{"id":"https://openalex.org/W2003285968","doi":"https://doi.org/10.1161/01.res.0000079488.91342.b7","title":"Hemodynamics Is a Key Epigenetic Factor in Development of the Cardiac Conduction System","display_name":"Hemodynamics Is a Key Epigenetic Factor in Development of the Cardiac Conduction System","publication_year":2003,"publication_date":"2003-06-04","ids":{"openalex":"https://openalex.org/W2003285968","doi":"https://doi.org/10.1161/01.res.0000079488.91342.b7","mag":"2003285968","pmid":"https://pubmed.ncbi.nlm.nih.gov/12775585"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.0000079488.91342.b7","doi":"https://doi.org/10.1161/01.res.0000079488.91342.b7","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.0000079488.91342.b7","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046500018","display_name":"M\u00e1ria Re\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-5065-7778","observed_orcids":["https://orcid.org/0000-0002-5065-7778"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Reckova","raw_affiliation_strings":["From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Ave, BSB 601, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Ave, BSB 601, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042462379","display_name":"Carlin Rosengarten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlin Rosengarten","raw_affiliation_strings":["From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109999000","display_name":"Angela C. deAlmeida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela deAlmeida","raw_affiliation_strings":["From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002933233","display_name":"Chiffvon P. Stanley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiffvon P. Stanley","raw_affiliation_strings":["From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017447077","display_name":"Andy Wessels","orcid":"https://orcid.org/0000-0002-3805-9361","observed_orcids":["https://orcid.org/0000-0002-3805-9361"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy Wessels","raw_affiliation_strings":["From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016255536","display_name":"Robert G. Gourdie","orcid":"https://orcid.org/0000-0001-6021-0796","observed_orcids":["https://orcid.org/0000-0001-6021-0796"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Gourdie","raw_affiliation_strings":["From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058401903","display_name":"Robert P. Thompson","orcid":"https://orcid.org/0000-0001-9459-5014","observed_orcids":["https://orcid.org/0000-0001-9459-5014"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Thompson","raw_affiliation_strings":["From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089127172","display_name":"David Sedmera","orcid":"https://orcid.org/0000-0002-6828-3671","observed_orcids":["https://orcid.org/0000-0002-6828-3671"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Sedmera","raw_affiliation_strings":["From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":null,"apc_paid":null,"fwci":7.8033,"has_fulltext":false,"cited_by_count":187,"citation_normalized_percentile":{"value":0.97753623,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"93","issue":"1","first_page":"77","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.11410000175237656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/his-purkinje-system","display_name":"His-Purkinje system","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mechanical-conditioning","display_name":"mechanical conditioning","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ventricular-activation-sequence","display_name":"ventricular activation sequence","score":0.718999981880188},{"id":"https://openalex.org/keywords/embryonic-chick-heart","display_name":"chick embryo heart","score":0.828000009059906},{"id":"https://openalex.org/keywords/voltage-sensitive-dye-imaging","display_name":"voltage-sensitive dye imaging","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7636326551437378},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6744881868362427},{"id":"https://openalex.org/C2777837822","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Embryonic heart","level":4,"score":0.6233190894126892},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.4919681251049042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44843265414237976},{"id":"https://openalex.org/C104397207","wikidata":"https://www.wikidata.org/wiki/Q72711","display_name":"Electrical conduction system of the heart","level":3,"score":0.43880799412727356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4267263412475586},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.39794230461120605},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34338581562042236},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34145835041999817},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3200695514678955},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3100377321243286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2714928984642029},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.1495542824268341},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13490909337997437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09705603122711182}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011690","descriptor_name":"Purkinje Fibers","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D011690","descriptor_name":"Purkinje Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011690","descriptor_name":"Purkinje Fibers","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012794","descriptor_name":"Sialic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018636","descriptor_name":"Hypoplastic Left Heart Syndrome","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D018636","descriptor_name":"Hypoplastic Left Heart Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018636","descriptor_name":"Hypoplastic Left Heart Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D039842","descriptor_name":"Neural Cell Adhesion Molecule L1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.res.0000079488.91342.b7","doi":"https://doi.org/10.1161/01.res.0000079488.91342.b7","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.res.0000079488.91342.b7","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.319.9509","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.319.9509","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://circres.ahajournals.org/content/93/1/77.full.pdf","raw_type":"text"},{"id":"pmid:12775585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12775585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1016.8020","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1016.8020","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circres.ahajournals.org/content/circresaha/93/1/77.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1847591888","display_name":"SC COBRE FOR DEVELOPMENTALLY BASED CARDIOVASCULAR DISEASES","funder_award_id":"P20RR016434","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3146790886","display_name":"Patterning by Invasive Mesenchyme in the Embryonic Heart","funder_award_id":"P01HD039946","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4200520076","display_name":"CARDIAC VALVULOSEPTAL MORPHOGENESIS","funder_award_id":"P01HL052813","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8767955877","display_name":"Myocyte proliferation in the embryonic chick heart","funder_award_id":"R01HL050582","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W168986857","https://openalex.org/W577652691","https://openalex.org/W1605626601","https://openalex.org/W1892221115","https://openalex.org/W1932853204","https://openalex.org/W1967639969","https://openalex.org/W1973174941","https://openalex.org/W1973706332","https://openalex.org/W1977862100","https://openalex.org/W1979408336","https://openalex.org/W1980141913","https://openalex.org/W1980165205","https://openalex.org/W1980646691","https://openalex.org/W1983712628","https://openalex.org/W2023367406","https://openalex.org/W2023450190","https://openalex.org/W2032980828","https://openalex.org/W2035536816","https://openalex.org/W2039183965","https://openalex.org/W2039503779","https://openalex.org/W2046032102","https://openalex.org/W2051014693","https://openalex.org/W2056458634","https://openalex.org/W2066048575","https://openalex.org/W2069099652","https://openalex.org/W2088204183","https://openalex.org/W2089247555","https://openalex.org/W2106418785","https://openalex.org/W2111332752","https://openalex.org/W2114437999","https://openalex.org/W2122008653","https://openalex.org/W2122867046","https://openalex.org/W2130070649","https://openalex.org/W2140034535","https://openalex.org/W2140802783","https://openalex.org/W2159999909","https://openalex.org/W2169764232","https://openalex.org/W2170791805","https://openalex.org/W2171952998","https://openalex.org/W2184890399","https://openalex.org/W2467138163","https://openalex.org/W2941355343"],"related_works":["https://openalex.org/W7095918276","https://openalex.org/W2111332752","https://openalex.org/W2076133822","https://openalex.org/W2016426885","https://openalex.org/W2030068863","https://openalex.org/W2043934828","https://openalex.org/W2087650779","https://openalex.org/W2051014693","https://openalex.org/W4402147433","https://openalex.org/W201889823"],"abstract_inverted_index":{"The":[0,163,200],"His-Purkinje":[1],"system":[2,110],"(HPS)":[3],"is":[4,35,111],"a":[5,38,206,223],"network":[6],"of":[7,15,28,44,46,54,60,72,92,101,107,120,128,159,169,183,214,222,228,237],"conduction":[8,109],"cells":[9],"responsible":[10],"for":[11,209,226],"coordinating":[12],"the":[13,16,25,29,32,42,47,52,68,73,93,99,102,108,160,167,170,220,229,238],"contraction":[14],"ventricles.":[17],"Earlier":[18],"studies":[19,227],"using":[20],"bipolar":[21],"electrodes":[22],"indicated":[23],"that":[24,80,98,166],"functional":[26],"maturation":[27,106],"HPS":[30,185,239],"in":[31,41,90,115,134,212,233,240],"chick":[33,135],"embryo":[34],"marked":[36],"by":[37,125],"topological":[39,103],"shift":[40,104,171],"sequence":[43,59],"activation":[45,62,122,174],"ventricle.":[48],"Namely,":[49],"at":[50],"around":[51],"completion":[53],"septation,":[55],"an":[56],"immature":[57],"base-to-apex":[58],"ventricular":[61,121],"was":[63,192],"reported":[64],"to":[65,67,113,172,180,188,197],"convert":[66],"apex-to-base":[69],"pattern":[70],"characteristic":[71],"mature":[74,173,184],"heart.":[75,162],"Previously,":[76],"we":[77],"have":[78],"proposed":[79],"hemodynamics":[81],"and/or":[82],"mechanical":[83],"conditioning":[84],"may":[85],"be":[86],"key":[87],"epigenetic":[88],"factors":[89,211],"development":[91],"HPS.":[94],"We":[95],"thus":[96],"hypothesized":[97],"timing":[100,168],"marking":[105],"sensitive":[112],"variation":[114],"hemodynamic":[116,157],"load.":[117],"Spatiotemporal":[118],"patterns":[119],"(as":[123],"revealed":[124,165],"high-speed":[126],"imaging":[127],"fluorescent":[129],"voltage-sensitive":[130],"dye)":[131],"were":[132],"mapped":[133],"hearts":[136],"over":[137],"normal":[138],"development,":[139],"and":[140,218,235],"following":[141],"procedures":[142],"previously":[143],"characterized":[144],"as":[145],"causing":[146],"increased":[147],"(conotruncal":[148],"banding,":[149],"CTB)":[150],"or":[151],"reduced":[152],"(left":[153],"atrial":[154],"ligation,":[155],"LAL)":[156],"loading":[158],"embryonic":[161],"results":[164,201],"displays":[175],"striking":[176],"plasticity.":[177],"CTB":[178],"led":[179],"precocious":[181],"emergence":[182],"function":[186],"relative":[187],"controls":[189],"whereas":[190],"LAL":[191],"associated":[193],"with":[194],"delayed":[195],"conversion":[196],"apical":[198],"initiation.":[199],"from":[202],"our":[203],"study":[204],"indicate":[205],"critical":[207],"role":[208],"biophysical":[210],"differentiation":[213],"specialized":[215],"cardiac":[216],"tissues":[217],"provide":[219],"basis":[221],"new":[224],"model":[225],"molecular":[230],"mechanisms":[231],"involved":[232],"induction":[234],"patterning":[236],"vivo.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
