{"id":"https://openalex.org/W2003286282","doi":"https://doi.org/10.1097/00000542-200211000-00019","title":"Negative and Positive Inotropic Effects of Propofol via L-type Calcium Channels and the Sodium-Calcium Exchanger in Rat Cardiac Trabeculae","display_name":"Negative and Positive Inotropic Effects of Propofol via L-type Calcium Channels and the Sodium-Calcium Exchanger in Rat Cardiac Trabeculae","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2003286282","doi":"https://doi.org/10.1097/00000542-200211000-00019","mag":"2003286282","pmid":"https://pubmed.ncbi.nlm.nih.gov/12411800"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-200211000-00019","doi":"https://doi.org/10.1097/00000542-200211000-00019","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200211000-00019","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/97/5/1146/405843/0000542-200211000-00019.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/97/5/1146/405843/0000542-200211000-00019.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023142491","display_name":"Wouter de Ruijter","orcid":"https://orcid.org/0000-0003-0179-8934","observed_orcids":["https://orcid.org/0000-0003-0179-8934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wouter de Ruijter","raw_affiliation_strings":["Research Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Fellow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019586059","display_name":"Ger J.M. Stienen","orcid":"https://orcid.org/0000-0001-5829-0328","observed_orcids":["https://orcid.org/0000-0001-5829-0328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ger\u00a0J. M. Stienen","raw_affiliation_strings":["Associate Professor, Laboratory for Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Laboratory for Physiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004686929","display_name":"Jan van Klarenbosch","orcid":"https://orcid.org/0000-0002-5338-1500","observed_orcids":["https://orcid.org/0000-0002-5338-1500"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan van Klarenbosch","raw_affiliation_strings":["Instructor and Staff Anesthesiologist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instructor and Staff Anesthesiologist","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111929644","display_name":"J. J. DE LANGE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob\u00a0J. de Lange","raw_affiliation_strings":["Professor, Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Department of Anesthesiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8304,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.76637445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"97","issue":"5","first_page":"1146","last_page":"1155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.16050000488758087,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":1.0},{"id":"https://openalex.org/keywords/negative-inotropic-effect","display_name":"negative inotropic effect","score":0.8939999938011169},{"id":"https://openalex.org/keywords/positive-inotropic-effect","display_name":"positive inotropic effect","score":0.9879999756813049},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9660000205039978},{"id":"https://openalex.org/keywords/na-ca2-exchanger","display_name":"Na+/Ca2+ exchanger","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiac-trabeculae","display_name":"cardiac trabeculae","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pacing-rate","display_name":"pacing rate","score":0.7429999709129333},{"id":"https://openalex.org/keywords/extracellular-calcium-concentration","display_name":"extracellular calcium concentration","score":0.9520000219345093},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.6759999990463257},{"id":"https://openalex.org/keywords/kb-r7943","display_name":"KB-R7943","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9199991226196289},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.8469405770301819},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7114103436470032},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.6274145245552063},{"id":"https://openalex.org/C2777735026","wikidata":"https://www.wikidata.org/wiki/Q24724654","display_name":"Sodium-calcium exchanger","level":3,"score":0.5332282185554504},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48139193654060364},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4773443043231964},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.46608966588974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39932703971862793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013890","descriptor_name":"Thiourea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-200211000-00019","doi":"https://doi.org/10.1097/00000542-200211000-00019","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200211000-00019","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/97/5/1146/405843/0000542-200211000-00019.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:12411800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12411800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/00000542-200211000-00019","doi":"https://doi.org/10.1097/00000542-200211000-00019","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200211000-00019","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/97/5/1146/405843/0000542-200211000-00019.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325658","display_name":"Debreceni Egyetem","ror":"https://ror.org/02xf66n48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003286282.pdf","grobid_xml":"https://content.openalex.org/works/W2003286282.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1974210961","https://openalex.org/W1978929579","https://openalex.org/W1988281099","https://openalex.org/W1997842787","https://openalex.org/W2001148888","https://openalex.org/W2006957172","https://openalex.org/W2007500927","https://openalex.org/W2008091977","https://openalex.org/W2009769456","https://openalex.org/W2019239392","https://openalex.org/W2021809105","https://openalex.org/W2021832915","https://openalex.org/W2022109153","https://openalex.org/W2027170238","https://openalex.org/W2034155248","https://openalex.org/W2035184694","https://openalex.org/W2036569505","https://openalex.org/W2044108807","https://openalex.org/W2044445123","https://openalex.org/W2045671224","https://openalex.org/W2047270291","https://openalex.org/W2048072493","https://openalex.org/W2048624819","https://openalex.org/W2053218623","https://openalex.org/W2060431443","https://openalex.org/W2068189750","https://openalex.org/W2071374942","https://openalex.org/W2074295722","https://openalex.org/W2081603047","https://openalex.org/W2094809287","https://openalex.org/W2120364576","https://openalex.org/W2160741486","https://openalex.org/W2166962209","https://openalex.org/W2168747964"],"related_works":["https://openalex.org/W2428256220","https://openalex.org/W2405416670","https://openalex.org/W2369770283","https://openalex.org/W2354276920","https://openalex.org/W2313970103","https://openalex.org/W3179641435","https://openalex.org/W2806907687","https://openalex.org/W2146270441","https://openalex.org/W2130792295","https://openalex.org/W2159098909"],"abstract_inverted_index":{"BACKGROUND:":[0],"Conflicting":[1],"opinions":[2],"are":[3],"present":[4],"in":[5,56,85,156],"the":[6,9,12,19,30,35,40,76,86,89,93,148,165,168,183,187,195,216,220,226,233,240,243,248],"literature":[7],"regarding":[8],"origin":[10],"of":[11,16,33,47,88,92,100,167,178,186,192,208,219,230,235,242],"negative":[13,115],"inotropic":[14,31,116,130,206,228],"effect":[15,46,99,117,131,146,207,229],"propofol":[17,34,50,101,182,193,209,231],"on":[18,51,102,108,147,194,198,239],"myocardium.":[20],"This":[21],"study":[22,83],"aims":[23],"to":[24,82],"resolve":[25],"these":[26],"discrepancies":[27],"by":[28,95,144,181],"investigating":[29],"effects":[32,191],"L-type":[36,149,244],"calcium":[37,67,112,150,179,202,214,245],"channels":[38],"and":[39,64,75,111,137,164,201,247],"sodium-calcium":[41],"exchanger":[42],"(NCX).":[43],"METHODS:":[44],"The":[45,98,190,204,222],"20":[48],"microg/ml":[49],"force":[52,106],"development":[53],"was":[54,118,132],"determined":[55],"rat":[57],"cardiac":[58],"trabeculae":[59],"at":[60,120,134],"different":[61,65],"pacing":[62,109,121,199],"frequencies":[63,122],"extracellular":[66],"concentrations.":[68],"Postrest":[69],"potentiation,":[70],"sodium":[71],"withdrawal":[72,161],"during":[73,162],"quiescence,":[74],"NCX":[77,94,170],"inhibitor":[78,171],"KB-R7943":[79,172],"were":[80],"used":[81],"changes":[84],"activity":[87],"reverse":[90,184,217],"mode":[91,185,218],"propofol.":[96],"RESULTS:":[97],"steady":[103],"state":[104],"peak":[105],"depended":[107],"frequency":[110,200],"concentration.":[113,203],"A":[114],"observed":[119,133],"greater":[123],"than":[124],"0.5":[125],"Hz,":[126],"but":[127],"a":[128,157],"positive":[129,205],"0.1":[135],"Hz":[136],"low":[138],"calcium,":[139],"which":[140],"cannot":[141],"be":[142],"explained":[143],"an":[145,176],"channel.":[151],"Propofol":[152],"enhanced":[153],"postrest":[154],"potentiation":[155],"calcium-dependent":[158],"manner.":[159],"Sodium":[160],"quiescence":[163],"use":[166],"specific":[169],"provided":[173],"evidence":[174],"for":[175],"enhancement":[177],"influx":[180,215],"NCX.":[188,221,249],"CONCLUSIONS:":[189],"myocardium":[196],"depend":[197],"is":[210,232],"associated":[211],"with":[212],"increased":[213],"authors":[223],"conclude":[224],"that":[225],"net":[227],"result":[234],"its":[236],"counteracting":[237],"influence":[238],"functioning":[241],"channel":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
