{"id":"https://openalex.org/W2003299841","doi":"https://doi.org/10.1021/jm980323u","title":"(R)-(\u2212)- and (S)-(+)-Synadenol: Synthesis, Absolute Configuration, and Enantioselectivity of Antiviral Effect","display_name":"(R)-(\u2212)- and (S)-(+)-Synadenol: Synthesis, Absolute Configuration, and Enantioselectivity of Antiviral Effect","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2003299841","doi":"https://doi.org/10.1021/jm980323u","mag":"2003299841","pmid":"https://pubmed.ncbi.nlm.nih.gov/9857093"},"language":"en","primary_location":{"id":"doi:10.1021/jm980323u","doi":"https://doi.org/10.1021/jm980323u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm980323u","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110929369","display_name":"Yao\u2010Ling Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Yao-Ling Qiu","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000210067","display_name":"A. Hempel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Andrew Hempel","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031779138","display_name":"N. Camerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Norman Camerman","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091601865","display_name":"A. Camerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Arthur Camerman","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031471721","display_name":"Fiona Geiser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Fiona Geiser","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004932382","display_name":"Roger G. Ptak","orcid":"https://orcid.org/0000-0002-8492-3085","observed_orcids":["https://orcid.org/0000-0002-8492-3085"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Roger G. Ptak","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076281231","display_name":"Julie M. Breitenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Julie M. Breitenbach","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113795969","display_name":"Toshiko Kira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Toshiko Kira","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090566144","display_name":"Ling Li","orcid":"https://orcid.org/0000-0001-5016-0123","observed_orcids":["https://orcid.org/0000-0001-5016-0123"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Ling Li","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089369644","display_name":"Elizabeth A. Gullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Elizabeth Gullen","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109916120","display_name":"Yung\u2010Chi Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Yung-Chi Cheng","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110073621","display_name":"John C. Drach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"John C. Drach","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006348104","display_name":"Ji\u0159\u00ed \u017demli\u010dka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Jiri Zemlicka","raw_affiliation_strings":["Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Experimental and Clinical Chemotherapy Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, Biochemistry Department, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Ardono Research, Seattle, Washington 98105, Chiral Technologies, Inc., Exton, Pennsylvania 19341, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510-8066, and Department of Biologic and Materials","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006348104"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I185443292","https://openalex.org/I32971472","https://openalex.org/I4210090317"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.8815,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.90007046,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"41","issue":"26","first_page":"5257","last_page":"5264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.15060000121593475,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/absolute-configuration","display_name":"absolute configuration","score":0.652999997138977},{"id":"https://openalex.org/keywords/enantioselectivity","display_name":"enantioselectivity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/enantiomeric-resolution","display_name":"enantiomer resolution","score":0.5109999775886536},{"id":"https://openalex.org/keywords/adenosine-deaminase","display_name":"adenosine deaminase","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hypoxanthine","display_name":"hypoxanthine","score":0.6660000085830688},{"id":"https://openalex.org/keywords/6-chloropurine","display_name":"6-chloropurine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.718999981880188},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.8479999899864197},{"id":"https://openalex.org/keywords/varicella-zoster-virus","display_name":"varicella-zoster virus","score":0.9570000171661377},{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9306705594062805},{"id":"https://openalex.org/C25170562","wikidata":"https://www.wikidata.org/wiki/Q2052053","display_name":"Absolute configuration","level":2,"score":0.7358698844909668},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.7291654348373413},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6123447418212891},{"id":"https://openalex.org/C2776460385","wikidata":"https://www.wikidata.org/wiki/Q420060","display_name":"Hydrochloride","level":2,"score":0.5790910720825195},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.459844708442688},{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.4597734212875366},{"id":"https://openalex.org/C2776844798","wikidata":"https://www.wikidata.org/wiki/Q34402","display_name":"Ribonucleoside","level":4,"score":0.4232845902442932},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.4225195348262787},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.4112374186515808},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21215534210205078},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.10605886578559875},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10593166947364807},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010948","descriptor_name":"Viral Plaque Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014645","descriptor_name":"Herpesvirus 3, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014645","descriptor_name":"Herpesvirus 3, Human","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm980323u","doi":"https://doi.org/10.1021/jm980323u","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm980323u","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:9857093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9857093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1627307014","display_name":null,"funder_award_id":"R01-CA-44358","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8552458023","display_name":"Antitumor and Antiviral Nucleoside Analogues","funder_award_id":"R01CA032779","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8722106665","display_name":"NEW INHIBITORS AND NEW TARGETS TO DEVELOP HCMV DRUGS","funder_award_id":"U19AI031718","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W303589913","https://openalex.org/W1482896844","https://openalex.org/W1563954963","https://openalex.org/W1620284542","https://openalex.org/W1968008788","https://openalex.org/W1999580476","https://openalex.org/W2014483516","https://openalex.org/W2015727269","https://openalex.org/W2027367379","https://openalex.org/W2057354316","https://openalex.org/W2089756788","https://openalex.org/W2128179591","https://openalex.org/W2488228502","https://openalex.org/W2952331848"],"related_works":["https://openalex.org/W2035438928","https://openalex.org/W2950704516","https://openalex.org/W2027367379","https://openalex.org/W2912769211","https://openalex.org/W2105891425","https://openalex.org/W2063669750","https://openalex.org/W1976683050","https://openalex.org/W2029043829","https://openalex.org/W2048421467","https://openalex.org/W3031778081"],"abstract_inverted_index":{"Synthesis":[0],"of":[1,31,54,71,75,87,126,141,148,163,173,177,247,282],"(R)-(-)-":[2],"and":[3,6,26,67,133,143,146,155,202,218,238,241,256],"(S)-(+)-synadenol":[4,50],"(1a":[5,14],"2a,":[7],"95-96%":[8],"ee)":[9],"is":[10,226,250,268,276],"described.":[11],"Racemic":[12,78],"synadenol":[13],"+":[15],"2a)":[16],"was":[17,56,82,94,101,117],"deaminated":[18],"with":[19,39,109,128,136,152,186,193],"adenosine":[20],"deaminase":[21],"to":[22,44,96,103,119],"give":[23,104],"(R)-(-)-synadenol":[24],"(1a)":[25],"(S)-(+)-hypoxanthine":[27],"derivative":[28,46],"5.":[29],"Acetylation":[30],"the":[32,88,120,149,161,191,194,265,273],"latter":[33,181],"compound":[34],"gave":[35],"acetate":[36,122],"6.":[37],"Reaction":[38],"N,":[40],"N-dimethylchloromethyleneammonium":[41],"chloride":[42],"led":[43],"6-chloropurine":[45],"7.":[47],"Ammonolysis":[48],"furnished":[49,113],"(2a).":[51],"Absolute":[52],"configuration":[53],"1a":[55,145,154,201,232,267],"established":[57,160],"by":[58,84,157,170],"two":[59],"methods:":[60],"(i)":[61],"synthesis":[62],"from":[63],"(R)-methylenecyclopropanecarboxylic":[64],"acid":[65,80],"(8)":[66],"(ii)":[68],"X-ray":[69,171],"diffraction":[70,172],"a":[72,85,139,174,183],"single":[73,175],"crystal":[74,176],"(-)-synadenol":[76,164,178],"hydrochloride.":[77,179],"methylenecyclopropanecarboxylic":[79],"(10)":[81],"resolved":[83],"modification":[86],"described":[89],"procedure.":[90],"The":[91,180,223],"R-enantiomer":[92,231,266],"8":[93],"converted":[95],"ethyl":[97],"ester":[98],"13":[99],"which":[100,116],"brominated":[102],"vicinal":[105],"dibromides":[106],"14.":[107],"Reduction":[108],"diisobutylaluminum":[110],"hydride":[111],"then":[112],"alcohol":[114],"15":[115],"acetylated":[118],"corresponding":[121],"16.":[123],"Alkylation-elimination":[124],"procedure":[125],"adenine":[127],"16":[129],"yielded":[130],"acetates":[131],"17":[132],"18.":[134],"Deprotection":[135],"ammonia":[137],"afforded":[138],"mixture":[140],"Z-":[142],"E-isomers":[144],"19":[147],"R-configuration.":[150],"Comparison":[151],"products":[153],"2a":[156,203,225,275],"chiral":[158],"HPLC":[159],"R-configuration":[162],"(1a).":[165],"These":[166],"results":[167],"were":[168],"confirmed":[169],"forms":[182],"pseudosymmetric":[184],"dimer":[185],"adenine-adenine":[187],"base":[188],"pairing":[189],"in":[190,196,233,252],"lattice":[192],"nucleobase":[195],"an":[197],"anti-like":[198],"conformation.":[199],"Enantiomers":[200],"exhibit":[204],"varied":[205],"enantioselectivity":[206,246],"toward":[207],"different":[208],"viruses.":[209],"Both":[210],"enantiomers":[211],"are":[212],"equipotent":[213],"against":[214],"human":[215,257],"cytomegalovirus":[216],"(HCMV)":[217],"varicella":[219],"zoster":[220],"virus":[221,236,254,259],"(VZV).":[222],"S-enantiomer":[224,274],"somewhat":[227],"more":[228],"effective":[229,278],"than":[230],"herpes":[234],"simplex":[235],"1":[237,261],"2":[239],"(HSV-1":[240],"HSV-2)":[242],"assays.":[243],"By":[244],"contrast,":[245],"antiviral":[248],"effect":[249],"reversed":[251],"Epstein-Barr":[253],"(EBV)":[255,279],"immunodeficiency":[258],"type":[260],"(HIV-1)":[262],"assays":[263],"where":[264],"preferred.":[269],"In":[270],"these":[271],"assays,":[272],"less":[277],"or":[280],"devoid":[281],"activity":[283],"(HIV-1).":[284]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}