex.org/W2049084804","https://openalex.org/W2059999488","https://openalex.org/W2062661073","https://openalex.org/W2071700698","https://openalex.org/W2073449138","https://openalex.org/W2076930715","https://openalex.org/W2080950303","https://openalex.org/W2082812551","https://openalex.org/W2090186172","https://openalex.org/W2105435030","https://openalex.org/W2105709389","https://openalex.org/W2114171595","https://openalex.org/W2117146478","https://openalex.org/W2119967034","https://openalex.org/W2123249056","https://openalex.org/W2129291628","https://openalex.org/W2131587128","https://openalex.org/W2136334823","https://openalex.org/W2139969490","https://openalex.org/W2140423522","https://openalex.org/W2148831483","https://openalex.org/W2157838058","https://openalex.org/W2170692626","https://openalex.org/W2223504320","https://openalex.org/W2270075492","https://openalex.org/W2320960819","https://openalex.org/W2334629408","https://openalex.org/W4232414730"],"related_works":["https://openalex.org/W2590426830","https://openalex.org/W2488477851","https://openalex.org/W2565593073","https://openalex.org/W2946507982","https://openalex.org/W2144039491","https://openalex.org/W2093975535","https://openalex.org/W2053507103","https://openalex.org/W2102682004","https://openalex.org/W1980243909","https://openalex.org/W2160792386"],"abstract_inverted_index":{"Acute":[0],"lymphoblastic":[1],"leukemia":[2],"(ALL)":[3],"is":[4],"the":[5,12,29,55,66,86,169],"most":[6],"common":[7],"malignancy":[8],"in":[9,28,144],"children,":[10],"with":[11,39,81,123,163,193],"majority":[13],"of":[14,17,31,51,57,68,121,180],"cases":[15,99,122],"being":[16],"precursor":[18],"B-cell":[19,32,58,97],"phenoltype.":[20],"Conventional":[21],"cytogenetic":[22],"analysis":[23,56,90,133],"plays":[24],"an":[25,72],"important":[26],"role":[27],"diagnosis":[30],"ALL,":[33],"identifying":[34],"characteristic":[35],"chromosomal":[36],"abnormalities":[37,70,79],"associated":[38],"a":[40,106,124,178],"given":[41],"prognosis":[42],"therein":[43],"facilitating":[44],"optimized":[45],"treatment.":[46],"The":[47,166],"more":[48],"recent":[49],"introduction":[50],"microarray":[52,89,132],"technology":[53],"to":[54,74,118],"ALL":[59,98],"has":[60],"afforded":[61,173],"both":[62],"higher":[63],"resolution":[64],"for":[65],"detection":[67,110],"known":[69,125],"and":[71,102,159,177,184],"ability":[73],"identify":[75],"novel":[76,107],"copy":[77],"number":[78],"(CNAs)":[80],"potential":[82,194],"clinical":[83],"relevance.":[84],"In":[85],"current":[87],"study,":[88],"was":[91,116,137],"performed":[92],"on":[93],"20":[94],"cytogenetically":[95],"abnormal":[96],"(10":[100],"pediatric":[101],"10":[103],"adult),":[104],"while":[105],"microarray-based":[108],"balanced-translocation":[109],"methodology":[111],"(translocation":[112],"CGH":[113],"or":[114,126],"tCGH)":[115],"applied":[117],"that":[119,135],"subset":[120],"suspected":[127],"recurrent":[128],"balanced":[129,152],"translocation.":[130],"Standard":[131],"identified":[134,149],"CNAs":[136,183],"not":[138],"detected":[139],"by":[140,174],"previous":[141],"conventional":[142],"cytogenetics":[143],"75%":[145],"(15/20)":[146],"cases.":[147],"tCGH":[148],"9/9":[150],"(100%)":[151],"translocations":[153],"defining":[154],"BCR/ABL1":[155],"(x4),":[156],"ETV6/RUNX1":[157],"(x3),":[158],"MLL/AFF1":[160],"(x2)":[161],"breakpoints":[162],"high":[164],"resolution.":[165],"results":[167],"illustrate":[168],"improved":[170],"molecular":[171],"detail":[172],"these":[175],"technologies":[176],"comparison":[179],"translocation":[181],"breakpoints,":[182],"patient":[185],"age":[186],"offers":[187],"new":[188],"insights":[189],"into":[190],"tumor":[191],"biology":[192],"prognostic":[195],"significance.":[196]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}