{"id":"https://openalex.org/W2003283600","doi":"https://doi.org/10.1038/85064","title":"BACE1 is the major \u03b2-secretase for generation of A\u03b2 peptides by neurons","display_name":"BACE1 is the major \u03b2-secretase for generation of A\u03b2 peptides by neurons","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2003283600","doi":"https://doi.org/10.1038/85064","mag":"2003283600","pmid":"https://pubmed.ncbi.nlm.nih.gov/11224536"},"language":"en","primary_location":{"id":"doi:10.1038/85064","doi":"https://doi.org/10.1038/85064","is_oa":false,"landing_page_url":"https://doi.org/10.1038/85064","pdf_url":null,"source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2003283600"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054853061","display_name":"Huaibin Cai","orcid":"https://orcid.org/0000-0002-8596-6108","observed_orcids":["https://orcid.org/0000-0002-8596-6108"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaibin Cai","raw_affiliation_strings":["Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037037671","display_name":"Yanshu Wang","orcid":"https://orcid.org/0000-0001-8473-8165","observed_orcids":["https://orcid.org/0000-0001-8473-8165"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanshu Wang","raw_affiliation_strings":["Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086135676","display_name":"Diane B. McCarthy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diane McCarthy","raw_affiliation_strings":["Ciphergen Biosystems, Fremont, 94555, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciphergen Biosystems, Fremont, 94555, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010922108","display_name":"Hongjin Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongjin Wen","raw_affiliation_strings":["Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038629622","display_name":"David Borchelt","orcid":"https://orcid.org/0000-0002-0813-6979","observed_orcids":["https://orcid.org/0000-0002-0813-6979"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Borchelt","raw_affiliation_strings":["Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105775039","display_name":"Donald L. Price","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald L. Price","raw_affiliation_strings":["Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082509711","display_name":"Philip C. Wong","orcid":"https://orcid.org/0000-0001-8162-3274","observed_orcids":["https://orcid.org/0000-0001-8162-3274"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip C. Wong","raw_affiliation_strings":["Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082509711"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":19.8066,"has_fulltext":false,"cited_by_count":1089,"citation_normalized_percentile":{"value":0.99885145,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"3","first_page":"233","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bace1","display_name":"BACE1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bace2","display_name":"BACE2","score":0.9129999876022339},{"id":"https://openalex.org/keywords/beta-secretase","display_name":"beta-secretase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7519999742507935},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.7929999828338623},{"id":"https://openalex.org/keywords/app-cleavage","display_name":"APP cleavage","score":0.753000020980835},{"id":"https://openalex.org/keywords/species-specificity","display_name":"species specificity","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.7820000052452087},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C19014433","wikidata":"https://www.wikidata.org/wiki/Q5130995","display_name":"Cleave","level":3,"score":0.8555811643600464},{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.7588620781898499},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.7044099569320679},{"id":"https://openalex.org/C41007966","wikidata":"https://www.wikidata.org/wiki/Q908080","display_name":"Alpha secretase","level":5,"score":0.5780688524246216},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.565538227558136},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.5128531455993652},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4893040359020233},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.4707793891429901},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45586633682250977},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.45046138763427734},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4092858135700226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40231645107269287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3651966452598572},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3255978226661682},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20755988359451294},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16541334986686707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1387847661972046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10056105256080627},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/85064","doi":"https://doi.org/10.1038/85064","is_oa":false,"landing_page_url":"https://doi.org/10.1038/85064","pdf_url":null,"source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},{"id":"pmid:11224536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11224536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7103205595","display_name":"Johns Hopkins Alzheimer's Disease Research Center","funder_award_id":"P50AG005146","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7707717941","display_name":"PRESENILINS IN MODELS OF FAMILIAL ALZHEIMERS DISEASE","funder_award_id":"P01AG014248","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1644122431","https://openalex.org/W1854324009","https://openalex.org/W1945588738","https://openalex.org/W1989972829","https://openalex.org/W2023531011","https://openalex.org/W2043659328","https://openalex.org/W2065447152","https://openalex.org/W2079651671","https://openalex.org/W2100120613","https://openalex.org/W2108649886","https://openalex.org/W2133019124","https://openalex.org/W2154375856","https://openalex.org/W2162815565"],"related_works":["https://openalex.org/W1552826563","https://openalex.org/W2093356656","https://openalex.org/W1628537354","https://openalex.org/W1996518142","https://openalex.org/W2536797771","https://openalex.org/W7028537102","https://openalex.org/W2001489479","https://openalex.org/W2139018071","https://openalex.org/W2519505494","https://openalex.org/W58577151"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":39},{"year":2018,"cited_by_count":39},{"year":2017,"cited_by_count":44},{"year":2016,"cited_by_count":53},{"year":2015,"cited_by_count":49},{"year":2014,"cited_by_count":65},{"year":2013,"cited_by_count":45},{"year":2012,"cited_by_count":55}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
